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Q21926

- SYIC_CAEEL

UniProt

Q21926 - SYIC_CAEEL

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Protein
Isoleucine--tRNA ligase, cytoplasmic
Gene
irs-1, R11A8.6
Organism
Caenorhabditis elegans
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Catalytic activityi

ATP + L-isoleucine + tRNA(Ile) = AMP + diphosphate + L-isoleucyl-tRNA(Ile).UniRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei604 – 6041ATP By similarity

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-KW
  2. aminoacyl-tRNA editing activity Source: InterPro
  3. isoleucine-tRNA ligase activity Source: UniProtKB-EC
Complete GO annotation...

GO - Biological processi

  1. isoleucyl-tRNA aminoacylation Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Aminoacyl-tRNA synthetase, Ligase

Keywords - Biological processi

Protein biosynthesis

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Isoleucine--tRNA ligase, cytoplasmic (EC:6.1.1.5)
Alternative name(s):
Isoleucyl-tRNA synthetase
Short name:
IleRS
Gene namesi
Name:irs-1
ORF Names:R11A8.6
OrganismiCaenorhabditis elegans
Taxonomic identifieri6239 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaNematodaChromadoreaRhabditidaRhabditoideaRhabditidaePeloderinaeCaenorhabditis
ProteomesiUP000001940: Chromosome IV

Organism-specific databases

WormBaseiR11A8.6; CE06304; WBGene00002152; iars-1.

Subcellular locationi

Cytoplasm UniRule annotation

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 11411141Isoleucine--tRNA ligase, cytoplasmicUniRule annotation
PRO_0000098599Add
BLAST

Proteomic databases

PaxDbiQ21926.
PRIDEiQ21926.

Interactioni

Protein-protein interaction databases

BioGridi43028. 1 interaction.
IntActiQ21926. 1 interaction.
MINTiMINT-114690.
STRINGi6239.R11A8.6.

Structurei

3D structure databases

ProteinModelPortaliQ21926.

Family & Domainsi

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi50 – 6011"HIGH" regionUniRule annotation
Add
BLAST
Motifi601 – 6055"KMSKS" regionUniRule annotation

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG0060.
GeneTreeiENSGT00550000074921.
HOGENOMiHOG000246403.
InParanoidiQ21926.
KOiK01870.
OMAiRVEHMVE.
PhylomeDBiQ21926.

Family and domain databases

Gene3Di1.10.730.10. 1 hit.
3.40.50.620. 2 hits.
3.90.740.10. 1 hit.
HAMAPiMF_02003. Ile_tRNA_synth_type2.
InterProiIPR001412. aa-tRNA-synth_I_CS.
IPR002300. aa-tRNA-synth_Ia.
IPR002301. Ile-tRNA-ligase.
IPR023586. Ile-tRNA-ligase_type2.
IPR014729. Rossmann-like_a/b/a_fold.
IPR009080. tRNAsynth_1a_anticodon-bd.
IPR013155. V/L/I-tRNA-synth_anticodon-bd.
IPR009008. Val/Leu/Ile-tRNA-synth_edit.
[Graphical view]
PfamiPF08264. Anticodon_1. 1 hit.
PF00133. tRNA-synt_1. 1 hit.
[Graphical view]
PRINTSiPR00984. TRNASYNTHILE.
SUPFAMiSSF47323. SSF47323. 1 hit.
SSF50677. SSF50677. 1 hit.
TIGRFAMsiTIGR00392. ileS. 1 hit.
PROSITEiPS00178. AA_TRNA_LIGASE_I. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q21926-1 [UniParc]FASTAAdd to Basket

