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Q218P8

- Q218P8_RHOPB

UniProt

Q218P8 - Q218P8_RHOPB

Protein

Isocitrate dehydrogenase [NADP]

Gene

RPC_1576

Organism
Rhodopseudomonas palustris (strain BisB18)
Status
Unreviewed - Annotation score: 2 out of 5- Protein inferred from homologyi
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    • History
      Entry version 62 (01 Oct 2014)
      Sequence version 1 (18 Apr 2006)
      Previous versions | rss
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    Functioni

    Catalytic activityi

    Isocitrate + NADP+ = 2-oxoglutarate + CO2 + NADPH.UniRule annotation

    Cofactori

    Binds 1 magnesium or manganese ion per subunit.UniRule annotation

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Binding sitei77 – 771SubstrateUniRule annotation
    Binding sitei82 – 821NADP
    Binding sitei109 – 1091SubstrateUniRule annotation
    Binding sitei132 – 1321SubstrateUniRule annotation
    Sitei139 – 1391Critical for catalysisUniRule annotation
    Sitei210 – 2101Critical for catalysisUniRule annotation
    Metal bindingi250 – 2501Magnesium or manganeseUniRule annotation
    Binding sitei258 – 2581NADP
    Metal bindingi273 – 2731Magnesium or manganeseUniRule annotation
    Binding sitei326 – 3261NADP; via amide nitrogen and carbonyl oxygen

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Nucleotide bindingi75 – 773NADP
    Nucleotide bindingi308 – 3136NADP

    GO - Molecular functioni

    1. isocitrate dehydrogenase (NADP+) activity Source: UniProtKB-EC
    2. magnesium ion binding Source: InterPro
    3. NAD binding Source: InterPro

    GO - Biological processi

    1. isocitrate metabolic process Source: InterPro
    2. tricarboxylic acid cycle Source: UniProtKB-KW

    Keywords - Molecular functioni

    OxidoreductaseUniRule annotationImported

    Keywords - Biological processi

    Tricarboxylic acid cycleUniRule annotation

    Keywords - Ligandi

    MagnesiumUniRule annotation, ManganeseUniRule annotation, Metal-bindingUniRule annotation, NADPUniRule annotation

    Enzyme and pathway databases

    BioCyciRPAL316056:GH3E-1599-MONOMER.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Isocitrate dehydrogenase [NADP]UniRule annotation (EC:1.1.1.42UniRule annotation)
    Gene namesi
    Ordered Locus Names:RPC_1576Imported
    OrganismiRhodopseudomonas palustris (strain BisB18)Imported
    Taxonomic identifieri316056 [NCBI]
    Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaRhizobialesBradyrhizobiaceaeRhodopseudomonas
    ProteomesiUP000001948: Chromosome

    Interactioni

    Protein-protein interaction databases

    STRINGi316056.RPC_1576.

    Structurei

    3D structure databases

    ProteinModelPortaliQ218P8.
    SMRiQ218P8. Positions 3-403.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni94 – 1007Substrate bindingUniRule annotation

    Sequence similaritiesi

    Belongs to the isocitrate and isopropylmalate dehydrogenases family.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG0538.
    HOGENOMiHOG000019858.
    KOiK00031.
    OMAiKNTIMKV.
    OrthoDBiEOG628F3X.

    Family and domain databases

    Gene3Di3.40.718.10. 1 hit.
    InterProiIPR019818. IsoCit/isopropylmalate_DH_CS.
    IPR004790. Isocitrate_DH_NADP.
    IPR024084. IsoPropMal-DH-like_dom.
    [Graphical view]
    PANTHERiPTHR11822. PTHR11822. 1 hit.
    PfamiPF00180. Iso_dh. 1 hit.
    [Graphical view]
    PIRSFiPIRSF000108. IDH_NADP. 1 hit.
    TIGRFAMsiTIGR00127. nadp_idh_euk. 1 hit.
    PROSITEiPS00470. IDH_IMDH. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q218P8-1 [UniParc]FASTAAdd to Basket

    « Hide

    MAKIKVTNPV VELDGDEMTR IIWQYIKDKL ITPFLDIDLM YFDLGMEHRD    50
    KTDDQVTIEA ANAIKQVGVG VKCATITPDE ARVKEFGLKQ MWKSPNGTIR 100
    NILGGVIFRE PIICKNVPRL VPGWTKPIII GRHAYGDQYR ATDIKFPGKG 150
    TLTMKFVGED GTVIEREVFQ APGAGVAMAM YNLDDSIRDF ARASLTYGLN 200
    RGYPVYLSTK NTIMKVYDGR FKDIFEEIYN SDFKKDFEAK GLTYEHRLID 250
    DMVASALKWS GGYVWACKNY DGDVQSDTVA QGYGSLGLMT SVLLTPDGQV 300
    VEAEAAHGTV TRHYREHQKG KATSTNSIAS IFAWTQGLAH RAKLDNNDEL 350
    AKFSKTLERV CVETVEAGYM TKDLALLVGA DQRWLSTEGF LDKVAENLTA 400
    AMAPAAA 407
    Length:407
    Mass (Da):45,257
    Last modified:April 18, 2006 - v1
    Checksum:iA82EC53377D08FE0
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000301 Genomic DNA. Translation: ABD87138.1.
    RefSeqiYP_531457.1. NC_007925.1.

    Genome annotation databases

    EnsemblBacteriaiABD87138; ABD87138; RPC_1576.
    GeneIDi3972924.
    KEGGirpc:RPC_1576.
    PATRICi23267844. VBIRhoPal29154_1621.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000301 Genomic DNA. Translation: ABD87138.1 .
    RefSeqi YP_531457.1. NC_007925.1.

    3D structure databases

    ProteinModelPortali Q218P8.
    SMRi Q218P8. Positions 3-403.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 316056.RPC_1576.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai ABD87138 ; ABD87138 ; RPC_1576 .
    GeneIDi 3972924.
    KEGGi rpc:RPC_1576.
    PATRICi 23267844. VBIRhoPal29154_1621.

    Phylogenomic databases

    eggNOGi COG0538.
    HOGENOMi HOG000019858.
    KOi K00031.
    OMAi KNTIMKV.
    OrthoDBi EOG628F3X.

    Enzyme and pathway databases

    BioCyci RPAL316056:GH3E-1599-MONOMER.

    Family and domain databases

    Gene3Di 3.40.718.10. 1 hit.
    InterProi IPR019818. IsoCit/isopropylmalate_DH_CS.
    IPR004790. Isocitrate_DH_NADP.
    IPR024084. IsoPropMal-DH-like_dom.
    [Graphical view ]
    PANTHERi PTHR11822. PTHR11822. 1 hit.
    Pfami PF00180. Iso_dh. 1 hit.
    [Graphical view ]
    PIRSFi PIRSF000108. IDH_NADP. 1 hit.
    TIGRFAMsi TIGR00127. nadp_idh_euk. 1 hit.
    PROSITEi PS00470. IDH_IMDH. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: BisB18Imported.

    Entry informationi

    Entry nameiQ218P8_RHOPB
    AccessioniPrimary (citable) accession number: Q218P8
    Entry historyi
    Integrated into UniProtKB/TrEMBL: April 18, 2006
    Last sequence update: April 18, 2006
    Last modified: October 1, 2014
    This is version 62 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiUnreviewed (UniProtKB/TrEMBL)

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteomeImported

    External Data

    Dasty 3