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Protein

Dephospho-CoA kinase

Gene

coaE

Organism
Rhodopseudomonas palustris (strain BisB18)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A.UniRule annotation

Catalytic activityi

ATP + 3'-dephospho-CoA = ADP + CoA.UniRule annotation

Pathwayi: coenzyme A biosynthesis

This protein is involved in step 5 of the subpathway that synthesizes CoA from (R)-pantothenate.UniRule annotation
Proteins known to be involved in the 5 steps of the subpathway in this organism are:
  1. Pantothenate kinase (coaA)
  2. Coenzyme A biosynthesis bifunctional protein CoaBC (RPC_0380)
  3. Coenzyme A biosynthesis bifunctional protein CoaBC (RPC_0380)
  4. Phosphopantetheine adenylyltransferase (coaD)
  5. Dephospho-CoA kinase (coaE)
This subpathway is part of the pathway coenzyme A biosynthesis, which is itself part of Cofactor biosynthesis.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes CoA from (R)-pantothenate, the pathway coenzyme A biosynthesis and in Cofactor biosynthesis.

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi8 – 15ATPUniRule annotation8

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionKinase, Transferase
Biological processCoenzyme A biosynthesis
LigandATP-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciRPAL316056:G1G6B-304-MONOMER
UniPathwayiUPA00241; UER00356

Names & Taxonomyi

Protein namesi
Recommended name:
Dephospho-CoA kinaseUniRule annotation (EC:2.7.1.24UniRule annotation)
Alternative name(s):
Dephosphocoenzyme A kinaseUniRule annotation
Gene namesi
Name:coaEUniRule annotation
Ordered Locus Names:RPC_0296
OrganismiRhodopseudomonas palustris (strain BisB18)
Taxonomic identifieri316056 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaRhizobialesBradyrhizobiaceaeRhodopseudomonas
Proteomesi
  • UP000001948 Componenti: Chromosome

Subcellular locationi

  • Cytoplasm UniRule annotation

GO - Cellular componenti

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002433291 – 199Dephospho-CoA kinaseAdd BLAST199

Proteomic databases

PRIDEiQ21CL5

Interactioni

Protein-protein interaction databases

STRINGi316056.RPC_0296

Structurei

3D structure databases

ProteinModelPortaliQ21CL5
SMRiQ21CL5
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini3 – 199DPCKUniRule annotationAdd BLAST197

Sequence similaritiesi

Belongs to the CoaE family.UniRule annotation

Phylogenomic databases

eggNOGiENOG4108ZQD Bacteria
COG0237 LUCA
HOGENOMiHOG000020768
KOiK00859
OMAiLVTEIWV
OrthoDBiPOG091H02KX

Family and domain databases

CDDicd02022 DPCK, 1 hit
HAMAPiMF_00376 Dephospho_CoA_kinase, 1 hit
InterProiView protein in InterPro
IPR001977 Depp_CoAkinase
IPR027417 P-loop_NTPase
PfamiView protein in Pfam
PF01121 CoaE, 1 hit
SUPFAMiSSF52540 SSF52540, 1 hit
TIGRFAMsiTIGR00152 TIGR00152, 1 hit
PROSITEiView protein in PROSITE
PS51219 DPCK, 1 hit

Sequencei

Sequence statusi: Complete.

Q21CL5-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MRILGLTGSI GMGKSTTARL FAEAGVPVYD ADATVHQIYE GEAAPAVETA
60 70 80 90 100
FPGTTVNGKV DRALLSARVL HDAAAMQRLE AIVHPMLRAH HQQFLADAEK
110 120 130 140 150
SGAPVAVVDV PLLYETGGDA RVDAVVVVTT SHQVQRARIL ARQGMTDEKL
160 170 180 190
DALLARQLPD AEKRQRADFV VDTSNGLEPV RAQIREILAA TAKMPQRRA
Length:199
Mass (Da):21,393
Last modified:April 18, 2006 - v1
Checksum:iEEFB6B5F1B29C38F
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000301 Genomic DNA Translation: ABD85871.1
RefSeqiWP_011470779.1, NC_007925.1

Genome annotation databases

EnsemblBacteriaiABD85871; ABD85871; RPC_0296
KEGGirpc:RPC_0296

Similar proteinsi

Entry informationi

Entry nameiCOAE_RHOPB
AccessioniPrimary (citable) accession number: Q21CL5
Entry historyiIntegrated into UniProtKB/Swiss-Prot: June 27, 2006
Last sequence update: April 18, 2006
Last modified: May 23, 2018
This is version 76 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

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