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Reviewed, UniProtKB/Swiss-Prot Q21LY9 (DNAE2_SACD2)

Last modified February 9, 2010. Version 31. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data | Customize display text xml rdf/xml gff fasta
Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents

Names and origin

Protein namesRecommended name:
    Error-prone DNA polymerase
    EC=2.7.7.7
Gene names
Name: dnaE2
Ordered Locus Names: Sde_1028
OrganismSaccharophagus degradans (strain 2-40 / ATCC 43961 / DSM 17024) [Complete proteome] [HAMAP]
Taxonomic identifier203122 [NCBI]
Taxonomic lineageBacteriaProteobacteriaGammaproteobacteriaAlteromonadalesAlteromonadaceaeSaccharophagus

Protein attributes

Sequence length1029 AA.
Sequence statusComplete.
Protein existenceInferred from homology.

General annotation (Comments)

Function

DNA polymerase involved in damage-induced mutagenesis and translesion synthesis (TLS). It is not the major replicative DNA polymerase By similarity. HAMAP MF_01902

Catalytic activity

Deoxynucleoside triphosphate + DNA(n) = diphosphate + DNA(n+1). HAMAP MF_01902

Subcellular location

Cytoplasm Probable HAMAP MF_01902.

Sequence similarities

Belongs to the DNA polymerase type-C family. DnaE2 subfamily.

Ontologies

Keywords
   Biological processDNA damage
DNA repair
DNA replication
   Cellular componentCytoplasm
   Molecular functionDNA-directed DNA polymerase
Nucleotidyltransferase
Transferase
   Technical termComplete proteome
Gene Ontology (GO)
   Biological processDNA repair

Inferred from electronic annotation. Source: UniProtKB-KW

DNA replication

Inferred from electronic annotation. Source: UniProtKB-KW

   Cellular componentcytoplasm

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular function3'-5' exonuclease activity

Inferred from electronic annotation. Source: InterPro

DNA binding

Inferred from electronic annotation. Source: InterPro

DNA-directed DNA polymerase activity

Inferred from electronic annotation. Source: HAMAP

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 10291029Error-prone DNA polymerase HAMAP MF_01902
PRO_1000073691

Sequences

Sequence LengthMass (Da)Tools
Q21LY9-1 [UniParc].

Last modified April 18, 2006. Version 1.
Checksum: 32D7E9BDFC895488

FASTA1,029115,435
        10         20         30         40         50         60 
MQYTQLQTLT NYSFLKSASH PQELVEEAKI LGYHALAITD ECSLAGIVKA HVAAKELNLK 

        70         80         90        100        110        120 
LLVGSYFELT NGFKIIAIAP NRQAYAELSG FISLARRRAS KGEYEAHLSD LRFRLQQCLI 

       130        140        150        160        170        180 
IWLPYFNNHI SDVDVTTLAT AFKQRLWIGV SHTLIAAEQR LFSHLNKLAN ALHVPLVASG 

       190        200        210        220        230        240 
LTYMHNKNCK PLLDILTAIR ENTPIQQLGT RLHSNAEVNL KPLHELNQLY PEALIQQTQV 

       250        260        270        280        290        300 
IAQLCNFSLD ELRYQYPKEL VPSNTTPIAH LKKLVKEGEA KRWPQGTPEH AQKIIAMELG 

       310        320        330        340        350        360 
LIEEMQYEYY FLTVHDIVHF ARSKNILCQG RGSAANSVVC YCLFITEIAP GQINVLFERF 

       370        380        390        400        410        420 
ISKERNEPPD IDVDFEHQRR EEVIQYIYQK YGRERAALAA TVITYRSRSA IRDVGKAMGL 

       430        440        450        460        470        480 
EAGLVGQLAK SLAWWDRTGD LIKRMESFGL NPETQKTMQH FFALVQQILG FPRHLSQHVG 

       490        500        510        520        530        540 
GFIITQDKVS DLVPLENASM PDRTIIQWDK YDIEAMGLLK VDVLALGMLT ALRKSLETVS 

