SubmitCancel

Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.

Q21HU3

- GCSP_SACD2

UniProt

Q21HU3 - GCSP_SACD2

(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

Protein

Glycine dehydrogenase (decarboxylating)

Gene
gcvP, Sde_2476
Organism
Saccharophagus degradans (strain 2-40 / ATCC 43961 / DSM 17024)
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO2 is released and the remaining methylamine moiety is then transferred to the lipoamide cofactor of the H protein By similarity.UniRule annotation

Catalytic activityi

Glycine + [glycine-cleavage complex H protein]-N(6)-lipoyl-L-lysine = [glycine-cleavage complex H protein]-S-aminomethyl-N(6)-dihydrolipoyl-L-lysine + CO2.UniRule annotation

Cofactori

Pyridoxal phosphate By similarity.UniRule annotation

GO - Molecular functioni

  1. glycine dehydrogenase (decarboxylating) activity Source: UniProtKB-EC
  2. pyridoxal phosphate binding Source: InterPro

GO - Biological processi

  1. glycine decarboxylation via glycine cleavage system Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Ligandi

Pyridoxal phosphate

Enzyme and pathway databases

BioCyciSDEG203122:GI2M-2514-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Glycine dehydrogenase (decarboxylating) (EC:1.4.4.2)
Alternative name(s):
Glycine cleavage system P-protein
Glycine decarboxylase
Glycine dehydrogenase (aminomethyl-transferring)
Gene namesi
Name:gcvP
Ordered Locus Names:Sde_2476
OrganismiSaccharophagus degradans (strain 2-40 / ATCC 43961 / DSM 17024)
Taxonomic identifieri203122 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaAlteromonadalesAlteromonadaceaeSaccharophagus
ProteomesiUP000001947: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 964964Glycine dehydrogenase (decarboxylating)UniRule annotationPRO_1000045605Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei710 – 7101N6-(pyridoxal phosphate)lysine By similarity

Interactioni

Subunit structurei

The glycine cleavage system is composed of four proteins: P, T, L and H By similarity.

Protein-protein interaction databases

STRINGi203122.Sde_2476.

Structurei

3D structure databases

ProteinModelPortaliQ21HU3.

Family & Domainsi

Sequence similaritiesi

Belongs to the GcvP family.

Phylogenomic databases

eggNOGiCOG1003.
HOGENOMiHOG000239369.
KOiK00281.
OMAiFDSRPYS.
OrthoDBiEOG6HMXDX.

Family and domain databases

Gene3Di3.40.640.10. 2 hits.
HAMAPiMF_00711. GcvP.
InterProiIPR020580. GDC-P_N.
IPR020581. GDC_P.
IPR003437. GDC_P_homo.
IPR015424. PyrdxlP-dep_Trfase.
IPR015421. PyrdxlP-dep_Trfase_major_sub1.
[Graphical view]
PANTHERiPTHR11773. PTHR11773. 1 hit.
PfamiPF02347. GDC-P. 2 hits.
[Graphical view]
SUPFAMiSSF53383. SSF53383. 3 hits.
TIGRFAMsiTIGR00461. gcvP. 1 hit.

Sequencei

Sequence statusi: Complete.

