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Q21FG6

- SYL_SACD2

UniProt

Q21FG6 - SYL_SACD2

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Protein

Leucine--tRNA ligase

Gene
leuS, Sde_3308
Organism
Saccharophagus degradans (strain 2-40 / ATCC 43961 / DSM 17024)
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Catalytic activityi

ATP + L-leucine + tRNA(Leu) = AMP + diphosphate + L-leucyl-tRNA(Leu).UniRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei580 – 5801ATP By similarity

GO - Molecular functioni

  1. aminoacyl-tRNA editing activity Source: InterPro
  2. ATP binding Source: UniProtKB-HAMAP
  3. leucine-tRNA ligase activity Source: UniProtKB-HAMAP

GO - Biological processi

  1. leucyl-tRNA aminoacylation Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Aminoacyl-tRNA synthetase, Ligase

Keywords - Biological processi

Protein biosynthesis

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciSDEG203122:GI2M-3358-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Leucine--tRNA ligase (EC:6.1.1.4)
Alternative name(s):
Leucyl-tRNA synthetase
Short name:
LeuRS
Gene namesi
Name:leuS
Ordered Locus Names:Sde_3308
OrganismiSaccharophagus degradans (strain 2-40 / ATCC 43961 / DSM 17024)
Taxonomic identifieri203122 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaAlteromonadalesAlteromonadaceaeSaccharophagus
ProteomesiUP000001947: Chromosome

Subcellular locationi

Cytoplasm By similarity UniRule annotation

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 819819Leucine--tRNA ligaseUniRule annotationPRO_1000009421Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi203122.Sde_3308.

Structurei

3D structure databases

ProteinModelPortaliQ21FG6.

Family & Domainsi

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi42 – 5211"HIGH" regionUniRule annotationAdd
BLAST
Motifi577 – 5815"KMSKS" regionUniRule annotation

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG0495.
HOGENOMiHOG000200747.
KOiK01869.
OMAiHISHELW.
OrthoDBiEOG63Z74X.

Family and domain databases

Gene3Di1.10.730.10. 1 hit.
3.40.50.620. 2 hits.
3.90.740.10. 1 hit.
HAMAPiMF_00049_B. Leu_tRNA_synth_B.
InterProiIPR001412. aa-tRNA-synth_I_CS.
IPR002300. aa-tRNA-synth_Ia.
IPR002302. Leu-tRNA-ligase.
IPR025709. Leu_tRNA-synth_edit.
IPR014729. Rossmann-like_a/b/a_fold.
IPR009080. tRNAsynth_1a_anticodon-bd.
IPR013155. V/L/I-tRNA-synth_anticodon-bd.
IPR009008. Val/Leu/Ile-tRNA-synth_edit.
[Graphical view]
PANTHERiPTHR11946:SF7. PTHR11946:SF7. 1 hit.
PfamiPF08264. Anticodon_1. 1 hit.
PF00133. tRNA-synt_1. 2 hits.
PF13603. tRNA-synt_1_2. 1 hit.
[Graphical view]
PRINTSiPR00985. TRNASYNTHLEU.
SUPFAMiSSF47323. SSF47323. 1 hit.
SSF50677. SSF50677. 1 hit.
TIGRFAMsiTIGR00396. leuS_bact. 1 hit.
PROSITEiPS00178. AA_TRNA_LIGASE_I. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q21FG6-1 [UniParc]FASTAAdd to Basket

