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Q21902

- MCM5_CAEEL

UniProt

Q21902 - MCM5_CAEEL

Protein

DNA replication licensing factor mcm-5

Gene

mcm-5

Organism
Caenorhabditis elegans
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 93 (01 Oct 2014)
      Sequence version 1 (01 Nov 1997)
      Previous versions | rss
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    Functioni

    Acts as component of the mcm2-7 complex (mcm complex) which is the putative replicative helicase essential for 'once per cell cycle' DNA replication initiation and elongation in eukaryotic cells. The active ATPase sites in the mcm2-7 ring are formed through the interaction surfaces of two neighboring subunits such that a critical structure of a conserved arginine finger motif is provided in trans relative to the ATP-binding site of the Walker A box of the adjacent subunit. The six ATPase active sites, however, are likely to contribute differentially to the complex helicase activity By similarity.By similarity

    Catalytic activityi

    ATP + H2O = ADP + phosphate.

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Nucleotide bindingi380 – 3878ATPSequence Analysis

    GO - Molecular functioni

    1. ATP binding Source: UniProtKB-KW
    2. DNA binding Source: UniProtKB-KW
    3. DNA helicase activity Source: InterPro

    GO - Biological processi

    1. cell cycle Source: UniProtKB-KW
    2. DNA replication initiation Source: InterPro

    Keywords - Molecular functioni

    Helicase, Hydrolase

    Keywords - Biological processi

    Cell cycle, DNA replication

    Keywords - Ligandi

    ATP-binding, DNA-binding, Nucleotide-binding

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    DNA replication licensing factor mcm-5 (EC:3.6.4.12)
    Gene namesi
    Name:mcm-5
    ORF Names:R10E4.4
    OrganismiCaenorhabditis elegans
    Taxonomic identifieri6239 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaEcdysozoaNematodaChromadoreaRhabditidaRhabditoideaRhabditidaePeloderinaeCaenorhabditis
    ProteomesiUP000001940: Chromosome III

    Organism-specific databases

    WormBaseiR10E4.4; CE03558; WBGene00003157; mcm-5.

    Subcellular locationi

    Nucleus Curated

    GO - Cellular componenti

    1. MCM complex Source: InterPro
    2. nucleus Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Nucleus

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 759759DNA replication licensing factor mcm-5PRO_0000194110Add
    BLAST

    Proteomic databases

    PaxDbiQ21902.

    Interactioni

    Subunit structurei

    Component of the mcm2-7 complex. The complex forms a toroidal hexameric ring with the proposed subunit order mcm2-mcm6-mcm4-mcm7-mcm3-mcm5 (By simililarity).

    Protein-protein interaction databases

    BioGridi40789. 1 interaction.
    STRINGi6239.R10E4.4.2.

    Structurei

    3D structure databases

    ProteinModelPortaliQ21902.
    SMRiQ21902. Positions 70-670.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini330 – 536207MCMAdd
    BLAST

    Motif

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Motifi511 – 5144Arginine finger

    Sequence similaritiesi

    Belongs to the MCM family.Curated
    Contains 1 MCM domain.Curated

    Phylogenomic databases

    eggNOGiCOG1241.
    GeneTreeiENSGT00550000074928.
    HOGENOMiHOG000224128.
    InParanoidiQ21902.
    KOiK02209.
    OMAiIVKDTHD.
    PhylomeDBiQ21902.

    Family and domain databases

    Gene3Di2.40.50.140. 2 hits.
    3.40.50.300. 1 hit.
    InterProiIPR008048. MCM5.
    IPR018525. MCM_CS.
    IPR001208. MCM_DNA-dep_ATPase.
    IPR027925. MCM_N.
    IPR012340. NA-bd_OB-fold.
    IPR027417. P-loop_NTPase.
    [Graphical view]
    PfamiPF00493. MCM. 1 hit.
    PF14551. MCM_N. 1 hit.
    [Graphical view]
    PRINTSiPR01657. MCMFAMILY.
    PR01661. MCMPROTEIN5.
    SMARTiSM00350. MCM. 1 hit.
    [Graphical view]
    SUPFAMiSSF50249. SSF50249. 1 hit.
    SSF52540. SSF52540. 1 hit.
    PROSITEiPS00847. MCM_1. 1 hit.
    PS50051. MCM_2. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q21902-1 [UniParc]FASTAAdd to Basket