Q21HU3-1 [UniParc]FASTAAdd to Basket

« Hide

MSHGTSLDEL FNSRDFIGRH IGPNADQTRA MLDAMGLDSI DQLIDLTVPA    50
SIRGEETRAL AAPVNEQQAL AELKNIAGNN QRFKSYIGMG YHPTYVPPVI 100
LRNVLENPGW YTAYTPYQPE IAQGRLEGLL NFQQMIIELT GMDMANASML 150
DEATAAAEAM AMAKRVARKN KSNTFFADKH CHPQTLAVLQ TRASHFGFEL 200
VIGDITQDLN KQEVFGAITQ YPGTSGEVKD LRPIVNQAHE QDALLIVAAD 250
ILSLVLLESP GAMGADIVVG SNQRFGIPMG FGGPHAAFFG FREKYKRATP 300
GRIIGVSVDT RGKRALRMAM QTREQHIRRE KANSNICTSQ VLLAVMSVFY 350
AMYHGSAGVT RIAQRVHTLT KMLAQGLTAQ GHKLAFDNYF DTLCVIVNDQ 400
QQGLFDRAQQ AGVNLRKLDK NALTISLNEC TSLEDIHQLL DIFSLGKHSQ 450
DVKSLETKAL AAEVIPASCR REGPALNHPV FEQYHSETEM LRYLKRLESK 500
DIALNHAMIP LGSCTMKLNA TAEMIPVTWP EFGELHPFAP MEQAAGYSTL 550
FTQLQDMLKA CTGYDAISLQ PNAGSQGEYA GLVAIRKYFE HLGQTERNIC 600
LIPASAHGTN PASAQMVEMK VVVVACDNLG NVDLNDLKAK VAQYGETIAA 650
LMVTYPSTHG VFEEEITAIC DLIHSVGAQV YIDGANMNAL VGLAAPGKFG 700
GDVSHLNLHK TFCIPHGGGG PGMGPIGVKS HLAPFLAGHP VQPVPNTLVE 750
NGTISAAPWG SASILTISWM YIRMMGAEGM KRATEFAILN ANYIAHRLQD 800
HYPILYKGKN GYIAHECLLD LRPLKESSGI TEEDIAKRLM DFGFHAPTMS 850
FPVAGTLMIE PTESESQAEL DRFCDAMIKI RQEASLVESG ELPRDNNPLV 900
NAPHTLDDAL DETWTRPYTR DEATRPLPYL HAHKIWPTVN RIDNVYGDRN 950
LICSCPSIES YTEE 964
Length:964
Mass (Da):105,798
Last modified:April 18, 2006 - v1
Checksum:iFB71E12D9684E34A
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000282 Genomic DNA. Translation: ABD81736.1.
RefSeqiWP_011468953.1. NC_007912.1.
YP_527948.1. NC_007912.1.

Genome annotation databases

EnsemblBacteriaiABD81736; ABD81736; Sde_2476.
GeneIDi3964923.
KEGGisde:Sde_2476.
PATRICi23403988. VBISacDeg56404_2666.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000282 Genomic DNA. Translation: ABD81736.1 .
RefSeqi WP_011468953.1. NC_007912.1.
YP_527948.1. NC_007912.1.

3D structure databases

ProteinModelPortali Q21HU3.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 203122.Sde_2476.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai ABD81736 ; ABD81736 ; Sde_2476 .
GeneIDi 3964923.
KEGGi sde:Sde_2476.
PATRICi 23403988. VBISacDeg56404_2666.

Phylogenomic databases

eggNOGi COG1003.
HOGENOMi HOG000239369.
KOi K00281.
OMAi FDSRPYS.
OrthoDBi EOG6HMXDX.

Enzyme and pathway databases

BioCyci SDEG203122:GI2M-2514-MONOMER.

Family and domain databases

Gene3Di 3.40.640.10. 2 hits.
HAMAPi MF_00711. GcvP.
InterProi IPR020580. GDC-P_N.
IPR020581. GDC_P.
IPR003437. GDC_P_homo.
IPR015424. PyrdxlP-dep_Trfase.
IPR015421. PyrdxlP-dep_Trfase_major_sub1.
[Graphical view ]
PANTHERi PTHR11773. PTHR11773. 1 hit.
Pfami PF02347. GDC-P. 2 hits.
[Graphical view ]
SUPFAMi SSF53383. SSF53383. 3 hits.
TIGRFAMsi TIGR00461. gcvP. 1 hit.
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: 2-40 / ATCC 43961 / DSM 17024.

Entry informationi

Entry nameiGCSP_SACD2
AccessioniPrimary (citable) accession number: Q21HU3
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 15, 2008
Last sequence update: April 18, 2006
Last modified: September 3, 2014
This is version 63 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi