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Protein

Catalase-peroxidase

Gene

katG

Organism
Saccharophagus degradans (strain 2-40 / ATCC 43961 / DSM 17024)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Bifunctional enzyme with both catalase and broad-spectrum peroxidase activity.UniRule annotation

Catalytic activityi

Donor + H2O2 = oxidized donor + 2 H2O.UniRule annotation
2 H2O2 = O2 + 2 H2O.UniRule annotation

Cofactori

heme bUniRule annotationNote: Binds 1 heme b (iron(II)-protoporphyrin IX) group per dimer.UniRule annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sitei101Transition state stabilizerUniRule annotation1
Active sitei105Proton acceptorUniRule annotation1
Metal bindingi267Iron (heme axial ligand)UniRule annotation1

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase, Peroxidase

Keywords - Biological processi

Hydrogen peroxide

Keywords - Ligandi

Heme, Iron, Metal-binding

Protein family/group databases

PeroxiBasei2699. SdCP01.

Names & Taxonomyi

Protein namesi
Recommended name:
Catalase-peroxidaseUniRule annotation (EC:1.11.1.21UniRule annotation)
Short name:
CPUniRule annotation
Alternative name(s):
Peroxidase/catalaseUniRule annotation
Gene namesi
Name:katGUniRule annotation
Ordered Locus Names:Sde_3888
OrganismiSaccharophagus degradans (strain 2-40 / ATCC 43961 / DSM 17024)
Taxonomic identifieri203122 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaCellvibrionalesCellvibrionaceaeSaccharophagus
Proteomesi
  • UP000001947 Componenti: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 24UniRule annotationAdd BLAST24
ChainiPRO_000035489925 – 738Catalase-peroxidaseAdd BLAST714

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Cross-linki104 ↔ 226Tryptophyl-tyrosyl-methioninium (Trp-Tyr) (with M-252)UniRule annotation
Cross-linki226 ↔ 252Tryptophyl-tyrosyl-methioninium (Tyr-Met) (with W-104)UniRule annotation

Post-translational modificationi

The covalent Trp-Tyr-Met adduct is important for the catalase, but not the peroxidase activity of the enzyme.UniRule annotation

Interactioni

Subunit structurei

Homodimer or homotetramer.UniRule annotation

Protein-protein interaction databases

STRINGi203122.Sde_3888.

Structurei

3D structure databases

ProteinModelPortaliQ21DT6.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the peroxidase family. Peroxidase/catalase subfamily.UniRule annotation

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiENOG4105C1X. Bacteria.
COG0376. LUCA.
HOGENOMiHOG000218110.
KOiK03782.
OMAiYGATTMG.
OrthoDBiPOG091H05R1.

