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Protein

Leucine--tRNA ligase

Gene

leuS

Organism
Rhodopseudomonas palustris (strain BisB18)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Catalytic activityi

ATP + L-leucine + tRNA(Leu) = AMP + diphosphate + L-leucyl-tRNA(Leu).UniRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei637 – 6371ATPUniRule annotation

GO - Molecular functioni

  1. aminoacyl-tRNA editing activity Source: InterPro
  2. ATP binding Source: UniProtKB-HAMAP
  3. leucine-tRNA ligase activity Source: UniProtKB-HAMAP

GO - Biological processi

  1. leucyl-tRNA aminoacylation Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Aminoacyl-tRNA synthetase, Ligase

Keywords - Biological processi

Protein biosynthesis

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciRPAL316056:GH3E-289-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Leucine--tRNA ligaseUniRule annotation (EC:6.1.1.4UniRule annotation)
Alternative name(s):
Leucyl-tRNA synthetaseUniRule annotation
Short name:
LeuRSUniRule annotation
Gene namesi
Name:leuSUniRule annotation
Ordered Locus Names:RPC_0284
OrganismiRhodopseudomonas palustris (strain BisB18)
Taxonomic identifieri316056 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaRhizobialesBradyrhizobiaceaeRhodopseudomonas
ProteomesiUP000001948: Chromosome

Subcellular locationi

Cytoplasm UniRule annotation

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 882882Leucine--tRNA ligasePRO_1000009411Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi316056.RPC_0284.

Structurei

3D structure databases

ProteinModelPortaliQ21CM7.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi43 – 5311"HIGH" regionAdd
BLAST
Motifi634 – 6385"KMSKS" region

Sequence similaritiesi

Belongs to the class-I aminoacyl-tRNA synthetase family.UniRule annotation

Phylogenomic databases

eggNOGiCOG0495.
HOGENOMiHOG000200747.
KOiK01869.
OMAiQSSWYFL.
OrthoDBiEOG63Z74X.

Family and domain databases

Gene3Di1.10.730.10. 1 hit.
3.40.50.620. 3 hits.
3.90.740.10. 1 hit.
HAMAPiMF_00049_B. Leu_tRNA_synth_B.
InterProiIPR001412. aa-tRNA-synth_I_CS.
IPR002300. aa-tRNA-synth_Ia.
IPR002302. Leu-tRNA-ligase.
IPR025709. Leu_tRNA-synth_edit.
IPR013155. M/V/L/I-tRNA-synth_anticd-bd.
IPR014729. Rossmann-like_a/b/a_fold.
IPR009080. tRNAsynth_1a_anticodon-bd.
IPR009008. Val/Leu/Ile-tRNA-synth_edit.
[Graphical view]
PANTHERiPTHR11946:SF7. PTHR11946:SF7. 1 hit.
PfamiPF08264. Anticodon_1. 1 hit.
PF00133. tRNA-synt_1. 3 hits.
PF13603. tRNA-synt_1_2. 1 hit.
[Graphical view]
PRINTSiPR00985. TRNASYNTHLEU.
SUPFAMiSSF47323. SSF47323. 1 hit.
SSF50677. SSF50677. 1 hit.
TIGRFAMsiTIGR00396. leuS_bact. 1 hit.
PROSITEiPS00178. AA_TRNA_LIGASE_I. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q21CM7-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MTNERYNARE SEPRWQRQWD DNAIFATQND DPRPKYYVLE MFPYPSGRIH
60 70 80 90 100
MGHVRNYTMG DVVARTMRAR GYNVLHPMGW DAFGMPAENA AMANKVHPKS
110 120 130 140 150
WTYANIATMK AQLKSMGLSL DWSREFATCD PSYYKHQQRM FIDFLAAGLV
160 170 180 190 200
ERKQSKVNWD PVDNTVLANE QVIDGRGWRS GALVEQRELT QWFFKISKYS
210 220 230 240 250
EDLLTALDRL DRWPDKVRIM QRNWIGRSEG LLLRFALDTS TTPNHETEVE
260 270 280 290 300
VFTTRPDTLF GAKFVALSPD HPLAAEAAKS NPALAAFIEE CRKTGTAQAE
310 320 330 340 350
IDTAEKQGFD TGIRAVHPFD PSWQLPVYVA NFVLMDYGTG AIFGCPAHDQ
360 370 380 390 400
RDLDFVNKYG LGNLPVVCPE GQDPATFVVT DIAYDGDGRL INSNNGFIAL
410 420 430 440 450
DGMSIADAKE AVAKRLEAIA LGNRPVAQRQ VNFRLRDWGI SRQRYWGCPI
460 470 480 490 500
PIIHCEVCGV VPVPIKDLPV KLPDDIEFDR PGNPLDRHPT WKHVACPQCG
510 520 530 540 550
GKARRETDTM DTFVDSSWYF SRFTDPWNED APTTRAVVDR MMPVDQYIGG
560 570 580 590 600
VEHAILHLLY SRFFTRAMQA TGHVGFDEPF RGMFTQGMVV HETYRKLDGT
610 620 630 640 650
FASPAEIRIV ADGDNRLASL LDSGQPVEIG PIEKMSKSKR NTVDPDDIIG
660 670 680 690 700
SYGADTARWF MLSDSPPDRD VIWSEDGVKG ASRFVQRVWR LVSAMAPQLP
710 720 730 740 750
APGTRLDAAN HPAAQALRVA AHRTLSEILA GIDRLRFNTA VAKLYVYVGE
760 770 780 790 800
LEAVLANAPQ GGLGGDPVLA AAAREAIDIL VLLIAPMMPH LAEECWAAIG
810 820 830 840 850
HSGLVSEARW PEIETALLVS DSITLPVQVN GKKRGEVTVA RDAQNPQIEA
860 870 880
AVLALDAVKQ ALDGKPVRKI IIVPQRIVNV VG
Length:882
Mass (Da):98,244
Last modified:April 18, 2006 - v1
Checksum:i07E5065633EE7FAB
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000301 Genomic DNA. Translation: ABD85859.1.
RefSeqiYP_530178.1. NC_007925.1.

