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Q218P8

- Q218P8_RHOPB

UniProt

Q218P8 - Q218P8_RHOPB

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Protein

Isocitrate dehydrogenase [NADP]

Gene

RPC_1576

Organism
Rhodopseudomonas palustris (strain BisB18)
Status
Unreviewed - Annotation score: 2 out of 5- Protein inferred from homologyi

Functioni

Catalytic activityi

Isocitrate + NADP+ = 2-oxoglutarate + CO2 + NADPH.UniRule annotation

Cofactori

Binds 1 magnesium or manganese ion per subunit.UniRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei77 – 771SubstrateUniRule annotation
Binding sitei82 – 821NADP
Binding sitei109 – 1091SubstrateUniRule annotation
Binding sitei132 – 1321SubstrateUniRule annotation
Sitei139 – 1391Critical for catalysisUniRule annotation
Sitei210 – 2101Critical for catalysisUniRule annotation
Metal bindingi250 – 2501Magnesium or manganeseUniRule annotation
Binding sitei258 – 2581NADP
Metal bindingi273 – 2731Magnesium or manganeseUniRule annotation
Binding sitei326 – 3261NADP; via amide nitrogen and carbonyl oxygen

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi75 – 773NADP
Nucleotide bindingi308 – 3136NADP

GO - Molecular functioni

  1. isocitrate dehydrogenase (NADP+) activity Source: UniProtKB-EC
  2. magnesium ion binding Source: InterPro
  3. NAD binding Source: InterPro

GO - Biological processi

  1. isocitrate metabolic process Source: InterPro
  2. tricarboxylic acid cycle Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

OxidoreductaseUniRule annotation

Keywords - Biological processi

Tricarboxylic acid cycleUniRule annotation

Keywords - Ligandi

MagnesiumUniRule annotation, ManganeseUniRule annotation, Metal-bindingUniRule annotation, NADPUniRule annotation

Enzyme and pathway databases

BioCyciRPAL316056:GH3E-1599-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Isocitrate dehydrogenase [NADP]UniRule annotation (EC:1.1.1.42UniRule annotation)
Gene namesi
Ordered Locus Names:RPC_1576Imported
OrganismiRhodopseudomonas palustris (strain BisB18)Imported
Taxonomic identifieri316056 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaRhizobialesBradyrhizobiaceaeRhodopseudomonas
ProteomesiUP000001948: Chromosome

Interactioni

Protein-protein interaction databases

STRINGi316056.RPC_1576.

Structurei

3D structure databases

ProteinModelPortaliQ218P8.
SMRiQ218P8. Positions 3-403.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni94 – 1007Substrate bindingUniRule annotation

Sequence similaritiesi

Belongs to the isocitrate and isopropylmalate dehydrogenases family.UniRule annotation

Phylogenomic databases

eggNOGiCOG0538.
HOGENOMiHOG000019858.
KOiK00031.
OMAiKNTIMKV.
OrthoDBiEOG628F3X.

Family and domain databases

Gene3Di3.40.718.10. 1 hit.
InterProiIPR019818. IsoCit/isopropylmalate_DH_CS.
IPR004790. Isocitrate_DH_NADP.
IPR024084. IsoPropMal-DH-like_dom.
[Graphical view]
PANTHERiPTHR11822. PTHR11822. 1 hit.
PfamiPF00180. Iso_dh. 1 hit.
[Graphical view]
PIRSFiPIRSF000108. IDH_NADP. 1 hit.
TIGRFAMsiTIGR00127. nadp_idh_euk. 1 hit.
PROSITEiPS00470. IDH_IMDH. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q218P8-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MAKIKVTNPV VELDGDEMTR IIWQYIKDKL ITPFLDIDLM YFDLGMEHRD
60 70 80 90 100
KTDDQVTIEA ANAIKQVGVG VKCATITPDE ARVKEFGLKQ MWKSPNGTIR
110 120 130 140 150
NILGGVIFRE PIICKNVPRL VPGWTKPIII GRHAYGDQYR ATDIKFPGKG
160 170 180 190 200
TLTMKFVGED GTVIEREVFQ APGAGVAMAM YNLDDSIRDF ARASLTYGLN
210 220 230 240 250
RGYPVYLSTK NTIMKVYDGR FKDIFEEIYN SDFKKDFEAK GLTYEHRLID
260 270 280 290 300
DMVASALKWS GGYVWACKNY DGDVQSDTVA QGYGSLGLMT SVLLTPDGQV
310 320 330 340 350
VEAEAAHGTV TRHYREHQKG KATSTNSIAS IFAWTQGLAH RAKLDNNDEL
360 370 380 390 400
AKFSKTLERV CVETVEAGYM TKDLALLVGA DQRWLSTEGF LDKVAENLTA

AMAPAAA
Length:407
Mass (Da):45,257
Last modified:April 18, 2006 - v1
Checksum:iA82EC53377D08FE0
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000301 Genomic DNA. Translation: ABD87138.1.
RefSeqiYP_531457.1. NC_007925.1.

Genome annotation databases

EnsemblBacteriaiABD87138; ABD87138; RPC_1576.
GeneIDi3972924.
KEGGirpc:RPC_1576.
PATRICi23267844. VBIRhoPal29154_1621.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000301 Genomic DNA. Translation: ABD87138.1 .
RefSeqi YP_531457.1. NC_007925.1.

3D structure databases

ProteinModelPortali Q218P8.
SMRi Q218P8. Positions 3-403.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 316056.RPC_1576.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai ABD87138 ; ABD87138 ; RPC_1576 .
GeneIDi 3972924.
KEGGi rpc:RPC_1576.
PATRICi 23267844. VBIRhoPal29154_1621.

Phylogenomic databases

eggNOGi COG0538.
HOGENOMi HOG000019858.
KOi K00031.
OMAi KNTIMKV.
OrthoDBi EOG628F3X.

Enzyme and pathway databases

BioCyci RPAL316056:GH3E-1599-MONOMER.

Family and domain databases

Gene3Di 3.40.718.10. 1 hit.
InterProi IPR019818. IsoCit/isopropylmalate_DH_CS.
IPR004790. Isocitrate_DH_NADP.
IPR024084. IsoPropMal-DH-like_dom.
[Graphical view ]
PANTHERi PTHR11822. PTHR11822. 1 hit.
Pfami PF00180. Iso_dh. 1 hit.
[Graphical view ]
PIRSFi PIRSF000108. IDH_NADP. 1 hit.
TIGRFAMsi TIGR00127. nadp_idh_euk. 1 hit.
PROSITEi PS00470. IDH_IMDH. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: BisB18Imported.

Entry informationi

Entry nameiQ218P8_RHOPB
AccessioniPrimary (citable) accession number: Q218P8
Entry historyi
Integrated into UniProtKB/TrEMBL: April 18, 2006
Last sequence update: April 18, 2006
Last modified: October 29, 2014
This is version 63 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported

External Data

Dasty 3