Family and domain databases

HAMAPiMF_01961. Catal_peroxid. 1 hit.
InterProiIPR000763. Catalase_peroxidase.
IPR010255. Haem_peroxidase.
IPR002016. Haem_peroxidase_pln/fun/bac.
IPR019794. Peroxidases_AS.
IPR019793. Peroxidases_heam-ligand_BS.
[Graphical view]
PfamiPF00141. peroxidase. 2 hits.
[Graphical view]
PRINTSiPR00460. BPEROXIDASE.
PR00458. PEROXIDASE.
SUPFAMiSSF48113. SSF48113. 2 hits.
TIGRFAMsiTIGR00198. cat_per_HPI. 1 hit.
PROSITEiPS00435. PEROXIDASE_1. 1 hit.
PS00436. PEROXIDASE_2. 1 hit.
PS50873. PEROXIDASE_4. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q21DT6-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MEPLFPKRLL SIAVLCVASA TAQADTGMNP DNDYWWPNRL SLEPLRDSSL
60 70 80 90 100
SADPRGANFD YNEALKDLDV EALKKDLKQV MTASQDWWPA DYGHYGPFFI
110 120 130 140 150
RLSWHAAGTY RMIDGRGGAD GGMQRFAPLN SWPDNASLDK ARRLLQPIKQ
160 170 180 190 200
KYGNNLSWSD LLVLAGTIGM EDMGFPIVGF AFGRDDEWEP EEVNWGPEGQ
210 220 230 240 250
WLTDRRHSGD RKLDKPFGAT EMGLIYVNPE GPHGNPDPIA AAHDIRQAFG
260 270 280 290 300
RMGMSDEETV ALIAGGHTFG KAHGAHKPSD CVGADPEAAS MEEQGLGWTN
310 320 330 340 350
KCGKGNAEDT VTSGLEGAWT VSPAEWTHNF LQNLYAFEWE LTTSPAGAKQ
360 370 380 390 400
WVPKGGAATN MVPDAHDSSK RHAPIMLTTD LALKEDPAYR KITQRWLEDP
410 420 430 440 450
EEFTRAFARA WFKLTHRDMG PVSRYKGELV PSDTFVWQDP VPVADYKQIG
460 470 480 490 500
ERDVKKLKAA ILDSGLSTSD LVKTAWASAA SFRTTDMRGG ANGARIRLAP
510 520 530 540 550
QKDWAVNQPQ DLQRVLKVLE GVQREFNKKS RKTKVSLADV IVLGGAAAIE
560 570 580 590 600
QAAKKAGHKV EVPFFPGRTD ASQEMTDVST FAWLEPKSDG FRNFHAEGYK
610 620 630 640 650
RNPAEALVER AALLGLTAPE MTALVGGLRV LQANADGSQH GVFTDNPGSL
660 670 680 690 700
TNDFFVNLVD MSTVWKKSDT EAGLYKGLDR NSGKVKWTAT SADLIFGSNS
710 720 730
ELRAIAEYYS QSDSQKTFVQ DFINAWSKVM TADRFDLK
Length:738
Mass (Da):81,426
Last modified:April 18, 2006 - v1
Checksum:iD3F86280D89C30A3
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000282 Genomic DNA. Translation: ABD83143.1.
RefSeqiWP_011470358.1. NC_007912.1.

Genome annotation databases

EnsemblBacteriaiABD83143; ABD83143; Sde_3888.
KEGGisde:Sde_3888.
PATRICi23407047. VBISacDeg56404_4184.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000282 Genomic DNA. Translation: ABD83143.1.
RefSeqiWP_011470358.1. NC_007912.1.

3D structure databases

ProteinModelPortaliQ21DT6.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi203122.Sde_3888.

Protein family/group databases

PeroxiBasei2699. SdCP01.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiABD83143; ABD83143; Sde_3888.
KEGGisde:Sde_3888.
PATRICi23407047. VBISacDeg56404_4184.

Phylogenomic databases

eggNOGiENOG4105C1X. Bacteria.
COG0376. LUCA.
HOGENOMiHOG000218110.
KOiK03782.
OMAiYGATTMG.
OrthoDBiPOG091H05R1.

Family and domain databases

HAMAPiMF_01961. Catal_peroxid. 1 hit.
InterProiIPR000763. Catalase_peroxidase.
IPR010255. Haem_peroxidase.
IPR002016. Haem_peroxidase_pln/fun/bac.
IPR019794. Peroxidases_AS.
IPR019793. Peroxidases_heam-ligand_BS.
[Graphical view]
PfamiPF00141. peroxidase. 2 hits.
[Graphical view]
PRINTSiPR00460. BPEROXIDASE.
PR00458. PEROXIDASE.
SUPFAMiSSF48113. SSF48113. 2 hits.
TIGRFAMsiTIGR00198. cat_per_HPI. 1 hit.
PROSITEiPS00435. PEROXIDASE_1. 1 hit.
PS00436. PEROXIDASE_2. 1 hit.
PS50873. PEROXIDASE_4. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiKATG_SACD2
AccessioniPrimary (citable) accession number: Q21DT6
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 25, 2008
Last sequence update: April 18, 2006
Last modified: November 2, 2016
This is version 73 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.