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Q21CW7

- MDH1_RHOPB

UniProt

Q21CW7 - MDH1_RHOPB

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Protein

Malate dehydrogenase 1

Gene

mdh1

Organism
Rhodopseudomonas palustris (strain BisB18)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi

Functioni

Catalyzes the reversible oxidation of malate to oxaloacetate.UniRule annotation

Catalytic activityi

(S)-malate + NAD+ = oxaloacetate + NADH.UniRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei34 – 341NADUniRule annotation
Binding sitei83 – 831SubstrateUniRule annotation
Binding sitei89 – 891SubstrateUniRule annotation
Binding sitei96 – 961NADUniRule annotation
Binding sitei121 – 1211SubstrateUniRule annotation
Binding sitei152 – 1521SubstrateUniRule annotation
Active sitei176 – 1761Proton acceptorUniRule annotation

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi10 – 156NADUniRule annotation
Nucleotide bindingi119 – 1213NADUniRule annotation

GO - Molecular functioni

  1. L-malate dehydrogenase activity Source: UniProtKB-HAMAP

GO - Biological processi

  1. cellular carbohydrate metabolic process Source: InterPro
  2. malate metabolic process Source: InterPro
  3. tricarboxylic acid cycle Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Biological processi

Tricarboxylic acid cycle

Keywords - Ligandi

NAD

Enzyme and pathway databases

BioCyciRPAL316056:GH3E-198-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Malate dehydrogenase 1UniRule annotation (EC:1.1.1.37UniRule annotation)
Gene namesi
Name:mdh1UniRule annotation
Ordered Locus Names:RPC_0194
OrganismiRhodopseudomonas palustris (strain BisB18)
Taxonomic identifieri316056 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaRhizobialesBradyrhizobiaceaeRhodopseudomonas
ProteomesiUP000001948: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 322322Malate dehydrogenase 1PRO_0000241962Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi316056.RPC_0194.

Structurei

3D structure databases

ProteinModelPortaliQ21CW7.
SMRiQ21CW7. Positions 1-313.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the LDH/MDH superfamily. MDH type 3 family.UniRule annotation

Phylogenomic databases

eggNOGiCOG0039.
HOGENOMiHOG000213794.
KOiK00024.
OMAiYGQNDIC.
OrthoDBiEOG6091FG.

Family and domain databases

Gene3Di3.40.50.720. 1 hit.
3.90.110.10. 1 hit.
HAMAPiMF_00487. Malate_dehydrog_3.
InterProiIPR001557. L-lactate/malate_DH.
IPR022383. Lactate/malate_DH_C.
IPR001236. Lactate/malate_DH_N.
IPR015955. Lactate_DH/Glyco_Ohase_4_C.
IPR011275. Malate_DH_type3.
IPR016040. NAD(P)-bd_dom.
[Graphical view]
PANTHERiPTHR11540. PTHR11540. 1 hit.
PfamiPF02866. Ldh_1_C. 1 hit.
PF00056. Ldh_1_N. 1 hit.
[Graphical view]
PIRSFiPIRSF000102. Lac_mal_DH. 1 hit.
PRINTSiPR00086. LLDHDRGNASE.
SUPFAMiSSF56327. SSF56327. 1 hit.
TIGRFAMsiTIGR01763. MalateDH_bact. 1 hit.

Sequencei

Sequence statusi: Complete.

Q21CW7-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MARDKIALIG SGQIGGTLAH LVGLKELGDV VMFDIAEGIP QGKSLDIAQS
60 70 80 90 100
SPVDGFDAKF TGANSYEAIE GARVVIVTAG VPRKPGMSRD DLLSINLKVM
110 120 130 140 150
EQVGAGIKKY APDAFVICIT NPLDAMVWAL QKASGLPHRK VVGMAGVLDS
160 170 180 190 200
ARFRYFLADE FNVSVEDVTA FVLGGHGDTM VPLVKYSTVA GIPLPDLVKM
210 220 230 240 250
GWTSQARLDE IVDRTRNGGA EIVNLLKTGS AFYAPAASAI AMAESYLKDK
260 270 280 290 300
KRVVPVAAYL NGEYGVKDMY VGVPVVIGDK GVERIVEIEL AGKDREAFDK
310 320
SVAAVQGLVE ACKKIAPELL GH
Length:322
Mass (Da):34,161
Last modified:April 18, 2006 - v1
Checksum:i4C73F78BA98959CB
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000301 Genomic DNA. Translation: ABD85769.1.
RefSeqiYP_530088.1. NC_007925.1.

Genome annotation databases

EnsemblBacteriaiABD85769; ABD85769; RPC_0194.
GeneIDi3971182.
KEGGirpc:RPC_0194.
PATRICi23264972. VBIRhoPal29154_0200.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000301 Genomic DNA. Translation: ABD85769.1 .
RefSeqi YP_530088.1. NC_007925.1.

3D structure databases

ProteinModelPortali Q21CW7.
SMRi Q21CW7. Positions 1-313.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 316056.RPC_0194.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai ABD85769 ; ABD85769 ; RPC_0194 .
GeneIDi 3971182.
KEGGi rpc:RPC_0194.
PATRICi 23264972. VBIRhoPal29154_0200.

Phylogenomic databases

eggNOGi COG0039.
HOGENOMi HOG000213794.
KOi K00024.
OMAi YGQNDIC.
OrthoDBi EOG6091FG.

Enzyme and pathway databases

BioCyci RPAL316056:GH3E-198-MONOMER.

Family and domain databases

Gene3Di 3.40.50.720. 1 hit.
3.90.110.10. 1 hit.
HAMAPi MF_00487. Malate_dehydrog_3.
InterProi IPR001557. L-lactate/malate_DH.
IPR022383. Lactate/malate_DH_C.
IPR001236. Lactate/malate_DH_N.
IPR015955. Lactate_DH/Glyco_Ohase_4_C.
IPR011275. Malate_DH_type3.
IPR016040. NAD(P)-bd_dom.
[Graphical view ]
PANTHERi PTHR11540. PTHR11540. 1 hit.
Pfami PF02866. Ldh_1_C. 1 hit.
PF00056. Ldh_1_N. 1 hit.
[Graphical view ]
PIRSFi PIRSF000102. Lac_mal_DH. 1 hit.
PRINTSi PR00086. LLDHDRGNASE.
SUPFAMi SSF56327. SSF56327. 1 hit.
TIGRFAMsi TIGR01763. MalateDH_bact. 1 hit.
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: BisB18.

Entry informationi

Entry nameiMDH1_RHOPB
AccessioniPrimary (citable) accession number: Q21CW7
Entry historyi
Integrated into UniProtKB/Swiss-Prot: June 27, 2006
Last sequence update: April 18, 2006
Last modified: October 29, 2014
This is version 58 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3