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Q21882

- HIUH1_CAEEL

UniProt

Q21882 - HIUH1_CAEEL

Protein

Probable 5-hydroxyisourate hydrolase R09H10.3

Gene

R09H10.3

Organism
Caenorhabditis elegans
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at protein leveli
  1. Functioni

    Catalyzes the hydrolysis of 5-hydroxyisourate (HIU) to 2-oxo-4-hydroxy-4-carboxy-5-ureidoimidazoline (OHCU).By similarity

    Catalytic activityi

    5-hydroxyisourate + H2O = 5-hydroxy-2-oxo-4-ureido-2,5-dihydro-1H-imidazole-5-carboxylate.

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Binding sitei30 – 301SubstrateBy similarity
    Binding sitei68 – 681SubstrateBy similarity
    Binding sitei132 – 1321SubstrateBy similarity

    GO - Molecular functioni

    1. hydroxyisourate hydrolase activity Source: UniProtKB-EC
    2. identical protein binding Source: IntAct
    3. protein binding Source: IntAct

    GO - Biological processi

    1. purine nucleobase metabolic process Source: UniProtKB-KW
    2. transport Source: InterPro

    Keywords - Molecular functioni

    Hydrolase

    Keywords - Biological processi

    Purine metabolism

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Probable 5-hydroxyisourate hydrolase R09H10.3 (EC:3.5.2.17)
    Short name:
    HIU hydrolase
    Short name:
    HIUHase
    Alternative name(s):
    Transthyretin-like protein R09H10.3
    Gene namesi
    ORF Names:R09H10.3
    OrganismiCaenorhabditis elegans
    Taxonomic identifieri6239 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaEcdysozoaNematodaChromadoreaRhabditidaRhabditoideaRhabditidaePeloderinaeCaenorhabditis
    ProteomesiUP000001940: Chromosome IV

    Organism-specific databases

    WormBaseiR09H10.3a; CE34083; WBGene00011181.
    R09H10.3b; CE12662; WBGene00011181.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Signal peptidei1 – 2020Sequence AnalysisAdd
    BLAST
    Chaini21 – 135115Probable 5-hydroxyisourate hydrolase R09H10.3PRO_0000050603Add
    BLAST

    Proteomic databases

    PaxDbiQ21882.

    Interactioni

    Subunit structurei

    Homotetramer.By similarity

    Binary interactionsi

    WithEntry#Exp.IntActNotes
    itself2EBI-311857,EBI-311857
    eps-8G5ED333EBI-311857,EBI-2315916

    Protein-protein interaction databases

    BioGridi52440. 1 interaction.
    IntActiQ21882. 3 interactions.
    MINTiMINT-1079512.
    STRINGi6239.R09H10.3a.1.

    Structurei

    3D structure databases

    ProteinModelPortaliQ21882.
    SMRiQ21882. Positions 27-135.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Keywords - Domaini

    Signal

    Phylogenomic databases

    eggNOGiCOG2351.
    GeneTreeiENSGT00390000005321.
    HOGENOMiHOG000251776.
    InParanoidiQ21882.
    KOiK07127.
    OMAiLCSPWSF.
    PhylomeDBiQ21882.

    Family and domain databases

    Gene3Di2.60.40.180. 1 hit.
    InterProiIPR014306. Hydroxyisourate_hydrolase.
    IPR023418. Thyroxine_BS.
    IPR000895. Transthyretin/HIU_hydrolase.
    IPR023416. Transthyretin/HIU_hydrolase_SF.
    IPR023419. Transthyretin_CS.
    [Graphical view]
    PfamiPF00576. Transthyretin. 1 hit.
    [Graphical view]
    PRINTSiPR00189. TRNSTHYRETIN.
    SMARTiSM00095. TR_THY. 1 hit.
    [Graphical view]
    SUPFAMiSSF49472. SSF49472. 1 hit.
    TIGRFAMsiTIGR02962. hdxy_isourate. 1 hit.
    PROSITEiPS00768. TRANSTHYRETIN_1. 1 hit.
    PS00769. TRANSTHYRETIN_2. 1 hit.
    [Graphical view]

    Sequences (2)i

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    This entry describes 2 isoformsi produced by alternative splicing. Align

    Isoform a (identifier: Q21882-1) [UniParc]FASTAAdd to Basket

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide

    MNKFSLFFAL TATLMTITES AVPTASISAH VLDISGGSPA GGVQILAYIQ    50
    QNDDWTKIGS EFTQDNGRVD WVSPDFTLIP GTYRLVYITE PYYKAKNVES 100
    FYPYVEVVFN IRDATQHYHV PLTLSPWGYS TYRGS 135

    Note: No experimental confirmation available.

