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Q21HI5

- LPXB_SACD2

UniProt

Q21HI5 - LPXB_SACD2

Protein

Lipid-A-disaccharide synthase

Gene

lpxB

Organism
Saccharophagus degradans (strain 2-40 / ATCC 43961 / DSM 17024)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi
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    • History
      Entry version 51 (01 Oct 2014)
      Sequence version 1 (18 Apr 2006)
      Previous versions | rss
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    Functioni

    Condensation of UDP-2,3-diacylglucosamine and 2,3-diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell.UniRule annotation

    Catalytic activityi

    UDP-2,3-bis(3-hydroxytetradecanoyl)glucosamine + 2,3-bis(3-hydroxytetradecanoyl)-beta-D-glucosaminyl 1-phosphate = UDP + 2,3-bis(3-hydroxytetradecanoyl)-D-glucosaminyl-1,6-beta-D-2,3-bis(3-hydroxytetradecanoyl)-beta-D-glucosaminyl 1-phosphate.UniRule annotation

    Pathwayi

    GO - Molecular functioni

    1. lipid-A-disaccharide synthase activity Source: UniProtKB-EC

    GO - Biological processi

    1. lipid A biosynthetic process Source: UniProtKB-KW

    Keywords - Molecular functioni

    Glycosyltransferase, Transferase

    Keywords - Biological processi

    Lipid A biosynthesis, Lipid biosynthesis, Lipid metabolism

    Enzyme and pathway databases

    BioCyciSDEG203122:GI2M-2629-MONOMER.
    UniPathwayiUPA00359; UER00481.

    Protein family/group databases

    CAZyiGT19. Glycosyltransferase Family 19.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Lipid-A-disaccharide synthaseUniRule annotation (EC:2.4.1.182UniRule annotation)
    Gene namesi
    Name:lpxBUniRule annotation
    Ordered Locus Names:Sde_2584
    OrganismiSaccharophagus degradans (strain 2-40 / ATCC 43961 / DSM 17024)
    Taxonomic identifieri203122 [NCBI]
    Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaAlteromonadalesAlteromonadaceaeSaccharophagus
    ProteomesiUP000001947: Chromosome

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 388388Lipid-A-disaccharide synthasePRO_0000255220Add
    BLAST

    Interactioni

    Protein-protein interaction databases

    STRINGi203122.Sde_2584.

    Structurei

    3D structure databases

    ProteinModelPortaliQ21HI5.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the LpxB family.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG0763.
    HOGENOMiHOG000018003.
    KOiK00748.
    OMAiVSPITYR.
    OrthoDBiEOG6FBWZR.

    Family and domain databases

    HAMAPiMF_00392. LpxB.
    InterProiIPR003835. Glyco_trans_19.
    [Graphical view]
    PfamiPF02684. LpxB. 1 hit.
    [Graphical view]
    TIGRFAMsiTIGR00215. lpxB. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    Q21HI5-1 [UniParc]FASTAAdd to Basket

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    MSSLKRVAIV VGEASGDILG AGLMAALKKR YPDCEFEGIG GPKMLALGFN    50
    SLYQMDRLAV MGFVEPLKRL PELLGIRKSL RQRYLTNPPD VFIGIDAPDF 100
    NLNLEVNLRE AGVPVVHYVS PSVWAWRRGR LKKIAKAVDL MLTLFPFESS 150
    FFNEQNIPNL FVGHPLADTI PLENEKTGAR ERLGLSAENN ERWVALLPGS 200
    RGGEVEHLCE RFLLAAQQSF AGRPNLRIII PAANDARHSQ ISEVLKRYSE 250
    LPVTLLHGQS HDAMLAADAI LIASGTATLE AMLLKRPMVI AYHMAAFSYW 300
    LLSKLVKSKF VGLPNLLADK ELVPELLQHN ATPSQLSAAL NVYLDSEKTT 350
    QQLIEQFNAI HLQLRRDASE TAAQGIVDML AAKRDIAR 388
    Length:388
    Mass (Da):42,934
    Last modified:April 18, 2006 - v1
    Checksum:iAC341C9DF3A03F65
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000282 Genomic DNA. Translation: ABD81844.1.
    RefSeqiWP_011469061.1. NC_007912.1.
    YP_528056.1. NC_007912.1.

    Genome annotation databases

    EnsemblBacteriaiABD81844; ABD81844; Sde_2584.
    GeneIDi3968634.
    KEGGisde:Sde_2584.
    PATRICi23404238. VBISacDeg56404_2784.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000282 Genomic DNA. Translation: ABD81844.1 .
    RefSeqi WP_011469061.1. NC_007912.1.
    YP_528056.1. NC_007912.1.

    3D structure databases

    ProteinModelPortali Q21HI5.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 203122.Sde_2584.

    Protein family/group databases

    CAZyi GT19. Glycosyltransferase Family 19.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai ABD81844 ; ABD81844 ; Sde_2584 .
    GeneIDi 3968634.
    KEGGi sde:Sde_2584.
    PATRICi 23404238. VBISacDeg56404_2784.

    Phylogenomic databases

    eggNOGi COG0763.
    HOGENOMi HOG000018003.
    KOi K00748.
    OMAi VSPITYR.
    OrthoDBi EOG6FBWZR.

    Enzyme and pathway databases

    UniPathwayi UPA00359 ; UER00481 .
    BioCyci SDEG203122:GI2M-2629-MONOMER.

    Family and domain databases

    HAMAPi MF_00392. LpxB.
    InterProi IPR003835. Glyco_trans_19.
    [Graphical view ]
    Pfami PF02684. LpxB. 1 hit.
    [Graphical view ]
    TIGRFAMsi TIGR00215. lpxB. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: 2-40 / ATCC 43961 / DSM 17024.

    Entry informationi

    Entry nameiLPXB_SACD2
    AccessioniPrimary (citable) accession number: Q21HI5
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: October 31, 2006
    Last sequence update: April 18, 2006
    Last modified: October 1, 2014
    This is version 51 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3