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Protein
Submitted name:

ASpartyl Protease

Gene

asp-4

Organism
Caenorhabditis elegans
Status
Unreviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at protein leveli

Functioni

GO - Molecular functioni

  • aspartic-type endopeptidase activity Source: WormBase

GO - Biological processi

  • necrotic cell death Source: WormBase
  • proteolysis Source: WormBase
Complete GO annotation...

Keywords - Molecular functioni

Aspartyl proteaseUniRule annotationSAAS annotation, Hydrolase, Protease

Names & Taxonomyi

Protein namesi
Submitted name:
ASpartyl ProteaseImported
Gene namesi
Name:asp-4Imported
ORF Names:CELE_R12H7.2Imported, R12H7.2Imported
OrganismiCaenorhabditis elegansImported
Taxonomic identifieri6239 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaNematodaChromadoreaRhabditidaRhabditoideaRhabditidaePeloderinaeCaenorhabditis
Proteomesi
  • UP000001940 Componenti: Chromosome X

Organism-specific databases

WormBaseiR12H7.2; CE03567; WBGene00000217; asp-4.

Subcellular locationi

GO - Cellular componenti

  • cytoplasm Source: WormBase
  • lysosome Source: WormBase
Complete GO annotation...

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 1717Sequence analysisAdd
BLAST
Chaini18 – 444427Sequence analysisPRO_5004199730Add
BLAST

Proteomic databases

EPDiQ21966.
PaxDbiQ21966.
PRIDEiQ21966.

Interactioni

Protein-protein interaction databases

STRINGi6239.R12H7.2.

Structurei

3D structure databases

ProteinModelPortaliQ21966.
SMRiQ21966. Positions 27-412.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini94 – 410317Peptidase A1InterPro annotationAdd
BLAST

Sequence similaritiesi

Belongs to the peptidase A1 family.UniRule annotationSAAS annotation
Contains peptidase A1 domain.SAAS annotation

Keywords - Domaini

SignalSequence analysis

Phylogenomic databases

eggNOGiKOG1339. Eukaryota.
ENOG410XNV7. LUCA.
GeneTreeiENSGT00760000118929.
HOGENOMiHOG000197681.
InParanoidiQ21966.
KOiK01379.
OMAiISCDKVP.
OrthoDBiEOG7HQN88.
PhylomeDBiQ21966.

Family and domain databases

Gene3Di2.40.70.10. 2 hits.
InterProiIPR001461. Aspartic_peptidase_A1.
IPR001969. Aspartic_peptidase_AS.
IPR033144. Cathepsin_D.
IPR033121. PEPTIDASE_A1.
IPR021109. Peptidase_aspartic_dom.
[Graphical view]
PANTHERiPTHR13683. PTHR13683. 1 hit.
PTHR13683:SF230. PTHR13683:SF230. 1 hit.
PfamiPF00026. Asp. 1 hit.
[Graphical view]
PRINTSiPR00792. PEPSIN.
SUPFAMiSSF50630. SSF50630. 1 hit.
PROSITEiPS00141. ASP_PROTEASE. 2 hits.
PS51767. PEPTIDASE_A1. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q21966-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MNRCILLLLG ALLLVQGLHV HKRQQKLRTV SLKKQPTLRE TLLQAGSFET
60 70 80 90 100
FAKHRHGYKK YLKTNGNHHF DKYQALNVEG EIDELLRNYM DAQYFGTISI
110 120 130 140 150
GTPAQNFTVI FDTGSSNLWI PSKKCPFYDI ACMLHHRYDS KSSSTYKEDG
160 170 180 190 200
RKMAIQYGTG SMKGFISKDS VCVAGVCAED QPFAEATSEP GITFVAAKFD
210 220 230 240 250
GILGMAYPEI AVLGVQPVFN TLFEQKKVPS NLFSFWLNRN PDSEIGGEIT
260 270 280 290 300
FGGIDSRRYV EPITYVPVTR KGYWQFKMDK VVGSGVLGCS NGCQAIADTG
310 320 330 340 350
TSLIAGPKAQ IEAIQNFIGA EPLIKGEYMI SCDKVPTLPP VSFVIGGQEF
360 370 380 390 400
SLKGEDYVLK VSQGGKTICL SGFMGIDLPE RVGELWILGD VFIGRYYSVF
410 420 430 440
DFDQNRVGFA QAKTADGRPV DPAPRPFRSV FDNESEESME QDDE
Length:444
Mass (Da):49,277
Last modified:November 1, 1996 - v1
Checksum:i8C0CA701B4571E7F
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BX284606 Genomic DNA. Translation: CAA90633.1.
PIRiT24204.
RefSeqiNP_510191.1. NM_077790.5.
UniGeneiCel.6607.

Genome annotation databases

EnsemblMetazoaiR12H7.2; R12H7.2; WBGene00000217.
GeneIDi181444.
KEGGicel:CELE_R12H7.2.
UCSCiR12H7.2. c. elegans.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BX284606 Genomic DNA. Translation: CAA90633.1.
PIRiT24204.
RefSeqiNP_510191.1. NM_077790.5.
UniGeneiCel.6607.

3D structure databases

ProteinModelPortaliQ21966.
SMRiQ21966. Positions 27-412.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi6239.R12H7.2.

Proteomic databases

EPDiQ21966.
PaxDbiQ21966.
PRIDEiQ21966.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblMetazoaiR12H7.2; R12H7.2; WBGene00000217.
GeneIDi181444.
KEGGicel:CELE_R12H7.2.
UCSCiR12H7.2. c. elegans.

Organism-specific databases

CTDi181444.
WormBaseiR12H7.2; CE03567; WBGene00000217; asp-4.

Phylogenomic databases

eggNOGiKOG1339. Eukaryota.
ENOG410XNV7. LUCA.
GeneTreeiENSGT00760000118929.
HOGENOMiHOG000197681.
InParanoidiQ21966.
KOiK01379.
OMAiISCDKVP.
OrthoDBiEOG7HQN88.
PhylomeDBiQ21966.

Miscellaneous databases

NextBioi913970.

Family and domain databases

Gene3Di2.40.70.10. 2 hits.
InterProiIPR001461. Aspartic_peptidase_A1.
IPR001969. Aspartic_peptidase_AS.
IPR033144. Cathepsin_D.
IPR033121. PEPTIDASE_A1.
IPR021109. Peptidase_aspartic_dom.
[Graphical view]
PANTHERiPTHR13683. PTHR13683. 1 hit.
PTHR13683:SF230. PTHR13683:SF230. 1 hit.
PfamiPF00026. Asp. 1 hit.
[Graphical view]
PRINTSiPR00792. PEPSIN.
SUPFAMiSSF50630. SSF50630. 1 hit.
PROSITEiPS00141. ASP_PROTEASE. 2 hits.
PS51767. PEPTIDASE_A1. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "Genome sequence of the nematode C. elegans: a platform for investigating biology."
    Caenorhabditis elegans Sequencing Consortium
    Sulson J.E., Waterston R.
    Science 282:2012-2018(1998) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: Bristol N2Imported.

Entry informationi

Entry nameiQ21966_CAEEL
AccessioniPrimary (citable) accession number: Q21966
Entry historyi
Integrated into UniProtKB/TrEMBL: November 1, 1996
Last sequence update: November 1, 1996
Last modified: May 11, 2016
This is version 122 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Proteomics identificationCombined sources, Reference proteomeImported

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.