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Q21882

- HIUH1_CAEEL

UniProt

Q21882 - HIUH1_CAEEL

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Protein

Probable 5-hydroxyisourate hydrolase R09H10.3

Gene

R09H10.3

Organism
Caenorhabditis elegans
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at protein leveli

Functioni

Catalyzes the hydrolysis of 5-hydroxyisourate (HIU) to 2-oxo-4-hydroxy-4-carboxy-5-ureidoimidazoline (OHCU).By similarity

Catalytic activityi

5-hydroxyisourate + H2O = 5-hydroxy-2-oxo-4-ureido-2,5-dihydro-1H-imidazole-5-carboxylate.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei30 – 301SubstrateBy similarity
Binding sitei68 – 681SubstrateBy similarity
Binding sitei132 – 1321SubstrateBy similarity

GO - Molecular functioni

  1. hydroxyisourate hydrolase activity Source: UniProtKB-EC
  2. identical protein binding Source: IntAct

GO - Biological processi

  1. purine nucleobase metabolic process Source: UniProtKB-KW
  2. transport Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Hydrolase

Keywords - Biological processi

Purine metabolism

Names & Taxonomyi

Protein namesi
Recommended name:
Probable 5-hydroxyisourate hydrolase R09H10.3 (EC:3.5.2.17)
Short name:
HIU hydrolase
Short name:
HIUHase
Alternative name(s):
Transthyretin-like protein R09H10.3
Gene namesi
ORF Names:R09H10.3
OrganismiCaenorhabditis elegans
Taxonomic identifieri6239 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaNematodaChromadoreaRhabditidaRhabditoideaRhabditidaePeloderinaeCaenorhabditis
ProteomesiUP000001940: Chromosome IV

Organism-specific databases

WormBaseiR09H10.3a; CE34083; WBGene00011181.
R09H10.3b; CE12662; WBGene00011181.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2020Sequence AnalysisAdd
BLAST
Chaini21 – 135115Probable 5-hydroxyisourate hydrolase R09H10.3PRO_0000050603Add
BLAST

Proteomic databases

PaxDbiQ21882.

Interactioni

Subunit structurei

Homotetramer.By similarity

Binary interactionsi

WithEntry#Exp.IntActNotes
itself2EBI-311857,EBI-311857
eps-8G5ED333EBI-311857,EBI-2315916

Protein-protein interaction databases

BioGridi52440. 1 interaction.
IntActiQ21882. 3 interactions.
MINTiMINT-1079512.
STRINGi6239.R09H10.3a.1.

Structurei

3D structure databases

ProteinModelPortaliQ21882.
SMRiQ21882. Positions 27-135.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiCOG2351.
GeneTreeiENSGT00390000005321.
HOGENOMiHOG000251776.
InParanoidiQ21882.
KOiK07127.
OMAiLCSPWSF.
PhylomeDBiQ21882.

Family and domain databases

Gene3Di2.60.40.180. 1 hit.
InterProiIPR014306. Hydroxyisourate_hydrolase.
IPR023418. Thyroxine_BS.
IPR000895. Transthyretin/HIU_hydrolase.
IPR023416. Transthyretin/HIU_hydrolase_SF.
IPR023419. Transthyretin_CS.
[Graphical view]
PfamiPF00576. Transthyretin. 1 hit.
[Graphical view]
PRINTSiPR00189. TRNSTHYRETIN.
SMARTiSM00095. TR_THY. 1 hit.
[Graphical view]
SUPFAMiSSF49472. SSF49472. 1 hit.
TIGRFAMsiTIGR02962. hdxy_isourate. 1 hit.
PROSITEiPS00768. TRANSTHYRETIN_1. 1 hit.
PS00769. TRANSTHYRETIN_2. 1 hit.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 2 isoformsi produced by alternative splicing. Align

Isoform a (identifier: Q21882-1) [UniParc]FASTAAdd to Basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MNKFSLFFAL TATLMTITES AVPTASISAH VLDISGGSPA GGVQILAYIQ
60 70 80 90 100
QNDDWTKIGS EFTQDNGRVD WVSPDFTLIP GTYRLVYITE PYYKAKNVES
110 120 130
FYPYVEVVFN IRDATQHYHV PLTLSPWGYS TYRGS

Note: No experimental confirmation available.

