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Q21FG6

- SYL_SACD2

UniProt

Q21FG6 - SYL_SACD2

Protein

Leucine--tRNA ligase

Gene

leuS

Organism
Saccharophagus degradans (strain 2-40 / ATCC 43961 / DSM 17024)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi
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    • History
      Entry version 66 (01 Oct 2014)
      Sequence version 1 (18 Apr 2006)
      Previous versions | rss
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    Functioni

    Catalytic activityi

    ATP + L-leucine + tRNA(Leu) = AMP + diphosphate + L-leucyl-tRNA(Leu).UniRule annotation

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Binding sitei580 – 5801ATPUniRule annotation

    GO - Molecular functioni

    1. aminoacyl-tRNA editing activity Source: InterPro
    2. ATP binding Source: UniProtKB-HAMAP
    3. leucine-tRNA ligase activity Source: UniProtKB-HAMAP

    GO - Biological processi

    1. leucyl-tRNA aminoacylation Source: UniProtKB-HAMAP

    Keywords - Molecular functioni

    Aminoacyl-tRNA synthetase, Ligase

    Keywords - Biological processi

    Protein biosynthesis

    Keywords - Ligandi

    ATP-binding, Nucleotide-binding

    Enzyme and pathway databases

    BioCyciSDEG203122:GI2M-3358-MONOMER.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Leucine--tRNA ligaseUniRule annotation (EC:6.1.1.4UniRule annotation)
    Alternative name(s):
    Leucyl-tRNA synthetaseUniRule annotation
    Short name:
    LeuRSUniRule annotation
    Gene namesi
    Name:leuSUniRule annotation
    Ordered Locus Names:Sde_3308
    OrganismiSaccharophagus degradans (strain 2-40 / ATCC 43961 / DSM 17024)
    Taxonomic identifieri203122 [NCBI]
    Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaAlteromonadalesAlteromonadaceaeSaccharophagus
    ProteomesiUP000001947: Chromosome

    Subcellular locationi

    Cytoplasm UniRule annotation

    GO - Cellular componenti

    1. cytoplasm Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cytoplasm

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 819819Leucine--tRNA ligasePRO_1000009421Add
    BLAST

    Interactioni

    Protein-protein interaction databases

    STRINGi203122.Sde_3308.

    Structurei

    3D structure databases

    ProteinModelPortaliQ21FG6.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Motif

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Motifi42 – 5211"HIGH" regionAdd
    BLAST
    Motifi577 – 5815"KMSKS" region

    Sequence similaritiesi

    Belongs to the class-I aminoacyl-tRNA synthetase family.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG0495.
    HOGENOMiHOG000200747.
    KOiK01869.
    OMAiHISHELW.
    OrthoDBiEOG63Z74X.

    Family and domain databases

    Gene3Di1.10.730.10. 1 hit.
    3.40.50.620. 2 hits.
    3.90.740.10. 1 hit.
    HAMAPiMF_00049_B. Leu_tRNA_synth_B.
    InterProiIPR001412. aa-tRNA-synth_I_CS.
    IPR002300. aa-tRNA-synth_Ia.
    IPR002302. Leu-tRNA-ligase.
    IPR025709. Leu_tRNA-synth_edit.
    IPR014729. Rossmann-like_a/b/a_fold.
    IPR009080. tRNAsynth_1a_anticodon-bd.
    IPR013155. V/L/I-tRNA-synth_anticodon-bd.
    IPR009008. Val/Leu/Ile-tRNA-synth_edit.
    [Graphical view]
    PANTHERiPTHR11946:SF7. PTHR11946:SF7. 1 hit.
    PfamiPF08264. Anticodon_1. 1 hit.
    PF00133. tRNA-synt_1. 2 hits.
    PF13603. tRNA-synt_1_2. 1 hit.
    [Graphical view]
    PRINTSiPR00985. TRNASYNTHLEU.
    SUPFAMiSSF47323. SSF47323. 1 hit.
    SSF50677. SSF50677. 1 hit.
    TIGRFAMsiTIGR00396. leuS_bact. 1 hit.
    PROSITEiPS00178. AA_TRNA_LIGASE_I. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q21FG6-1 [UniParc]FASTAAdd to Basket

