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Protein

Guanine nucleotide-binding protein alpha-7 subunit

Gene

gpa-7

Organism
Caenorhabditis elegans
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Guanine nucleotide-binding proteins (G proteins) are involved as modulators or transducers in various transmembrane signaling systems.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi47 – 471MagnesiumBy similarity
Metal bindingi180 – 1801MagnesiumBy similarity
Binding sitei324 – 3241GTP; via amide nitrogenBy similarity

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi40 – 478GTPBy similarity
Nucleotide bindingi174 – 1807GTPBy similarity
Nucleotide bindingi199 – 2035GTPBy similarity
Nucleotide bindingi268 – 2714GTPBy similarity

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Transducer

Keywords - Ligandi

GTP-binding, Magnesium, Metal-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Guanine nucleotide-binding protein alpha-7 subunit
Gene namesi
Name:gpa-7
ORF Names:R10H10.5
OrganismiCaenorhabditis elegans
Taxonomic identifieri6239 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaNematodaChromadoreaRhabditidaRhabditoideaRhabditidaePeloderinaeCaenorhabditis
Proteomesi
  • UP000001940 Componenti: Chromosome IV

Organism-specific databases

WormBaseiR10H10.5; CE06296; WBGene00001669; gpa-7.

Subcellular locationi

GO - Cellular componenti

  • cytosol Source: WormBase
  • heterotrimeric G-protein complex Source: GO_Central
  • nucleus Source: WormBase
Complete GO annotation...

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Initiator methionineiRemovedSequence analysis
Chaini2 – 352351Guanine nucleotide-binding protein alpha-7 subunitPRO_0000203641Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Lipidationi2 – 21N-myristoyl glycineSequence analysis
Lipidationi4 – 41S-palmitoyl cysteineSequence analysis

Keywords - PTMi

Lipoprotein, Myristate, Palmitate

Proteomic databases

EPDiQ21917.
PaxDbiQ21917.
PRIDEiQ21917.

PTM databases

iPTMnetiQ21917.

Interactioni

Subunit structurei

G proteins are composed of 3 units; alpha, beta and gamma. The alpha chain contains the guanine nucleotide binding site.

Binary interactionsi

WithEntry#Exp.IntActNotes
nhr-22Q095873EBI-6094232,EBI-323124

GO - Molecular functioni

Protein-protein interaction databases

IntActiQ21917. 1 interaction.
STRINGi6239.R10H10.5.

Structurei

3D structure databases

ProteinModelPortaliQ21917.
SMRiQ21917. Positions 35-343.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the G-alpha family. G(i/o/t/z) subfamily.Curated

Phylogenomic databases

eggNOGiKOG0082. Eukaryota.
ENOG410XNVQ. LUCA.
GeneTreeiENSGT00760000118851.
HOGENOMiHOG000038730.
InParanoidiQ21917.
KOiK04534.
OMAiDMIIARN.
OrthoDBiEOG72C50B.
PhylomeDBiQ21917.

Family and domain databases

Gene3Di1.10.400.10. 1 hit.
3.40.50.300. 2 hits.
InterProiIPR001408. Gprotein_alpha_I.
IPR001019. Gprotein_alpha_su.
IPR011025. GproteinA_insert.
IPR027417. P-loop_NTPase.
[Graphical view]
PANTHERiPTHR10218. PTHR10218. 1 hit.
PfamiPF00503. G-alpha. 1 hit.
[Graphical view]
PRINTSiPR00318. GPROTEINA.
PR00441. GPROTEINAI.
SMARTiSM00275. G_alpha. 1 hit.
[Graphical view]
SUPFAMiSSF47895. SSF47895. 1 hit.
SSF52540. SSF52540. 2 hits.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q21917-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MGHCTSKDQK EGKRLNRRID EQIKKDQSMS LRIIKLLLLG AGESGKSTIL
60 70 80 90 100
KQMRILHKDG FSQQDLEMIR PVVYSNCIHS MLSILRAMFH LQIEYGEPDR
110 120 130 140 150
VRDSQLVFAT VHANKEELTE ELAAAMQRLW HDPGVRECYR RSNEYQIDDS
160 170 180 190 200
AKYFLDNLPR LSSPNYVPSE QDLLRTRIKT TGITEVLFEL KGLTFRVIDV
210 220 230 240 250
GGQRSERKKW IHCFDNVNAI IFISSLSEYD QTLREDNCTN RMQESLKLFD
260 270 280 290 300
SICNSPWFAD IHFILFLNKK DLFAEKIVRS PLTVCFPEYK GQQNQTECIN
310 320 330 340 350
YIQWKFEQLN RSSQREIYCH HTCATDTNNV QFVLDACLDM IIAKNLKSMG

