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Q21926

- SYIC_CAEEL

UniProt

Q21926 - SYIC_CAEEL

Protein

Isoleucine--tRNA ligase, cytoplasmic

Gene

irs-1

Organism
Caenorhabditis elegans
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi
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    • History
      Entry version 103 (01 Oct 2014)
      Sequence version 1 (01 Nov 1996)
      Previous versions | rss
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    Functioni

    Catalytic activityi

    ATP + L-isoleucine + tRNA(Ile) = AMP + diphosphate + L-isoleucyl-tRNA(Ile).

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Binding sitei604 – 6041ATPBy similarity

    GO - Molecular functioni

    1. aminoacyl-tRNA editing activity Source: InterPro
    2. ATP binding Source: UniProtKB-KW
    3. isoleucine-tRNA ligase activity Source: UniProtKB-EC

    GO - Biological processi

    1. isoleucyl-tRNA aminoacylation Source: InterPro

    Keywords - Molecular functioni

    Aminoacyl-tRNA synthetase, Ligase

    Keywords - Biological processi

    Protein biosynthesis

    Keywords - Ligandi

    ATP-binding, Nucleotide-binding

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Isoleucine--tRNA ligase, cytoplasmic (EC:6.1.1.5)
    Alternative name(s):
    Isoleucyl-tRNA synthetase
    Short name:
    IleRS
    Gene namesi
    Name:irs-1
    ORF Names:R11A8.6
    OrganismiCaenorhabditis elegans
    Taxonomic identifieri6239 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaEcdysozoaNematodaChromadoreaRhabditidaRhabditoideaRhabditidaePeloderinaeCaenorhabditis
    ProteomesiUP000001940: Chromosome IV

    Organism-specific databases

    WormBaseiR11A8.6; CE06304; WBGene00002152; iars-1.

    Subcellular locationi

    GO - Cellular componenti

    1. cytoplasm Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cytoplasm

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 11411141Isoleucine--tRNA ligase, cytoplasmicPRO_0000098599Add
    BLAST

    Proteomic databases

    PaxDbiQ21926.
    PRIDEiQ21926.

    Interactioni

    Protein-protein interaction databases

    BioGridi43028. 1 interaction.
    IntActiQ21926. 1 interaction.
    MINTiMINT-114690.
    STRINGi6239.R11A8.6.

    Structurei

    3D structure databases

    ProteinModelPortaliQ21926.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Motif

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Motifi50 – 6011"HIGH" regionAdd
    BLAST
    Motifi601 – 6055"KMSKS" region

    Sequence similaritiesi

    Phylogenomic databases

    eggNOGiCOG0060.
    GeneTreeiENSGT00550000074921.
    HOGENOMiHOG000246403.
    InParanoidiQ21926.
    KOiK01870.
    OMAiRVEHMVE.
    PhylomeDBiQ21926.

    Family and domain databases

    Gene3Di1.10.730.10. 1 hit.
    3.40.50.620. 2 hits.
    3.90.740.10. 1 hit.
    HAMAPiMF_02003. Ile_tRNA_synth_type2.
    InterProiIPR001412. aa-tRNA-synth_I_CS.
    IPR002300. aa-tRNA-synth_Ia.
    IPR002301. Ile-tRNA-ligase.
    IPR023586. Ile-tRNA-ligase_type2.
    IPR014729. Rossmann-like_a/b/a_fold.
    IPR009080. tRNAsynth_1a_anticodon-bd.
    IPR013155. V/L/I-tRNA-synth_anticodon-bd.
    IPR009008. Val/Leu/Ile-tRNA-synth_edit.
    [Graphical view]
    PfamiPF08264. Anticodon_1. 1 hit.
    PF00133. tRNA-synt_1. 1 hit.
    [Graphical view]
    PRINTSiPR00984. TRNASYNTHILE.
    SUPFAMiSSF47323. SSF47323. 1 hit.
    SSF50677. SSF50677. 1 hit.
    TIGRFAMsiTIGR00392. ileS. 1 hit.
    PROSITEiPS00178. AA_TRNA_LIGASE_I. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q21926-1 [UniParc]FASTAAdd to Basket