    Length:135
    Mass (Da):15,129
    Last modified:March 29, 2004 - v2
    Checksum:i5D5AC6D752D94843
    GO
    Isoform b (identifier: Q21882-2) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         1-14: Missing.

    Note: No experimental confirmation available.

    Show »
    Length:121
    Mass (Da):13,543
    Checksum:iD3F222DC67E595E6
    GO

    Alternative sequence

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Alternative sequencei1 – 1414Missing in isoform b. CuratedVSP_020154Add
    BLAST

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    Z77134 Genomic DNA. Translation: CAB00872.2.
    Z77134 Genomic DNA. Translation: CAJ90503.1.
    PIRiT24096.
    RefSeqiNP_001040980.1. NM_001047515.4. [Q21882-1]
    NP_001040981.1. NM_001047516.3. [Q21882-2]
    UniGeneiCel.18183.

    Genome annotation databases

    EnsemblMetazoaiR09H10.3a; R09H10.3a; WBGene00011181. [Q21882-1]
    GeneIDi187757.
    KEGGicel:CELE_R09H10.3.
    UCSCiR09H10.3a.1. c. elegans. [Q21882-1]

    Keywords - Coding sequence diversityi

    Alternative splicing

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    Z77134 Genomic DNA. Translation: CAB00872.2 .
    Z77134 Genomic DNA. Translation: CAJ90503.1 .
    PIRi T24096.
    RefSeqi NP_001040980.1. NM_001047515.4. [Q21882-1 ]
    NP_001040981.1. NM_001047516.3. [Q21882-2 ]
    UniGenei Cel.18183.

    3D structure databases

    ProteinModelPortali Q21882.
    SMRi Q21882. Positions 27-135.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 52440. 1 interaction.
    IntActi Q21882. 3 interactions.
    MINTi MINT-1079512.
    STRINGi 6239.R09H10.3a.1.

    Proteomic databases

    PaxDbi Q21882.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblMetazoai R09H10.3a ; R09H10.3a ; WBGene00011181 . [Q21882-1 ]
    GeneIDi 187757.
    KEGGi cel:CELE_R09H10.3.
    UCSCi R09H10.3a.1. c. elegans. [Q21882-1 ]

    Organism-specific databases

    CTDi 187757.
    WormBasei R09H10.3a ; CE34083 ; WBGene00011181 .
    R09H10.3b ; CE12662 ; WBGene00011181 .

    Phylogenomic databases

    eggNOGi COG2351.
    GeneTreei ENSGT00390000005321.
    HOGENOMi HOG000251776.
    InParanoidi Q21882.
    KOi K07127.
    OMAi LCSPWSF.
    PhylomeDBi Q21882.

    Miscellaneous databases

    NextBioi 936396.
    PROi Q21882.

    Family and domain databases

    Gene3Di 2.60.40.180. 1 hit.
    InterProi IPR014306. Hydroxyisourate_hydrolase.
    IPR023418. Thyroxine_BS.
    IPR000895. Transthyretin/HIU_hydrolase.
    IPR023416. Transthyretin/HIU_hydrolase_SF.
    IPR023419. Transthyretin_CS.
    [Graphical view ]
    Pfami PF00576. Transthyretin. 1 hit.
    [Graphical view ]
    PRINTSi PR00189. TRNSTHYRETIN.
    SMARTi SM00095. TR_THY. 1 hit.
    [Graphical view ]
    SUPFAMi SSF49472. SSF49472. 1 hit.
    TIGRFAMsi TIGR02962. hdxy_isourate. 1 hit.
    PROSITEi PS00768. TRANSTHYRETIN_1. 1 hit.
    PS00769. TRANSTHYRETIN_2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Genome sequence of the nematode C. elegans: a platform for investigating biology."
      The C. elegans sequencing consortium
      Science 282:2012-2018(1998) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA], ALTERNATIVE SPLICING.
      Strain: Bristol N2.

    Entry informationi

    Entry nameiHIUH1_CAEEL
    AccessioniPrimary (citable) accession number: Q21882
    Secondary accession number(s): Q1NZ16
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: December 15, 1998
    Last sequence update: March 29, 2004
    Last modified: October 1, 2014
    This is version 97 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programCaenorhabditis annotation project

    Miscellaneousi

    Miscellaneous

    HIU hydrolysis also occurs spontaneously, but more slowly.

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Caenorhabditis elegans
      Caenorhabditis elegans: entries, gene names and cross-references to WormBase
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3