       550        560        570        580        590        600 
QYDAAVYSLA TIPREDPATY AMLSKGDSIG VFQVESRAQM SMLPRLRPKC FYDLVIEIAI 

       610        620        630        640        650        660 
VRPGPIQGDM VHPYLRRRDG IEEVHYQNDK IKSVLEPTLG IPIFQEQAIR LAMVAADFSG 

       670        680        690        700        710        720 
GEADQLRRAM ASWGKNGSLL KFEDKFIQGM LNNGYPLDFA HRLFEQIKGF GGYGFPESHS 

       730        740        750        760        770        780 
ASFALLCYAS SWLKCHHPAA FYCALLNSQP MGFYSASQLI QDARRHKVVV LPVEVNASGY 

       790        800        810        820        830        840 
ESHVVLTNHN TSAPPNIIQL GLHMIKGLSI LTAERIVLAK GDKPFTTLKE LSLRAQLSSA 

       850        860        870        880        890        900 
DLQLLASADA LHKLTGNRHN SRWQAAALMP HSPLLDGAEL EEDALNTPAP SIEKNIQTDF 

       910        920        930        940        950        960 
NSTGLSLRLH PMALLRAQQP FNRCKKQSEL ASIHNGGFAQ VAGLVTGRQR PGTAKGTLFL 

       970        980        990       1000       1010       1020 
TLEDETGNIN IVVWTSTQER CRQALLTAKL LLVKGRLETK DNVTHIIAGQ MFDYSHMLSE 


FDIKSRDFH 

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References

[1]"Complete genome sequence of the complex carbohydrate-degrading marine bacterium, Saccharophagus degradans strain 2-40 T."
Weiner R.M., Taylor L.E. II, Henrissat B., Hauser L., Land M., Coutinho P.M., Rancurel C., Saunders E.H., Longmire A.G., Zhang H., Bayer E.A., Gilbert H.J., Larimer F., Zhulin I.B., Ekborg N.A., Lamed R., Richardson P.M., Borovok I., Hutcheson S.
PLoS Genet. 4:E1000087-E1000087(2008) [PubMed: 18516288] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
CP000282 Genomic DNA. Translation: ABD80290.1.
RefSeqYP_526502.1.

3D structure databases

SMRQ21LY9. Positions 2-869.
ModBaseSearch...

Protein-protein interaction databases

STRINGQ21LY9.

Genome annotation databases

GeneID3967782.
GenomeReviewsGene locus Sde_1028 in contig CP000282_GR.
KEGGsde:Sde_1028.
NMPDRfig|203122.1.peg.3184.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG0587.
HOGENOMHBG734490.
OMAMGFYSPD.

Enzyme and pathway databases

BioCycSDEG203122:SDE_1028-MONOMER.

Family and domain databases

HAMAPMF_01902. DNApol_error_prone.
[Tree]
InterProIPR011708. DNA_pol3_alpha.
IPR004365. NA_bd_OB_tRNA-helicase.
IPR004013. PHP_C.
IPR003141. Pol/His_phosphatase_N.
IPR016195. Pol/histidinol_Pase-like.
IPR004805. PolC_alpha.
[Graphical view]
PfamPF07733. DNA_pol3_alpha. 1 hit.
PF02811. PHP. 1 hit.
PF01336. tRNA_anti. 1 hit.
[Graphical view]
SMARTSM00481. POLIIIAc. 1 hit.
[Graphical view]
TIGRFAMsTIGR00594. polc. 1 hit.
ProtoNetSearch...

Entry information

Entry nameDNAE2_SACD2
AccessionPrimary (citable) accession number: Q21LY9
Entry history
Integrated into UniProtKB/Swiss-Prot: February 26, 2008
Last sequence update: April 18, 2006
Last modified: February 9, 2010
This is version 31 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation projectHAMAP (High-quality Automated and Manual Annotation of microbial Proteomes)

Relevant documents

SIMILARITY comments

Index of protein domains and families

Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents