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Protein

RNA-binding protein 8A

Gene

rnp-4

Organism
Caenorhabditis elegans
Status
Unreviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Core component of the splicing-dependent multiprotein exon junction complex (EJC) deposited at splice junctions on mRNAs.UniRule annotation

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

mRNA processing, mRNA splicingUniRule annotation, mRNA transportUniRule annotation, Transport

Keywords - Ligandi

RNA-bindingUniRule annotation

Enzyme and pathway databases

ReactomeiR-CEL-109688. Cleavage of Growing Transcript in the Termination Region.
R-CEL-159236. Transport of Mature mRNA derived from an Intron-Containing Transcript.
R-CEL-72163. mRNA Splicing - Major Pathway.
R-CEL-72187. mRNA 3'-end processing.
R-CEL-975957. Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC).

Names & Taxonomyi

Protein namesi
Recommended name:
RNA-binding protein 8AUniRule annotation
Gene namesi
Name:rnp-4Imported
Synonyms:RBM8Imported, Y14Imported
ORF Names:CELE_R07E5.14Imported, R07E5.14Imported
OrganismiCaenorhabditis elegansImported
Taxonomic identifieri6239 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaNematodaChromadoreaRhabditidaRhabditoideaRhabditidaePeloderinaeCaenorhabditis
Proteomesi
  • UP000001940 Componenti: Chromosome III

Organism-specific databases

WormBaseiR07E5.14; CE01044; WBGene00004387; rnp-4.

Subcellular locationi

  • Nucleus UniRule annotation
  • Nucleus speckle UniRule annotation
  • Cytoplasm UniRule annotation

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

CytoplasmUniRule annotation, NucleusUniRule annotation

Interactioni

Subunit structurei

Heterodimer with MAGOH. Part of the mRNA splicing-dependent exon junction complex (EJC) complex; the core complex contains CASC3, EIF4A3, MAGOH and RBM8A.UniRule annotation

Protein-protein interaction databases

DIPiDIP-26500N.
MINTiMINT-1100537.
STRINGi6239.R07E5.14.1.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini55 – 13379RRM (RNA recognition motif)InterPro annotationAdd
BLAST

Sequence similaritiesi

Belongs to the RBM8A family.UniRule annotation
Contains 1 RRM (RNA recognition motif) domain.UniRule annotation

Phylogenomic databases

eggNOGiKOG0130. Eukaryota.
ENOG4111IHM. LUCA.
GeneTreeiENSGT00730000111185.
HOGENOMiHOG000183826.
KOiK12876.
OMAiNIHEEAT.

Family and domain databases

Gene3Di3.30.70.330. 1 hit.
InterProiIPR012677. Nucleotide-bd_a/b_plait.
IPR008111. RNA-bd_8.
IPR000504. RRM_dom.
[Graphical view]
PANTHERiPTHR23139:SF72. PTHR23139:SF72. 1 hit.
PfamiPF00076. RRM_1. 1 hit.
[Graphical view]
PRINTSiPR01738. RNABINDINGM8.
SMARTiSM00360. RRM. 1 hit.
[Graphical view]
SUPFAMiSSF54928. SSF54928. 1 hit.
PROSITEiPS50102. RRM. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q21832-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSDNEVEMED VVANAERSRG RGLAQSRNRE RITYDVVDEE SSATSGAPQR
60 70 80 90 100
SVEGWIVFVT NIHEEATEDD VHDKFSEYGK IKNIHLNLDR RTGFLKGYAL
110 120 130 140
VEYETQKEAN EAIDQSNDTD LLGQNVKVDW CFVKGKKTSG KR
Length:142
Mass (Da):16,114
Last modified:November 1, 1996 - v1
Checksum:i4A7B461EDAB18B76
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
KF051018 mRNA. Translation: AHX83804.1.
BX284603 Genomic DNA. Translation: CAA83626.1.
PIRiF88427.
RefSeqiNP_497891.1. NM_065490.4.
UniGeneiCel.37550.

Genome annotation databases

EnsemblMetazoaiR07E5.14.1; R07E5.14.1; WBGene00004387.
R07E5.14.2; R07E5.14.2; WBGene00004387.
GeneIDi175572.
KEGGicel:CELE_R07E5.14.
UCSCiR07E5.14.2. c. elegans.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
KF051018 mRNA. Translation: AHX83804.1.
BX284603 Genomic DNA. Translation: CAA83626.1.
PIRiF88427.
RefSeqiNP_497891.1. NM_065490.4.
UniGeneiCel.37550.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

DIPiDIP-26500N.
MINTiMINT-1100537.
STRINGi6239.R07E5.14.1.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblMetazoaiR07E5.14.1; R07E5.14.1; WBGene00004387.
R07E5.14.2; R07E5.14.2; WBGene00004387.
GeneIDi175572.
KEGGicel:CELE_R07E5.14.
UCSCiR07E5.14.2. c. elegans.

Organism-specific databases

CTDi175572.
WormBaseiR07E5.14; CE01044; WBGene00004387; rnp-4.

Phylogenomic databases

eggNOGiKOG0130. Eukaryota.
ENOG4111IHM. LUCA.
GeneTreeiENSGT00730000111185.
HOGENOMiHOG000183826.
KOiK12876.
OMAiNIHEEAT.

Enzyme and pathway databases

ReactomeiR-CEL-109688. Cleavage of Growing Transcript in the Termination Region.
R-CEL-159236. Transport of Mature mRNA derived from an Intron-Containing Transcript.
R-CEL-72163. mRNA Splicing - Major Pathway.
R-CEL-72187. mRNA 3'-end processing.
R-CEL-975957. Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC).

Family and domain databases

Gene3Di3.30.70.330. 1 hit.
InterProiIPR012677. Nucleotide-bd_a/b_plait.
IPR008111. RNA-bd_8.
IPR000504. RRM_dom.
[Graphical view]
PANTHERiPTHR23139:SF72. PTHR23139:SF72. 1 hit.
PfamiPF00076. RRM_1. 1 hit.
[Graphical view]
PRINTSiPR01738. RNABINDINGM8.
SMARTiSM00360. RRM. 1 hit.
[Graphical view]
SUPFAMiSSF54928. SSF54928. 1 hit.
PROSITEiPS50102. RRM. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Genome sequence of the nematode C. elegans: a platform for investigating biology."
    Caenorhabditis elegans Sequencing Consortium
    Sulson J.E., Waterston R.
    Science 282:2012-2018(1998) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: Bristol N2Imported.
  2. Alber B.E., Fuchs G.
    Submitted (MAR-2003) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE.
    Strain: Bristol N2Imported.
  3. "Slow co-evolution of the MAGO and Y14 protein families is required for the maintenance of their obligate heterodimerization mode."
    Gong P., Zhao M., He C.
    PLoS ONE 9:E84842-E84842(2014) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE.
  4. WormBase Consortium
    WormBase
    Submitted (MAY-2016) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE.
    Strain: Bristol N2Imported.

Entry informationi

Entry nameiQ21832_CAEEL
AccessioniPrimary (citable) accession number: Q21832
Entry historyi
Integrated into UniProtKB/TrEMBL: November 1, 1996
Last sequence update: November 1, 1996
Last modified: July 6, 2016
This is version 125 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Proteomics identificationCombined sources, Reference proteomeImported

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.