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Q21CM7

- SYL_RHOPB

UniProt

Q21CM7 - SYL_RHOPB

Protein

Leucine--tRNA ligase

Gene

leuS

Organism
Rhodopseudomonas palustris (strain BisB18)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi
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    • History
      Entry version 67 (01 Oct 2014)
      Sequence version 1 (18 Apr 2006)
      Previous versions | rss
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    Functioni

    Catalytic activityi

    ATP + L-leucine + tRNA(Leu) = AMP + diphosphate + L-leucyl-tRNA(Leu).UniRule annotation

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Binding sitei637 – 6371ATPUniRule annotation

    GO - Molecular functioni

    1. aminoacyl-tRNA editing activity Source: InterPro
    2. ATP binding Source: UniProtKB-HAMAP
    3. leucine-tRNA ligase activity Source: UniProtKB-HAMAP

    GO - Biological processi

    1. leucyl-tRNA aminoacylation Source: UniProtKB-HAMAP

    Keywords - Molecular functioni

    Aminoacyl-tRNA synthetase, Ligase

    Keywords - Biological processi

    Protein biosynthesis

    Keywords - Ligandi

    ATP-binding, Nucleotide-binding

    Enzyme and pathway databases

    BioCyciRPAL316056:GH3E-289-MONOMER.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Leucine--tRNA ligaseUniRule annotation (EC:6.1.1.4UniRule annotation)
    Alternative name(s):
    Leucyl-tRNA synthetaseUniRule annotation
    Short name:
    LeuRSUniRule annotation
    Gene namesi
    Name:leuSUniRule annotation
    Ordered Locus Names:RPC_0284
    OrganismiRhodopseudomonas palustris (strain BisB18)
    Taxonomic identifieri316056 [NCBI]
    Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaRhizobialesBradyrhizobiaceaeRhodopseudomonas
    ProteomesiUP000001948: Chromosome

    Subcellular locationi

    Cytoplasm UniRule annotation

    GO - Cellular componenti

    1. cytoplasm Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cytoplasm

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 882882Leucine--tRNA ligasePRO_1000009411Add
    BLAST

    Interactioni

    Protein-protein interaction databases

    STRINGi316056.RPC_0284.

    Structurei

    3D structure databases

    ProteinModelPortaliQ21CM7.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Motif

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Motifi43 – 5311"HIGH" regionAdd
    BLAST
    Motifi634 – 6385"KMSKS" region

    Sequence similaritiesi

    Belongs to the class-I aminoacyl-tRNA synthetase family.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG0495.
    HOGENOMiHOG000200747.
    KOiK01869.
    OMAiMAFAGPP.
    OrthoDBiEOG63Z74X.

    Family and domain databases

    Gene3Di1.10.730.10. 1 hit.
    3.40.50.620. 3 hits.
    3.90.740.10. 1 hit.
    HAMAPiMF_00049_B. Leu_tRNA_synth_B.
    InterProiIPR001412. aa-tRNA-synth_I_CS.
    IPR002300. aa-tRNA-synth_Ia.
    IPR002302. Leu-tRNA-ligase.
    IPR025709. Leu_tRNA-synth_edit.
    IPR014729. Rossmann-like_a/b/a_fold.
    IPR009080. tRNAsynth_1a_anticodon-bd.
    IPR013155. V/L/I-tRNA-synth_anticodon-bd.
    IPR009008. Val/Leu/Ile-tRNA-synth_edit.
    [Graphical view]
    PANTHERiPTHR11946:SF7. PTHR11946:SF7. 1 hit.
    PfamiPF08264. Anticodon_1. 1 hit.
    PF00133. tRNA-synt_1. 3 hits.
    PF13603. tRNA-synt_1_2. 1 hit.
    [Graphical view]
    PRINTSiPR00985. TRNASYNTHLEU.
    SUPFAMiSSF47323. SSF47323. 1 hit.
    SSF50677. SSF50677. 1 hit.
    TIGRFAMsiTIGR00396. leuS_bact. 1 hit.
    PROSITEiPS00178. AA_TRNA_LIGASE_I. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q21CM7-1 [UniParc]FASTAAdd to Basket

