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Q21HU3 (GCSP_SACD2) Reviewed, UniProtKB/Swiss-Prot

Last modified February 19, 2014. Version 61. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Glycine dehydrogenase (decarboxylating)

EC=1.4.4.2
Alternative name(s):
Glycine cleavage system P-protein
Glycine decarboxylase
Glycine dehydrogenase (aminomethyl-transferring)
Gene names
Name:gcvP
Ordered Locus Names:Sde_2476
OrganismSaccharophagus degradans (strain 2-40 / ATCC 43961 / DSM 17024) [Complete proteome] [HAMAP]
Taxonomic identifier203122 [NCBI]
Taxonomic lineageBacteriaProteobacteriaGammaproteobacteriaAlteromonadalesAlteromonadaceaeSaccharophagus

Protein attributes

Sequence length964 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO2 is released and the remaining methylamine moiety is then transferred to the lipoamide cofactor of the H protein By similarity. HAMAP-Rule MF_00711

Catalytic activity

Glycine + [glycine-cleavage complex H protein]-N(6)-lipoyl-L-lysine = [glycine-cleavage complex H protein]-S-aminomethyl-N(6)-dihydrolipoyl-L-lysine + CO2. HAMAP-Rule MF_00711

Cofactor

Pyridoxal phosphate By similarity. HAMAP-Rule MF_00711

Subunit structure

The glycine cleavage system is composed of four proteins: P, T, L and H By similarity.

Sequence similarities

Belongs to the GcvP family.

Ontologies

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 964964Glycine dehydrogenase (decarboxylating) HAMAP-Rule MF_00711
PRO_1000045605

Amino acid modifications

Modified residue7101N6-(pyridoxal phosphate)lysine By similarity

Sequences

Sequence LengthMass (Da)Tools
Q21HU3 [UniParc].

Last modified April 18, 2006. Version 1.
Checksum: FB71E12D9684E34A

FASTA964105,798
        10         20         30         40         50         60 
MSHGTSLDEL FNSRDFIGRH IGPNADQTRA MLDAMGLDSI DQLIDLTVPA SIRGEETRAL 

        70         80         90        100        110        120 
AAPVNEQQAL AELKNIAGNN QRFKSYIGMG YHPTYVPPVI LRNVLENPGW YTAYTPYQPE 

       130        140        150        160        170        180 
IAQGRLEGLL NFQQMIIELT GMDMANASML DEATAAAEAM AMAKRVARKN KSNTFFADKH 

       190        200        210        220        230        240 
CHPQTLAVLQ TRASHFGFEL VIGDITQDLN KQEVFGAITQ YPGTSGEVKD LRPIVNQAHE 

       250        260        270        280        290        300 
QDALLIVAAD ILSLVLLESP GAMGADIVVG SNQRFGIPMG FGGPHAAFFG FREKYKRATP 

       310        320        330        340        350        360 
GRIIGVSVDT RGKRALRMAM QTREQHIRRE KANSNICTSQ VLLAVMSVFY AMYHGSAGVT 

       370        380        390        400        410        420 
RIAQRVHTLT KMLAQGLTAQ GHKLAFDNYF DTLCVIVNDQ QQGLFDRAQQ AGVNLRKLDK 

       430        440        450        460        470        480 
NALTISLNEC TSLEDIHQLL DIFSLGKHSQ DVKSLETKAL AAEVIPASCR REGPALNHPV 

       490        500        510        520        530        540 
FEQYHSETEM LRYLKRLESK DIALNHAMIP LGSCTMKLNA TAEMIPVTWP EFGELHPFAP 

       550        560        570        580        590        600 
MEQAAGYSTL FTQLQDMLKA CTGYDAISLQ PNAGSQGEYA GLVAIRKYFE HLGQTERNIC 

       610        620        630        640        650        660 
LIPASAHGTN PASAQMVEMK VVVVACDNLG NVDLNDLKAK VAQYGETIAA LMVTYPSTHG 

       670        680        690        700        710        720 
VFEEEITAIC DLIHSVGAQV YIDGANMNAL VGLAAPGKFG GDVSHLNLHK TFCIPHGGGG 

       730        740        750        760        770        780 
PGMGPIGVKS HLAPFLAGHP VQPVPNTLVE NGTISAAPWG SASILTISWM YIRMMGAEGM 

       790        800        810        820        830        840 
KRATEFAILN ANYIAHRLQD HYPILYKGKN GYIAHECLLD LRPLKESSGI TEEDIAKRLM 

       850        860        870        880        890        900 
DFGFHAPTMS FPVAGTLMIE PTESESQAEL DRFCDAMIKI RQEASLVESG ELPRDNNPLV 

       910        920        930        940        950        960 
NAPHTLDDAL DETWTRPYTR DEATRPLPYL HAHKIWPTVN RIDNVYGDRN LICSCPSIES 


YTEE 

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References

[1]"Complete genome sequence of the complex carbohydrate-degrading marine bacterium, Saccharophagus degradans strain 2-40 T."
Weiner R.M., Taylor L.E. II, Henrissat B., Hauser L., Land M., Coutinho P.M., Rancurel C., Saunders E.H., Longmire A.G., Zhang H., Bayer E.A., Gilbert H.J., Larimer F., Zhulin I.B., Ekborg N.A., Lamed R., Richardson P.M., Borovok I., Hutcheson S.
PLoS Genet. 4:E1000087-E1000087(2008) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: 2-40 / ATCC 43961 / DSM 17024.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
CP000282 Genomic DNA. Translation: ABD81736.1.
RefSeqYP_527948.1. NC_007912.1.

3D structure databases

ProteinModelPortalQ21HU3.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING203122.Sde_2476.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaABD81736; ABD81736; Sde_2476.
GeneID3964923.
KEGGsde:Sde_2476.
PATRIC23403988. VBISacDeg56404_2666.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG1003.
HOGENOMHOG000239369.
KOK00281.
OMAQTMVCDL.
OrthoDBEOG6HMXDX.
ProtClustDBPRK05367.

Enzyme and pathway databases

BioCycSDEG203122:GI2M-2514-MONOMER.

Family and domain databases

Gene3D3.40.640.10. 2 hits.
HAMAPMF_00711. GcvP.
InterProIPR020580. GDC-P_N.
IPR020581. GDC_P.
IPR003437. GDC_P_homo.
IPR015424. PyrdxlP-dep_Trfase.
IPR015421. PyrdxlP-dep_Trfase_major_sub1.
[Graphical view]
PANTHERPTHR11773. PTHR11773. 1 hit.
PfamPF02347. GDC-P. 2 hits.
[Graphical view]
SUPFAMSSF53383. SSF53383. 3 hits.
TIGRFAMsTIGR00461. gcvP. 1 hit.
ProtoNetSearch...

Entry information

Entry nameGCSP_SACD2
AccessionPrimary (citable) accession number: Q21HU3
Entry history
Integrated into UniProtKB/Swiss-Prot: January 15, 2008
Last sequence update: April 18, 2006
Last modified: February 19, 2014
This is version 61 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families