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Protein

Nuclear hormone receptor family member nhr-1

Gene

nhr-1

Organism
Caenorhabditis elegans
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

Orphan nuclear receptor.

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
DNA bindingi70 – 145Nuclear receptorPROSITE-ProRule annotationAdd BLAST76
Zinc fingeri73 – 93NR C4-typePROSITE-ProRule annotationAdd BLAST21
Zinc fingeri109 – 133NR C4-typePROSITE-ProRule annotationAdd BLAST25

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Receptor

Keywords - Biological processi

Transcription, Transcription regulation

Keywords - Ligandi

DNA-binding, Metal-binding, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
Nuclear hormone receptor family member nhr-1
Gene namesi
Name:nhr-1
ORF Names:R09G11.2
OrganismiCaenorhabditis elegans
Taxonomic identifieri6239 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaNematodaChromadoreaRhabditidaRhabditoideaRhabditidaePeloderinaeCaenorhabditis
Proteomesi
  • UP000001940 Componenti: Chromosome X

Organism-specific databases

WormBaseiR09G11.2a; CE34353; WBGene00003600; nhr-1.
R09G11.2c; CE33812; WBGene00003600; nhr-1.

Subcellular locationi

  • Nucleus PROSITE-ProRule annotation

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000537551 – 445Nuclear hormone receptor family member nhr-1Add BLAST445

Proteomic databases

PaxDbiQ21878.
PeptideAtlasiQ21878.

PTM databases

iPTMnetiQ21878.

Expressioni

Gene expression databases

BgeeiWBGene00003600.
ExpressionAtlasiQ21878. differential.

Interactioni

Protein-protein interaction databases

BioGridi46654. 1 interactor.
IntActiQ21878. 2 interactors.
MINTiMINT-1077252.
STRINGi6239.R09G11.2a.1.

Structurei

3D structure databases

ProteinModelPortaliQ21878.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the nuclear hormone receptor family.Curated
Contains 1 nuclear receptor DNA-binding domain.PROSITE-ProRule annotation

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri73 – 93NR C4-typePROSITE-ProRule annotationAdd BLAST21
Zinc fingeri109 – 133NR C4-typePROSITE-ProRule annotationAdd BLAST25

Keywords - Domaini

Zinc-finger

Phylogenomic databases

eggNOGiKOG3575. Eukaryota.
ENOG410XRZC. LUCA.
GeneTreeiENSGT00860000134113.
HOGENOMiHOG000016341.
InParanoidiQ21878.
OMAiAQNEENM.
OrthoDBiEOG091G0A89.
PhylomeDBiQ21878.

Family and domain databases

Gene3Di1.10.565.10. 1 hit.
3.30.50.10. 1 hit.
InterProiIPR000536. Nucl_hrmn_rcpt_lig-bd.
IPR001723. Nuclear_hrmn_rcpt.
IPR001628. Znf_hrmn_rcpt.
IPR013088. Znf_NHR/GATA.
[Graphical view]
PfamiPF00104. Hormone_recep. 1 hit.
PF00105. zf-C4. 1 hit.
[Graphical view]
PRINTSiPR00398. STRDHORMONER.
PR00047. STROIDFINGER.
SMARTiSM00430. HOLI. 1 hit.
SM00399. ZnF_C4. 1 hit.
[Graphical view]
SUPFAMiSSF48508. SSF48508. 1 hit.
PROSITEiPS00031. NUCLEAR_REC_DBD_1. 1 hit.
PS51030. NUCLEAR_REC_DBD_2. 1 hit.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q21878-1) [UniParc]FASTAAdd to basket
Also known as: a

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MNGTLADQLQ SHLANYGQPM VNSQRNEDPS MYMNGSAASV SHTNGSSSMG
60 70 80 90 100
NDQKFPSYKR MAQRRKVPEG ELCAVCSDLA TGYHYGVASC NGCKTFFRRT
110 120 130 140 150
IVSEQTFICQ YNGNCDVNKN IRCACRHCRF NKCLLVGMDA KALQIPAIQN
160 170 180 190 200
DRDRIGPTKK IKMSSGSDDE QATTPHRLQD QEIIDQLTQV EGLCQELRRC
210 220 230 240 250
IIPEVTGVTH ALTSPCLLFE TTDLKVDVSL TNTIFKELFP ASMNDIRMWN
260 270 280 290 300
IREMRICIEW AKTFDVYQRL NLFDQFALVR NFAFAFNLLN RVFYSPDHGP
310 320 330 340 350
DKIVFQNGAF IMRQPQQQVQ LSGCRPIYTR QMDEIMIPFR KLQLSVAEFA
360 370 380 390 400
TFKAALFFNP DALDLSPQAK QEVFEERNKY LGGLFTCITQ KIGIPTGVQK
410 420 430 440
YGSLLMMTAS IQNILAQNEE NMQVMELFKN WEVDPFVKEL CMKRA
Length:445
Mass (Da):50,670
Last modified:July 11, 2003 - v4
Checksum:i3A4EE6FCFE6FF0A0
GO
Isoform 2 (identifier: Q21878-2) [UniParc]FASTAAdd to basket
Also known as: c

The sequence of this isoform differs from the canonical sequence as follows:
     142-146: Missing.

