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Q21MS9

- PDXA_SACD2

UniProt

Q21MS9 - PDXA_SACD2

Protein

4-hydroxythreonine-4-phosphate dehydrogenase

Gene

pdxA

Organism
Saccharophagus degradans (strain 2-40 / ATCC 43961 / DSM 17024)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 59 (01 Oct 2014)
      Sequence version 1 (18 Apr 2006)
      Previous versions | rss
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    Functioni

    Catalyzes the NAD(P)-dependent oxidation of 4-(phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4-(phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP).UniRule annotation

    Catalytic activityi

    4-phosphonooxy-L-threonine + NAD+ = 3-amino-2-oxopropyl phosphate + CO2 + NADH.

    Cofactori

    Binds 1 divalent metal cation per subunit. Can use ions such as zinc, magnesium or cobalt.UniRule annotation

    Pathwayi

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Binding sitei135 – 1351SubstrateUniRule annotation
    Binding sitei136 – 1361SubstrateUniRule annotation
    Metal bindingi165 – 1651Divalent metal cation; shared with dimeric partnerUniRule annotation
    Metal bindingi210 – 2101Divalent metal cation; shared with dimeric partnerUniRule annotation
    Metal bindingi265 – 2651Divalent metal cation; shared with dimeric partnerUniRule annotation
    Binding sitei273 – 2731SubstrateUniRule annotation
    Binding sitei282 – 2821SubstrateUniRule annotation
    Binding sitei291 – 2911SubstrateUniRule annotation

    GO - Molecular functioni

    1. 4-hydroxythreonine-4-phosphate dehydrogenase activity Source: UniProtKB-HAMAP
    2. cobalt ion binding Source: UniProtKB-HAMAP
    3. magnesium ion binding Source: UniProtKB-HAMAP
    4. NAD binding Source: InterPro
    5. zinc ion binding Source: UniProtKB-HAMAP

    GO - Biological processi

    1. pyridoxal phosphate biosynthetic process Source: UniProtKB-HAMAP
    2. pyridoxine biosynthetic process Source: UniProtKB-HAMAP

    Keywords - Molecular functioni

    Oxidoreductase

    Keywords - Biological processi

    Pyridoxine biosynthesis

    Keywords - Ligandi

    Cobalt, Magnesium, Metal-binding, NAD, NADP, Zinc

    Enzyme and pathway databases

    BioCyciSDEG203122:GI2M-743-MONOMER.
    UniPathwayiUPA00244; UER00312.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    4-hydroxythreonine-4-phosphate dehydrogenaseUniRule annotation (EC:1.1.1.262UniRule annotation)
    Alternative name(s):
    4-(phosphohydroxy)-L-threonine dehydrogenaseUniRule annotation
    Gene namesi
    Name:pdxAUniRule annotation
    Ordered Locus Names:Sde_0738
    OrganismiSaccharophagus degradans (strain 2-40 / ATCC 43961 / DSM 17024)
    Taxonomic identifieri203122 [NCBI]
    Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaAlteromonadalesAlteromonadaceaeSaccharophagus
    ProteomesiUP000001947: Chromosome

    Subcellular locationi

    Cytoplasm UniRule annotation

    GO - Cellular componenti

    1. cytoplasm Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cytoplasm

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 3353354-hydroxythreonine-4-phosphate dehydrogenasePRO_1000051513Add
    BLAST

    Interactioni

    Subunit structurei

    Homodimer.UniRule annotation

    Protein-protein interaction databases

    STRINGi203122.Sde_0738.

    Structurei

    3D structure databases

    ProteinModelPortaliQ21MS9.
    SMRiQ21MS9. Positions 7-320.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the PdxA family.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG1995.
    HOGENOMiHOG000221592.
    KOiK00097.
    OMAiAIGTEDE.
    OrthoDBiEOG6GN6ZC.

    Family and domain databases

    Gene3Di3.40.718.10. 1 hit.
    HAMAPiMF_00536. PdxA.
    InterProiIPR024084. IsoPropMal-DH-like_dom.
    IPR005255. PdxA.
    [Graphical view]
    PfamiPF04166. PdxA. 1 hit.
    [Graphical view]
    TIGRFAMsiTIGR00557. pdxA. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    Q21MS9-1 [UniParc]FASTAAdd to Basket

    « Hide

    MSHPAIIALT PGEPAGIGPD LTVMAAQQAR DYPLVALCDP QLLKDRAKLL    50
    GLPLTVSTYI QGSAVTTSAQ HISVMPIPLG APCEAGTLDS TNAAYVIETL 100
    KQATEGCLSG EFAAVVTGPV QKSVINEAGI NFSGHTEYFA DNSNTPRVVM 150
    MLATEGLRVA LATTHLPLKD VSAAITTASL TETLNILLAD LQLKFGLSQP 200
    RVLVCGLNPH AGEGGHLGME EIDTIIPVLE QFRARGHNLV GPLPADTLFN 250
    PKYLSDADAV LAMYHDQGLP VLKYKGFGNA VNITLGLPFI RTSVDHGTAL 300
    DLAGTGKANI GSLQVALGYA QNLAMQQASI NEIAG 335
    Length:335
    Mass (Da):35,022
    Last modified:April 18, 2006 - v1
    Checksum:i2C97F33B5DF966A5
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000282 Genomic DNA. Translation: ABD80000.1.
    RefSeqiWP_011467221.1. NC_007912.1.
    YP_526212.1. NC_007912.1.

    Genome annotation databases

    EnsemblBacteriaiABD80000; ABD80000; Sde_0738.
    GeneIDi3966259.
    KEGGisde:Sde_0738.
    PATRICi23400225. VBISacDeg56404_0816.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000282 Genomic DNA. Translation: ABD80000.1 .
    RefSeqi WP_011467221.1. NC_007912.1.
    YP_526212.1. NC_007912.1.

    3D structure databases

    ProteinModelPortali Q21MS9.
    SMRi Q21MS9. Positions 7-320.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 203122.Sde_0738.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai ABD80000 ; ABD80000 ; Sde_0738 .
    GeneIDi 3966259.
    KEGGi sde:Sde_0738.
    PATRICi 23400225. VBISacDeg56404_0816.

    Phylogenomic databases

    eggNOGi COG1995.
    HOGENOMi HOG000221592.
    KOi K00097.
    OMAi AIGTEDE.
    OrthoDBi EOG6GN6ZC.

    Enzyme and pathway databases

    UniPathwayi UPA00244 ; UER00312 .
    BioCyci SDEG203122:GI2M-743-MONOMER.

    Family and domain databases

    Gene3Di 3.40.718.10. 1 hit.
    HAMAPi MF_00536. PdxA.
    InterProi IPR024084. IsoPropMal-DH-like_dom.
    IPR005255. PdxA.
    [Graphical view ]
    Pfami PF04166. PdxA. 1 hit.
    [Graphical view ]
    TIGRFAMsi TIGR00557. pdxA. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: 2-40 / ATCC 43961 / DSM 17024.

    Entry informationi

    Entry nameiPDXA_SACD2
    AccessioniPrimary (citable) accession number: Q21MS9
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: January 15, 2008
    Last sequence update: April 18, 2006
    Last modified: October 1, 2014
    This is version 59 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Miscellaneous

    The active site is located at the dimer interface.UniRule annotation

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3