Q21MT2 (APAH_SACD2) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Bis(5'-nucleosyl)-tetraphosphatase, symmetrical
EC=3.6.1.41

Alternative name(s):
Ap4A hydrolase
Diadenosine 5',5'''-P1,P4-tetraphosphate pyrophosphohydrolase
Diadenosine tetraphosphatase

Gene names

Name:	apaH
Ordered Locus Names:	Sde_0735

Organism

Saccharophagus degradans (strain 2-40 / ATCC 43961 / DSM 17024) [Complete proteome] [HAMAP]

Taxonomic identifier

203122 [NCBI]

Taxonomic lineage

Bacteria › Proteobacteria › Gammaproteobacteria › Alteromonadales › Alteromonadaceae › Saccharophagus

Protein attributes

Sequence length	271 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Function	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP By similarity. HAMAP MF_00199
Catalytic activity	P1,P(4)-bis(5'-adenosyl) tetraphosphate + H2O = 2 ADP. HAMAP MF_00199
Sequence similarities	Belongs to the Ap4A hydrolase family.

Ontologies

Keywords
Molecular function	Hydrolase
Technical term	Complete proteome
Gene Ontology (GO)
Molecular function	bis(5'-nucleosyl)-tetraphosphatase (symmetrical) activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 271	271	Bis(5'-nucleosyl)-tetraphosphatase, symmetrical HAMAP MF_00199		PRO_1000012085

Sequences

	Sequence		Length	Mass (Da)
	Q21MT2 [UniParc]. Last modified April 18, 2006. Version 1. Checksum: B4026CC8271AC00B	FASTA	271	30,183
	10 20 30 40 50 60 MATYAVGDIQ GCYRALKLLL KKVKFNADND HLWVAGDLVN RGPESLKSLR YIKKLGPSAT 70 80 90 100 110 120 LVLGNHDLHL LAHAYGVRTL NPKDTLAPIL TAKDSDELLE WLQAQPLLHY DAEFDAVLVH 130 140 150 160 170 180 AGIPPIWSIE NALNYALEVE QALSTTQTAA AFFVDMYGNQ PDVWQPSLEG TARLRLITNY 190 200 210 220 230 240 LTRMRFCSPT GKLELQTKNA PSLPPTGFAP WYTHKHNKWG NTKILFGHWA ALMGETRSKQ 250 260 270 FIGLDTGCVW GGALTMMRLE DGQFFAVDCP C

References

[1]

"Complete genome sequence of the complex carbohydrate-degrading marine bacterium, Saccharophagus degradans strain 2-40 T." Weiner R.M., Taylor L.E. II, Henrissat B., Hauser L., Land M., Coutinho P.M., Rancurel C., Saunders E.H., Longmire A.G., Zhang H., Bayer E.A., Gilbert H.J., Larimer F., Zhulin I.B., Ekborg N.A., Lamed R., Richardson P.M., Borovok I., Hutcheson S. PLoS Genet. 4:E1000087-E1000087(2008) [PubMed: 18516288] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: 2-40 / ATCC 43961 / DSM 17024.

Cross-references

Sequence databases
EMBL GenBank DDBJ	CP000282 Genomic DNA. Translation: ABD79997.1.
RefSeq	YP_526209.1. NC_007912.1.
3D structure databases
ProteinModelPortal	Q21MT2.
ModBase	Search...
Protein-protein interaction databases
STRING	Q21MT2.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	3966256.
GenomeReviews	Gene locus Sde_0735 in contig CP000282_GR.
KEGG	sde:Sde_0735.
NMPDR	fig|203122.1.peg.4323.
PATRIC	23400219. VBISacDeg56404_0813.
Organism-specific databases
CMR	Search...
Phylogenomic databases
eggNOG	COG0639.
HOGENOM	HBG724457.
OMA	LVFGHWA.
PhylomeDB	Q21MT2.
ProtClustDB	PRK00166.
Enzyme and pathway databases
BioCyc	SDEG203122:SDE_0735-MONOMER.
Family and domain databases
HAMAP	MF_00199. ApaH. [Tree]
InterPro	IPR004617. ApaH. IPR004843. Metallo_PEstase_dom. [Graphical view]
KO	K01525.
Pfam	PF00149. Metallophos. 1 hit. [Graphical view]
PIRSF	PIRSF000903. B5n-ttraPtase_sm. 1 hit.
TIGRFAMs	TIGR00668. ApaH. 1 hit.
ProtoNet	Search...

Entry information

Entry name

APAH_SACD2

Accession

Primary (citable) accession number: Q21MT2

Entry history

Integrated into UniProtKB/Swiss-Prot:	January 15, 2008
Last sequence update:	April 18, 2006
Last modified:	January 25, 2012
This is version 37 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program