Q21MC3 (PUR5_SACD2) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Phosphoribosylformylglycinamidine cyclo-ligase
EC=6.3.3.1

Alternative name(s):
AIR synthase
AIRS
Phosphoribosyl-aminoimidazole synthetase

Gene names

Name:	purM
Ordered Locus Names:	Sde_0894

Organism

Saccharophagus degradans (strain 2-40 / ATCC 43961 / DSM 17024) [Complete proteome] [HAMAP]

Taxonomic identifier

203122 [NCBI]

Taxonomic lineage

cellular organisms › Bacteria › Proteobacteria › Gammaproteobacteria › Alteromonadales › Alteromonadaceae › Saccharophagus › Saccharophagus degradans

Protein attributes

Sequence length	352 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Catalytic activity	ATP + 2-(formamido)-N(1)-(5-phospho-D-ribosyl)acetamidine = ADP + phosphate + 5-amino-1-(5-phospho-D-ribosyl)imidazole. HAMAP-Rule MF_00741
Pathway	Purine metabolism; IMP biosynthesis via de novo pathway; 5-amino-1-(5-phospho-D-ribosyl)imidazole from N(2)-formyl-N(1)-(5-phospho-D-ribosyl)glycinamide: step 2/2. HAMAP-Rule MF_00741
Subcellular location	Cytoplasm By similarity.
Sequence similarities	Belongs to the AIR synthase family.
Sequence caution	The sequence ABD80156.1 differs from that shown. Reason: Erroneous initiation.

Ontologies

Keywords
Biological process	Purine biosynthesis
Cellular component	Cytoplasm
Ligand	ATP-binding Nucleotide-binding
Molecular function	Ligase
Technical term	Complete proteome
Gene Ontology (GO)
Biological_process	'de novo' IMP biosynthetic process Inferred from electronic annotation. Source: UniProtKB-UniPathway
Cellular_component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular_function	ATP binding Inferred from electronic annotation. Source: UniProtKB-KW phosphoribosylformylglycinamidine cyclo-ligase activity Inferred from electronic annotation. Source: HAMAP
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 352	352	Phosphoribosylformylglycinamidine cyclo-ligase HAMAP-Rule MF_00741		PRO_0000258399

Sequences

	Sequence		Length	Mass (Da)
	Q21MC3 [UniParc]. Last modified October 31, 2006. Version 2. Checksum: 874DA43356064372	FASTA	352	36,976
	10 20 30 40 50 60 MTDSKSNSNS PSLSYKDAGV DIDAGNALVE RIKSVAKRTR RPEVMAGLGG FGALFELPKG 70 80 90 100 110 120 YQEPVLVAGT DGVGTKLKLA MQLNKHDTIG IDLVAMCVND LIVGGAEPLF FLDYYATGKL 130 140 150 160 170 180 SVDVAASVVE GIGAGCELSG CSLVGGETAE MPGMYEGEDY DLAGFCVGIV EKSKILDGSK 190 200 210 220 230 240 VAAGDVLLGI PSSGPHSNGY SLIRKVLEVS GASLDDKVGD TTLGQALLEP TRIYVKPLLE 250 260 270 280 290 300 LFKNVQVNAL SHITGGGLLE NIPRVLPENT RAQIDCASWE LPPVFKWLQE QGNINAVEMY 310 320 330 340 350 RTFNCGVGMI VCVPAAEAAN AIAQLKQSGE DAFEIGKIVA AEGAPEVDLL NL

References

[1]

"Complete genome sequence of the complex carbohydrate-degrading marine bacterium, Saccharophagus degradans strain 2-40 T." Weiner R.M., Taylor L.E. II, Henrissat B., Hauser L., Land M., Coutinho P.M., Rancurel C., Saunders E.H., Longmire A.G., Zhang H., Bayer E.A., Gilbert H.J., Larimer F., Zhulin I.B., Ekborg N.A., Lamed R., Richardson P.M., Borovok I., Hutcheson S. PLoS Genet. 4:E1000087-E1000087(2008) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: 2-40 / ATCC 43961 / DSM 17024.

Cross-references

Sequence databases
EMBL GenBank DDBJ	CP000282 Genomic DNA. Translation: ABD80156.1. Different initiation.
RefSeq	YP_526368.1. NC_007912.1.
3D structure databases
ProteinModelPortal	Q21MC3.
SMR	Q21MC3. Positions 12-347.
ModBase	Search...
Protein-protein interaction databases
STRING	203122.Sde_0894.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
EnsemblBacteria	ABD80156; ABD80156; Sde_0894.
GeneID	3965491.
KEGG	sde:Sde_0894.
PATRIC	23400553. VBISacDeg56404_0980.
Organism-specific databases
CMR	Search...
Phylogenomic databases
eggNOG	COG0150.
HOGENOM	HOG000229091.
KO	K01933.
ProtClustDB	PRK05385.
Enzyme and pathway databases
BioCyc	SDEG203122:GI2M-903-MONOMER.
UniPathway	UPA00074; UER00129.
Family and domain databases
HAMAP	MF_00741_B. AIRS_B.
InterPro	IPR010918. AIR_synth_C_dom. IPR000728. AIR_synth_N_dom. IPR004733. PurM_cligase. IPR016188. PurM_N-like. [Graphical view]
Pfam	PF00586. AIRS. 1 hit. PF02769. AIRS_C. 1 hit. [Graphical view]
SUPFAM	SSF56042. AIR_synth_C. 1 hit. SSF55326. PurM_N-like. 1 hit.
TIGRFAMs	TIGR00878. purM. 1 hit.
ProtoNet	Search...

Entry information

Entry name

PUR5_SACD2

Accession

Primary (citable) accession number: Q21MC3

Entry history

Integrated into UniProtKB/Swiss-Prot:	October 31, 2006
Last sequence update:	October 31, 2006
Last modified:	May 1, 2013
This is version 51 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program