« Hide

MNEYYQPSEI EAQAQKYWEE NKSFNVTEDP TKEKFYCLAM FPYPSGRLHM    50
GHVRNYTISD VISRFHRMQG KNVLHPMGWD AFGLPAENAA IKNNTAPAKW 100
TYSNTDYMRK QLTELGFGFD WSREVTTCKP DYYKWEQWFF TRLYEKGLAY 150
KKVASVNWCP NDQTVLANEQ VVDGQCWRCD TAVERKEIPQ WFIRITDYAE 200
ELLADLDKLP NWPEQVKTMQ RNWIGKSQGV EMRFDLANPI AGTTGFDVYT 250
TRPDTLMGVT YVSLAAEHPI AKALAETNPA LAAFIQECKV QSVAEADMAN 300
MEKKGIDTGI KAKHPITGDE VSVWVANYVL MDYGSGAVMA VPAHDQRDWE 350
FAKKYDLEIK QVIAPEDGSD IDLTKEAFVD KGVLVNSGEY DGLNFNAAFE 400
AISQTLQAAN KGKVTTNFRL RDWGVSRQRY WGSPIPIFNL PDGGVIPVPA 450
DRLPVLLPED VQMDGVQSPI KADKEWCKAE LNGQAVEHET DTFDTFMESS 500
WYYARYTSPN ADSMLDPDKA NYWLPVDQYV GGIEHAILHL LYARFFHKLM 550
RDEGLVECDE PFERLLCQGM VLKDGTKMSK SKGNTVDPED LIKTYGADTV 600
RLFSMFAAPP EQSLEWTDSG VEGAFRFLKK LWKAVASHLE AGSAGEIDAN 650
SLDEQQKALR RKTHETISKV SDDYGRRQTF NTAIAAVMEL LNEITRSADR 700
STPNGLAVER EALEAATLLL APIVPHACHA LWQAFGNEVA VLDAPWPTVD 750
EAALVKDTIT IVAQVNGKVR AKLDAPANAD KDALEKIALA DESVLKHIDG 800
KMIRKVIVVP GKLVNIVAN 819
Length:819
Mass (Da):92,026
Last modified:April 18, 2006 - v1
Checksum:i513F6286CAE6CF0C
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000282 Genomic DNA. Translation: ABD82563.1.
RefSeqiYP_528775.1. NC_007912.1.

Genome annotation databases

EnsemblBacteriaiABD82563; ABD82563; Sde_3308.
GeneIDi3965819.
KEGGisde:Sde_3308.
PATRICi23405813. VBISacDeg56404_3567.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000282 Genomic DNA. Translation: ABD82563.1 .
RefSeqi YP_528775.1. NC_007912.1.

3D structure databases

ProteinModelPortali Q21FG6.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 203122.Sde_3308.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai ABD82563 ; ABD82563 ; Sde_3308 .
GeneIDi 3965819.
KEGGi sde:Sde_3308.
PATRICi 23405813. VBISacDeg56404_3567.

Phylogenomic databases

eggNOGi COG0495.
HOGENOMi HOG000200747.
KOi K01869.
OMAi HISHELW.
OrthoDBi EOG63Z74X.

Enzyme and pathway databases

BioCyci SDEG203122:GI2M-3358-MONOMER.

Family and domain databases

Gene3Di 1.10.730.10. 1 hit.
3.40.50.620. 2 hits.
3.90.740.10. 1 hit.
HAMAPi MF_00049_B. Leu_tRNA_synth_B.
InterProi IPR001412. aa-tRNA-synth_I_CS.
IPR002300. aa-tRNA-synth_Ia.
IPR002302. Leu-tRNA-ligase.
IPR025709. Leu_tRNA-synth_edit.
IPR014729. Rossmann-like_a/b/a_fold.
IPR009080. tRNAsynth_1a_anticodon-bd.
IPR013155. V/L/I-tRNA-synth_anticodon-bd.
IPR009008. Val/Leu/Ile-tRNA-synth_edit.
[Graphical view ]
PANTHERi PTHR11946:SF7. PTHR11946:SF7. 1 hit.
Pfami PF08264. Anticodon_1. 1 hit.
PF00133. tRNA-synt_1. 2 hits.
PF13603. tRNA-synt_1_2. 1 hit.
[Graphical view ]
PRINTSi PR00985. TRNASYNTHLEU.
SUPFAMi SSF47323. SSF47323. 1 hit.
SSF50677. SSF50677. 1 hit.
TIGRFAMsi TIGR00396. leuS_bact. 1 hit.
PROSITEi PS00178. AA_TRNA_LIGASE_I. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: 2-40 / ATCC 43961 / DSM 17024.

Entry informationi

Entry nameiSYL_SACD2
AccessioniPrimary (citable) accession number: Q21FG6
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 15, 2008
Last sequence update: April 18, 2006
Last modified: May 14, 2014
This is version 65 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. Aminoacyl-tRNA synthetases
    List of aminoacyl-tRNA synthetase entries
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi