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Protein

Glycine dehydrogenase (decarboxylating)

Gene

gcvP

Organism
Saccharophagus degradans (strain 2-40 / ATCC 43961 / DSM 17024)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO2 is released and the remaining methylamine moiety is then transferred to the lipoamide cofactor of the H protein.UniRule annotation

Catalytic activityi

Glycine + [glycine-cleavage complex H protein]-N6-lipoyl-L-lysine = [glycine-cleavage complex H protein]-S-aminomethyl-N6-dihydrolipoyl-L-lysine + CO2.UniRule annotation

Cofactori

pyridoxal 5'-phosphateUniRule annotation

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionOxidoreductase
LigandPyridoxal phosphate

Enzyme and pathway databases

BioCyciSDEG203122:G1G67-2607-MONOMER

Names & Taxonomyi

Protein namesi
Recommended name:
Glycine dehydrogenase (decarboxylating)UniRule annotation (EC:1.4.4.2UniRule annotation)
Alternative name(s):
Glycine cleavage system P-proteinUniRule annotation
Glycine decarboxylaseUniRule annotation
Glycine dehydrogenase (aminomethyl-transferring)UniRule annotation
Gene namesi
Name:gcvPUniRule annotation
Ordered Locus Names:Sde_2476
OrganismiSaccharophagus degradans (strain 2-40 / ATCC 43961 / DSM 17024)
Taxonomic identifieri203122 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaCellvibrionalesCellvibrionaceaeSaccharophagus
Proteomesi
  • UP000001947 Componenti: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_10000456051 – 964Glycine dehydrogenase (decarboxylating)Add BLAST964

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei710N6-(pyridoxal phosphate)lysineUniRule annotation1

Proteomic databases

PRIDEiQ21HU3

Interactioni

Subunit structurei

The glycine cleavage system is composed of four proteins: P, T, L and H.UniRule annotation

Protein-protein interaction databases

STRINGi203122.Sde_2476

Structurei

3D structure databases

ProteinModelPortaliQ21HU3
SMRiQ21HU3
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the GcvP family.UniRule annotation

Phylogenomic databases

eggNOGiENOG4105CBI Bacteria
COG0403 LUCA
COG1003 LUCA
HOGENOMiHOG000239369
KOiK00281
OMAiQTMVCDL
OrthoDBiPOG091H03O6

Family and domain databases

CDDicd00613 GDC-P, 2 hits
Gene3Di3.40.640.10, 2 hits
3.90.1150.10, 1 hit
HAMAPiMF_00711 GcvP, 1 hit
InterProiView protein in InterPro
IPR003437 GcvP
IPR020581 GDC_P
IPR015424 PyrdxlP-dep_Trfase
IPR015422 PyrdxlP-dep_Trfase_dom1
IPR015421 PyrdxlP-dep_Trfase_major
PANTHERiPTHR11773 PTHR11773, 1 hit
PfamiView protein in Pfam
PF02347 GDC-P, 2 hits
SUPFAMiSSF53383 SSF53383, 3 hits
TIGRFAMsiTIGR00461 gcvP, 1 hit

Sequencei

Sequence statusi: Complete.

Q21HU3-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSHGTSLDEL FNSRDFIGRH IGPNADQTRA MLDAMGLDSI DQLIDLTVPA
60 70 80 90 100
SIRGEETRAL AAPVNEQQAL AELKNIAGNN QRFKSYIGMG YHPTYVPPVI
110 120 130 140 150
LRNVLENPGW YTAYTPYQPE IAQGRLEGLL NFQQMIIELT GMDMANASML
160 170 180 190 200
DEATAAAEAM AMAKRVARKN KSNTFFADKH CHPQTLAVLQ TRASHFGFEL
210 220 230 240 250
VIGDITQDLN KQEVFGAITQ YPGTSGEVKD LRPIVNQAHE QDALLIVAAD
260 270 280 290 300
ILSLVLLESP GAMGADIVVG SNQRFGIPMG FGGPHAAFFG FREKYKRATP
310 320 330 340 350
GRIIGVSVDT RGKRALRMAM QTREQHIRRE KANSNICTSQ VLLAVMSVFY
360 370 380 390 400
AMYHGSAGVT RIAQRVHTLT KMLAQGLTAQ GHKLAFDNYF DTLCVIVNDQ
410 420 430 440 450
QQGLFDRAQQ AGVNLRKLDK NALTISLNEC TSLEDIHQLL DIFSLGKHSQ
460 470 480 490 500
DVKSLETKAL AAEVIPASCR REGPALNHPV FEQYHSETEM LRYLKRLESK
510 520 530 540 550
DIALNHAMIP LGSCTMKLNA TAEMIPVTWP EFGELHPFAP MEQAAGYSTL
560 570 580 590 600
FTQLQDMLKA CTGYDAISLQ PNAGSQGEYA GLVAIRKYFE HLGQTERNIC
610 620 630 640 650
LIPASAHGTN PASAQMVEMK VVVVACDNLG NVDLNDLKAK VAQYGETIAA
660 670 680 690 700
LMVTYPSTHG VFEEEITAIC DLIHSVGAQV YIDGANMNAL VGLAAPGKFG
710 720 730 740 750
GDVSHLNLHK TFCIPHGGGG PGMGPIGVKS HLAPFLAGHP VQPVPNTLVE
760 770 780 790 800
NGTISAAPWG SASILTISWM YIRMMGAEGM KRATEFAILN ANYIAHRLQD
810 820 830 840 850
HYPILYKGKN GYIAHECLLD LRPLKESSGI TEEDIAKRLM DFGFHAPTMS
860 870 880 890 900
FPVAGTLMIE PTESESQAEL DRFCDAMIKI RQEASLVESG ELPRDNNPLV
910 920 930 940 950
NAPHTLDDAL DETWTRPYTR DEATRPLPYL HAHKIWPTVN RIDNVYGDRN
960
LICSCPSIES YTEE
Length:964
Mass (Da):105,798
Last modified:April 18, 2006 - v1
Checksum:iFB71E12D9684E34A
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000282 Genomic DNA Translation: ABD81736.1
RefSeqiWP_011468953.1, NC_007912.1

Genome annotation databases

EnsemblBacteriaiABD81736; ABD81736; Sde_2476
KEGGisde:Sde_2476

Similar proteinsi

Entry informationi

Entry nameiGCSP_SACD2
AccessioniPrimary (citable) accession number: Q21HU3
Entry historyiIntegrated into UniProtKB/Swiss-Prot: January 15, 2008
Last sequence update: April 18, 2006
Last modified: May 23, 2018
This is version 82 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

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