LC
Length:352
Mass (Da):41,021
Last modified:November 1, 1996 - v1
Checksum:i375A1A4D462EFE5E
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY008130 mRNA. Translation: AAG32083.1.
Z70686 Genomic DNA. Translation: CAA94612.1.
PIRiT24154.
RefSeqiNP_501921.1. NM_069520.1.
UniGeneiCel.12772.

Genome annotation databases

EnsemblMetazoaiR10H10.5; R10H10.5; WBGene00001669.
GeneIDi177931.
KEGGicel:CELE_R10H10.5.
UCSCiR10H10.5. c. elegans.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY008130 mRNA. Translation: AAG32083.1.
Z70686 Genomic DNA. Translation: CAA94612.1.
PIRiT24154.
RefSeqiNP_501921.1. NM_069520.1.
UniGeneiCel.12772.

3D structure databases

ProteinModelPortaliQ21917.
SMRiQ21917. Positions 35-343.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiQ21917. 1 interaction.
STRINGi6239.R10H10.5.

PTM databases

iPTMnetiQ21917.

Proteomic databases

EPDiQ21917.
PaxDbiQ21917.
PRIDEiQ21917.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblMetazoaiR10H10.5; R10H10.5; WBGene00001669.
GeneIDi177931.
KEGGicel:CELE_R10H10.5.
UCSCiR10H10.5. c. elegans.

Organism-specific databases

CTDi177931.
WormBaseiR10H10.5; CE06296; WBGene00001669; gpa-7.

Phylogenomic databases

eggNOGiKOG0082. Eukaryota.
ENOG410XNVQ. LUCA.
GeneTreeiENSGT00760000118851.
HOGENOMiHOG000038730.
InParanoidiQ21917.
KOiK04534.
OMAiDMIIARN.
OrthoDBiEOG72C50B.
PhylomeDBiQ21917.

Miscellaneous databases

PROiQ21917.

Family and domain databases

Gene3Di1.10.400.10. 1 hit.
3.40.50.300. 2 hits.
InterProiIPR001408. Gprotein_alpha_I.
IPR001019. Gprotein_alpha_su.
IPR011025. GproteinA_insert.
IPR027417. P-loop_NTPase.
[Graphical view]
PANTHERiPTHR10218. PTHR10218. 1 hit.
PfamiPF00503. G-alpha. 1 hit.
[Graphical view]
PRINTSiPR00318. GPROTEINA.
PR00441. GPROTEINAI.
SMARTiSM00275. G_alpha. 1 hit.
[Graphical view]
SUPFAMiSSF47895. SSF47895. 1 hit.
SSF52540. SSF52540. 2 hits.
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Interaction analysis of the complete G-alpha subfamily of heterotrimeric G proteins from Caenorhabditis elegans."
    Cuppen E., Jansen G., Plasterk R.H.A.
    Submitted (SEP-2000) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Strain: Bristol N2.
  2. "Genome sequence of the nematode C. elegans: a platform for investigating biology."
    The C. elegans sequencing consortium
    Science 282:2012-2018(1998) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: Bristol N2.
  3. "The complete family of genes encoding G proteins of Caenorhabditis elegans."
    Jansen G., Thijssen K.L., Werner P., van der Horst M., Hazendonk E., Plasterk R.H.A.
    Nat. Genet. 21:414-419(1999) [PubMed] [Europe PMC] [Abstract]
    Cited for: GENE FAMILY, NOMENCLATURE.

Entry informationi

Entry nameiGPA7_CAEEL
AccessioniPrimary (citable) accession number: Q21917
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 27, 2002
Last sequence update: November 1, 1996
Last modified: July 6, 2016
This is version 115 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programCaenorhabditis annotation project

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Caenorhabditis elegans
    Caenorhabditis elegans: entries, gene names and cross-references to WormBase
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.