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Q21C73

- UPPP_RHOPB

UniProt

Q21C73 - UPPP_RHOPB

Protein

Undecaprenyl-diphosphatase

Gene

uppP

Organism
Rhodopseudomonas palustris (strain BisB18)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 60 (01 Oct 2014)
      Sequence version 1 (18 Apr 2006)
      Previous versions | rss
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    Functioni

    Catalyzes the dephosphorylation of undecaprenyl diphosphate (UPP). Confers resistance to bacitracin.UniRule annotation

    Catalytic activityi

    Ditrans,octacis-undecaprenyl diphosphate + H2O = ditrans,octacis-undecaprenyl phosphate + phosphate.UniRule annotation

    GO - Molecular functioni

    1. undecaprenyl-diphosphatase activity Source: UniProtKB-HAMAP

    GO - Biological processi

    1. dephosphorylation Source: InterPro
    2. peptidoglycan biosynthetic process Source: UniProtKB-KW
    3. regulation of cell shape Source: UniProtKB-KW
    4. response to antibiotic Source: UniProtKB-HAMAP

    Keywords - Molecular functioni

    Hydrolase

    Keywords - Biological processi

    Antibiotic resistance, Cell shape, Cell wall biogenesis/degradation, Peptidoglycan synthesis

    Enzyme and pathway databases

    BioCyciRPAL316056:GH3E-445-MONOMER.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Undecaprenyl-diphosphataseUniRule annotation (EC:3.6.1.27UniRule annotation)
    Alternative name(s):
    Bacitracin resistance proteinUniRule annotation
    Undecaprenyl pyrophosphate phosphataseUniRule annotation
    Gene namesi
    Name:uppPUniRule annotation
    Ordered Locus Names:RPC_0438
    OrganismiRhodopseudomonas palustris (strain BisB18)
    Taxonomic identifieri316056 [NCBI]
    Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaRhizobialesBradyrhizobiaceaeRhodopseudomonas
    ProteomesiUP000001948: Chromosome

    Subcellular locationi

    Cell inner membrane UniRule annotation; Multi-pass membrane protein UniRule annotation

    GO - Cellular componenti

    1. integral component of membrane Source: UniProtKB-KW
    2. plasma membrane Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cell inner membrane, Cell membrane, Membrane

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 268268Undecaprenyl-diphosphatasePRO_0000250256Add
    BLAST

    Interactioni

    Protein-protein interaction databases

    STRINGi316056.RPC_0438.

    Structurei

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei47 – 6721HelicalUniRule annotationAdd
    BLAST
    Transmembranei83 – 10321HelicalUniRule annotationAdd
    BLAST
    Transmembranei109 – 12921HelicalUniRule annotationAdd
    BLAST
    Transmembranei144 – 16421HelicalUniRule annotationAdd
    BLAST
    Transmembranei184 – 20421HelicalUniRule annotationAdd
    BLAST
    Transmembranei217 – 23721HelicalUniRule annotationAdd
    BLAST
    Transmembranei246 – 26621HelicalUniRule annotationAdd
    BLAST

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the UppP family.UniRule annotation

    Keywords - Domaini

    Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiCOG1968.
    HOGENOMiHOG000218356.
    KOiK06153.
    OMAiLYIGCAQ.
    OrthoDBiEOG6QP13M.

    Family and domain databases

    HAMAPiMF_01006. Undec_diphosphatase.
    InterProiIPR003824. UppP.
    [Graphical view]
    PfamiPF02673. BacA. 1 hit.
    [Graphical view]
    TIGRFAMsiTIGR00753. undec_PP_bacA. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    Q21C73-1 [UniParc]FASTAAdd to Basket

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    MLSDILRAVI LGIVEGVTEF LPVSSTGHLL LAERFFDLGD TNFWKSFTIL    50
    IQLGAILAIL ALYFAKLWRI ALGMFSDPAA QRFVIGVLVA FLPAAVIGAL 100
    AGGYIKSYLF NPWVVCFSLI VGGAILLWVD QLDLQPTQDE ATAFPLPMYL 150
    YIGCAQCLAM IPGVSRSGAT IVGAMLLGAD KRAAAEFSFF LAIPTMVGAF 200
    VYDLYKNRAD MTMDHSLIVA IGFAVSFVTA IIVVKSFLAY VTRHGFTLFA 250
    WWRVIVGTLG LIALALGK 268
    Length:268
    Mass (Da):29,030
    Last modified:April 18, 2006 - v1
    Checksum:i616727FA4286774B
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000301 Genomic DNA. Translation: ABD86013.1.
    RefSeqiYP_530332.1. NC_007925.1.

    Genome annotation databases

    EnsemblBacteriaiABD86013; ABD86013; RPC_0438.
    GeneIDi3970200.
    KEGGirpc:RPC_0438.
    PATRICi23265478. VBIRhoPal29154_0450.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000301 Genomic DNA. Translation: ABD86013.1 .
    RefSeqi YP_530332.1. NC_007925.1.

    3D structure databases

    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 316056.RPC_0438.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai ABD86013 ; ABD86013 ; RPC_0438 .
    GeneIDi 3970200.
    KEGGi rpc:RPC_0438.
    PATRICi 23265478. VBIRhoPal29154_0450.

    Phylogenomic databases

    eggNOGi COG1968.
    HOGENOMi HOG000218356.
    KOi K06153.
    OMAi LYIGCAQ.
    OrthoDBi EOG6QP13M.

    Enzyme and pathway databases

    BioCyci RPAL316056:GH3E-445-MONOMER.

    Family and domain databases

    HAMAPi MF_01006. Undec_diphosphatase.
    InterProi IPR003824. UppP.
    [Graphical view ]
    Pfami PF02673. BacA. 1 hit.
    [Graphical view ]
    TIGRFAMsi TIGR00753. undec_PP_bacA. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: BisB18.

    Entry informationi

    Entry nameiUPPP_RHOPB
    AccessioniPrimary (citable) accession number: Q21C73
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: September 19, 2006
    Last sequence update: April 18, 2006
    Last modified: October 1, 2014
    This is version 60 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Miscellaneous

    Bacitracin is thought to be involved in the inhibition of peptidoglycan synthesis by sequestering undecaprenyl diphosphate, thereby reducing the pool of lipid carrier available.

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3