Q21MP3 (ARAA_SACD2) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
L-arabinose isomerase
EC=5.3.1.4

Gene names

Name:	araA
Ordered Locus Names:	Sde_0774

Organism

Saccharophagus degradans (strain 2-40 / ATCC 43961 / DSM 17024) [Complete proteome] [HAMAP]

Taxonomic identifier

203122 [NCBI]

Taxonomic lineage

Bacteria › Proteobacteria › Gammaproteobacteria › Alteromonadales › Alteromonadaceae › Saccharophagus

Protein attributes

Sequence length	500 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Function	Catalyzes the conversion of L-arabinose to L-ribulose By similarity. HAMAP MF_00519
Catalytic activity	L-arabinose = L-ribulose. HAMAP MF_00519
Cofactor	Binds 1 manganese ion per subunit By similarity. HAMAP MF_00519
Pathway	Carbohydrate degradation; L-arabinose degradation via L-ribulose; D-xylulose 5-phosphate from L-arabinose (bacterial route): step 1/3. HAMAP MF_00519
Sequence similarities	Belongs to the arabinose isomerase family.

Ontologies

Keywords
Biological process	Arabinose catabolism Carbohydrate metabolism
Ligand	Manganese Metal-binding
Molecular function	Isomerase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	arabinose catabolic process Inferred from electronic annotation. Source: UniProtKB-KW fucose metabolic process Inferred from electronic annotation. Source: InterPro
Cellular component	cytoplasm Inferred from electronic annotation. Source: InterPro
Molecular function	L-arabinose isomerase activity Inferred from electronic annotation. Source: EC L-fucose isomerase activity Inferred from electronic annotation. Source: InterPro metal ion binding Inferred from electronic annotation. Source: UniProtKB-KW
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 500	500	L-arabinose isomerase HAMAP MF_00519		PRO_0000312616
Sites
	Metal binding	306	1	Manganese By similarity
	Metal binding	333	1	Manganese By similarity
	Metal binding	349	1	Manganese By similarity
	Metal binding	448	1	Manganese By similarity

Sequences

	Sequence		Length	Mass (Da)
	Q21MP3 [UniParc]. Last modified April 18, 2006. Version 1. Checksum: 109BB54E5E4948B9	FASTA	500	55,133
	10 20 30 40 50 60 MKIYGEKKIW FVTGSQHLYG PGVLAQVAEN SQAIAAGLTA SEHVSANIES RGVVTTPKEI 70 80 90 100 110 120 LDVCQAANSD ENCVGLILWM HTFSPAKMWI AGLSALNKPY MHLHTQFGAA LPWGDINMNY 130 140 150 160 170 180 MNLNQSAHGD REFGYIGTRL RQERKVVVGH WQKESVQIQV DDWVRAAMGW AESQTLKVAR 190 200 210 220 230 240 FGDNMRQVAV TEGDKVSAQI QFGYEVHAFG LGDLAKACEK ITAEQITAQL ELYKQDYEID 250 260 270 280 290 300 ADVFTDVHSL EMLQNEARLE LGMEAFLEEG NFKAFTNCFE NLTGLSGLPG LATQRLMSKG 310 320 330 340 350 360 YGYGGEGDWK TAAMCRIVKV MSLGKAAGTS FMEDYTYNFG DPDQVLGAHM LEVCPSISNE 370 380 390 400 410 420 KPKVVVERHT IGIKKDIARL IFTGTPGPAI NISTIDMGTR FRIIANEVDT VKPPQDLPNL 430 440 450 460 470 480 PVAKALWEPR PSLEVAAAAW IHAGGAHHSV YTQGINLDQL NDFAEMAGVE MVVIGADTNV 490 500 NEFKKELRFN AVYYHLSHGI

References

[1]

"Complete genome sequence of the complex carbohydrate-degrading marine bacterium, Saccharophagus degradans strain 2-40 T." Weiner R.M., Taylor L.E. II, Henrissat B., Hauser L., Land M., Coutinho P.M., Rancurel C., Saunders E.H., Longmire A.G., Zhang H., Bayer E.A., Gilbert H.J., Larimer F., Zhulin I.B., Ekborg N.A., Lamed R., Richardson P.M., Borovok I., Hutcheson S. PLoS Genet. 4:E1000087-E1000087(2008) [PubMed: 18516288] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: 2-40 / ATCC 43961 / DSM 17024.

Cross-references

Sequence databases
EMBL GenBank DDBJ	CP000282 Genomic DNA. Translation: ABD80036.1.
RefSeq	YP_526248.1. NC_007912.1.
3D structure databases
ProteinModelPortal	Q21MP3.
SMR	Q21MP3. Positions 1-496.
ModBase	Search...
Protein-protein interaction databases
STRING	Q21MP3.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	3965827.
GenomeReviews	Gene locus Sde_0774 in contig CP000282_GR.
KEGG	sde:Sde_0774.
NMPDR	fig|203122.1.peg.4280.
PATRIC	23400301. VBISacDeg56404_0854.
Organism-specific databases
CMR	Search...
Phylogenomic databases
eggNOG	COG2160.
HOGENOM	HBG297198.
OMA	EVCPTIA.
PhylomeDB	Q21MP3.
ProtClustDB	PRK02929.
Enzyme and pathway databases
BioCyc	SDEG203122:SDE_0774-MONOMER.
Family and domain databases
HAMAP	MF_00519. Arabinose_Isome. [Tree]
InterPro	IPR024664. Ara_Isoase_C. IPR004216. Fuc/Ara_isomerase_C. IPR009015. Fucose_isomerase_N/cen. IPR003762. Lara_isomerase. [Graphical view]
KO	K01804.
Pfam	PF11762. Arabinose_Iso_C. 1 hit. PF02610. Arabinose_Isome. 1 hit. [Graphical view]
PIRSF	PIRSF001478. L-ara_isomerase. 1 hit.
ProDom	PD018364. Lara_isomerase. 1 hit. [Graphical view] [Entries sharing at least one domain]
SUPFAM	SSF50443. Fuc_isomerase_C. 1 hit. SSF53743. Fuc_isomerase_N. 1 hit.
ProtoNet	Search...

Entry information

Entry name

ARAA_SACD2

Accession

Primary (citable) accession number: Q21MP3

Entry history

Integrated into UniProtKB/Swiss-Prot:	December 4, 2007
Last sequence update:	April 18, 2006
Last modified:	January 25, 2012
This is version 35 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program