Reviewed,
UniProtKB/Swiss-Prot Q21926 (SYIC_CAEEL)
Last modified
June 16, 2009.
Version 61.
History...
Clusters with 100%,
90%,
50% identity |
Documents (3) |
Third-party data |
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Names and origin
| Protein names | Recommended name: Isoleucyl-tRNA synthetase, cytoplasmic EC=6.1.1.5 Alternative name(s): Isoleucine--tRNA ligase Short name=IleRS | ||||
| Gene names |
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| Organism | Caenorhabditis elegans [Complete proteome] | ||||
| Taxonomic identifier | 6239 [NCBI] | ||||
| Taxonomic lineage | Eukaryota › Metazoa › Nematoda › Chromadorea › Rhabditida › Rhabditoidea › Rhabditidae › Peloderinae › Caenorhabditis |
Protein attributes
| Sequence length | 1141 AA. |
| Sequence status | Complete. |
| Sequence processing | The displayed sequence is not processed. |
| Protein existence | Evidence at transcript level. |
General annotation (Comments)
| Catalytic activity | ATP + L-isoleucine + tRNA(Ile) = AMP + diphosphate + L-isoleucyl-tRNA(Ile). |
| Subcellular location | |
| Sequence similarities | Belongs to the class-I aminoacyl-tRNA synthetase family. |
Ontologies
| Keywords | |
|---|---|
| Biological process | Protein biosynthesis |
| Cellular component | Cytoplasm |
| Ligand | ATP-binding Nucleotide-binding |
| Molecular function | Aminoacyl-tRNA synthetase Ligase |
| Technical term | Complete proteome |
| Gene Ontology (GO) | |
| Biological process | embryonic development ending in birth or egg hatching Inferred from mutant phenotype. Source: WormBase isoleucyl-tRNA aminoacylationInferred from electronic annotation. Source: InterPro positive regulation of growth rateInferred from mutant phenotype. Source: WormBase reproductionInferred from mutant phenotype. Source: WormBase |
| Cellular component | cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell |
| Molecular function | ATP binding Inferred from electronic annotation. Source: UniProtKB-KW isoleucine-tRNA ligase activityInferred from electronic annotation. Source: EC zinc ion bindingInferred from electronic annotation. Source: InterPro |
| Complete GO annotation... | |
Sequence annotation (Features)
Sequences
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References
| [1] | "Genome sequence of the nematode C. elegans: a platform for investigating biology." The C. elegans sequencing consortium Science 282:2012-2018(1998) [PubMed: 9851916] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: Bristol N2. |
Cross-references
Sequence databases | |
|---|---|
| Z70310 Genomic DNA. Translation: CAA94369.1. | |
| PIR | T24176. |
| RefSeq | NP_501914.1. |
| UniGene | Cel.17394 |
3D structure databases | |
| HSSP | HSSP built from PDB template 1ILE based on UniProtKB P56690. |
| ModBase | Search... |
Protein-protein interaction databases | |
| IntAct | Q21926. 1 interaction. |
Genome annotation databases | |
| Ensembl | R11A8.6. Caenorhabditis elegans. [Contig view] |
| GeneID | 177926. |
| KEGG | cel:R11A8.6. |
| NMPDR | fig|6239.3.peg.14890. |
Organism-specific databases | |
| WormBase | WBGene00002152. irs-1. |
| WormPep | R11A8.6. CE06304. [WorfDB] |
Phylogenomic databases | |
| OMA | Q21926. SNWYVRR. |
Enzyme and pathway databases | |
| BRENDA | 6.1.1.5. 672. |
Gene expression databases | |
| ArrayExpress | Q21926. |
Family and domain databases | |
| InterPro | IPR001412. aa-tRNA-synth_I_CS. IPR002300. aa-tRNA-synth_Ia. IPR002301. Ile-tRNA-synt_Ia. IPR015905. Ile-tRNA-synt_Ia_N. IPR018353. Isoleucyl-tRNA_synthetase. IPR014729. Rossmann-like_a/b/a_fold. IPR013155. V/L/I-tRNA-synth_anticodon-bd. [Graphical view] |
| Gene3D | G3DSA:3.40.50.620. Rossmann-like_a/b/a_fold. 1 hit. |
| PANTHER | PTHR11946:SF9. Ile-tRNA-synt_Ia. 1 hit. |
| Pfam | PF08264. Anticodon_1. 1 hit. PF00133. tRNA-synt_1. 1 hit. [Graphical view] |
| PRINTS | PR00984. TRNASYNTHILE. |
| TIGRFAMs | TIGR00392. ileS. 1 hit. |
| PROSITE | PS00178. AA_TRNA_LIGASE_I. 1 hit. [Graphical view] |
| ProtoNet | Search... |
Other Resources | |
| NextBio | 898988. |
Entry information
| Entry name | SYIC_CAEEL | ||||||||
| Accession | Primary (citable) accession number: Q21926 | ||||||||
| Entry history |
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| Entry status | Reviewed (UniProtKB/Swiss-Prot) | ||||||||
| Annotation project | Caenorhabditis annotation project | ||||||||
Relevant documents
| Aminoacyl-tRNA synthetases List of aminoacyl-tRNA synthetase entries |
| Caenorhabditis elegans Caenorhabditis elegans: entries, gene names and cross-references to WormPep |
| SIMILARITY comments Index of protein domains and families |

Clusters with