Show »
Length:440
Mass (Da):50,148
Checksum:iEBE7A7810E2D8F46
GO

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_007763142 – 146Missing in isoform 2. 1 Publication5

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY204163 mRNA. Translation: AAO39167.1.
AY204164 mRNA. Translation: AAO39168.1.
AY204165 mRNA. Translation: AAO39169.1.
AY204166 mRNA. Translation: AAO39170.1.
FO081263 Genomic DNA. Translation: CCD70297.1.
FO081263 Genomic DNA. Translation: CCD70296.1.
PIRiT28881.
RefSeqiNP_001024853.1. NM_001029682.3. [Q21878-1]
NP_001024855.1. NM_001029684.3. [Q21878-2]
UniGeneiCel.17829.

Genome annotation databases

EnsemblMetazoaiR09G11.2a.1; R09G11.2a.1; WBGene00003600. [Q21878-1]
R09G11.2a.2; R09G11.2a.2; WBGene00003600. [Q21878-1]
GeneIDi181783.
KEGGicel:CELE_R09G11.2.
UCSCiR09G11.2d. c. elegans. [Q21878-1]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY204163 mRNA. Translation: AAO39167.1.
AY204164 mRNA. Translation: AAO39168.1.
AY204165 mRNA. Translation: AAO39169.1.
AY204166 mRNA. Translation: AAO39170.1.
FO081263 Genomic DNA. Translation: CCD70297.1.
FO081263 Genomic DNA. Translation: CCD70296.1.
PIRiT28881.
RefSeqiNP_001024853.1. NM_001029682.3. [Q21878-1]
NP_001024855.1. NM_001029684.3. [Q21878-2]
UniGeneiCel.17829.

3D structure databases

ProteinModelPortaliQ21878.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi46654. 1 interactor.
IntActiQ21878. 2 interactors.
MINTiMINT-1077252.
STRINGi6239.R09G11.2a.1.

PTM databases

iPTMnetiQ21878.

Proteomic databases

PaxDbiQ21878.
PeptideAtlasiQ21878.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblMetazoaiR09G11.2a.1; R09G11.2a.1; WBGene00003600. [Q21878-1]
R09G11.2a.2; R09G11.2a.2; WBGene00003600. [Q21878-1]
GeneIDi181783.
KEGGicel:CELE_R09G11.2.
UCSCiR09G11.2d. c. elegans. [Q21878-1]

Organism-specific databases

CTDi181783.
WormBaseiR09G11.2a; CE34353; WBGene00003600; nhr-1.
R09G11.2c; CE33812; WBGene00003600; nhr-1.

Phylogenomic databases

eggNOGiKOG3575. Eukaryota.
ENOG410XRZC. LUCA.
GeneTreeiENSGT00860000134113.
HOGENOMiHOG000016341.
InParanoidiQ21878.
OMAiAQNEENM.
OrthoDBiEOG091G0A89.
PhylomeDBiQ21878.

Miscellaneous databases

PROiQ21878.

Gene expression databases

BgeeiWBGene00003600.
ExpressionAtlasiQ21878. differential.

Family and domain databases

Gene3Di1.10.565.10. 1 hit.
3.30.50.10. 1 hit.
InterProiIPR000536. Nucl_hrmn_rcpt_lig-bd.
IPR001723. Nuclear_hrmn_rcpt.
IPR001628. Znf_hrmn_rcpt.
IPR013088. Znf_NHR/GATA.
[Graphical view]
PfamiPF00104. Hormone_recep. 1 hit.
PF00105. zf-C4. 1 hit.
[Graphical view]
PRINTSiPR00398. STRDHORMONER.
PR00047. STROIDFINGER.
SMARTiSM00430. HOLI. 1 hit.
SM00399. ZnF_C4. 1 hit.
[Graphical view]
SUPFAMiSSF48508. SSF48508. 1 hit.
PROSITEiPS00031. NUCLEAR_REC_DBD_1. 1 hit.
PS51030. NUCLEAR_REC_DBD_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiNHR1_CAEEL
AccessioniPrimary (citable) accession number: Q21878
Secondary accession number(s): Q867F1, Q86PL0, Q86PL1
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 30, 2003
Last sequence update: July 11, 2003
Last modified: November 30, 2016
This is version 133 of the entry and version 4 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programCaenorhabditis annotation project

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Caenorhabditis elegans
    Caenorhabditis elegans: entries, gene names and cross-references to WormBase
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.