ID   Q21IE0_SACD2            Unreviewed;       574 AA.
AC   Q21IE0;
DT   18-APR-2006, integrated into UniProtKB/TrEMBL.
DT   18-APR-2006, sequence version 1.
DT   27-MAR-2024, entry version 92.
DE   RecName: Full=non-specific serine/threonine protein kinase {ECO:0000256|ARBA:ARBA00012513};
DE            EC=2.7.11.1 {ECO:0000256|ARBA:ARBA00012513};
GN   OrderedLocusNames=Sde_2279 {ECO:0000313|EMBL:ABD81539.1};
OS   Saccharophagus degradans (strain 2-40 / ATCC 43961 / DSM 17024).
OC   Bacteria; Pseudomonadota; Gammaproteobacteria; Cellvibrionales;
OC   Cellvibrionaceae; Saccharophagus.
OX   NCBI_TaxID=203122 {ECO:0000313|EMBL:ABD81539.1, ECO:0000313|Proteomes:UP000001947};
RN   [1] {ECO:0000313|EMBL:ABD81539.1, ECO:0000313|Proteomes:UP000001947}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=2-40 / ATCC 43961 / DSM 17024
RC   {ECO:0000313|Proteomes:UP000001947};
RX   PubMed=18516288; DOI=10.1371/journal.pgen.1000087;
RA   Weiner R.M., Taylor L.E.II., Henrissat B., Hauser L., Land M.,
RA   Coutinho P.M., Rancurel C., Saunders E.H., Longmire A.G., Zhang H.,
RA   Bayer E.A., Gilbert H.J., Larimer F., Zhulin I.B., Ekborg N.A., Lamed R.,
RA   Richardson P.M., Borovok I., Hutcheson S.;
RT   "Complete genome sequence of the complex carbohydrate-degrading marine
RT   bacterium, Saccharophagus degradans strain 2-40 T.";
RL   PLoS Genet. 4:E1000087-E1000087(2008).
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DR   EMBL; CP000282; ABD81539.1; -; Genomic_DNA.
DR   RefSeq; WP_011468757.1; NC_007912.1.
DR   AlphaFoldDB; Q21IE0; -.
DR   STRING; 203122.Sde_2279; -.
DR   KEGG; sde:Sde_2279; -.
DR   eggNOG; COG0515; Bacteria.
DR   eggNOG; COG0631; Bacteria.
DR   HOGENOM; CLU_034273_0_0_6; -.
DR   OrthoDB; 9801841at2; -.
DR   Proteomes; UP000001947; Chromosome.
DR   GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005524; F:ATP binding; IEA:InterPro.
DR   GO; GO:0004674; F:protein serine/threonine kinase activity; IEA:UniProtKB-KW.
DR   GO; GO:0016310; P:phosphorylation; IEA:UniProtKB-KW.
DR   CDD; cd00143; PP2Cc; 1.
DR   CDD; cd14014; STKc_PknB_like; 1.
DR   Gene3D; 3.60.40.10; PPM-type phosphatase domain; 1.
DR   Gene3D; 1.10.510.10; Transferase(Phosphotransferase) domain 1; 1.
DR   InterPro; IPR011009; Kinase-like_dom_sf.
DR   InterPro; IPR036457; PPM-type-like_dom_sf.
DR   InterPro; IPR001932; PPM-type_phosphatase-like_dom.
DR   InterPro; IPR000719; Prot_kinase_dom.
DR   PANTHER; PTHR43289; MITOGEN-ACTIVATED PROTEIN KINASE KINASE KINASE 20-RELATED; 1.
DR   PANTHER; PTHR43289:SF32; SERINE_THREONINE-PROTEIN KINASE PKAB; 1.
DR   Pfam; PF00069; Pkinase; 1.
DR   Pfam; PF13672; PP2C_2; 1.
DR   SMART; SM00331; PP2C_SIG; 1.
DR   SMART; SM00332; PP2Cc; 1.
DR   SMART; SM00220; S_TKc; 1.
DR   SUPFAM; SSF81606; PP2C-like; 1.
DR   SUPFAM; SSF56112; Protein kinase-like (PK-like); 1.
DR   PROSITE; PS51746; PPM_2; 1.
DR   PROSITE; PS50011; PROTEIN_KINASE_DOM; 1.
PE   4: Predicted;
KW   Kinase {ECO:0000313|EMBL:ABD81539.1}; Membrane {ECO:0000256|SAM:Phobius};
KW   Reference proteome {ECO:0000313|Proteomes:UP000001947};
KW   Serine/threonine-protein kinase {ECO:0000313|EMBL:ABD81539.1};
KW   Transferase {ECO:0000313|EMBL:ABD81539.1};
KW   Transmembrane {ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM        550..570
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   DOMAIN          11..238
FT                   /note="PPM-type phosphatase"
FT                   /evidence="ECO:0000259|PROSITE:PS51746"
FT   DOMAIN          271..551
FT                   /note="Protein kinase"
FT                   /evidence="ECO:0000259|PROSITE:PS50011"
SQ   SEQUENCE   574 AA;  64048 MW;  FCC34BA405014814 CRC64;
     MNHLSSSLSI RFAQHSDQGR KPENQDTVGA MIPEGSQLSL KGIAIAIADG VSSSDSAKQA
     SQSAICGFLT DYYATPDTWR TQQSAIRVIQ SLNRYLWGQS QNSVMGEGYL TTFTSLIFKG
     DKYFIFHVGD TRVYRMRDNV LELLTRDHTQ KIDSKTTYLS RALGADSALE IDMHSEELRV
     DDVFILTTDG IHDSLNAHDF ECTVRKHLND PEALIKALEA EALDAGSKDN ISVQVAVIDS
     LGTPSQADAI TVLSQLPFPP ILSVGNKLDG LQVEKILHES ERSQVYLVKD ENGTPYVMKT
     PSINYDDDPA YIERFVMESW IGTRIQNQHV VRIATPPESR STLYYLTEHI AGPTLGQLIR
     ERAPMDITDA VELVEQLAKG VRAFHRRDTL HQDIKPDNVI VGRNGAVIID FGSCYVAGVH
     EVASSFERDK ILGTLTYSAP EYRCGGNVGM HSDQYSIAVI LYEMLTGKLP FGEAYSEASS
     LKDFQKLKYH PARIHNPLVP VWLDKALEKA LSLQTSARYP ALSEWLKDIK RPNPLWRTQQ
     EIPLAERNPL LMWKSIAAVG WLTVLGLLLL NFRG
//