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Protein

Lipid-A-disaccharide synthase

Gene

lpxB

Organism
Saccharophagus degradans (strain 2-40 / ATCC 43961 / DSM 17024)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Condensation of UDP-2,3-diacylglucosamine and 2,3-diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell.UniRule annotation

Catalytic activityi

UDP-2-N,3-O-bis((3R)-3-hydroxytetradecanoyl)-alpha-D-glucosamine + 2-N,3-O-bis((3R)-3-hydroxytetradecanoyl)-alpha-D-glucosaminyl 1-phosphate = UDP + 2-N,3-O-bis((3R)-3-hydroxytetradecanoyl)-beta-D-glucosaminyl-(1->6)-2-N,3-O-bis((3R)-3-hydroxytetradecanoyl)-alpha-D-glucosaminyl 1-phosphate.UniRule annotation

Pathwayi: lipid IV(A) biosynthesis

This protein is involved in step 5 of the subpathway that synthesizes lipid IV(A) from (3R)-3-hydroxytetradecanoyl-[acyl-carrier-protein] and UDP-N-acetyl-alpha-D-glucosamine.UniRule annotation
Proteins known to be involved in the 6 steps of the subpathway in this organism are:
  1. Acyl-[acyl-carrier-protein]--UDP-N-acetylglucosamine O-acyltransferase (lpxA)
  2. UDP-3-O-acyl-N-acetylglucosamine deacetylase (lpxC)
  3. no protein annotated in this organism
  4. UDP-2,3-diacylglucosamine hydrolase (lpxH)
  5. Lipid-A-disaccharide synthase (lpxB)
  6. Tetraacyldisaccharide 4'-kinase (lpxK)
This subpathway is part of the pathway lipid IV(A) biosynthesis, which is itself part of Glycolipid biosynthesis.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes lipid IV(A) from (3R)-3-hydroxytetradecanoyl-[acyl-carrier-protein] and UDP-N-acetyl-alpha-D-glucosamine, the pathway lipid IV(A) biosynthesis and in Glycolipid biosynthesis.

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionGlycosyltransferase, Transferase
Biological processLipid A biosynthesis, Lipid biosynthesis, Lipid metabolism

Enzyme and pathway databases

BioCyciSDEG203122:G1G67-2725-MONOMER
UniPathwayiUPA00359; UER00481

Protein family/group databases

CAZyiGT19 Glycosyltransferase Family 19

Names & Taxonomyi

Protein namesi
Recommended name:
Lipid-A-disaccharide synthaseUniRule annotation (EC:2.4.1.182UniRule annotation)
Gene namesi
Name:lpxBUniRule annotation
Ordered Locus Names:Sde_2584
OrganismiSaccharophagus degradans (strain 2-40 / ATCC 43961 / DSM 17024)
Taxonomic identifieri203122 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaCellvibrionalesCellvibrionaceaeSaccharophagus
Proteomesi
  • UP000001947 Componenti: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002552201 – 388Lipid-A-disaccharide synthaseAdd BLAST388

Proteomic databases

PRIDEiQ21HI5

Interactioni

Protein-protein interaction databases

STRINGi203122.Sde_2584

Structurei

3D structure databases

ProteinModelPortaliQ21HI5
SMRiQ21HI5
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the LpxB family.UniRule annotation

Phylogenomic databases

eggNOGiENOG4105D0V Bacteria
COG0763 LUCA
HOGENOMiHOG000018003
KOiK00748
OMAiPTVWAWR
OrthoDBiPOG091H01NW

Family and domain databases

HAMAPiMF_00392 LpxB, 1 hit
InterProiView protein in InterPro
IPR003835 Glyco_trans_19
PANTHERiPTHR30372 PTHR30372, 1 hit
PfamiView protein in Pfam
PF02684 LpxB, 1 hit
TIGRFAMsiTIGR00215 lpxB, 1 hit

Sequencei

Sequence statusi: Complete.

Q21HI5-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSSLKRVAIV VGEASGDILG AGLMAALKKR YPDCEFEGIG GPKMLALGFN
60 70 80 90 100
SLYQMDRLAV MGFVEPLKRL PELLGIRKSL RQRYLTNPPD VFIGIDAPDF
110 120 130 140 150
NLNLEVNLRE AGVPVVHYVS PSVWAWRRGR LKKIAKAVDL MLTLFPFESS
160 170 180 190 200
FFNEQNIPNL FVGHPLADTI PLENEKTGAR ERLGLSAENN ERWVALLPGS
210 220 230 240 250
RGGEVEHLCE RFLLAAQQSF AGRPNLRIII PAANDARHSQ ISEVLKRYSE
260 270 280 290 300
LPVTLLHGQS HDAMLAADAI LIASGTATLE AMLLKRPMVI AYHMAAFSYW
310 320 330 340 350
LLSKLVKSKF VGLPNLLADK ELVPELLQHN ATPSQLSAAL NVYLDSEKTT
360 370 380
QQLIEQFNAI HLQLRRDASE TAAQGIVDML AAKRDIAR
Length:388
Mass (Da):42,934
Last modified:April 18, 2006 - v1
Checksum:iAC341C9DF3A03F65
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000282 Genomic DNA Translation: ABD81844.1
RefSeqiWP_011469061.1, NC_007912.1

Genome annotation databases

EnsemblBacteriaiABD81844; ABD81844; Sde_2584
KEGGisde:Sde_2584

Similar proteinsi

Entry informationi

Entry nameiLPXB_SACD2
AccessioniPrimary (citable) accession number: Q21HI5
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 31, 2006
Last sequence update: April 18, 2006
Last modified: May 23, 2018
This is version 65 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

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