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Protein
Submitted name:

ASpartyl Protease

Gene

asp-4

Organism
Caenorhabditis elegans
Status
Unreviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei112PROSITE-ProRule annotation1
Active sitei298PROSITE-ProRule annotation1

GO - Molecular functioni

  • aspartic-type endopeptidase activity Source: WormBase

GO - Biological processi

  • necrotic cell death Source: WormBase
  • protein catabolic process Source: GO_Central
  • proteolysis Source: WormBase

Keywordsi

Molecular functionAspartyl proteasePROSITE-ProRule annotationSAAS annotation, Hydrolase, Protease

Protein family/group databases

MEROPSiA01.068.

Names & Taxonomyi

Protein namesi
Submitted name:
ASpartyl ProteaseImported
Gene namesi
Name:asp-4Imported
ORF Names:CELE_R12H7.2Imported, R12H7.2Imported
OrganismiCaenorhabditis elegansImported
Taxonomic identifieri6239 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaNematodaChromadoreaRhabditidaRhabditoideaRhabditidaePeloderinaeCaenorhabditis
Proteomesi
  • UP000001940 Componenti: Chromosome X

Organism-specific databases

WormBaseiR12H7.2; CE03567; WBGene00000217; asp-4.

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 17Sequence analysisAdd BLAST17
ChainiPRO_500419973018 – 444Sequence analysisAdd BLAST427

Proteomic databases

EPDiQ21966.
PaxDbiQ21966.
PeptideAtlasiQ21966.

Expressioni

Gene expression databases

BgeeiWBGene00000217.

Interactioni

Protein-protein interaction databases

STRINGi6239.R12H7.2.

Structurei

3D structure databases

ProteinModelPortaliQ21966.
SMRiQ21966.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini94 – 410Peptidase A1InterPro annotationAdd BLAST317

Sequence similaritiesi

Belongs to the peptidase A1 family.PROSITE-ProRule annotationSAAS annotation

Keywords - Domaini

SignalSequence analysis

Phylogenomic databases

eggNOGiKOG1339. Eukaryota.
ENOG410XNV7. LUCA.
GeneTreeiENSGT00760000118929.
HOGENOMiHOG000197681.
InParanoidiQ21966.
KOiK01379.
OMAiWNGQYTV.
OrthoDBiEOG091G0JP7.
PhylomeDBiQ21966.

Family and domain databases

Gene3Di2.40.70.10. 2 hits.
InterProiView protein in InterPro
IPR001461. Aspartic_peptidase_A1.
IPR001969. Aspartic_peptidase_AS.
IPR033121. PEPTIDASE_A1.
IPR021109. Peptidase_aspartic_dom_sf.
PANTHERiPTHR13683. PTHR13683. 1 hit.
PfamiView protein in Pfam
PF00026. Asp. 1 hit.
PRINTSiPR00792. PEPSIN.
SUPFAMiSSF50630. SSF50630. 1 hit.
PROSITEiView protein in PROSITE
PS00141. ASP_PROTEASE. 2 hits.
PS51767. PEPTIDASE_A1. 1 hit.

Sequencei

Sequence statusi: Complete.

Q21966-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MNRCILLLLG ALLLVQGLHV HKRQQKLRTV SLKKQPTLRE TLLQAGSFET
60 70 80 90 100
FAKHRHGYKK YLKTNGNHHF DKYQALNVEG EIDELLRNYM DAQYFGTISI
110 120 130 140 150
GTPAQNFTVI FDTGSSNLWI PSKKCPFYDI ACMLHHRYDS KSSSTYKEDG
160 170 180 190 200
RKMAIQYGTG SMKGFISKDS VCVAGVCAED QPFAEATSEP GITFVAAKFD
210 220 230 240 250
GILGMAYPEI AVLGVQPVFN TLFEQKKVPS NLFSFWLNRN PDSEIGGEIT
260 270 280 290 300
FGGIDSRRYV EPITYVPVTR KGYWQFKMDK VVGSGVLGCS NGCQAIADTG
310 320 330 340 350
TSLIAGPKAQ IEAIQNFIGA EPLIKGEYMI SCDKVPTLPP VSFVIGGQEF
360 370 380 390 400
SLKGEDYVLK VSQGGKTICL SGFMGIDLPE RVGELWILGD VFIGRYYSVF
410 420 430 440
DFDQNRVGFA QAKTADGRPV DPAPRPFRSV FDNESEESME QDDE
Length:444
Mass (Da):49,277
Last modified:November 1, 1996 - v1
Checksum:i8C0CA701B4571E7F
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BX284606 Genomic DNA. Translation: CAA90633.1.
PIRiT24204.
RefSeqiNP_510191.1. NM_077790.5.
UniGeneiCel.6607.

Genome annotation databases

EnsemblMetazoaiR12H7.2; R12H7.2; WBGene00000217.
GeneIDi181444.
KEGGicel:CELE_R12H7.2.
UCSCiR12H7.2. c. elegans.

Similar proteinsi

Entry informationi

Entry nameiQ21966_CAEEL
AccessioniPrimary (citable) accession number: Q21966
Entry historyiIntegrated into UniProtKB/TrEMBL: November 1, 1996
Last sequence update: November 1, 1996
Last modified: November 22, 2017
This is version 136 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Caution

Lacks conserved residue(s) required for the propagation of feature annotation.PROSITE-ProRule annotation

Keywords - Technical termi

Complete proteome, Proteomics identificationCombined sources, Reference proteomeImported