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Q21MS9

- PDXA_SACD2

UniProt

Q21MS9 - PDXA_SACD2

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Protein
4-hydroxythreonine-4-phosphate dehydrogenase
Gene
pdxA, Sde_0738
Organism
Saccharophagus degradans (strain 2-40 / ATCC 43961 / DSM 17024)
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Catalyzes the NAD(P)-dependent oxidation of 4-(phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4-(phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP) By similarity.UniRule annotation

Catalytic activityi

4-phosphonooxy-L-threonine + NAD+ = 3-amino-2-oxopropyl phosphate + CO2 + NADH.UniRule annotation

Cofactori

Binds 1 divalent metal cation per subunit. Can use ions such as zinc, magnesium or cobalt By similarity.

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei135 – 1351Substrate By similarity
Binding sitei136 – 1361Substrate By similarity
Metal bindingi165 – 1651Divalent metal cation; shared with dimeric partner By similarity
Metal bindingi210 – 2101Divalent metal cation; shared with dimeric partner By similarity
Metal bindingi265 – 2651Divalent metal cation; shared with dimeric partner By similarity
Binding sitei273 – 2731Substrate By similarity
Binding sitei282 – 2821Substrate By similarity
Binding sitei291 – 2911Substrate By similarity

GO - Molecular functioni

  1. 4-hydroxythreonine-4-phosphate dehydrogenase activity Source: UniProtKB-HAMAP
  2. NAD binding Source: InterPro
  3. cobalt ion binding Source: UniProtKB-HAMAP
  4. magnesium ion binding Source: UniProtKB-HAMAP
  5. zinc ion binding Source: UniProtKB-HAMAP

GO - Biological processi

  1. pyridoxal phosphate biosynthetic process Source: UniProtKB-HAMAP
  2. pyridoxine biosynthetic process Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Biological processi

Pyridoxine biosynthesis

Keywords - Ligandi

Cobalt, Magnesium, Metal-binding, NAD, NADP, Zinc

Enzyme and pathway databases

BioCyciSDEG203122:GI2M-743-MONOMER.
UniPathwayiUPA00244; UER00312.

Names & Taxonomyi

Protein namesi
Recommended name:
4-hydroxythreonine-4-phosphate dehydrogenase (EC:1.1.1.262)
Alternative name(s):
4-(phosphohydroxy)-L-threonine dehydrogenase
Gene namesi
Name:pdxA
Ordered Locus Names:Sde_0738
OrganismiSaccharophagus degradans (strain 2-40 / ATCC 43961 / DSM 17024)
Taxonomic identifieri203122 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaAlteromonadalesAlteromonadaceaeSaccharophagus
ProteomesiUP000001947: Chromosome

Subcellular locationi

Cytoplasm By similarity UniRule annotation

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 3353354-hydroxythreonine-4-phosphate dehydrogenaseUniRule annotation
PRO_1000051513Add
BLAST

Interactioni

Subunit structurei

Homodimer By similarity.UniRule annotation

Protein-protein interaction databases

STRINGi203122.Sde_0738.

Structurei

3D structure databases

ProteinModelPortaliQ21MS9.
SMRiQ21MS9. Positions 7-320.

Family & Domainsi

Sequence similaritiesi

Belongs to the PdxA family.

Phylogenomic databases

eggNOGiCOG1995.
HOGENOMiHOG000221592.
KOiK00097.
OMAiAIGTEDE.
OrthoDBiEOG6GN6ZC.

Family and domain databases

Gene3Di3.40.718.10. 1 hit.
HAMAPiMF_00536. PdxA.
InterProiIPR024084. IsoPropMal-DH-like_dom.
IPR005255. PdxA.
[Graphical view]
PfamiPF04166. PdxA. 1 hit.
[Graphical view]
TIGRFAMsiTIGR00557. pdxA. 1 hit.

Sequencei

Sequence statusi: Complete.

Q21MS9-1 [UniParc]FASTAAdd to Basket

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MSHPAIIALT PGEPAGIGPD LTVMAAQQAR DYPLVALCDP QLLKDRAKLL    50
GLPLTVSTYI QGSAVTTSAQ HISVMPIPLG APCEAGTLDS TNAAYVIETL 100
KQATEGCLSG EFAAVVTGPV QKSVINEAGI NFSGHTEYFA DNSNTPRVVM 150
MLATEGLRVA LATTHLPLKD VSAAITTASL TETLNILLAD LQLKFGLSQP 200
RVLVCGLNPH AGEGGHLGME EIDTIIPVLE QFRARGHNLV GPLPADTLFN 250
PKYLSDADAV LAMYHDQGLP VLKYKGFGNA VNITLGLPFI RTSVDHGTAL 300
DLAGTGKANI GSLQVALGYA QNLAMQQASI NEIAG 335
Length:335
Mass (Da):35,022
Last modified:April 18, 2006 - v1
Checksum:i2C97F33B5DF966A5
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000282 Genomic DNA. Translation: ABD80000.1.
RefSeqiWP_011467221.1. NC_007912.1.
YP_526212.1. NC_007912.1.

Genome annotation databases

EnsemblBacteriaiABD80000; ABD80000; Sde_0738.
GeneIDi3966259.
KEGGisde:Sde_0738.
PATRICi23400225. VBISacDeg56404_0816.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000282 Genomic DNA. Translation: ABD80000.1 .
RefSeqi WP_011467221.1. NC_007912.1.
YP_526212.1. NC_007912.1.

3D structure databases

ProteinModelPortali Q21MS9.
SMRi Q21MS9. Positions 7-320.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 203122.Sde_0738.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai ABD80000 ; ABD80000 ; Sde_0738 .
GeneIDi 3966259.
KEGGi sde:Sde_0738.
PATRICi 23400225. VBISacDeg56404_0816.

Phylogenomic databases

eggNOGi COG1995.
HOGENOMi HOG000221592.
KOi K00097.
OMAi AIGTEDE.
OrthoDBi EOG6GN6ZC.

Enzyme and pathway databases

UniPathwayi UPA00244 ; UER00312 .
BioCyci SDEG203122:GI2M-743-MONOMER.

Family and domain databases

Gene3Di 3.40.718.10. 1 hit.
HAMAPi MF_00536. PdxA.
InterProi IPR024084. IsoPropMal-DH-like_dom.
IPR005255. PdxA.
[Graphical view ]
Pfami PF04166. PdxA. 1 hit.
[Graphical view ]
TIGRFAMsi TIGR00557. pdxA. 1 hit.
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: 2-40 / ATCC 43961 / DSM 17024.

Entry informationi

Entry nameiPDXA_SACD2
AccessioniPrimary (citable) accession number: Q21MS9
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 15, 2008
Last sequence update: April 18, 2006
Last modified: September 3, 2014
This is version 58 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Miscellaneous

The active site is located at the dimer interface By similarity.

Keywords - Technical termi

Complete proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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