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    MNEYYQPSEI EAQAQKYWEE NKSFNVTEDP TKEKFYCLAM FPYPSGRLHM    50
    GHVRNYTISD VISRFHRMQG KNVLHPMGWD AFGLPAENAA IKNNTAPAKW 100
    TYSNTDYMRK QLTELGFGFD WSREVTTCKP DYYKWEQWFF TRLYEKGLAY 150
    KKVASVNWCP NDQTVLANEQ VVDGQCWRCD TAVERKEIPQ WFIRITDYAE 200
    ELLADLDKLP NWPEQVKTMQ RNWIGKSQGV EMRFDLANPI AGTTGFDVYT 250
    TRPDTLMGVT YVSLAAEHPI AKALAETNPA LAAFIQECKV QSVAEADMAN 300
    MEKKGIDTGI KAKHPITGDE VSVWVANYVL MDYGSGAVMA VPAHDQRDWE 350
    FAKKYDLEIK QVIAPEDGSD IDLTKEAFVD KGVLVNSGEY DGLNFNAAFE 400
    AISQTLQAAN KGKVTTNFRL RDWGVSRQRY WGSPIPIFNL PDGGVIPVPA 450
    DRLPVLLPED VQMDGVQSPI KADKEWCKAE LNGQAVEHET DTFDTFMESS 500
    WYYARYTSPN ADSMLDPDKA NYWLPVDQYV GGIEHAILHL LYARFFHKLM 550
    RDEGLVECDE PFERLLCQGM VLKDGTKMSK SKGNTVDPED LIKTYGADTV 600
    RLFSMFAAPP EQSLEWTDSG VEGAFRFLKK LWKAVASHLE AGSAGEIDAN 650
    SLDEQQKALR RKTHETISKV SDDYGRRQTF NTAIAAVMEL LNEITRSADR 700
    STPNGLAVER EALEAATLLL APIVPHACHA LWQAFGNEVA VLDAPWPTVD 750
    EAALVKDTIT IVAQVNGKVR AKLDAPANAD KDALEKIALA DESVLKHIDG 800
    KMIRKVIVVP GKLVNIVAN 819
    Length:819
    Mass (Da):92,026
    Last modified:April 18, 2006 - v1
    Checksum:i513F6286CAE6CF0C
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000282 Genomic DNA. Translation: ABD82563.1.
    RefSeqiYP_528775.1. NC_007912.1.

    Genome annotation databases

    EnsemblBacteriaiABD82563; ABD82563; Sde_3308.
    GeneIDi3965819.
    KEGGisde:Sde_3308.
    PATRICi23405813. VBISacDeg56404_3567.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000282 Genomic DNA. Translation: ABD82563.1 .
    RefSeqi YP_528775.1. NC_007912.1.

    3D structure databases

    ProteinModelPortali Q21FG6.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 203122.Sde_3308.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai ABD82563 ; ABD82563 ; Sde_3308 .
    GeneIDi 3965819.
    KEGGi sde:Sde_3308.
    PATRICi 23405813. VBISacDeg56404_3567.

    Phylogenomic databases

    eggNOGi COG0495.
    HOGENOMi HOG000200747.
    KOi K01869.
    OMAi HISHELW.
    OrthoDBi EOG63Z74X.

    Enzyme and pathway databases

    BioCyci SDEG203122:GI2M-3358-MONOMER.

    Family and domain databases

    Gene3Di 1.10.730.10. 1 hit.
    3.40.50.620. 2 hits.
    3.90.740.10. 1 hit.
    HAMAPi MF_00049_B. Leu_tRNA_synth_B.
    InterProi IPR001412. aa-tRNA-synth_I_CS.
    IPR002300. aa-tRNA-synth_Ia.
    IPR002302. Leu-tRNA-ligase.
    IPR025709. Leu_tRNA-synth_edit.
    IPR014729. Rossmann-like_a/b/a_fold.
    IPR009080. tRNAsynth_1a_anticodon-bd.
    IPR013155. V/L/I-tRNA-synth_anticodon-bd.
    IPR009008. Val/Leu/Ile-tRNA-synth_edit.
    [Graphical view ]
    PANTHERi PTHR11946:SF7. PTHR11946:SF7. 1 hit.
    Pfami PF08264. Anticodon_1. 1 hit.
    PF00133. tRNA-synt_1. 2 hits.
    PF13603. tRNA-synt_1_2. 1 hit.
    [Graphical view ]
    PRINTSi PR00985. TRNASYNTHLEU.
    SUPFAMi SSF47323. SSF47323. 1 hit.
    SSF50677. SSF50677. 1 hit.
    TIGRFAMsi TIGR00396. leuS_bact. 1 hit.
    PROSITEi PS00178. AA_TRNA_LIGASE_I. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: 2-40 / ATCC 43961 / DSM 17024.

    Entry informationi

    Entry nameiSYL_SACD2
    AccessioniPrimary (citable) accession number: Q21FG6
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: January 15, 2008
    Last sequence update: April 18, 2006
    Last modified: October 1, 2014
    This is version 66 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Aminoacyl-tRNA synthetases
      List of aminoacyl-tRNA synthetase entries
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3