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MSGLSTVPDN INFAREEDKV AQKWQDENTF QRSVELSKDR PHFTFYDGPP     50
FATGLPHYGH MLTSTIKDVV GRWAHQNGHY VERRFGWDTH GLPVEYEIDK 100
TLGISGPQDV MKMGIANYNN ECRKIVMRYS GEWEKTMGRL GRWVDFKHDY 150
KTLYPWFMES VWWAFSELHK KGLVYKGVKV MPFSTACSTP LSNFEAGQNY 200
KDVVDPAVFV GFKLLDCPNR QLVAWTTTPW TLPSNLALVV HPDMLYVVTK 250
DKTTGIEYVV LEERLGELKN DNLEVIEKLA GSQLKDLRYE PLFPYFAYMR 300
EERNAFRVLN DTFVTSDSGT GVVHQAPYFG EIDFQVCVAN GVIAKDQKMI 350
CPVDESGKYT SEVPDYQGVY VKDADKLIIK RLKEMGNLVR QAEVKHSYPF 400
CWRSDTPLLY KAVPSWFINV ETLIPRLLAN NDETYWVPAF VKEKRFANWL 450
RDARDWAVSR NRFWGTPINL WVSEDGEEVV CVGSIAELEE LSGQKITDLH 500
RESVDDVTIP SRSGRGVLKR VSEVFDCWFE SGSMPYAQNH YPFENRKIFE 550
DNFPADFIAE GIDQTRGWFY TLLVLSTALF NKPPFKNLIC NGLVLASDGA 600
KMSKSKKNYP DPMLIVNKYG ADALRLYLIN SPVVRGENLR FREEGVRDLL 650
KDVFLPWFNA YRFFVQNVQA YEHETGNVFD MNVHVASENV MDRWIESFTN 700
SLVAFVRKEM DSYRLYAVVG PLTKFFDTLT NIYIRLNRKR VKGDNGLHEQ 750
HHALAALGRV LILIVRLMAP FTPFFCEYIW LNLKKVIGST EESVHFLMLP 800
KPDESLIDET VERRVEVMRN VIDLVRLVRD REGLAVKYPL KEMIVINRDS 850
QFLEDVKSLE SYILLELNVR KLTVSQDKQK YGITLKAEPN FKILGARLKG 900
EQKKVADYLK NQITESELEK FLLEGKLTVL GHELSSEEVA VSYAAGSDQG 950
HGYKTHSDAK TIVMIDTTED ESLIEEGLCR EVTNRVQRLR KQAKLVSTDT 1000
AHVHIVVSPA DSQLAKVVAA KLNDIVSATG TPIKLGSPPA AAKAPTATSK 1050
SAIKDSEVEL WLFAEGDSFD GITVVDGSKK VRVHVKTEKE HLKGYADLLY 1100
HVRSALDLWN GKIALKNVDG SAVHPTVDVT SLVGQTLQLV R 1141
Length:1,141
Mass (Da):130,012
Last modified:November 1, 1996 - v1
Checksum:i151E6AD6D6360EB0
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
Z70310 Genomic DNA. Translation: CAA94369.1.
PIRiT24176.
RefSeqiNP_501914.1. NM_069513.4.
UniGeneiCel.17394.

Genome annotation databases

EnsemblMetazoaiR11A8.6.1; R11A8.6.1; WBGene00002152.
R11A8.6.2; R11A8.6.2; WBGene00002152.
GeneIDi177926.
KEGGicel:CELE_R11A8.6.
UCSCiR11A8.6. c. elegans.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
Z70310 Genomic DNA. Translation: CAA94369.1 .
PIRi T24176.
RefSeqi NP_501914.1. NM_069513.4.
UniGenei Cel.17394.

3D structure databases

ProteinModelPortali Q21926.
ModBasei Search...

Protein-protein interaction databases

BioGridi 43028. 1 interaction.
IntActi Q21926. 1 interaction.
MINTi MINT-114690.
STRINGi 6239.R11A8.6.

Proteomic databases

PaxDbi Q21926.
PRIDEi Q21926.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblMetazoai R11A8.6.1 ; R11A8.6.1 ; WBGene00002152 .
R11A8.6.2 ; R11A8.6.2 ; WBGene00002152 .
GeneIDi 177926.
KEGGi cel:CELE_R11A8.6.
UCSCi R11A8.6. c. elegans.

Organism-specific databases

CTDi 177926.
WormBasei R11A8.6 ; CE06304 ; WBGene00002152 ; iars-1.

Phylogenomic databases

eggNOGi COG0060.
GeneTreei ENSGT00550000074921.
HOGENOMi HOG000246403.
InParanoidi Q21926.
KOi K01870.
OMAi RVEHMVE.
PhylomeDBi Q21926.

Miscellaneous databases

NextBioi 898988.
PROi Q21926.

Family and domain databases

Gene3Di 1.10.730.10. 1 hit.
3.40.50.620. 2 hits.
3.90.740.10. 1 hit.
HAMAPi MF_02003. Ile_tRNA_synth_type2.
InterProi IPR001412. aa-tRNA-synth_I_CS.
IPR002300. aa-tRNA-synth_Ia.
IPR002301. Ile-tRNA-ligase.
IPR023586. Ile-tRNA-ligase_type2.
IPR014729. Rossmann-like_a/b/a_fold.
IPR009080. tRNAsynth_1a_anticodon-bd.
IPR013155. V/L/I-tRNA-synth_anticodon-bd.
IPR009008. Val/Leu/Ile-tRNA-synth_edit.
[Graphical view ]
Pfami PF08264. Anticodon_1. 1 hit.
PF00133. tRNA-synt_1. 1 hit.
[Graphical view ]
PRINTSi PR00984. TRNASYNTHILE.
SUPFAMi SSF47323. SSF47323. 1 hit.
SSF50677. SSF50677. 1 hit.
TIGRFAMsi TIGR00392. ileS. 1 hit.
PROSITEi PS00178. AA_TRNA_LIGASE_I. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Genome sequence of the nematode C. elegans: a platform for investigating biology."
    The C. elegans sequencing consortium
    Science 282:2012-2018(1998) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: Bristol N2.

Entry informationi

Entry nameiSYIC_CAEEL
AccessioniPrimary (citable) accession number: Q21926
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: November 1, 1996
Last modified: June 11, 2014
This is version 102 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programCaenorhabditis annotation project

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Aminoacyl-tRNA synthetases
    List of aminoacyl-tRNA synthetase entries
  2. Caenorhabditis elegans
    Caenorhabditis elegans: entries, gene names and cross-references to WormBase
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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