Genome annotation databases

EnsemblBacteriaiABD85859; ABD85859; RPC_0284.
GeneIDi3971043.
KEGGirpc:RPC_0284.
PATRICi23265160. VBIRhoPal29154_0293.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000301 Genomic DNA. Translation: ABD85859.1.
RefSeqiYP_530178.1. NC_007925.1.

3D structure databases

ProteinModelPortaliQ21CM7.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi316056.RPC_0284.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiABD85859; ABD85859; RPC_0284.
GeneIDi3971043.
KEGGirpc:RPC_0284.
PATRICi23265160. VBIRhoPal29154_0293.

Phylogenomic databases

eggNOGiCOG0495.
HOGENOMiHOG000200747.
KOiK01869.
OMAiQSSWYFL.
OrthoDBiEOG63Z74X.

Enzyme and pathway databases

BioCyciRPAL316056:GH3E-289-MONOMER.

Family and domain databases

Gene3Di1.10.730.10. 1 hit.
3.40.50.620. 3 hits.
3.90.740.10. 1 hit.
HAMAPiMF_00049_B. Leu_tRNA_synth_B.
InterProiIPR001412. aa-tRNA-synth_I_CS.
IPR002300. aa-tRNA-synth_Ia.
IPR002302. Leu-tRNA-ligase.
IPR025709. Leu_tRNA-synth_edit.
IPR013155. M/V/L/I-tRNA-synth_anticd-bd.
IPR014729. Rossmann-like_a/b/a_fold.
IPR009080. tRNAsynth_1a_anticodon-bd.
IPR009008. Val/Leu/Ile-tRNA-synth_edit.
[Graphical view]
PANTHERiPTHR11946:SF7. PTHR11946:SF7. 1 hit.
PfamiPF08264. Anticodon_1. 1 hit.
PF00133. tRNA-synt_1. 3 hits.
PF13603. tRNA-synt_1_2. 1 hit.
[Graphical view]
PRINTSiPR00985. TRNASYNTHLEU.
SUPFAMiSSF47323. SSF47323. 1 hit.
SSF50677. SSF50677. 1 hit.
TIGRFAMsiTIGR00396. leuS_bact. 1 hit.
PROSITEiPS00178. AA_TRNA_LIGASE_I. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: BisB18.

Entry informationi

Entry nameiSYL_RHOPB
AccessioniPrimary (citable) accession number: Q21CM7
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 15, 2008
Last sequence update: April 18, 2006
Last modified: January 7, 2015
This is version 70 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Aminoacyl-tRNA synthetases
    List of aminoacyl-tRNA synthetase entries
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.