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Reviewed, UniProtKB/Swiss-Prot Q21AX5 (HGD_RHOPB)

Last modified February 9, 2010. Version 26. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data | Customize display text xml rdf/xml gff fasta
Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents

Names and origin

Protein namesRecommended name:
    Homogentisate 1,2-dioxygenase
    EC=1.13.11.5
Alternative name(s):
    Homogentisicase
    Homogentisate oxygenase
    Homogentisic acid oxidase
Gene names
Name: hmgA
Ordered Locus Names: RPC_0891
OrganismRhodopseudomonas palustris (strain BisB18) [Complete proteome] [HAMAP]
Taxonomic identifier316056 [NCBI]
Taxonomic lineageBacteriaProteobacteriaAlphaproteobacteriaRhizobialesBradyrhizobiaceaeRhodopseudomonas

Protein attributes

Sequence length448 AA.
Sequence statusComplete.
Protein existenceInferred from homology.

General annotation (Comments)

Catalytic activity

Homogentisate + O2 = 4-maleylacetoacetate. HAMAP MF_00334

Cofactor

Iron By similarity. HAMAP MF_00334

Pathway

Amino-acid degradation; L-phenylalanine degradation; acetoacetate and fumarate from L-phenylalanine: step 4/6. HAMAP MF_00334

Sequence similarities

Belongs to the homogentisate dioxygenase family.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 448448Homogentisate 1,2-dioxygenase HAMAP MF_00334
PRO_1000019542

Sites

Metal binding3461Iron By similarity
Metal binding3521Iron By similarity
Metal binding3821Iron By similarity

Sequences

Sequence LengthMass (Da)Tools
Q21AX5-1 [UniParc].

Last modified April 18, 2006. Version 1.
Checksum: 4DFD3FC377497474

FASTA44849,318
        10         20         30         40         50         60 
MNITTAPGLI GRSTQAITPG YMSGFGNSFE TEALPGALPI GRNSPQRAPY GLYAEQLSGS 

        70         80         90        100        110        120 
PFTAPRGSNE RSWLYRIRPS VQHSGRFEKA EAGLWRSAPC HEHDMPIAQL RWDPPPLPQR 

       130        140        150        160        170        180 
AQTFLQGVET MTTAGDVNTQ AGMAAHMYLI SASMVNQHFY NADGELMFVP QQGGLRLVTE 

       190        200        210        220        230        240 
FGVIGVAPGE IAVIPRGVKF RVELIDGPAR GYLCENYGGG FTLPERGPIG ANCLANARDF 

       250        260        270        280        290        300 
LTPVAAYEDS DTPTELYVKW GGALWVTQLP HSPIDVVAWH GNYAPYKYDL RTFSPVGAIG 

       310        320        330        340        350        360 
FDHPDPSIFT VLTSPSETAG TANIDFVIFP ERWMVAENTF RPPWYHMNIM SEFMGLIYGV 

       370        380        390        400        410        420 
YDAKPQGFLP GGASLHNMML PHGPDREAFD HASNAELKPV KLEGTLAFMF ETRYPQRVTV 

       430        440 
HAATSSTLQA DYAECWRGLQ KRFDPTKP 

« Hide

References

[1]"Complete sequence of Rhodopseudomonas palustris BisB18."
Copeland A., Lucas S., Lapidus A., Barry K., Detter J.C., Glavina del Rio T., Hammon N., Israni S., Dalin E., Tice H., Pitluck S., Chain P., Malfatti S., Shin M., Vergez L., Schmutz J., Larimer F., Land M. expand/collapse author list , Hauser L., Pelletier D.A., Kyrpides N., Anderson I., Oda Y., Harwood C.S., Richardson P.
Submitted (MAR-2006) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
CP000301 Genomic DNA. Translation: ABD86461.1.
RefSeqYP_530780.1.

3D structure databases

ModBaseSearch...

Protein-protein interaction databases

STRINGQ21AX5.

Genome annotation databases

GeneID3969810.
GenomeReviewsGene locus RPC_0891 in contig CP000301_GR.
KEGGrpc:RPC_0891.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG3508.
HOGENOMHBG293508.
OMARNCMSEF.

Enzyme and pathway databases

BioCycRPAL316056:RPC_0891-MONOMER.

Family and domain databases

HAMAPMF_00334. Homogentis_dioxygen.
[Tree]
InterProIPR011051. Cupin_RmlC_type.
IPR005708. Homogentis_dOase.
[Graphical view]
PANTHERPTHR11056. Homogentis_dOase. 1 hit.
PfamPF04209. HgmA. 1 hit.
[Graphical view]
TIGRFAMsTIGR01015. hmgA. 1 hit.
ProtoNetSearch...

Entry information

Entry nameHGD_RHOPB
AccessionPrimary (citable) accession number: Q21AX5
Entry history
Integrated into UniProtKB/Swiss-Prot: January 15, 2008
Last sequence update: April 18, 2006
Last modified: February 9, 2010
This is version 26 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation projectHAMAP (High-quality Automated and Manual Annotation of microbial Proteomes)

Relevant documents

PATHWAY comments

Index of metabolic and biosynthesis pathways

SIMILARITY comments

Index of protein domains and families

Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents