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Q21D03

- PROB_RHOPB

UniProt

Q21D03 - PROB_RHOPB

Protein

Glutamate 5-kinase

Gene

proB

Organism
Rhodopseudomonas palustris (strain BisB18)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 60 (01 Oct 2014)
      Sequence version 1 (18 Apr 2006)
      Previous versions | rss
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    Functioni

    Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate.UniRule annotation

    Catalytic activityi

    ATP + L-glutamate = ADP + L-glutamate 5-phosphate.UniRule annotation

    Pathwayi

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Binding sitei15 – 151ATPUniRule annotation
    Binding sitei56 – 561SubstrateUniRule annotation
    Binding sitei143 – 1431SubstrateUniRule annotation
    Binding sitei155 – 1551Substrate; via amide nitrogenUniRule annotation

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Nucleotide bindingi175 – 1762ATPUniRule annotation

    GO - Molecular functioni

    1. ATP binding Source: UniProtKB-KW
    2. glutamate 5-kinase activity Source: UniProtKB-HAMAP
    3. RNA binding Source: InterPro

    GO - Biological processi

    1. L-proline biosynthetic process Source: UniProtKB-UniPathway

    Keywords - Molecular functioni

    Kinase, Transferase

    Keywords - Biological processi

    Amino-acid biosynthesis, Proline biosynthesis

    Keywords - Ligandi

    ATP-binding, Nucleotide-binding

    Enzyme and pathway databases

    BioCyciRPAL316056:GH3E-162-MONOMER.
    UniPathwayiUPA00098; UER00359.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Glutamate 5-kinaseUniRule annotation (EC:2.7.2.11UniRule annotation)
    Alternative name(s):
    Gamma-glutamyl kinaseUniRule annotation
    Short name:
    GKUniRule annotation
    Gene namesi
    Name:proBUniRule annotation
    Ordered Locus Names:RPC_0158
    OrganismiRhodopseudomonas palustris (strain BisB18)
    Taxonomic identifieri316056 [NCBI]
    Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaRhizobialesBradyrhizobiaceaeRhodopseudomonas
    ProteomesiUP000001948: Chromosome

    Subcellular locationi

    Cytoplasm UniRule annotation

    GO - Cellular componenti

    1. cytoplasm Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cytoplasm

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 376376Glutamate 5-kinasePRO_0000252996Add
    BLAST

    Interactioni

    Protein-protein interaction databases

    STRINGi316056.RPC_0158.

    Structurei

    3D structure databases

    ProteinModelPortaliQ21D03.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini281 – 35878PUAUniRule annotationAdd
    BLAST

    Sequence similaritiesi

    Belongs to the glutamate 5-kinase family.UniRule annotation
    Contains 1 PUA domain.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG0263.
    HOGENOMiHOG000246368.
    KOiK00931.
    OMAiIDGLYSC.
    OrthoDBiEOG6PGK7G.

    Family and domain databases

    Gene3Di2.30.130.10. 1 hit.
    3.40.1160.10. 1 hit.
    HAMAPiMF_00456. ProB.
    InterProiIPR001048. Asp/Glu/Uridylate_kinase.
    IPR001057. Glu/AcGlu_kinase.
    IPR011529. Glu_5kinase.
    IPR005715. Glu_5kinase/COase_Synthase.
    IPR019797. Glutamate_5-kinase_CS.
    IPR002478. PUA.
    IPR015947. PUA-like_domain.
    [Graphical view]
    PfamiPF00696. AA_kinase. 1 hit.
    PF01472. PUA. 1 hit.
    [Graphical view]
    PIRSFiPIRSF000729. GK. 1 hit.
    PRINTSiPR00474. GLU5KINASE.
    SMARTiSM00359. PUA. 1 hit.
    [Graphical view]
    SUPFAMiSSF53633. SSF53633. 1 hit.
    SSF88697. SSF88697. 1 hit.
    TIGRFAMsiTIGR01027. proB. 1 hit.
    PROSITEiPS00902. GLUTAMATE_5_KINASE. 1 hit.
    PS50890. PUA. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q21D03-1 [UniParc]FASTAAdd to Basket

