Q21929 (DCXR_CAEEL) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Probable L-xylulose reductase
Short name=XR
EC=1.1.1.10

Alternative name(s):
Dicarbonyl/L-xylulose reductase
Short-chain dehydrogenase 21

Gene names

Name:	dhs-21
ORF Names:	R11D1.11

Organism

Caenorhabditis elegans

Taxonomic identifier

6239 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Nematoda › Chromadorea › Rhabditida › Rhabditoidea › Rhabditidae › Peloderinae › Caenorhabditis

Protein attributes

Sequence length	251 AA.
Sequence status	Complete.
Protein existence	Evidence at transcript level

General annotation (Comments)

Function	Catalyzes the NADPH-dependent reduction of L-xylulose, D-xylulose, D-fructose, and L-sorbose, with the highest affinity for L-xylulose By similarity.
Catalytic activity	Xylitol + NADP+ = L-xylulose + NADPH.
Pathway	Carbohydrate degradation; L-arabinose degradation via L-arabinitol; D-xylulose 5-phosphate from L-arabinose (fungal route): step 3/5.
Sequence similarities	Belongs to the short-chain dehydrogenases/reductases (SDR) family.

Ontologies

Keywords
Biological process	Carbohydrate metabolism Xylose metabolism
Ligand	NADP
Molecular function	Oxidoreductase
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological process	D-xylose metabolic process Inferred from electronic annotation. Source: UniProtKB-KW glucose metabolic process Inferred from sequence or structural similarity. Source: UniProtKB protein homotetramerization Inferred from sequence or structural similarity. Source: UniProtKB xylulose catabolic process Inferred from direct assay. Source: WormBase
Cellular component	plasma membrane Inferred from direct assay. Source: WormBase
Molecular function	L-xylulose reductase (NADP+) activity Inferred from sequence or structural similarity. Source: UniProtKB nucleotide binding Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 251	251	Probable L-xylulose reductase		PRO_0000054549
Regions
	Nucleotide binding	11 – 41	31	NADP By similarity
	Compositional bias	203 – 206	4	Poly-Lys
Sites
	Active site	156	1	Proton acceptor By similarity
	Binding site	143	1	Substrate By similarity

Sequences

	Sequence		Length	Mass (Da)
	Q21929 [UniParc]. Last modified September 5, 2006. Version 2. Checksum: CB760AD64210E146	FASTA	251	27,219
	10 20 30 40 50 60 MPANYDFTDK RILVTGASQG IGKEICLSLA KAGAQVIAFA RNEANLLSLV KETTSLRYTI 70 80 90 100 110 120 IPIVGDVSAN EEVLFKLIVP HFPIHGLVNN AGIATNHAIG QITQQSIDRT FAVNVRGPIL 130 140 150 160 170 180 IAQLVARNFV DRQIKGSIVN ISSQAAIRPL DNHTVYCASK AALDMVTRCL ANELGSQNIR 190 200 210 220 230 240 VNSVNPTVVM TDMGRDNWSD PDKKKKMLDR MPIKRFAEVD EVVNAVLFLL SDNASMTTGS 250 TLPVDGGFSN N

References

[1]	"Genome sequence of the nematode C. elegans: a platform for investigating biology." The C. elegans sequencing consortium Science 282:2012-2018(1998) [PubMed: 9851916] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: Bristol N2.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	Z75527, Z75547 Genomic DNA. Translation: CAJ80819.1. Z75547, Z75527 Genomic DNA. Translation: CAA99897.2.
PIR	T24180.
RefSeq	NP_506182.2. NM_073781.5.
UniGene	Cel.2795.
3D structure databases
ProteinModelPortal	Q21929.
SMR	Q21929. Positions 3-250.
ModBase	Search...
Proteomic databases
PRIDE	Q21929.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
EnsemblMetazoa	R11D1.11; R11D1.11; R11D1.11.
GeneID	179741.
KEGG	cel:R11D1.11.
UCSC	R11D1.11. c. elegans.
Organism-specific databases
CTD	179741.
WormBase	R11D1.11; CE39954; WBGene00000984; dhs-21.
Phylogenomic databases
eggNOG	meNOG12147.
GeneTree	EMGT00050000004556.
HOGENOM	HBG750976.
InParanoid	Q21929.
OMA	HAIGQIT.
PhylomeDB	Q21929.
Gene expression databases
ArrayExpress	Q21929.
Family and domain databases
InterPro	IPR002198. DH_sc/Rdtase_SDR. IPR002347. Glc/ribitol_DH. IPR016040. NAD(P)-bd_dom. IPR020904. Sc_DH/Rdtase_CS. [Graphical view]
Gene3D	G3DSA:3.40.50.720. NAD(P)-bd. 1 hit.
KO	K03331.
Pfam	PF00106. adh_short. 1 hit. [Graphical view]
PRINTS	PR00081. GDHRDH. PR00080. SDRFAMILY.
PROSITE	PS00061. ADH_SHORT. 1 hit. [Graphical view]
ProtoNet	Search...
Other
NextBio	906670.

Entry information

Entry name

DCXR_CAEEL

Accession

Primary (citable) accession number: Q21929
Secondary accession number(s): Q27GP8

Entry history

Integrated into UniProtKB/Swiss-Prot:	December 15, 1998
Last sequence update:	September 5, 2006
Last modified:	January 25, 2012
This is version 79 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Caenorhabditis annotation project