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Q21AX5

- HGD_RHOPB

UniProt

Q21AX5 - HGD_RHOPB

Protein

Homogentisate 1,2-dioxygenase

Gene

hmgA

Organism
Rhodopseudomonas palustris (strain BisB18)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 54 (01 Oct 2014)
      Sequence version 1 (18 Apr 2006)
      Previous versions | rss
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    Functioni

    Involved in the catabolism of homogentisate (2,5-dihydroxyphenylacetate or 2,5-OH-PhAc), a central intermediate in the degradation of phenylalanine and tyrosine. Catalyzes the oxidative ring cleavage of the aromatic ring of homogentisate to yield maleylacetoacetate.UniRule annotation

    Catalytic activityi

    Homogentisate + O2 = 4-maleylacetoacetate.UniRule annotation

    Cofactori

    Iron.UniRule annotation

    Pathwayi

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Active sitei303 – 3031Proton acceptorUniRule annotation
    Metal bindingi346 – 3461IronUniRule annotation
    Metal bindingi352 – 3521IronUniRule annotation
    Binding sitei361 – 3611homogentisateUniRule annotation
    Metal bindingi382 – 3821IronUniRule annotation
    Binding sitei382 – 3821homogentisateUniRule annotation

    GO - Molecular functioni

    1. homogentisate 1,2-dioxygenase activity Source: UniProtKB-HAMAP
    2. iron ion binding Source: UniProtKB-HAMAP

    GO - Biological processi

    1. L-phenylalanine catabolic process Source: UniProtKB-HAMAP
    2. tyrosine catabolic process Source: UniProtKB-HAMAP

    Keywords - Molecular functioni

    Dioxygenase, Oxidoreductase

    Keywords - Biological processi

    Phenylalanine catabolism, Tyrosine catabolism

    Keywords - Ligandi

    Iron, Metal-binding

    Enzyme and pathway databases

    BioCyciRPAL316056:GH3E-903-MONOMER.
    UniPathwayiUPA00139; UER00339.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Homogentisate 1,2-dioxygenaseUniRule annotation (EC:1.13.11.5UniRule annotation)
    Short name:
    HGDOUniRule annotation
    Alternative name(s):
    Homogentisate oxygenaseUniRule annotation
    Homogentisic acid oxidaseUniRule annotation
    HomogentisicaseUniRule annotation
    Gene namesi
    Name:hmgAUniRule annotation
    Ordered Locus Names:RPC_0891
    OrganismiRhodopseudomonas palustris (strain BisB18)
    Taxonomic identifieri316056 [NCBI]
    Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaRhizobialesBradyrhizobiaceaeRhodopseudomonas
    ProteomesiUP000001948: Chromosome

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 448448Homogentisate 1,2-dioxygenasePRO_1000019542Add
    BLAST

    Interactioni

    Subunit structurei

    Hexamer; dimer of trimers.UniRule annotation

    Protein-protein interaction databases

    STRINGi316056.RPC_0891.

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the homogentisate dioxygenase family.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG3508.
    HOGENOMiHOG000139824.
    KOiK00451.
    OMAiTTETHKL.
    OrthoDBiEOG6D5FZK.

    Family and domain databases

    Gene3Di2.60.120.10. 2 hits.
    HAMAPiMF_00334. Homogentis_dioxygen.
    InterProiIPR005708. Homogentis_dOase.
    IPR022950. Homogentis_dOase_bac.
    IPR014710. RmlC-like_jellyroll.
    IPR011051. RmlC_Cupin.
    [Graphical view]
    PANTHERiPTHR11056. PTHR11056. 1 hit.
    PfamiPF04209. HgmA. 1 hit.
    [Graphical view]
    SUPFAMiSSF51182. SSF51182. 1 hit.
    TIGRFAMsiTIGR01015. hmgA. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    Q21AX5-1 [UniParc]FASTAAdd to Basket

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    MNITTAPGLI GRSTQAITPG YMSGFGNSFE TEALPGALPI GRNSPQRAPY    50
    GLYAEQLSGS PFTAPRGSNE RSWLYRIRPS VQHSGRFEKA EAGLWRSAPC 100
    HEHDMPIAQL RWDPPPLPQR AQTFLQGVET MTTAGDVNTQ AGMAAHMYLI 150
    SASMVNQHFY NADGELMFVP QQGGLRLVTE FGVIGVAPGE IAVIPRGVKF 200
    RVELIDGPAR GYLCENYGGG FTLPERGPIG ANCLANARDF LTPVAAYEDS 250
    DTPTELYVKW GGALWVTQLP HSPIDVVAWH GNYAPYKYDL RTFSPVGAIG 300
    FDHPDPSIFT VLTSPSETAG TANIDFVIFP ERWMVAENTF RPPWYHMNIM 350
    SEFMGLIYGV YDAKPQGFLP GGASLHNMML PHGPDREAFD HASNAELKPV 400
    KLEGTLAFMF ETRYPQRVTV HAATSSTLQA DYAECWRGLQ KRFDPTKP 448
    Length:448
    Mass (Da):49,318
    Last modified:April 18, 2006 - v1
    Checksum:i4DFD3FC377497474
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000301 Genomic DNA. Translation: ABD86461.1.
    RefSeqiWP_011471369.1. NC_007925.1.
    YP_530780.1. NC_007925.1.

    Genome annotation databases

    EnsemblBacteriaiABD86461; ABD86461; RPC_0891.
    GeneIDi3969810.
    KEGGirpc:RPC_0891.
    PATRICi23266436. VBIRhoPal29154_0924.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000301 Genomic DNA. Translation: ABD86461.1 .
    RefSeqi WP_011471369.1. NC_007925.1.
    YP_530780.1. NC_007925.1.

    3D structure databases

    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 316056.RPC_0891.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai ABD86461 ; ABD86461 ; RPC_0891 .
    GeneIDi 3969810.
    KEGGi rpc:RPC_0891.
    PATRICi 23266436. VBIRhoPal29154_0924.

    Phylogenomic databases

    eggNOGi COG3508.
    HOGENOMi HOG000139824.
    KOi K00451.
    OMAi TTETHKL.
    OrthoDBi EOG6D5FZK.

    Enzyme and pathway databases

    UniPathwayi UPA00139 ; UER00339 .
    BioCyci RPAL316056:GH3E-903-MONOMER.

    Family and domain databases

    Gene3Di 2.60.120.10. 2 hits.
    HAMAPi MF_00334. Homogentis_dioxygen.
    InterProi IPR005708. Homogentis_dOase.
    IPR022950. Homogentis_dOase_bac.
    IPR014710. RmlC-like_jellyroll.
    IPR011051. RmlC_Cupin.
    [Graphical view ]
    PANTHERi PTHR11056. PTHR11056. 1 hit.
    Pfami PF04209. HgmA. 1 hit.
    [Graphical view ]
    SUPFAMi SSF51182. SSF51182. 1 hit.
    TIGRFAMsi TIGR01015. hmgA. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: BisB18.

    Entry informationi

    Entry nameiHGD_RHOPB
    AccessioniPrimary (citable) accession number: Q21AX5
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: January 15, 2008
    Last sequence update: April 18, 2006
    Last modified: October 1, 2014
    This is version 54 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3