    « Hide

    MTNERYNARE SEPRWQRQWD DNAIFATQND DPRPKYYVLE MFPYPSGRIH    50
    MGHVRNYTMG DVVARTMRAR GYNVLHPMGW DAFGMPAENA AMANKVHPKS 100
    WTYANIATMK AQLKSMGLSL DWSREFATCD PSYYKHQQRM FIDFLAAGLV 150
    ERKQSKVNWD PVDNTVLANE QVIDGRGWRS GALVEQRELT QWFFKISKYS 200
    EDLLTALDRL DRWPDKVRIM QRNWIGRSEG LLLRFALDTS TTPNHETEVE 250
    VFTTRPDTLF GAKFVALSPD HPLAAEAAKS NPALAAFIEE CRKTGTAQAE 300
    IDTAEKQGFD TGIRAVHPFD PSWQLPVYVA NFVLMDYGTG AIFGCPAHDQ 350
    RDLDFVNKYG LGNLPVVCPE GQDPATFVVT DIAYDGDGRL INSNNGFIAL 400
    DGMSIADAKE AVAKRLEAIA LGNRPVAQRQ VNFRLRDWGI SRQRYWGCPI 450
    PIIHCEVCGV VPVPIKDLPV KLPDDIEFDR PGNPLDRHPT WKHVACPQCG 500
    GKARRETDTM DTFVDSSWYF SRFTDPWNED APTTRAVVDR MMPVDQYIGG 550
    VEHAILHLLY SRFFTRAMQA TGHVGFDEPF RGMFTQGMVV HETYRKLDGT 600
    FASPAEIRIV ADGDNRLASL LDSGQPVEIG PIEKMSKSKR NTVDPDDIIG 650
    SYGADTARWF MLSDSPPDRD VIWSEDGVKG ASRFVQRVWR LVSAMAPQLP 700
    APGTRLDAAN HPAAQALRVA AHRTLSEILA GIDRLRFNTA VAKLYVYVGE 750
    LEAVLANAPQ GGLGGDPVLA AAAREAIDIL VLLIAPMMPH LAEECWAAIG 800
    HSGLVSEARW PEIETALLVS DSITLPVQVN GKKRGEVTVA RDAQNPQIEA 850
    AVLALDAVKQ ALDGKPVRKI IIVPQRIVNV VG 882
    Length:882
    Mass (Da):98,244
    Last modified:April 18, 2006 - v1
    Checksum:i07E5065633EE7FAB
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000301 Genomic DNA. Translation: ABD85859.1.
    RefSeqiYP_530178.1. NC_007925.1.

    Genome annotation databases

    EnsemblBacteriaiABD85859; ABD85859; RPC_0284.
    GeneIDi3971043.
    KEGGirpc:RPC_0284.
    PATRICi23265160. VBIRhoPal29154_0293.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000301 Genomic DNA. Translation: ABD85859.1 .
    RefSeqi YP_530178.1. NC_007925.1.

    3D structure databases

    ProteinModelPortali Q21CM7.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 316056.RPC_0284.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai ABD85859 ; ABD85859 ; RPC_0284 .
    GeneIDi 3971043.
    KEGGi rpc:RPC_0284.
    PATRICi 23265160. VBIRhoPal29154_0293.

    Phylogenomic databases

    eggNOGi COG0495.
    HOGENOMi HOG000200747.
    KOi K01869.
    OMAi MAFAGPP.
    OrthoDBi EOG63Z74X.

    Enzyme and pathway databases

    BioCyci RPAL316056:GH3E-289-MONOMER.

    Family and domain databases

    Gene3Di 1.10.730.10. 1 hit.
    3.40.50.620. 3 hits.
    3.90.740.10. 1 hit.
    HAMAPi MF_00049_B. Leu_tRNA_synth_B.
    InterProi IPR001412. aa-tRNA-synth_I_CS.
    IPR002300. aa-tRNA-synth_Ia.
    IPR002302. Leu-tRNA-ligase.
    IPR025709. Leu_tRNA-synth_edit.
    IPR014729. Rossmann-like_a/b/a_fold.
    IPR009080. tRNAsynth_1a_anticodon-bd.
    IPR013155. V/L/I-tRNA-synth_anticodon-bd.
    IPR009008. Val/Leu/Ile-tRNA-synth_edit.
    [Graphical view ]
    PANTHERi PTHR11946:SF7. PTHR11946:SF7. 1 hit.
    Pfami PF08264. Anticodon_1. 1 hit.
    PF00133. tRNA-synt_1. 3 hits.
    PF13603. tRNA-synt_1_2. 1 hit.
    [Graphical view ]
    PRINTSi PR00985. TRNASYNTHLEU.
    SUPFAMi SSF47323. SSF47323. 1 hit.
    SSF50677. SSF50677. 1 hit.
    TIGRFAMsi TIGR00396. leuS_bact. 1 hit.
    PROSITEi PS00178. AA_TRNA_LIGASE_I. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: BisB18.

    Entry informationi

    Entry nameiSYL_RHOPB
    AccessioniPrimary (citable) accession number: Q21CM7
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: January 15, 2008
    Last sequence update: April 18, 2006
    Last modified: October 1, 2014
    This is version 67 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Aminoacyl-tRNA synthetases
      List of aminoacyl-tRNA synthetase entries
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3