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Q21882 (HIUH1_CAEEL) Reviewed, UniProtKB/Swiss-Prot

Last modified July 9, 2014. Version 96. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Interactions·Alt products·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Probable 5-hydroxyisourate hydrolase R09H10.3

Short name=HIU hydrolase
Short name=HIUHase
EC=3.5.2.17
Alternative name(s):
Transthyretin-like protein R09H10.3
Gene names
ORF Names:R09H10.3
OrganismCaenorhabditis elegans [Reference proteome]
Taxonomic identifier6239 [NCBI]
Taxonomic lineageEukaryotaMetazoaEcdysozoaNematodaChromadoreaRhabditidaRhabditoideaRhabditidaePeloderinaeCaenorhabditis

Protein attributes

Sequence length135 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

Catalyzes the hydrolysis of 5-hydroxyisourate (HIU) to 2-oxo-4-hydroxy-4-carboxy-5-ureidoimidazoline (OHCU) By similarity.

Catalytic activity

5-hydroxyisourate + H2O = 5-hydroxy-2-oxo-4-ureido-2,5-dihydro-1H-imidazole-5-carboxylate.

Subunit structure

Homotetramer By similarity.

Miscellaneous

HIU hydrolysis also occurs spontaneously, but more slowly.

Sequence similarities

Belongs to the transthyretin family. 5-hydroxyisourate hydrolase subfamily.

Binary interactions

With

Entry

#Exp.

IntAct

Notes

itself2EBI-311857,EBI-311857
eps-8G5ED333EBI-311857,EBI-2315916

Alternative products

This entry describes 2 isoforms produced by alternative splicing. [Align] [Select]
Isoform a (identifier: Q21882-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.
Note: No experimental confirmation available.
Isoform b (identifier: Q21882-2)

The sequence of this isoform differs from the canonical sequence as follows:
     1-14: Missing.
Note: No experimental confirmation available.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Signal peptide1 – 2020 Potential
Chain21 – 135115Probable 5-hydroxyisourate hydrolase R09H10.3
PRO_0000050603

Sites

Binding site301Substrate By similarity
Binding site681Substrate By similarity
Binding site1321Substrate By similarity

Natural variations

Alternative sequence1 – 1414Missing in isoform b.
VSP_020154

Sequences

Sequence LengthMass (Da)Tools
Isoform a [UniParc].

Last modified March 29, 2004. Version 2.
Checksum: 5D5AC6D752D94843

FASTA13515,129
        10         20         30         40         50         60 
MNKFSLFFAL TATLMTITES AVPTASISAH VLDISGGSPA GGVQILAYIQ QNDDWTKIGS 

        70         80         90        100        110        120 
EFTQDNGRVD WVSPDFTLIP GTYRLVYITE PYYKAKNVES FYPYVEVVFN IRDATQHYHV 

       130 
PLTLSPWGYS TYRGS 

« Hide

Isoform b [UniParc].

Checksum: D3F222DC67E595E6
Show »

FASTA12113,543

References

[1]"Genome sequence of the nematode C. elegans: a platform for investigating biology."
The C. elegans sequencing consortium
Science 282:2012-2018(1998) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA], ALTERNATIVE SPLICING.
Strain: Bristol N2.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
Z77134 Genomic DNA. Translation: CAB00872.2.
Z77134 Genomic DNA. Translation: CAJ90503.1.
PIRT24096.
RefSeqNP_001040980.1. NM_001047515.4. [Q21882-1]
NP_001040981.1. NM_001047516.3. [Q21882-2]
UniGeneCel.18183.

3D structure databases

ProteinModelPortalQ21882.
SMRQ21882. Positions 27-135.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

BioGrid52440. 1 interaction.
IntActQ21882. 3 interactions.
MINTMINT-1079512.
STRING6239.R09H10.3a.1.

Proteomic databases

PaxDbQ21882.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblMetazoaR09H10.3a; R09H10.3a; WBGene00011181. [Q21882-1]
GeneID187757.
KEGGcel:CELE_R09H10.3.
UCSCR09H10.3a.1. c. elegans. [Q21882-1]

Organism-specific databases

CTD187757.
WormBaseR09H10.3a; CE34083; WBGene00011181.
R09H10.3b; CE12662; WBGene00011181.

Phylogenomic databases

eggNOGCOG2351.
GeneTreeENSGT00390000005321.
HOGENOMHOG000251776.
InParanoidQ21882.
KOK07127.
OMALCSPWSF.
PhylomeDBQ21882.

Family and domain databases

Gene3D2.60.40.180. 1 hit.
InterProIPR014306. Hydroxyisourate_hydrolase.
IPR023418. Thyroxine_BS.
IPR000895. Transthyretin/HIU_hydrolase.
IPR023416. Transthyretin/HIU_hydrolase_SF.
IPR023419. Transthyretin_CS.
[Graphical view]
PfamPF00576. Transthyretin. 1 hit.
[Graphical view]
PRINTSPR00189. TRNSTHYRETIN.
SMARTSM00095. TR_THY. 1 hit.
[Graphical view]
SUPFAMSSF49472. SSF49472. 1 hit.
TIGRFAMsTIGR02962. hdxy_isourate. 1 hit.
PROSITEPS00768. TRANSTHYRETIN_1. 1 hit.
PS00769. TRANSTHYRETIN_2. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

NextBio936396.
PROQ21882.

Entry information

Entry nameHIUH1_CAEEL
AccessionPrimary (citable) accession number: Q21882
Secondary accession number(s): Q1NZ16
Entry history
Integrated into UniProtKB/Swiss-Prot: December 15, 1998
Last sequence update: March 29, 2004
Last modified: July 9, 2014
This is version 96 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programCaenorhabditis annotation project

Relevant documents

SIMILARITY comments

Index of protein domains and families

Caenorhabditis elegans

Caenorhabditis elegans: entries, gene names and cross-references to WormBase