    « Hide

    MSNLDNPGIY YQERFFANDG VPDTGRELIA EYRQLITQFR NFIRDFSTGG    50
    FGMIYRDQLK RNYFSHEYRL EINLNHLKNF DEDIEMKLRK FPGKVLPALE 100
    EAAKIVADEI TTPRPKGEEK LHDIQVTLTL DEYPTSLRQV KSAQVSQVVK 150
    ISGIIVAAAQ VRSKATKVTL QCRQCKHTIP DVSIKPGLEG FALPRTCAAP 200
    QQGQMQRCPI DPYIMLPDKC ECVDYQTLKL QENPEDVPHG EMPRHLQLFT 250
    ERYLTDKVVP GNRVTIVGVY SIKKLIQKKG GDKSLQGIRT PYLRVLGIHM 300
    ETSGPGRTNF TTFTPEEERM FKTLAQRKDA YELIAKSIAP SIYGSADIKK 350
    SIACLLFGGA RKKLPDGITR RGDINVLLLG DPGTAKSQLL KFVEQVSPIG 400
    VYTSGKGSSA AGLTASVIRD PQSRSFIMEG GAMVLADGGV VCIDEFDKMR 450
    EDDRVAIHEA MEQQTISIAK AGITTTLNSR CSVLAAANSV YGRWDESRGD 500
    DNIDFMPTIL SRFDMIYIVK DTHDVLKDAT LAKHVIEVHV NASAAKERDI 550
    AGVPKTATTD SDGVMTMFDT DGFLTIEFLK KFVTYARLNC GPRLTPQASE 600
    KLVNHYVKMR NPVVNADAFK SGKKAHNSAI PITVRQLEAI VRIAESIAKM 650
    ELQQFATDKH VEEALRLFRV STIEAAATGN LAGVEGFTST ADQEALNRIE 700
    VQMKKRFAIG THVSEHLIVQ DFVARQHYRE SLVKKVIDNL VRRGDLQQKM 750
    QRKMLYRVR 759
    Length:759
    Mass (Da):84,936
    Last modified:November 1, 1997 - v1
    Checksum:i8D81B2AB5090A92B
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    Z50874 Genomic DNA. Translation: CAA90765.1.
    PIRiT24130.
    RefSeqiNP_497858.1. NM_065457.4.
    UniGeneiCel.10253.

    Genome annotation databases

    EnsemblMetazoaiR10E4.4.1; R10E4.4.1; WBGene00003157.
    R10E4.4.2; R10E4.4.2; WBGene00003157.
    GeneIDi175552.
    KEGGicel:CELE_R10E4.4.
    UCSCiR10E4.4.1. c. elegans.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    Z50874 Genomic DNA. Translation: CAA90765.1 .
    PIRi T24130.
    RefSeqi NP_497858.1. NM_065457.4.
    UniGenei Cel.10253.

    3D structure databases

    ProteinModelPortali Q21902.
    SMRi Q21902. Positions 70-670.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 40789. 1 interaction.
    STRINGi 6239.R10E4.4.2.

    Proteomic databases

    PaxDbi Q21902.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblMetazoai R10E4.4.1 ; R10E4.4.1 ; WBGene00003157 .
    R10E4.4.2 ; R10E4.4.2 ; WBGene00003157 .
    GeneIDi 175552.
    KEGGi cel:CELE_R10E4.4.
    UCSCi R10E4.4.1. c. elegans.

    Organism-specific databases

    CTDi 175552.
    WormBasei R10E4.4 ; CE03558 ; WBGene00003157 ; mcm-5.

    Phylogenomic databases

    eggNOGi COG1241.
    GeneTreei ENSGT00550000074928.
    HOGENOMi HOG000224128.
    InParanoidi Q21902.
    KOi K02209.
    OMAi IVKDTHD.
    PhylomeDBi Q21902.

    Miscellaneous databases

    NextBioi 888644.
    PROi Q21902.

    Family and domain databases

    Gene3Di 2.40.50.140. 2 hits.
    3.40.50.300. 1 hit.
    InterProi IPR008048. MCM5.
    IPR018525. MCM_CS.
    IPR001208. MCM_DNA-dep_ATPase.
    IPR027925. MCM_N.
    IPR012340. NA-bd_OB-fold.
    IPR027417. P-loop_NTPase.
    [Graphical view ]
    Pfami PF00493. MCM. 1 hit.
    PF14551. MCM_N. 1 hit.
    [Graphical view ]
    PRINTSi PR01657. MCMFAMILY.
    PR01661. MCMPROTEIN5.
    SMARTi SM00350. MCM. 1 hit.
    [Graphical view ]
    SUPFAMi SSF50249. SSF50249. 1 hit.
    SSF52540. SSF52540. 1 hit.
    PROSITEi PS00847. MCM_1. 1 hit.
    PS50051. MCM_2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Genome sequence of the nematode C. elegans: a platform for investigating biology."
      The C. elegans sequencing consortium
      Science 282:2012-2018(1998) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: Bristol N2.

    Entry informationi

    Entry nameiMCM5_CAEEL
    AccessioniPrimary (citable) accession number: Q21902
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: November 1, 1997
    Last sequence update: November 1, 1997
    Last modified: October 1, 2014
    This is version 93 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programCaenorhabditis annotation project

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Caenorhabditis elegans
      Caenorhabditis elegans: entries, gene names and cross-references to WormBase
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3