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Q21FG6

- SYL_SACD2

UniProt

Q21FG6 - SYL_SACD2

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Protein

Leucine--tRNA ligase

Gene

leuS

Organism
Saccharophagus degradans (strain 2-40 / ATCC 43961 / DSM 17024)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi

Functioni

Catalytic activityi

ATP + L-leucine + tRNA(Leu) = AMP + diphosphate + L-leucyl-tRNA(Leu).UniRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei580 – 5801ATPUniRule annotation

GO - Molecular functioni

  1. aminoacyl-tRNA editing activity Source: InterPro
  2. ATP binding Source: UniProtKB-HAMAP
  3. leucine-tRNA ligase activity Source: UniProtKB-HAMAP

GO - Biological processi

  1. leucyl-tRNA aminoacylation Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Aminoacyl-tRNA synthetase, Ligase

Keywords - Biological processi

Protein biosynthesis

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciSDEG203122:GI2M-3358-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Leucine--tRNA ligaseUniRule annotation (EC:6.1.1.4UniRule annotation)
Alternative name(s):
Leucyl-tRNA synthetaseUniRule annotation
Short name:
LeuRSUniRule annotation
Gene namesi
Name:leuSUniRule annotation
Ordered Locus Names:Sde_3308
OrganismiSaccharophagus degradans (strain 2-40 / ATCC 43961 / DSM 17024)
Taxonomic identifieri203122 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaAlteromonadalesAlteromonadaceaeSaccharophagus
ProteomesiUP000001947: Chromosome

Subcellular locationi

Cytoplasm UniRule annotation

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 819819Leucine--tRNA ligasePRO_1000009421Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi203122.Sde_3308.

Structurei

3D structure databases

ProteinModelPortaliQ21FG6.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi42 – 5211"HIGH" regionAdd
BLAST
Motifi577 – 5815"KMSKS" region

Sequence similaritiesi

Belongs to the class-I aminoacyl-tRNA synthetase family.UniRule annotation

Phylogenomic databases

eggNOGiCOG0495.
HOGENOMiHOG000200747.
KOiK01869.
OMAiHISHELW.
OrthoDBiEOG63Z74X.

Family and domain databases

Gene3Di1.10.730.10. 1 hit.
3.40.50.620. 2 hits.
3.90.740.10. 1 hit.
HAMAPiMF_00049_B. Leu_tRNA_synth_B.
InterProiIPR001412. aa-tRNA-synth_I_CS.
IPR002300. aa-tRNA-synth_Ia.
IPR002302. Leu-tRNA-ligase.
IPR025709. Leu_tRNA-synth_edit.
IPR014729. Rossmann-like_a/b/a_fold.
IPR009080. tRNAsynth_1a_anticodon-bd.
IPR013155. V/L/I-tRNA-synth_anticodon-bd.
IPR009008. Val/Leu/Ile-tRNA-synth_edit.
[Graphical view]
PANTHERiPTHR11946:SF7. PTHR11946:SF7. 1 hit.
PfamiPF08264. Anticodon_1. 1 hit.
PF00133. tRNA-synt_1. 2 hits.
PF13603. tRNA-synt_1_2. 1 hit.
[Graphical view]
PRINTSiPR00985. TRNASYNTHLEU.
SUPFAMiSSF47323. SSF47323. 1 hit.
SSF50677. SSF50677. 1 hit.
TIGRFAMsiTIGR00396. leuS_bact. 1 hit.
PROSITEiPS00178. AA_TRNA_LIGASE_I. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q21FG6-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MNEYYQPSEI EAQAQKYWEE NKSFNVTEDP TKEKFYCLAM FPYPSGRLHM
60 70 80 90 100
GHVRNYTISD VISRFHRMQG KNVLHPMGWD AFGLPAENAA IKNNTAPAKW
110 120 130 140 150
TYSNTDYMRK QLTELGFGFD WSREVTTCKP DYYKWEQWFF TRLYEKGLAY
160 170 180 190 200
KKVASVNWCP NDQTVLANEQ VVDGQCWRCD TAVERKEIPQ WFIRITDYAE
210 220 230 240 250
ELLADLDKLP NWPEQVKTMQ RNWIGKSQGV EMRFDLANPI AGTTGFDVYT
260 270 280 290 300
TRPDTLMGVT YVSLAAEHPI AKALAETNPA LAAFIQECKV QSVAEADMAN
310 320 330 340 350
MEKKGIDTGI KAKHPITGDE VSVWVANYVL MDYGSGAVMA VPAHDQRDWE
360 370 380 390 400
FAKKYDLEIK QVIAPEDGSD IDLTKEAFVD KGVLVNSGEY DGLNFNAAFE
410 420 430 440 450
AISQTLQAAN KGKVTTNFRL RDWGVSRQRY WGSPIPIFNL PDGGVIPVPA
460 470 480 490 500
DRLPVLLPED VQMDGVQSPI KADKEWCKAE LNGQAVEHET DTFDTFMESS
510 520 530 540 550
WYYARYTSPN ADSMLDPDKA NYWLPVDQYV GGIEHAILHL LYARFFHKLM
560 570 580 590 600
RDEGLVECDE PFERLLCQGM VLKDGTKMSK SKGNTVDPED LIKTYGADTV
610 620 630 640 650
RLFSMFAAPP EQSLEWTDSG VEGAFRFLKK LWKAVASHLE AGSAGEIDAN
660 670 680 690 700
SLDEQQKALR RKTHETISKV SDDYGRRQTF NTAIAAVMEL LNEITRSADR
710 720 730 740 750
STPNGLAVER EALEAATLLL APIVPHACHA LWQAFGNEVA VLDAPWPTVD
760 770 780 790 800
EAALVKDTIT IVAQVNGKVR AKLDAPANAD KDALEKIALA DESVLKHIDG
810
KMIRKVIVVP GKLVNIVAN
Length:819
Mass (Da):92,026
Last modified:April 18, 2006 - v1
Checksum:i513F6286CAE6CF0C
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000282 Genomic DNA. Translation: ABD82563.1.
RefSeqiWP_011469779.1. NC_007912.1.
YP_528775.1. NC_007912.1.

