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Q21IH6

- Q21IH6_SACD2

UniProt

Q21IH6 - Q21IH6_SACD2

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Protein

Ribonuclease 3

Gene

rnc

Organism
Saccharophagus degradans (strain 2-40 / ATCC 43961 / DSM 17024)
Status
Unreviewed - Annotation score: 3 out of 5- Protein inferred from homologyi

Functioni

Digests double-stranded RNA. Involved in the processing of primary rRNA transcript to yield the immediate precursors to the large and small rRNAs (23S and 16S). Processes some mRNAs, and tRNAs when they are encoded in the rRNA operon. Processes pre-crRNA and tracrRNA of type II CRISPR loci if present in the organism.UniRule annotation

Catalytic activityi

Endonucleolytic cleavage to 5'-phosphomonoester.UniRule annotationSAAS annotation

Cofactori

Mg2+.UniRule annotationSAAS annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi39 – 391MagnesiumUniRule annotation
Active sitei43 – 431UniRule annotation
Metal bindingi112 – 1121MagnesiumUniRule annotation
Active sitei115 – 1151UniRule annotation
Metal bindingi115 – 1151MagnesiumUniRule annotation

GO - Molecular functioni

  1. metal ion binding Source: UniProtKB-KW
  2. ribonuclease III activity Source: UniProtKB-HAMAP
  3. rRNA binding Source: UniProtKB-KW

GO - Biological processi

  1. mRNA processing Source: UniProtKB-HAMAP
  2. rRNA catabolic process Source: InterPro
  3. rRNA processing Source: UniProtKB-HAMAP
  4. tRNA processing Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

EndonucleaseUniRule annotationSAAS annotation, Hydrolase, Nuclease

Keywords - Biological processi

mRNA processingUniRule annotationSAAS annotation, rRNA processingUniRule annotationSAAS annotation, tRNA processingUniRule annotationSAAS annotation

Keywords - Ligandi

MagnesiumUniRule annotationSAAS annotation, Metal-bindingUniRule annotationSAAS annotation, RNA-binding, rRNA-bindingUniRule annotationSAAS annotation

Enzyme and pathway databases

BioCyciSDEG203122:GI2M-2281-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Ribonuclease 3UniRule annotation (EC:3.1.26.3UniRule annotation)
Alternative name(s):
Ribonuclease IIIUniRule annotation
Gene namesi
Name:rncUniRule annotation
Ordered Locus Names:Sde_2243Imported
OrganismiSaccharophagus degradans (strain 2-40 / ATCC 43961 / DSM 17024)Imported
Taxonomic identifieri203122 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaAlteromonadalesAlteromonadaceaeSaccharophagus
ProteomesiUP000001947: Chromosome

Subcellular locationi

Cytoplasm UniRule annotationSAAS annotation

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

CytoplasmUniRule annotationSAAS annotation

Interactioni

Subunit structurei

Homodimer.UniRule annotationSAAS annotation

Protein-protein interaction databases

STRINGi203122.Sde_2243.

Structurei

3D structure databases

ProteinModelPortaliQ21IH6.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini4 – 126123RNase IIIUniRule annotationAdd
BLAST
Domaini155 – 22571DRBMUniRule annotationAdd
BLAST

Sequence similaritiesi

Contains 1 DRBM (double-stranded RNA-binding) domain.UniRule annotation
Contains 1 RNase III domain.UniRule annotation
Contains DRBM (double-stranded RNA-binding) domain.SAAS annotation
Contains RNase III domain.SAAS annotation

Phylogenomic databases

eggNOGiCOG0571.
HOGENOMiHOG000246809.
KOiK03685.
OMAiHRFPKVN.
OrthoDBiEOG6T1WVS.

Family and domain databases

Gene3Di1.10.1520.10. 1 hit.
3.30.160.20. 1 hit.
HAMAPiMF_00104. RNase_III.
InterProiIPR014720. dsRNA-bd_dom.
IPR011907. RNase_III.
IPR000999. RNase_III_dom.
[Graphical view]
PANTHERiPTHR11207. PTHR11207. 1 hit.
PfamiPF00035. dsrm. 1 hit.
PF14622. Ribonucleas_3_3. 1 hit.
[Graphical view]
SMARTiSM00358. DSRM. 1 hit.
SM00535. RIBOc. 1 hit.
[Graphical view]
SUPFAMiSSF69065. SSF69065. 1 hit.
TIGRFAMsiTIGR02191. RNaseIII. 1 hit.
PROSITEiPS50137. DS_RBD. 1 hit.
PS50142. RNASE_3_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q21IH6 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MNQNDRLVAR LGYTFKDKSL LKLALSHRSY GKQNNERVEF LGDSLLNFII
60 70 80 90 100
AEALFAKFPT AKEGQLTQLR ANLVKGETLA EIAREFGLGD FLLLGEGELK
110 120 130 140 150
SGGFRRASIL ADAVEALIGA IYLDSNSSMP TCRERVLAWY ATRLDKVELK
160 170 180 190 200
ATAKDAKTLL QEYLQERKMP LPTYTVLAEG GEAHSRQFTV ECTITGKSKP
210 220
CSAVGNSKRI AEKLAAEKML SQLTNA
Length:226
Mass (Da):24,949
Last modified:April 18, 2006 - v1
Checksum:i48135BDA30D38A52
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000282 Genomic DNA. Translation: ABD81503.1.
RefSeqiYP_527715.1. NC_007912.1.

Genome annotation databases

EnsemblBacteriaiABD81503; ABD81503; Sde_2243.
GeneIDi3964847.
KEGGisde:Sde_2243.
PATRICi23403490. VBISacDeg56404_2417.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000282 Genomic DNA. Translation: ABD81503.1 .
RefSeqi YP_527715.1. NC_007912.1.

3D structure databases

ProteinModelPortali Q21IH6.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 203122.Sde_2243.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai ABD81503 ; ABD81503 ; Sde_2243 .
GeneIDi 3964847.
KEGGi sde:Sde_2243.
PATRICi 23403490. VBISacDeg56404_2417.

Phylogenomic databases

eggNOGi COG0571.
HOGENOMi HOG000246809.
KOi K03685.
OMAi HRFPKVN.
OrthoDBi EOG6T1WVS.

Enzyme and pathway databases

BioCyci SDEG203122:GI2M-2281-MONOMER.

Family and domain databases

Gene3Di 1.10.1520.10. 1 hit.
3.30.160.20. 1 hit.
HAMAPi MF_00104. RNase_III.
InterProi IPR014720. dsRNA-bd_dom.
IPR011907. RNase_III.
IPR000999. RNase_III_dom.
[Graphical view ]
PANTHERi PTHR11207. PTHR11207. 1 hit.
Pfami PF00035. dsrm. 1 hit.
PF14622. Ribonucleas_3_3. 1 hit.
[Graphical view ]
SMARTi SM00358. DSRM. 1 hit.
SM00535. RIBOc. 1 hit.
[Graphical view ]
SUPFAMi SSF69065. SSF69065. 1 hit.
TIGRFAMsi TIGR02191. RNaseIII. 1 hit.
PROSITEi PS50137. DS_RBD. 1 hit.
PS50142. RNASE_3_2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: 2-40 / ATCC 43961 / DSM 17024Imported.

Entry informationi

Entry nameiQ21IH6_SACD2
AccessioniPrimary (citable) accession number: Q21IH6
Entry historyi
Integrated into UniProtKB/TrEMBL: April 18, 2006
Last sequence update: April 18, 2006
Last modified: October 29, 2014
This is version 59 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported

External Data

Dasty 3