ID   MDH1_RHOPB              Reviewed;         322 AA.
AC   Q21CW7;
DT   27-JUN-2006, integrated into UniProtKB/Swiss-Prot.
DT   18-APR-2006, sequence version 1.
DT   16-JUN-2009, entry version 22.
DE   RecName: Full=Malate dehydrogenase 1;
DE            EC=1.1.1.37;
GN   Name=mdh1; OrderedLocusNames=RPC_0194;
OS   Rhodopseudomonas palustris (strain BisB18).
OC   Bacteria; Proteobacteria; Alphaproteobacteria; Rhizobiales;
OC   Bradyrhizobiaceae; Rhodopseudomonas.
OX   NCBI_TaxID=316056;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA   Copeland A., Lucas S., Lapidus A., Barry K., Detter J.C.,
RA   Glavina del Rio T., Hammon N., Israni S., Dalin E., Tice H.,
RA   Pitluck S., Chain P., Malfatti S., Shin M., Vergez L., Schmutz J.,
RA   Larimer F., Land M., Hauser L., Pelletier D.A., Kyrpides N.,
RA   Anderson I., Oda Y., Harwood C.S., Richardson P.;
RT   "Complete sequence of Rhodopseudomonas palustris BisB18.";
RL   Submitted (MAR-2006) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Catalyzes the reversible oxidation of malate to
CC       oxaloacetate (By similarity).
CC   -!- CATALYTIC ACTIVITY: (S)-malate + NAD(+) = oxaloacetate + NADH.
CC   -!- SIMILARITY: Belongs to the LDH/MDH superfamily. MDH type 3 family.
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DR   EMBL; CP000301; ABD85769.1; -; Genomic_DNA.
DR   RefSeq; YP_530088.1; -.
DR   GeneID; 3971182; -.
DR   GenomeReviews; CP000301_GR; RPC_0194.
DR   KEGG; rpc:RPC_0194; -.
DR   HOGENOM; Q21CW7; -.
DR   OMA; Q21CW7; CINIAPS.
DR   BioCyc; RPAL316056:RPC_0194-MON; -.
DR   GO; GO:0005488; F:binding; IEA:InterPro.
DR   GO; GO:0030060; F:L-malate dehydrogenase activity; IEA:HAMAP.
DR   GO; GO:0006096; P:glycolysis; IEA:InterPro.
DR   GO; GO:0006108; P:malate metabolic process; IEA:InterPro.
DR   GO; GO:0055114; P:oxidation reduction; IEA:UniProtKB-KW.
DR   GO; GO:0006099; P:tricarboxylic acid cycle; IEA:HAMAP.
DR   HAMAP; MF_00487; -; 1.
DR   InterPro; IPR001557; L-lactate/malate_DH.
DR   InterPro; IPR001236; Lactate/malate_DH.
DR   InterPro; IPR015955; Lactate_DH/Glyco_Ohase_4_C.
DR   InterPro; IPR011275; Malate_DH_NAD-dep_bac.
DR   InterPro; IPR016040; NAD(P)-bd_dom.
DR   Gene3D; G3DSA:3.90.110.10; lact_mal_DH; 1.
DR   Gene3D; G3DSA:3.40.50.720; NAD(P)-bd; 1.
DR   Pfam; PF02866; Ldh_1_C; 1.
DR   Pfam; PF00056; Ldh_1_N; 1.
DR   PIRSF; PIRSF000102; Lac_mal_DH; 1.
DR   PRINTS; PR00086; LLDHDRGNASE.
DR   TIGRFAMs; TIGR01763; MalateDH_bact; 1.
PE   3: Inferred from homology;
KW   Complete proteome; NAD; Oxidoreductase; Tricarboxylic acid cycle.
FT   CHAIN         1    322       Malate dehydrogenase 1.
FT                                /FTId=PRO_0000241962.
FT   NP_BIND      10     15       NAD (By similarity).
FT   NP_BIND     119    121       NAD (By similarity).
FT   ACT_SITE    176    176       Proton acceptor (By similarity).
FT   BINDING      34     34       NAD (By similarity).
FT   BINDING      83     83       Substrate (By similarity).
FT   BINDING      89     89       Substrate (By similarity).
FT   BINDING      96     96       NAD (By similarity).
FT   BINDING     121    121       Substrate (By similarity).
FT   BINDING     152    152       Substrate (By similarity).
SQ   SEQUENCE   322 AA;  34161 MW;  4C73F78BA98959CB CRC64;
     MARDKIALIG SGQIGGTLAH LVGLKELGDV VMFDIAEGIP QGKSLDIAQS SPVDGFDAKF
     TGANSYEAIE GARVVIVTAG VPRKPGMSRD DLLSINLKVM EQVGAGIKKY APDAFVICIT
     NPLDAMVWAL QKASGLPHRK VVGMAGVLDS ARFRYFLADE FNVSVEDVTA FVLGGHGDTM
     VPLVKYSTVA GIPLPDLVKM GWTSQARLDE IVDRTRNGGA EIVNLLKTGS AFYAPAASAI
     AMAESYLKDK KRVVPVAAYL NGEYGVKDMY VGVPVVIGDK GVERIVEIEL AGKDREAFDK
     SVAAVQGLVE ACKKIAPELL GH
//