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Q218P8

- Q218P8_RHOPB

UniProt

Q218P8 - Q218P8_RHOPB

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Protein

Isocitrate dehydrogenase [NADP]

Gene
RPC_1576
Organism
Rhodopseudomonas palustris (strain BisB18)
Status
Unreviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Catalytic activityi

Isocitrate + NADP+ = 2-oxoglutarate + CO2 + NADPH.UniRule annotation

Cofactori

Binds 1 magnesium or manganese ion per subunit By similarity.UniRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei77 – 771Substrate By similarityUniRule annotation
Binding sitei82 – 821NADP By similarityUniRule annotation
Binding sitei109 – 1091Substrate By similarityUniRule annotation
Binding sitei132 – 1321Substrate By similarityUniRule annotation
Sitei139 – 1391Critical for catalysis By similarity
Sitei210 – 2101Critical for catalysis By similarityUniRule annotation
Metal bindingi250 – 2501Magnesium or manganese By similarityUniRule annotation
Binding sitei258 – 2581NADP By similarityUniRule annotation
Metal bindingi273 – 2731Magnesium or manganese By similarityUniRule annotation
Binding sitei326 – 3261NADP; via amide nitrogen and carbonyl oxygen By similarityUniRule annotation

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi75 – 773NADP By similarityUniRule annotation
Nucleotide bindingi308 – 3136NADP By similarityUniRule annotation

GO - Molecular functioni

  1. isocitrate dehydrogenase (NADP+) activity Source: UniProtKB-EC
  2. magnesium ion binding Source: InterPro
  3. NAD binding Source: InterPro

GO - Biological processi

  1. isocitrate metabolic process Source: InterPro
  2. tricarboxylic acid cycle Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

OxidoreductaseUniRule annotationImported

Keywords - Biological processi

Tricarboxylic acid cycleUniRule annotation

Keywords - Ligandi

MagnesiumUniRule annotation, ManganeseUniRule annotation, Metal-bindingUniRule annotation, NADPUniRule annotation

Enzyme and pathway databases

BioCyciRPAL316056:GH3E-1599-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Isocitrate dehydrogenase [NADP]UniRule annotation (EC:1.1.1.42UniRule annotation)
Gene namesi
Ordered Locus Names:RPC_1576Imported
OrganismiRhodopseudomonas palustris (strain BisB18)Imported
Taxonomic identifieri316056 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaRhizobialesBradyrhizobiaceaeRhodopseudomonas
ProteomesiUP000001948: Chromosome

Interactioni

Protein-protein interaction databases

STRINGi316056.RPC_1576.

Structurei

3D structure databases

ProteinModelPortaliQ218P8.
SMRiQ218P8. Positions 3-403.

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni94 – 1007Substrate binding By similarityUniRule annotation

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG0538.
HOGENOMiHOG000019858.
KOiK00031.
OMAiKNTIMKV.
OrthoDBiEOG628F3X.

Family and domain databases

Gene3Di3.40.718.10. 1 hit.
InterProiIPR019818. IsoCit/isopropylmalate_DH_CS.
IPR004790. Isocitrate_DH_NADP.
IPR024084. IsoPropMal-DH-like_dom.
[Graphical view]
PANTHERiPTHR11822. PTHR11822. 1 hit.
PfamiPF00180. Iso_dh. 1 hit.
[Graphical view]
PIRSFiPIRSF000108. IDH_NADP. 1 hit.
TIGRFAMsiTIGR00127. nadp_idh_euk. 1 hit.
PROSITEiPS00470. IDH_IMDH. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q218P8-1 [UniParc]FASTAAdd to Basket

« Hide

MAKIKVTNPV VELDGDEMTR IIWQYIKDKL ITPFLDIDLM YFDLGMEHRD    50
KTDDQVTIEA ANAIKQVGVG VKCATITPDE ARVKEFGLKQ MWKSPNGTIR 100
NILGGVIFRE PIICKNVPRL VPGWTKPIII GRHAYGDQYR ATDIKFPGKG 150
TLTMKFVGED GTVIEREVFQ APGAGVAMAM YNLDDSIRDF ARASLTYGLN 200
RGYPVYLSTK NTIMKVYDGR FKDIFEEIYN SDFKKDFEAK GLTYEHRLID 250
DMVASALKWS GGYVWACKNY DGDVQSDTVA QGYGSLGLMT SVLLTPDGQV 300
VEAEAAHGTV TRHYREHQKG KATSTNSIAS IFAWTQGLAH RAKLDNNDEL 350
AKFSKTLERV CVETVEAGYM TKDLALLVGA DQRWLSTEGF LDKVAENLTA 400
AMAPAAA 407
Length:407
Mass (Da):45,257
Last modified:April 18, 2006 - v1
Checksum:iA82EC53377D08FE0
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000301 Genomic DNA. Translation: ABD87138.1.
RefSeqiYP_531457.1. NC_007925.1.

Genome annotation databases

EnsemblBacteriaiABD87138; ABD87138; RPC_1576.
GeneIDi3972924.
KEGGirpc:RPC_1576.
PATRICi23267844. VBIRhoPal29154_1621.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000301 Genomic DNA. Translation: ABD87138.1 .
RefSeqi YP_531457.1. NC_007925.1.

3D structure databases

ProteinModelPortali Q218P8.
SMRi Q218P8. Positions 3-403.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 316056.RPC_1576.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai ABD87138 ; ABD87138 ; RPC_1576 .
GeneIDi 3972924.
KEGGi rpc:RPC_1576.
PATRICi 23267844. VBIRhoPal29154_1621.

Phylogenomic databases

eggNOGi COG0538.
HOGENOMi HOG000019858.
KOi K00031.
OMAi KNTIMKV.
OrthoDBi EOG628F3X.

Enzyme and pathway databases

BioCyci RPAL316056:GH3E-1599-MONOMER.

Family and domain databases

Gene3Di 3.40.718.10. 1 hit.
InterProi IPR019818. IsoCit/isopropylmalate_DH_CS.
IPR004790. Isocitrate_DH_NADP.
IPR024084. IsoPropMal-DH-like_dom.
[Graphical view ]
PANTHERi PTHR11822. PTHR11822. 1 hit.
Pfami PF00180. Iso_dh. 1 hit.
[Graphical view ]
PIRSFi PIRSF000108. IDH_NADP. 1 hit.
TIGRFAMsi TIGR00127. nadp_idh_euk. 1 hit.
PROSITEi PS00470. IDH_IMDH. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: BisB18Imported.

Entry informationi

Entry nameiQ218P8_RHOPB
AccessioniPrimary (citable) accession number: Q218P8
Entry historyi
Integrated into UniProtKB/TrEMBL: April 18, 2006
Last sequence update: April 18, 2006
Last modified: July 9, 2014
This is version 61 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome

External Data

Dasty 3

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