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Q21HU3

- GCSP_SACD2

UniProt

Q21HU3 - GCSP_SACD2

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Protein

Glycine dehydrogenase (decarboxylating)

Gene

gcvP

Organism
Saccharophagus degradans (strain 2-40 / ATCC 43961 / DSM 17024)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi

Functioni

The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO2 is released and the remaining methylamine moiety is then transferred to the lipoamide cofactor of the H protein.UniRule annotation

Catalytic activityi

Glycine + [glycine-cleavage complex H protein]-N(6)-lipoyl-L-lysine = [glycine-cleavage complex H protein]-S-aminomethyl-N(6)-dihydrolipoyl-L-lysine + CO2.UniRule annotation

Cofactori

pyridoxal 5'-phosphateUniRule annotation

GO - Molecular functioni

  1. glycine dehydrogenase (decarboxylating) activity Source: UniProtKB-EC
  2. pyridoxal phosphate binding Source: InterPro

GO - Biological processi

  1. glycine decarboxylation via glycine cleavage system Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Ligandi

Pyridoxal phosphate

Enzyme and pathway databases

BioCyciSDEG203122:GI2M-2514-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Glycine dehydrogenase (decarboxylating)UniRule annotation (EC:1.4.4.2UniRule annotation)
Alternative name(s):
Glycine cleavage system P-proteinUniRule annotation
Glycine decarboxylaseUniRule annotation
Glycine dehydrogenase (aminomethyl-transferring)UniRule annotation
Gene namesi
Name:gcvPUniRule annotation
Ordered Locus Names:Sde_2476
OrganismiSaccharophagus degradans (strain 2-40 / ATCC 43961 / DSM 17024)
Taxonomic identifieri203122 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaAlteromonadalesAlteromonadaceaeSaccharophagus
ProteomesiUP000001947: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 964964Glycine dehydrogenase (decarboxylating)PRO_1000045605Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei710 – 7101N6-(pyridoxal phosphate)lysineUniRule annotation

Interactioni

Subunit structurei

The glycine cleavage system is composed of four proteins: P, T, L and H.UniRule annotation

Protein-protein interaction databases

STRINGi203122.Sde_2476.

Structurei

3D structure databases

ProteinModelPortaliQ21HU3.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the GcvP family.UniRule annotation

Phylogenomic databases

eggNOGiCOG1003.
HOGENOMiHOG000239369.
KOiK00281.
OMAiFDSRPYS.
OrthoDBiEOG6HMXDX.

Family and domain databases

Gene3Di3.40.640.10. 2 hits.
HAMAPiMF_00711. GcvP.
InterProiIPR020580. GDC-P_N.
IPR020581. GDC_P.
IPR003437. GDC_P_homo.
IPR015424. PyrdxlP-dep_Trfase.
IPR015421. PyrdxlP-dep_Trfase_major_sub1.
[Graphical view]
PANTHERiPTHR11773. PTHR11773. 1 hit.
PfamiPF02347. GDC-P. 2 hits.
[Graphical view]
SUPFAMiSSF53383. SSF53383. 3 hits.
TIGRFAMsiTIGR00461. gcvP. 1 hit.

Sequencei

Sequence statusi: Complete.