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    MHRPELKNFR RIVVKVGSSL LIDSEAGEVK AAWLAALAAD IAELHLHGRD    50
    VLIVSSGSIA LGRSRLKLAR GPLKLEESQA AAAVGQIALA RIWSEVLGDH 100
    GIGAGQILVT LQDTEERRRY LNARSTIGKL LEWRAVPVIN ENDTVATAEI 150
    RYGDNDRLAA RVATMSSADL LILLSDIDGL YDAPPGANPD AKLIPVVEQV 200
    TAEIEAMAGG AESELSRGGM RTKIEAAKIA TTAGTHMLIA SGKIDHPLRA 250
    IANGGACTWF LTPANPVTAR KRWIAGSLEP KGTLTIDAGA VTALRAGKSL 300
    LPAGVIRVDG HFARGDAVVV RGPDTDEIGR GLVAYDADDA DRIKGHSSPD 350
    VMSILGITGR AEMIHRDDLV MGAVPG 376
    Length:376
    Mass (Da):39,666
    Last modified:April 18, 2006 - v1
    Checksum:i8EB19709207F3650
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000301 Genomic DNA. Translation: ABD85733.1.
    RefSeqiWP_011470641.1. NC_007925.1.
    YP_530052.1. NC_007925.1.

    Genome annotation databases

    EnsemblBacteriaiABD85733; ABD85733; RPC_0158.
    GeneIDi3971263.
    KEGGirpc:RPC_0158.
    PATRICi23264898. VBIRhoPal29154_0163.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000301 Genomic DNA. Translation: ABD85733.1 .
    RefSeqi WP_011470641.1. NC_007925.1.
    YP_530052.1. NC_007925.1.

    3D structure databases

    ProteinModelPortali Q21D03.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 316056.RPC_0158.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai ABD85733 ; ABD85733 ; RPC_0158 .
    GeneIDi 3971263.
    KEGGi rpc:RPC_0158.
    PATRICi 23264898. VBIRhoPal29154_0163.

    Phylogenomic databases

    eggNOGi COG0263.
    HOGENOMi HOG000246368.
    KOi K00931.
    OMAi IDGLYSC.
    OrthoDBi EOG6PGK7G.

    Enzyme and pathway databases

    UniPathwayi UPA00098 ; UER00359 .
    BioCyci RPAL316056:GH3E-162-MONOMER.

    Family and domain databases

    Gene3Di 2.30.130.10. 1 hit.
    3.40.1160.10. 1 hit.
    HAMAPi MF_00456. ProB.
    InterProi IPR001048. Asp/Glu/Uridylate_kinase.
    IPR001057. Glu/AcGlu_kinase.
    IPR011529. Glu_5kinase.
    IPR005715. Glu_5kinase/COase_Synthase.
    IPR019797. Glutamate_5-kinase_CS.
    IPR002478. PUA.
    IPR015947. PUA-like_domain.
    [Graphical view ]
    Pfami PF00696. AA_kinase. 1 hit.
    PF01472. PUA. 1 hit.
    [Graphical view ]
    PIRSFi PIRSF000729. GK. 1 hit.
    PRINTSi PR00474. GLU5KINASE.
    SMARTi SM00359. PUA. 1 hit.
    [Graphical view ]
    SUPFAMi SSF53633. SSF53633. 1 hit.
    SSF88697. SSF88697. 1 hit.
    TIGRFAMsi TIGR01027. proB. 1 hit.
    PROSITEi PS00902. GLUTAMATE_5_KINASE. 1 hit.
    PS50890. PUA. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: BisB18.

    Entry informationi

    Entry nameiPROB_RHOPB
    AccessioniPrimary (citable) accession number: Q21D03
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: October 17, 2006
    Last sequence update: April 18, 2006
    Last modified: October 1, 2014
    This is version 60 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3