Length:135
Mass (Da):15,129
Last modified:March 29, 2004 - v2
Checksum:i5D5AC6D752D94843
GO
Isoform b (identifier: Q21882-2) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-14: Missing.

Note: No experimental confirmation available.

Show »
Length:121
Mass (Da):13,543
Checksum:iD3F222DC67E595E6
GO

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei1 – 1414Missing in isoform b. CuratedVSP_020154Add
BLAST

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
Z77134 Genomic DNA. Translation: CAB00872.2.
Z77134 Genomic DNA. Translation: CAJ90503.1.
PIRiT24096.
RefSeqiNP_001040980.1. NM_001047515.4. [Q21882-1]
NP_001040981.1. NM_001047516.3. [Q21882-2]
UniGeneiCel.18183.

Genome annotation databases

EnsemblMetazoaiR09H10.3a; R09H10.3a; WBGene00011181. [Q21882-1]
GeneIDi187757.
KEGGicel:CELE_R09H10.3.
UCSCiR09H10.3a.1. c. elegans. [Q21882-1]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
Z77134 Genomic DNA. Translation: CAB00872.2 .
Z77134 Genomic DNA. Translation: CAJ90503.1 .
PIRi T24096.
RefSeqi NP_001040980.1. NM_001047515.4. [Q21882-1 ]
NP_001040981.1. NM_001047516.3. [Q21882-2 ]
UniGenei Cel.18183.

3D structure databases

ProteinModelPortali Q21882.
SMRi Q21882. Positions 27-135.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 52440. 1 interaction.
IntActi Q21882. 3 interactions.
MINTi MINT-1079512.
STRINGi 6239.R09H10.3a.1.

Proteomic databases

PaxDbi Q21882.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblMetazoai R09H10.3a ; R09H10.3a ; WBGene00011181 . [Q21882-1 ]
GeneIDi 187757.
KEGGi cel:CELE_R09H10.3.
UCSCi R09H10.3a.1. c. elegans. [Q21882-1 ]

Organism-specific databases

CTDi 187757.
WormBasei R09H10.3a ; CE34083 ; WBGene00011181 .
R09H10.3b ; CE12662 ; WBGene00011181 .

Phylogenomic databases

eggNOGi COG2351.
GeneTreei ENSGT00390000005321.
HOGENOMi HOG000251776.
InParanoidi Q21882.
KOi K07127.
OMAi LCSPWSF.
PhylomeDBi Q21882.

Miscellaneous databases

NextBioi 936396.
PROi Q21882.

Family and domain databases

Gene3Di 2.60.40.180. 1 hit.
InterProi IPR014306. Hydroxyisourate_hydrolase.
IPR023418. Thyroxine_BS.
IPR000895. Transthyretin/HIU_hydrolase.
IPR023416. Transthyretin/HIU_hydrolase_SF.
IPR023419. Transthyretin_CS.
[Graphical view ]
Pfami PF00576. Transthyretin. 1 hit.
[Graphical view ]
PRINTSi PR00189. TRNSTHYRETIN.
SMARTi SM00095. TR_THY. 1 hit.
[Graphical view ]
SUPFAMi SSF49472. SSF49472. 1 hit.
TIGRFAMsi TIGR02962. hdxy_isourate. 1 hit.
PROSITEi PS00768. TRANSTHYRETIN_1. 1 hit.
PS00769. TRANSTHYRETIN_2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Genome sequence of the nematode C. elegans: a platform for investigating biology."
    The C. elegans sequencing consortium
    Science 282:2012-2018(1998) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA], ALTERNATIVE SPLICING.
    Strain: Bristol N2.

Entry informationi

Entry nameiHIUH1_CAEEL
AccessioniPrimary (citable) accession number: Q21882
Secondary accession number(s): Q1NZ16
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 15, 1998
Last sequence update: March 29, 2004
Last modified: October 29, 2014
This is version 98 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programCaenorhabditis annotation project

Miscellaneousi

Miscellaneous

HIU hydrolysis also occurs spontaneously, but more slowly.

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Caenorhabditis elegans
    Caenorhabditis elegans: entries, gene names and cross-references to WormBase
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3