Q21HU3-1 [UniParc]FASTAAdd to Basket

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        10         20         30         40         50
MSHGTSLDEL FNSRDFIGRH IGPNADQTRA MLDAMGLDSI DQLIDLTVPA
60 70 80 90 100
SIRGEETRAL AAPVNEQQAL AELKNIAGNN QRFKSYIGMG YHPTYVPPVI
110 120 130 140 150
LRNVLENPGW YTAYTPYQPE IAQGRLEGLL NFQQMIIELT GMDMANASML
160 170 180 190 200
DEATAAAEAM AMAKRVARKN KSNTFFADKH CHPQTLAVLQ TRASHFGFEL
210 220 230 240 250
VIGDITQDLN KQEVFGAITQ YPGTSGEVKD LRPIVNQAHE QDALLIVAAD
260 270 280 290 300
ILSLVLLESP GAMGADIVVG SNQRFGIPMG FGGPHAAFFG FREKYKRATP
310 320 330 340 350
GRIIGVSVDT RGKRALRMAM QTREQHIRRE KANSNICTSQ VLLAVMSVFY
360 370 380 390 400
AMYHGSAGVT RIAQRVHTLT KMLAQGLTAQ GHKLAFDNYF DTLCVIVNDQ
410 420 430 440 450
QQGLFDRAQQ AGVNLRKLDK NALTISLNEC TSLEDIHQLL DIFSLGKHSQ
460 470 480 490 500
DVKSLETKAL AAEVIPASCR REGPALNHPV FEQYHSETEM LRYLKRLESK
510 520 530 540 550
DIALNHAMIP LGSCTMKLNA TAEMIPVTWP EFGELHPFAP MEQAAGYSTL
560 570 580 590 600
FTQLQDMLKA CTGYDAISLQ PNAGSQGEYA GLVAIRKYFE HLGQTERNIC
610 620 630 640 650
LIPASAHGTN PASAQMVEMK VVVVACDNLG NVDLNDLKAK VAQYGETIAA
660 670 680 690 700
LMVTYPSTHG VFEEEITAIC DLIHSVGAQV YIDGANMNAL VGLAAPGKFG
710 720 730 740 750
GDVSHLNLHK TFCIPHGGGG PGMGPIGVKS HLAPFLAGHP VQPVPNTLVE
760 770 780 790 800
NGTISAAPWG SASILTISWM YIRMMGAEGM KRATEFAILN ANYIAHRLQD
810 820 830 840 850
HYPILYKGKN GYIAHECLLD LRPLKESSGI TEEDIAKRLM DFGFHAPTMS
860 870 880 890 900
FPVAGTLMIE PTESESQAEL DRFCDAMIKI RQEASLVESG ELPRDNNPLV
910 920 930 940 950
NAPHTLDDAL DETWTRPYTR DEATRPLPYL HAHKIWPTVN RIDNVYGDRN
960
LICSCPSIES YTEE
Length:964
Mass (Da):105,798
Last modified:April 18, 2006 - v1
Checksum:iFB71E12D9684E34A
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000282 Genomic DNA. Translation: ABD81736.1.
RefSeqiWP_011468953.1. NC_007912.1.
YP_527948.1. NC_007912.1.

Genome annotation databases

EnsemblBacteriaiABD81736; ABD81736; Sde_2476.
GeneIDi3964923.
KEGGisde:Sde_2476.
PATRICi23403988. VBISacDeg56404_2666.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000282 Genomic DNA. Translation: ABD81736.1 .
RefSeqi WP_011468953.1. NC_007912.1.
YP_527948.1. NC_007912.1.

3D structure databases

ProteinModelPortali Q21HU3.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 203122.Sde_2476.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai ABD81736 ; ABD81736 ; Sde_2476 .
GeneIDi 3964923.
KEGGi sde:Sde_2476.
PATRICi 23403988. VBISacDeg56404_2666.

Phylogenomic databases

eggNOGi COG1003.
HOGENOMi HOG000239369.
KOi K00281.
OMAi FDSRPYS.
OrthoDBi EOG6HMXDX.

Enzyme and pathway databases

BioCyci SDEG203122:GI2M-2514-MONOMER.

Family and domain databases

Gene3Di 3.40.640.10. 2 hits.
HAMAPi MF_00711. GcvP.
InterProi IPR020580. GDC-P_N.
IPR020581. GDC_P.
IPR003437. GDC_P_homo.
IPR015424. PyrdxlP-dep_Trfase.
IPR015421. PyrdxlP-dep_Trfase_major_sub1.
[Graphical view ]
PANTHERi PTHR11773. PTHR11773. 1 hit.
Pfami PF02347. GDC-P. 2 hits.
[Graphical view ]
SUPFAMi SSF53383. SSF53383. 3 hits.
TIGRFAMsi TIGR00461. gcvP. 1 hit.
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: 2-40 / ATCC 43961 / DSM 17024.

Entry informationi

Entry nameiGCSP_SACD2
AccessioniPrimary (citable) accession number: Q21HU3
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 15, 2008
Last sequence update: April 18, 2006
Last modified: November 26, 2014
This is version 65 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3