ID   GLPK_CAEEL              Reviewed;         502 AA.
AC   Q21944;
DT   30-MAY-2000, integrated into UniProtKB/Swiss-Prot.
DT   01-NOV-1996, sequence version 1.
DT   16-JUN-2009, entry version 56.
DE   RecName: Full=Probable glycerol kinase;
DE            EC=2.7.1.30;
DE   AltName: Full=ATP:glycerol 3-phosphotransferase;
DE   AltName: Full=Glycerokinase;
DE            Short=GK;
GN   ORFNames=R11F4.1;
OS   Caenorhabditis elegans.
OC   Eukaryota; Metazoa; Nematoda; Chromadorea; Rhabditida; Rhabditoidea;
OC   Rhabditidae; Peloderinae; Caenorhabditis.
OX   NCBI_TaxID=6239;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Bristol N2;
RX   MEDLINE=99069613; PubMed=9851916; DOI=10.1126/science.282.5396.2012;
RG   The C. elegans sequencing consortium;
RT   "Genome sequence of the nematode C. elegans: a platform for
RT   investigating biology.";
RL   Science 282:2012-2018(1998).
CC   -!- CATALYTIC ACTIVITY: ATP + glycerol = ADP + sn-glycerol 3-
CC       phosphate.
CC   -!- PATHWAY: Polyol metabolism; glycerol degradation via glycerol
CC       kinase pathway; sn-glycerol 3-phosphate from glycerol: step 1/1.
CC   -!- SIMILARITY: Belongs to the FGGY kinase family.
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DR   EMBL; U38378; AAA79749.1; -; Genomic_DNA.
DR   PIR; T16716; T16716.
DR   RefSeq; NP_494721.1; -.
DR   UniGene; Cel.17478; -.
DR   HSSP; P08859; 1GLC.
DR   DIP; DIP:26828N; -.
DR   IntAct; Q21944; 1.
DR   Ensembl; R11F4.1; Caenorhabditis elegans.
DR   GeneID; 173747; -.
DR   KEGG; cel:R11F4.1; -.
DR   WormBase; WBGene00020007; R11F4.1.
DR   WormPep; R11F4.1; CE04828.
DR   OMA; Q21944; NARNINY.
DR   BRENDA; 2.7.1.30; 672.
DR   NextBio; 880915; -.
DR   ArrayExpress; Q21944; -.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR   GO; GO:0004370; F:glycerol kinase activity; IEA:EC.
DR   GO; GO:0005975; P:carbohydrate metabolic process; IEA:InterPro.
DR   GO; GO:0006072; P:glycerol-3-phosphate metabolic process; IEA:InterPro.
DR   InterPro; IPR000577; Carb_kinase_FGGY.
DR   InterPro; IPR018485; Carb_kinase_FGGY_C.
DR   InterPro; IPR018483; Carb_kinase_FGGY_CS.
DR   InterPro; IPR018484; Carb_kinase_FGGY_N.
DR   InterPro; IPR005999; Glycerol_kin.
DR   PANTHER; PTHR10196; FGGY_kin; 1.
DR   PANTHER; PTHR10196:SF9; Glycerol_kin; 1.
DR   Pfam; PF02782; FGGY_C; 1.
DR   Pfam; PF00370; FGGY_N; 1.
DR   TIGRFAMs; TIGR01311; glycerol_kin; 1.
DR   PROSITE; PS00933; FGGY_KINASES_1; 1.
DR   PROSITE; PS00445; FGGY_KINASES_2; FALSE_NEG.
PE   2: Evidence at transcript level;
KW   ATP-binding; Complete proteome; Glycerol metabolism; Kinase;
KW   Nucleotide-binding; Transferase.
FT   CHAIN         1    502       Probable glycerol kinase.
FT                                /FTId=PRO_0000059540.
FT   NP_BIND     416    420       ATP (By similarity).
FT   BINDING      11     11       Substrate (By similarity).
FT   BINDING      15     15       ATP (By similarity).
FT   BINDING      85     85       Substrate (By similarity).
FT   BINDING     140    140       Substrate (By similarity).
FT   BINDING     246    246       Substrate (By similarity).
FT   BINDING     268    268       ATP (By similarity).
FT   BINDING     313    313       ATP; via carbonyl oxygen (By similarity).
SQ   SEQUENCE   502 AA;  55165 MW;  F0438E95F1A1B189 CRC64;
     MVLLAAIDQG TSSSRFLVFE ADTGELVTSH QIEVRQLFPH GGWVEMDPME LYDTVVSCIS
     KTIEKLENLG ISADEIKSVG VANQRETSIV WDKETGKPLY NAIVWLDTRT SSLADEAISR
     TASKSKDEFR AKTGLPIHPY FSALKLKWLF QNVPEVKKAY ADGNLMFGTV DTWLIWKLTG
     AYVTDVSNAS RTLLLDLHKR KWSTQLCEFF DLPIEILPEI RSSAEVYGHF DKGPLEGVPL
     SGCLGDQQAA MVGHQCLNAG QTKNTYGTGT FMLCNIGTRP IISKNGLLTT VGFQFGADSP
     VVYALEGSGS IGGNVVRFLR DNFKFISDAK EMEGLCRSVE DTSGAYFVPS FTGLYTPYWD
     STARGTILGL TQVTQREHIC LAALRAVAFQ SAEMIAAVEQ DLEGGTKVTT LKVDGGMIAN
     KLFNEIQADI MGRDIVTPKI TEISGWGAAV AGGIGAQQIS LDEFLQQSSE DNRYTPQKDD
     NWRSAELARW KEAVKRSCGW AQ
//