Reviewed, UniProtKB/Swiss-Prot Q21QL9 (CCMA_RHOFD)

Names and origin

Protein names

Recommended name:
    Cytochrome c biogenesis ATP-binding export protein ccmA
    EC=3.6.3.41
Alternative name(s):
    Heme exporter protein A

Gene names

Name:	ccmA
Ordered Locus Names:	Rfer_0045

Organism

Rhodoferax ferrireducens (strain DSM 15236 / ATCC BAA-621 / T118) [Complete proteome] [HAMAP]

Taxonomic identifier

338969 [NCBI]

Taxonomic lineage

Bacteria › Proteobacteria › Betaproteobacteria › Burkholderiales › Comamonadaceae › Rhodoferax

Protein attributes

Sequence length	210 AA.
Sequence status	Complete.
Protein existence	Inferred from homology.

General annotation (Comments)

Function	Part of the ABC transporter complex ccmAB involved in the biogenesis of c-type cytochromes; once thought to export heme, this seems not to be the case, but its exact role is uncertain. Responsible for energy coupling to the transport system By similarity. HAMAP MF_01707
Catalytic activity	ATP + H2O + heme(In) = ADP + phosphate + heme(Out). HAMAP MF_01707
Subunit structure	The complex is composed of two ATP-binding proteins (ccmA) and two transmembrane proteins (ccmB) Probable. HAMAP MF_01707
Subcellular location	Cell inner membrane; Peripheral membrane protein By similarity HAMAP MF_01707.
Sequence similarities	Belongs to the ABC transporter superfamily. CcmA exporter (TC 3.A.1.107) family. [View classification] Contains 1 ABC transporter domain.

Ontologies

Keywords
Biological process	Cytochrome c-type biogenesis Transport
Cellular component	Cell inner membrane Cell membrane Membrane
Ligand	ATP-binding Nucleotide-binding
Molecular function	Hydrolase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	cytochrome complex assembly Inferred from electronic annotation. Source: UniProtKB-KW transport Inferred from electronic annotation. Source: HAMAP
Cellular component	extrinsic to membrane Inferred from electronic annotation. Source: UniProtKB-SubCell outer membrane-bounded periplasmic space Inferred from electronic annotation. Source: InterPro plasma membrane Inferred from electronic annotation. Source: UniProtKB-KW
Molecular function	ATP binding Inferred from electronic annotation. Source: UniProtKB-KW heme-transporting ATPase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 210	210	Cytochrome c biogenesis ATP-binding export protein ccmA HAMAP MF_01707		PRO_0000271948
Regions
	Domain	4 – 208	205	ABC transporter
	Nucleotide binding	39 – 46	8	ATP Potential

Sequences

	Sequence		Length	Mass (Da)
	Q21QL9-1 [UniParc]. Last modified April 18, 2006. Version 1. Checksum: 113F086B096EC6E1	FASTA	210	22,682
	10 20 30 40 50 60 MKTVPTLSFS KLGCSRGGRQ LFQNIDCVLE SGHWLYVAGA NGVGKTSLLR MVCGLAPIES 70 80 90 100 110 120 GEIFWNGTPI HAQADAYRQD LCYLGHLNAL QESMTVHENL AFTAALGGMA PDMAQTQSVL 130 140 150 160 170 180 AHFGVAGRDR QLVRHLSQGQ KRRVALSRLA LSQARLWVLD EPFVAMDEAG VRMLADLIAA 190 200 210 HLTQGGLAVL TSHQQVDIGA IPAQLLELRA

References

[1]

"Complete sequence of chromosome of Rhodoferax ferrireducens DSM 15236." Copeland A., Lucas S., Lapidus A., Barry K., Detter J.C., Glavina del Rio T., Hammon N., Israni S., Pitluck S., Brettin T., Bruce D., Han C., Tapia R., Gilna P., Kiss H., Schmutz J., Larimer F., Land M. , Kyrpides N., Ivanova N., Richardson P. Submitted (FEB-2006) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

Cross-references

Sequence databases
EMBL GenBank DDBJ	CP000267 Genomic DNA. Translation: ABD67807.1.
RefSeq	YP_521338.1.
3D structure databases
SMR	Q21QL9. Positions 7-198.
ModBase	Search...
Protein-protein interaction databases
STRING	Q21QL9.
Genome annotation databases
GeneID	3960300.
GenomeReviews	Gene locus Rfer_0045 in contig CP000267_GR.
KEGG	rfr:Rfer_0045.
NMPDR	fig|338969.3.peg.324.
Organism-specific databases
CMR	Search...
Phylogenomic databases
eggNOG	COG4133.
HOGENOM	HBG758042.
OMA	QTGVKRE.
PhylomeDB	Q21QL9.
Enzyme and pathway databases
BioCyc	RFER338969:RFER_0045-MONOMER.
Family and domain databases
HAMAP	MF_01707. ABC_ATPase_CcmA. [Tree]
InterPro	IPR003439. ABC_transporter-like. IPR017871. ABC_transporter_CS. IPR005895. ABC_transptr_haem_export_CcmA. IPR003593. ATPase_AAA+_core. [Graphical view]
PANTHER	PTHR19222:SF5. CcmA. 1 hit.
Pfam	PF00005. ABC_tran. 1 hit. [Graphical view]
SMART	SM00382. AAA. 1 hit. [Graphical view]
TIGRFAMs	TIGR01189. ccmA. 1 hit.
PROSITE	PS00211. ABC_TRANSPORTER_1. 1 hit. PS50893. ABC_TRANSPORTER_2. 1 hit. PS51243. CCMA. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

CCMA_RHOFD

Accession

Primary (citable) accession number: Q21QL9

Entry history

Integrated into UniProtKB/Swiss-Prot:	January 9, 2007
Last sequence update:	April 18, 2006
Last modified:	February 9, 2010
This is version 36 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HAMAP (High-quality Automated and Manual Annotation of microbial Proteomes)