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Protein

Ribonuclease 3

Gene

rnc

Organism
Saccharophagus degradans (strain 2-40 / ATCC 43961 / DSM 17024)
Status
Unreviewed-Annotation score: -Protein inferred from homologyi

Functioni

Digests double-stranded RNA. Involved in the processing of primary rRNA transcript to yield the immediate precursors to the large and small rRNAs (23S and 16S). Processes some mRNAs, and tRNAs when they are encoded in the rRNA operon. Processes pre-crRNA and tracrRNA of type II CRISPR loci if present in the organism.UniRule annotation

Catalytic activityi

Endonucleolytic cleavage to 5'-phosphomonoester.UniRule annotationSAAS annotation

Cofactori

Mg2+UniRule annotationSAAS annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi39MagnesiumUniRule annotation1
Active sitei43UniRule annotation1
Metal bindingi112MagnesiumUniRule annotation1
Active sitei115UniRule annotation1
Metal bindingi115MagnesiumUniRule annotation1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionEndonucleaseUniRule annotationSAAS annotation, Hydrolase, Nuclease, RNA-binding, rRNA-bindingUniRule annotationSAAS annotation
Biological processmRNA processingUniRule annotationSAAS annotation, rRNA processingUniRule annotationSAAS annotation, tRNA processingUniRule annotationSAAS annotation
LigandMagnesiumUniRule annotationSAAS annotation, Metal-bindingUniRule annotationSAAS annotation

Enzyme and pathway databases

BioCyciSDEG203122:G1G67-2365-MONOMER

Names & Taxonomyi

Protein namesi
Recommended name:
Ribonuclease 3UniRule annotation (EC:3.1.26.3UniRule annotation)
Alternative name(s):
Ribonuclease IIIUniRule annotation
Short name:
RNase IIIUniRule annotation
Gene namesi
Name:rncUniRule annotation
Ordered Locus Names:Sde_2243Imported
OrganismiSaccharophagus degradans (strain 2-40 / ATCC 43961 / DSM 17024)Imported
Taxonomic identifieri203122 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaCellvibrionalesCellvibrionaceaeSaccharophagus
Proteomesi
  • UP000001947 Componenti: Chromosome

Subcellular locationi

  • Cytoplasm UniRule annotationSAAS annotation

GO - Cellular componenti

Keywords - Cellular componenti

CytoplasmUniRule annotationSAAS annotation

Interactioni

Subunit structurei

Homodimer.UniRule annotationSAAS annotation

Protein-protein interaction databases

STRINGi203122.Sde_2243

Structurei

3D structure databases

ProteinModelPortaliQ21IH6
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini4 – 126RNase IIIInterPro annotationAdd BLAST123
Domaini155 – 225DRBMInterPro annotationAdd BLAST71

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili146 – 166Sequence analysisAdd BLAST21

Sequence similaritiesi

Belongs to the ribonuclease III family.SAAS annotation

Keywords - Domaini

Coiled coilSequence analysis

Phylogenomic databases

eggNOGiENOG4108ZBM Bacteria
COG0571 LUCA
HOGENOMiHOG000246809
KOiK03685
OMAiLTHKSCK
OrthoDBiPOG091H00R1

Family and domain databases

CDDicd00593 RIBOc, 1 hit
Gene3Di1.10.1520.10, 1 hit
HAMAPiMF_00104 RNase_III, 1 hit
InterProiView protein in InterPro
IPR014720 dsRBD_dom
IPR011907 RNase_III
IPR000999 RNase_III_dom
IPR036389 RNase_III_sf
PfamiView protein in Pfam
PF00035 dsrm, 1 hit
PF14622 Ribonucleas_3_3, 1 hit
SMARTiView protein in SMART
SM00358 DSRM, 1 hit
SM00535 RIBOc, 1 hit
SUPFAMiSSF69065 SSF69065, 1 hit
TIGRFAMsiTIGR02191 RNaseIII, 1 hit
PROSITEiView protein in PROSITE
PS50137 DS_RBD, 1 hit
PS50142 RNASE_3_2, 1 hit

Sequencei

Sequence statusi: Complete.

Q21IH6-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MNQNDRLVAR LGYTFKDKSL LKLALSHRSY GKQNNERVEF LGDSLLNFII
60 70 80 90 100
AEALFAKFPT AKEGQLTQLR ANLVKGETLA EIAREFGLGD FLLLGEGELK
110 120 130 140 150
SGGFRRASIL ADAVEALIGA IYLDSNSSMP TCRERVLAWY ATRLDKVELK
160 170 180 190 200
ATAKDAKTLL QEYLQERKMP LPTYTVLAEG GEAHSRQFTV ECTITGKSKP
210 220
CSAVGNSKRI AEKLAAEKML SQLTNA
Length:226
Mass (Da):24,949
Last modified:April 18, 2006 - v1
Checksum:i48135BDA30D38A52
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000282 Genomic DNA Translation: ABD81503.1
RefSeqiWP_011468721.1, NC_007912.1

Genome annotation databases

EnsemblBacteriaiABD81503; ABD81503; Sde_2243
KEGGisde:Sde_2243

Similar proteinsi

Entry informationi

Entry nameiQ21IH6_SACD2
AccessioniPrimary (citable) accession number: Q21IH6
Entry historyiIntegrated into UniProtKB/TrEMBL: April 18, 2006
Last sequence update: April 18, 2006
Last modified: March 28, 2018
This is version 87 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported
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Main funding by: National Institutes of Health