Genome annotation databases

EnsemblBacteriaiABD82563; ABD82563; Sde_3308.
GeneIDi3965819.
KEGGisde:Sde_3308.
PATRICi23405813. VBISacDeg56404_3567.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000282 Genomic DNA. Translation: ABD82563.1 .
RefSeqi WP_011469779.1. NC_007912.1.
YP_528775.1. NC_007912.1.

3D structure databases

ProteinModelPortali Q21FG6.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 203122.Sde_3308.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai ABD82563 ; ABD82563 ; Sde_3308 .
GeneIDi 3965819.
KEGGi sde:Sde_3308.
PATRICi 23405813. VBISacDeg56404_3567.

Phylogenomic databases

eggNOGi COG0495.
HOGENOMi HOG000200747.
KOi K01869.
OMAi HISHELW.
OrthoDBi EOG63Z74X.

Enzyme and pathway databases

BioCyci SDEG203122:GI2M-3358-MONOMER.

Family and domain databases

Gene3Di 1.10.730.10. 1 hit.
3.40.50.620. 2 hits.
3.90.740.10. 1 hit.
HAMAPi MF_00049_B. Leu_tRNA_synth_B.
InterProi IPR001412. aa-tRNA-synth_I_CS.
IPR002300. aa-tRNA-synth_Ia.
IPR002302. Leu-tRNA-ligase.
IPR025709. Leu_tRNA-synth_edit.
IPR014729. Rossmann-like_a/b/a_fold.
IPR009080. tRNAsynth_1a_anticodon-bd.
IPR013155. V/L/I-tRNA-synth_anticodon-bd.
IPR009008. Val/Leu/Ile-tRNA-synth_edit.
[Graphical view ]
PANTHERi PTHR11946:SF7. PTHR11946:SF7. 1 hit.
Pfami PF08264. Anticodon_1. 1 hit.
PF00133. tRNA-synt_1. 2 hits.
PF13603. tRNA-synt_1_2. 1 hit.
[Graphical view ]
PRINTSi PR00985. TRNASYNTHLEU.
SUPFAMi SSF47323. SSF47323. 1 hit.
SSF50677. SSF50677. 1 hit.
TIGRFAMsi TIGR00396. leuS_bact. 1 hit.
PROSITEi PS00178. AA_TRNA_LIGASE_I. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: 2-40 / ATCC 43961 / DSM 17024.

Entry informationi

Entry nameiSYL_SACD2
AccessioniPrimary (citable) accession number: Q21FG6
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 15, 2008
Last sequence update: April 18, 2006
Last modified: October 29, 2014
This is version 67 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Aminoacyl-tRNA synthetases
    List of aminoacyl-tRNA synthetase entries
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3