Q21944 (GLPK_CAEEL) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Probable glycerol kinase
Short name=GK
Short name=Glycerokinase
EC=2.7.1.30

Alternative name(s):
ATP:glycerol 3-phosphotransferase

Gene names

ORF Names:

R11F4.1

Organism

Caenorhabditis elegans

Taxonomic identifier

6239 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Nematoda › Chromadorea › Rhabditida › Rhabditoidea › Rhabditidae › Peloderinae › Caenorhabditis

Protein attributes

Sequence length	502 AA.
Sequence status	Complete.
Protein existence	Evidence at transcript level

General annotation (Comments)

Catalytic activity	ATP + glycerol = ADP + sn-glycerol 3-phosphate.
Pathway	Polyol metabolism; glycerol degradation via glycerol kinase pathway; sn-glycerol 3-phosphate from glycerol: step 1/1.
Sequence similarities	Belongs to the FGGY kinase family.

Ontologies

Keywords
Biological process	Glycerol metabolism
Ligand	ATP-binding Nucleotide-binding
Molecular function	Kinase Transferase
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological process	glycerol-3-phosphate metabolic process Inferred from electronic annotation. Source: InterPro
Molecular function	ATP binding Inferred from electronic annotation. Source: UniProtKB-KW glycerol kinase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 502	502	Probable glycerol kinase		PRO_0000059540
Regions
	Nucleotide binding	416 – 420	5	ATP By similarity
Sites
	Binding site	11	1	Substrate By similarity
	Binding site	15	1	ATP By similarity
	Binding site	85	1	Substrate By similarity
	Binding site	140	1	Substrate By similarity
	Binding site	246	1	Substrate By similarity
	Binding site	268	1	ATP By similarity
	Binding site	313	1	ATP; via carbonyl oxygen By similarity

Sequences

	Sequence		Length	Mass (Da)
	Q21944 [UniParc]. Last modified November 1, 1996. Version 1. Checksum: F0438E95F1A1B189	FASTA	502	55,165
	10 20 30 40 50 60 MVLLAAIDQG TSSSRFLVFE ADTGELVTSH QIEVRQLFPH GGWVEMDPME LYDTVVSCIS 70 80 90 100 110 120 KTIEKLENLG ISADEIKSVG VANQRETSIV WDKETGKPLY NAIVWLDTRT SSLADEAISR 130 140 150 160 170 180 TASKSKDEFR AKTGLPIHPY FSALKLKWLF QNVPEVKKAY ADGNLMFGTV DTWLIWKLTG 190 200 210 220 230 240 AYVTDVSNAS RTLLLDLHKR KWSTQLCEFF DLPIEILPEI RSSAEVYGHF DKGPLEGVPL 250 260 270 280 290 300 SGCLGDQQAA MVGHQCLNAG QTKNTYGTGT FMLCNIGTRP IISKNGLLTT VGFQFGADSP 310 320 330 340 350 360 VVYALEGSGS IGGNVVRFLR DNFKFISDAK EMEGLCRSVE DTSGAYFVPS FTGLYTPYWD 370 380 390 400 410 420 STARGTILGL TQVTQREHIC LAALRAVAFQ SAEMIAAVEQ DLEGGTKVTT LKVDGGMIAN 430 440 450 460 470 480 KLFNEIQADI MGRDIVTPKI TEISGWGAAV AGGIGAQQIS LDEFLQQSSE DNRYTPQKDD 490 500 NWRSAELARW KEAVKRSCGW AQ

References

[1]	"Genome sequence of the nematode C. elegans: a platform for investigating biology." The C. elegans sequencing consortium Science 282:2012-2018(1998) [PubMed: 9851916] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: Bristol N2.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	FO081682 Genomic DNA. Translation: CCD73301.1.
PIR	T16716.
RefSeq	NP_494721.1. NM_062320.3.
UniGene	Cel.17478.
3D structure databases
ProteinModelPortal	Q21944.
SMR	Q21944. Positions 2-502.
ModBase	Search...
Protein-protein interaction databases
DIP	DIP-26828N.
MINT	MINT-1082027.
STRING	Q21944.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
EnsemblMetazoa	R11F4.1.1; R11F4.1.1; R11F4.1. R11F4.1.2; R11F4.1.2; R11F4.1.
GeneID	173747.
KEGG	cel:R11F4.1.
UCSC	R11F4.1.1. c. elegans.
Organism-specific databases
CTD	173747.
WormBase	R11F4.1; CE04828; WBGene00020007.
Phylogenomic databases
eggNOG	meNOG05113.
GeneTree	EMGT00050000011666.
HOGENOM	HBG511469.
InParanoid	Q21944.
OMA	VRPTMSE.
PhylomeDB	Q21944.
Gene expression databases
ArrayExpress	Q21944.
Family and domain databases
InterPro	IPR000577. Carb_kinase_FGGY. IPR018485. Carb_kinase_FGGY_C. IPR018483. Carb_kinase_FGGY_CS. IPR018484. Carb_kinase_FGGY_N. IPR005999. Glycerol_kin. [Graphical view]
KO	K00864.
PANTHER	PTHR10196. FGGY_kin. 1 hit. PTHR10196:SF9. Glycerol_kin. 1 hit.
Pfam	PF02782. FGGY_C. 1 hit. PF00370. FGGY_N. 1 hit. [Graphical view]
TIGRFAMs	TIGR01311. Glycerol_kin. 1 hit.
PROSITE	PS00933. FGGY_KINASES_1. 1 hit. PS00445. FGGY_KINASES_2. False negative. [Graphical view]
ProtoNet	Search...
Other
NextBio	880915.

Entry information

Entry name

GLPK_CAEEL

Accession

Primary (citable) accession number: Q21944

Entry history

Integrated into UniProtKB/Swiss-Prot:	May 30, 2000
Last sequence update:	November 1, 1996
Last modified:	December 14, 2011
This is version 75 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Caenorhabditis annotation project