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Q218P8 (Q218P8_RHOPB) Unreviewed, UniProtKB/TrEMBL

Last modified July 9, 2014. Version 61. Feed History...

Clusters with 100%, 90%, 50% identity | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry infoCustomize order

Names and origin

Protein namesRecommended name:
Isocitrate dehydrogenase [NADP] PIRNR PIRNR000108

EC=1.1.1.42 PIRNR PIRNR000108
Gene names
Ordered Locus Names:RPC_1576 EMBL ABD87138.1
OrganismRhodopseudomonas palustris (strain BisB18) [Complete proteome] [HAMAP] EMBL ABD87138.1
Taxonomic identifier316056 [NCBI]
Taxonomic lineageBacteriaProteobacteriaAlphaproteobacteriaRhizobialesBradyrhizobiaceaeRhodopseudomonas

Protein attributes

Sequence length407 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Catalytic activity

Isocitrate + NADP+ = 2-oxoglutarate + CO2 + NADPH. PIRNR PIRNR000108

Cofactor

Binds 1 magnesium or manganese ion per subunit By similarity. PIRNR PIRNR000108 PIRSR PIRSR000108-3

Sequence similarities

Belongs to the isocitrate and isopropylmalate dehydrogenases family. PIRNR PIRNR000108 RuleBase RU004443

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Regions

Nucleotide binding75 – 773NADP By similarity PIRSR PIRSR000108-4
Nucleotide binding308 – 3136NADP By similarity PIRSR PIRSR000108-4
Region94 – 1007Substrate binding By similarity PIRSR PIRSR000108-2

Sites

Metal binding2501Magnesium or manganese By similarity PIRSR PIRSR000108-3
Metal binding2731Magnesium or manganese By similarity PIRSR PIRSR000108-3
Binding site771Substrate By similarity PIRSR PIRSR000108-2
Binding site821NADP By similarity PIRSR PIRSR000108-4
Binding site1091Substrate By similarity PIRSR PIRSR000108-2
Binding site1321Substrate By similarity PIRSR PIRSR000108-2
Binding site2581NADP By similarity PIRSR PIRSR000108-4
Binding site3261NADP; via amide nitrogen and carbonyl oxygen By similarity PIRSR PIRSR000108-4
Site1391Critical for catalysis By similarity
Site2101Critical for catalysis By similarity PIRSR PIRSR000108-1

Sequences

Sequence LengthMass (Da)Tools
Q218P8 [UniParc].

Last modified April 18, 2006. Version 1.
Checksum: A82EC53377D08FE0

FASTA40745,257
        10         20         30         40         50         60 
MAKIKVTNPV VELDGDEMTR IIWQYIKDKL ITPFLDIDLM YFDLGMEHRD KTDDQVTIEA 

        70         80         90        100        110        120 
ANAIKQVGVG VKCATITPDE ARVKEFGLKQ MWKSPNGTIR NILGGVIFRE PIICKNVPRL 

       130        140        150        160        170        180 
VPGWTKPIII GRHAYGDQYR ATDIKFPGKG TLTMKFVGED GTVIEREVFQ APGAGVAMAM 

       190        200        210        220        230        240 
YNLDDSIRDF ARASLTYGLN RGYPVYLSTK NTIMKVYDGR FKDIFEEIYN SDFKKDFEAK 

       250        260        270        280        290        300 
GLTYEHRLID DMVASALKWS GGYVWACKNY DGDVQSDTVA QGYGSLGLMT SVLLTPDGQV 

       310        320        330        340        350        360 
VEAEAAHGTV TRHYREHQKG KATSTNSIAS IFAWTQGLAH RAKLDNNDEL AKFSKTLERV 

       370        380        390        400 
CVETVEAGYM TKDLALLVGA DQRWLSTEGF LDKVAENLTA AMAPAAA 

« Hide

References

[1]"Complete sequence of Rhodopseudomonas palustris BisB18."
US DOE Joint Genome Institute
Copeland A., Lucas S., Lapidus A., Barry K., Detter J.C., Glavina del Rio T., Hammon N., Israni S., Dalin E., Tice H., Pitluck S., Chain P., Malfatti S., Shin M., Vergez L., Schmutz J., Larimer F., Land M. expand/collapse author list , Hauser L., Pelletier D.A., Kyrpides N., Anderson I., Oda Y., Harwood C.S., Richardson P.
Submitted (MAR-2006) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: BisB18 EMBL ABD87138.1.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
CP000301 Genomic DNA. Translation: ABD87138.1.
RefSeqYP_531457.1. NC_007925.1.

3D structure databases

ProteinModelPortalQ218P8.
SMRQ218P8. Positions 3-403.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING316056.RPC_1576.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaABD87138; ABD87138; RPC_1576.
GeneID3972924.
KEGGrpc:RPC_1576.
PATRIC23267844. VBIRhoPal29154_1621.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG0538.
HOGENOMHOG000019858.
KOK00031.
OMAKNTIMKV.
OrthoDBEOG628F3X.

Enzyme and pathway databases

BioCycRPAL316056:GH3E-1599-MONOMER.

Family and domain databases

Gene3D3.40.718.10. 1 hit.
InterProIPR019818. IsoCit/isopropylmalate_DH_CS.
IPR004790. Isocitrate_DH_NADP.
IPR024084. IsoPropMal-DH-like_dom.
[Graphical view]
PANTHERPTHR11822. PTHR11822. 1 hit.
PfamPF00180. Iso_dh. 1 hit.
[Graphical view]
PIRSFPIRSF000108. IDH_NADP. 1 hit.
TIGRFAMsTIGR00127. nadp_idh_euk. 1 hit.
PROSITEPS00470. IDH_IMDH. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameQ218P8_RHOPB
AccessionPrimary (citable) accession number: Q218P8
Entry history
Integrated into UniProtKB/TrEMBL: April 18, 2006
Last sequence update: April 18, 2006
Last modified: July 9, 2014
This is version 61 of the entry and version 1 of the sequence. [Complete history]
Entry statusUnreviewed (UniProtKB/TrEMBL)