    « Hide

    MSGLSTVPDN INFAREEDKV AQKWQDENTF QRSVELSKDR PHFTFYDGPP     50
    FATGLPHYGH MLTSTIKDVV GRWAHQNGHY VERRFGWDTH GLPVEYEIDK 100
    TLGISGPQDV MKMGIANYNN ECRKIVMRYS GEWEKTMGRL GRWVDFKHDY 150
    KTLYPWFMES VWWAFSELHK KGLVYKGVKV MPFSTACSTP LSNFEAGQNY 200
    KDVVDPAVFV GFKLLDCPNR QLVAWTTTPW TLPSNLALVV HPDMLYVVTK 250
    DKTTGIEYVV LEERLGELKN DNLEVIEKLA GSQLKDLRYE PLFPYFAYMR 300
    EERNAFRVLN DTFVTSDSGT GVVHQAPYFG EIDFQVCVAN GVIAKDQKMI 350
    CPVDESGKYT SEVPDYQGVY VKDADKLIIK RLKEMGNLVR QAEVKHSYPF 400
    CWRSDTPLLY KAVPSWFINV ETLIPRLLAN NDETYWVPAF VKEKRFANWL 450
    RDARDWAVSR NRFWGTPINL WVSEDGEEVV CVGSIAELEE LSGQKITDLH 500
    RESVDDVTIP SRSGRGVLKR VSEVFDCWFE SGSMPYAQNH YPFENRKIFE 550
    DNFPADFIAE GIDQTRGWFY TLLVLSTALF NKPPFKNLIC NGLVLASDGA 600
    KMSKSKKNYP DPMLIVNKYG ADALRLYLIN SPVVRGENLR FREEGVRDLL 650
    KDVFLPWFNA YRFFVQNVQA YEHETGNVFD MNVHVASENV MDRWIESFTN 700
    SLVAFVRKEM DSYRLYAVVG PLTKFFDTLT NIYIRLNRKR VKGDNGLHEQ 750
    HHALAALGRV LILIVRLMAP FTPFFCEYIW LNLKKVIGST EESVHFLMLP 800
    KPDESLIDET VERRVEVMRN VIDLVRLVRD REGLAVKYPL KEMIVINRDS 850
    QFLEDVKSLE SYILLELNVR KLTVSQDKQK YGITLKAEPN FKILGARLKG 900
    EQKKVADYLK NQITESELEK FLLEGKLTVL GHELSSEEVA VSYAAGSDQG 950
    HGYKTHSDAK TIVMIDTTED ESLIEEGLCR EVTNRVQRLR KQAKLVSTDT 1000
    AHVHIVVSPA DSQLAKVVAA KLNDIVSATG TPIKLGSPPA AAKAPTATSK 1050
    SAIKDSEVEL WLFAEGDSFD GITVVDGSKK VRVHVKTEKE HLKGYADLLY 1100
    HVRSALDLWN GKIALKNVDG SAVHPTVDVT SLVGQTLQLV R 1141
    Length:1,141
    Mass (Da):130,012
    Last modified:November 1, 1996 - v1
    Checksum:i151E6AD6D6360EB0
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    Z70310 Genomic DNA. Translation: CAA94369.1.
    PIRiT24176.
    RefSeqiNP_501914.1. NM_069513.4.
    UniGeneiCel.17394.

    Genome annotation databases

    EnsemblMetazoaiR11A8.6.1; R11A8.6.1; WBGene00002152.
    R11A8.6.2; R11A8.6.2; WBGene00002152.
    GeneIDi177926.
    KEGGicel:CELE_R11A8.6.
    UCSCiR11A8.6. c. elegans.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    Z70310 Genomic DNA. Translation: CAA94369.1 .
    PIRi T24176.
    RefSeqi NP_501914.1. NM_069513.4.
    UniGenei Cel.17394.

    3D structure databases

    ProteinModelPortali Q21926.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 43028. 1 interaction.
    IntActi Q21926. 1 interaction.
    MINTi MINT-114690.
    STRINGi 6239.R11A8.6.

    Proteomic databases

    PaxDbi Q21926.
    PRIDEi Q21926.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblMetazoai R11A8.6.1 ; R11A8.6.1 ; WBGene00002152 .
    R11A8.6.2 ; R11A8.6.2 ; WBGene00002152 .
    GeneIDi 177926.
    KEGGi cel:CELE_R11A8.6.
    UCSCi R11A8.6. c. elegans.

    Organism-specific databases

    CTDi 177926.
    WormBasei R11A8.6 ; CE06304 ; WBGene00002152 ; iars-1.

    Phylogenomic databases

    eggNOGi COG0060.
    GeneTreei ENSGT00550000074921.
    HOGENOMi HOG000246403.
    InParanoidi Q21926.
    KOi K01870.
    OMAi RVEHMVE.
    PhylomeDBi Q21926.

    Miscellaneous databases

    NextBioi 898988.
    PROi Q21926.

    Family and domain databases

    Gene3Di 1.10.730.10. 1 hit.
    3.40.50.620. 2 hits.
    3.90.740.10. 1 hit.
    HAMAPi MF_02003. Ile_tRNA_synth_type2.
    InterProi IPR001412. aa-tRNA-synth_I_CS.
    IPR002300. aa-tRNA-synth_Ia.
    IPR002301. Ile-tRNA-ligase.
    IPR023586. Ile-tRNA-ligase_type2.
    IPR014729. Rossmann-like_a/b/a_fold.
    IPR009080. tRNAsynth_1a_anticodon-bd.
    IPR013155. V/L/I-tRNA-synth_anticodon-bd.
    IPR009008. Val/Leu/Ile-tRNA-synth_edit.
    [Graphical view ]
    Pfami PF08264. Anticodon_1. 1 hit.
    PF00133. tRNA-synt_1. 1 hit.
    [Graphical view ]
    PRINTSi PR00984. TRNASYNTHILE.
    SUPFAMi SSF47323. SSF47323. 1 hit.
    SSF50677. SSF50677. 1 hit.
    TIGRFAMsi TIGR00392. ileS. 1 hit.
    PROSITEi PS00178. AA_TRNA_LIGASE_I. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Genome sequence of the nematode C. elegans: a platform for investigating biology."
      The C. elegans sequencing consortium
      Science 282:2012-2018(1998) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: Bristol N2.

    Entry informationi

    Entry nameiSYIC_CAEEL
    AccessioniPrimary (citable) accession number: Q21926
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: November 1, 1997
    Last sequence update: November 1, 1996
    Last modified: October 1, 2014
    This is version 103 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programCaenorhabditis annotation project

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Aminoacyl-tRNA synthetases
      List of aminoacyl-tRNA synthetase entries
    2. Caenorhabditis elegans
      Caenorhabditis elegans: entries, gene names and cross-references to WormBase
    3. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3