Q21MZ8 (PUR7_SACD2) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Phosphoribosylaminoimidazole-succinocarboxamide synthase
EC=6.3.2.6

Alternative name(s):
SAICAR synthetase

Gene names

Name:	purC
Ordered Locus Names:	Sde_0669

Organism

Saccharophagus degradans (strain 2-40 / ATCC 43961 / DSM 17024) [Complete proteome] [HAMAP]

Taxonomic identifier

203122 [NCBI]

Taxonomic lineage

Bacteria › Proteobacteria › Gammaproteobacteria › Alteromonadales › Alteromonadaceae › Saccharophagus

Protein attributes

Sequence length	367 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Catalytic activity	ATP + 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxylate + L-aspartate = ADP + phosphate + (S)-2-(5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxamido)succinate. HAMAP MF_00137
Pathway	Purine metabolism; IMP biosynthesis via de novo pathway; 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide from 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxylate: step 1/2. HAMAP MF_00137
Sequence similarities	Belongs to the SAICAR synthetase family.

Ontologies

Keywords
Biological process	Purine biosynthesis
Ligand	ATP-binding Nucleotide-binding
Molecular function	Ligase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	purine nucleotide biosynthetic process Inferred from electronic annotation. Source: UniProtKB-KW
Molecular function	ATP binding Inferred from electronic annotation. Source: UniProtKB-KW phosphoribosylaminoimidazolesuccinocarboxamide synthase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 367	367	Phosphoribosylaminoimidazole-succinocarboxamide synthase HAMAP MF_00137		PRO_1000117842

Sequences

	Sequence		Length	Mass (Da)
	Q21MZ8 [UniParc]. Last modified April 18, 2006. Version 1. Checksum: D60275ED2C5B1E07	FASTA	367	41,284
	10 20 30 40 50 60 MSLAHQVLAV NNDLPIRTDK PVHSGKVRSV YWLTAEDSAR LIKEKGYNVA ADAPLAIMVI 70 80 90 100 110 120 SDRLSAFDCI WHAEGDVRGV PGKGAALNAI SNHWFELFRQ NGLADSHILD IPHPFIWIVQ 130 140 150 160 170 180 KAKPVMIEAI CRQYITGSMW RAYSKGERNF CGINLEDGLQ KDQKLSELLI TPSTKGILKG 190 200 210 220 230 240 VPGVPEVDDV NITRADIENN FAAFQFKQKS DIDQYEKLLK EGFNLISGAL EELDQIFVDT 250 260 270 280 290 300 KFEFGYVTDA SGNDKLIYMD EVGTPDSSRI WDGENYRNGK IIEKSKEGFR QTLLSHFPDP 310 320 330 340 350 360 DILLNKDRMP ERQALAQDNA LPIDVFMDLS STYLDIAEKI TGQKIVLSEN PKQEIIDILA RDFDVII

References

[1]

"Complete genome sequence of the complex carbohydrate-degrading marine bacterium, Saccharophagus degradans strain 2-40 T." Weiner R.M., Taylor L.E. II, Henrissat B., Hauser L., Land M., Coutinho P.M., Rancurel C., Saunders E.H., Longmire A.G., Zhang H., Bayer E.A., Gilbert H.J., Larimer F., Zhulin I.B., Ekborg N.A., Lamed R., Richardson P.M., Borovok I., Hutcheson S. PLoS Genet. 4:E1000087-E1000087(2008) [PubMed: 18516288] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: 2-40 / ATCC 43961 / DSM 17024.

Cross-references

Sequence databases
EMBL GenBank DDBJ	CP000282 Genomic DNA. Translation: ABD79931.1.
RefSeq	YP_526143.1. NC_007912.1.
3D structure databases
ProteinModelPortal	Q21MZ8.
ModBase	Search...
Protein-protein interaction databases
STRING	Q21MZ8.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	3967643.
GenomeReviews	Gene locus Sde_0669 in contig CP000282_GR.
KEGG	sde:Sde_0669.
NMPDR	fig|203122.1.peg.347.
PATRIC	23400075. VBISacDeg56404_0742.
Organism-specific databases
CMR	Search...
Phylogenomic databases
eggNOG	COG0152.
HOGENOM	HBG555040.
OMA	SSRIWDG.
PhylomeDB	Q21MZ8.
ProtClustDB	PRK13960.
Enzyme and pathway databases
BioCyc	SDEG203122:SDE_0669-MONOMER.
Family and domain databases
HAMAP	MF_00137. SAICAR_synth. [Tree]
InterPro	IPR013816. ATP_grasp_subdomain_2. IPR014106. PurC_vibrio. IPR001636. SAICAR_synth. [Graphical view]
Gene3D	G3DSA:3.30.470.20. ATP_grasp_subdomain_2. 1 hit.
KO	K01923.
PANTHER	PTHR11609. SAICAR_synt. 1 hit.
Pfam	PF01259. SAICAR_synt. 1 hit. [Graphical view]
TIGRFAMs	TIGR02735. PurC_vibrio. 1 hit.
PROSITE	PS01057. SAICAR_SYNTHETASE_1. False negative. PS01058. SAICAR_SYNTHETASE_2. False negative. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

PUR7_SACD2

Accession

Primary (citable) accession number: Q21MZ8

Entry history

Integrated into UniProtKB/Swiss-Prot:	April 14, 2009
Last sequence update:	April 18, 2006
Last modified:	January 25, 2012
This is version 47 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program