ID   MIG23_CAEEL             Reviewed;         552 AA.
AC   Q21815;
DT   01-NOV-1997, integrated into UniProtKB/Swiss-Prot.
DT   06-JUN-2002, sequence version 2.
DT   16-JUN-2009, entry version 62.
DE   RecName: Full=Nucleoside-diphosphatase mig-23;
DE            Short=NDPase;
DE            EC=3.6.1.6;
DE   AltName: Full=Abnormal cell migration protein 23;
GN   Name=mig-23; ORFNames=R07E4.4;
OS   Caenorhabditis elegans.
OC   Eukaryota; Metazoa; Nematoda; Chromadorea; Rhabditida; Rhabditoidea;
OC   Rhabditidae; Peloderinae; Caenorhabditis.
OX   NCBI_TaxID=6239;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA], FUNCTION, SUBCELLULAR LOCATION, TISSUE
RP   SPECIFICITY, AND MUTAGENESIS OF GLY-268 AND ASP-290.
RX   PubMed=14688791; DOI=10.1038/ncb1079;
RA   Nishiwaki K., Kubota Y., Chigira Y., Roy S.K., Suzuki M.,
RA   Schvarzstein M., Jigami Y., Hisamoto N., Matsumoto K.;
RT   "An NDPase links ADAM protease glycosylation with organ morphogenesis
RT   in C. elegans.";
RL   Nat. Cell Biol. 6:31-37(2004).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Bristol N2;
RX   MEDLINE=99069613; PubMed=9851916; DOI=10.1126/science.282.5396.2012;
RG   The C. elegans sequencing consortium;
RT   "Genome sequence of the nematode C. elegans: a platform for
RT   investigating biology.";
RL   Science 282:2012-2018(1998).
RN   [3]
RP   LACK OF INDUCTION BY STRESS.
RX   PubMed=15102851; DOI=10.1074/jbc.M402624200;
RA   Uccelletti D., O'Callaghan C., Berninsone P., Zemtseva I., Abeijon C.,
RA   Hirschberg C.B.;
RT   "ire-1-dependent transcriptional up-regulation of a lumenal uridine
RT   diphosphatase from Caenorhabditis elegans.";
RL   J. Biol. Chem. 279:27390-27398(2004).
RN   [4]
RP   SUBCELLULAR LOCATION.
RX   PubMed=16354716; DOI=10.1242/dev.02195;
RA   Kubota Y., Sano M., Goda S., Suzuki N., Nishiwaki K.;
RT   "The conserved oligomeric Golgi complex acts in organ morphogenesis
RT   via glycosylation of an ADAM protease in C. elegans.";
RL   Development 133:263-273(2006).
CC   -!- FUNCTION: Seems to be able to hydrolyze ADP, UDP and GDP. Supports
CC       mig-17 glycosylation and surface expression, which is required for
CC       proper migration of distal tip cells during gonad morphogenesis.
CC   -!- CATALYTIC ACTIVITY: A nucleoside diphosphate + H(2)O = a
CC       nucleotide + phosphate.
CC   -!- SUBCELLULAR LOCATION: Golgi apparatus membrane; Multi-pass
CC       membrane protein.
CC   -!- TISSUE SPECIFICITY: Expressed in body wall muscles.
CC   -!- INDUCTION: In contrast to uda-1, expression is not induced by
CC       stress.
CC   -!- SIMILARITY: Belongs to the GDA1/CD39 NTPase family.
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DR   EMBL; AB126261; BAD02168.1; -; mRNA.
DR   EMBL; U39652; AAA80403.2; -; Genomic_DNA.
DR   PIR; T16696; T16696.
DR   RefSeq; NP_508994.1; -.
DR   UniGene; Cel.6413; -.
DR   Ensembl; R07E4.4; Caenorhabditis elegans.
DR   GeneID; 180860; -.
DR   KEGG; cel:R07E4.4; -.
DR   WormBase; WBGene00003254; mig-23.
DR   WormPep; R07E4.4; CE28748.
DR   OMA; Q21815; SAWITSV.
DR   BRENDA; 3.6.1.6; 672.
DR   NextBio; 911292; -.
DR   ArrayExpress; Q21815; -.
DR   GO; GO:0000139; C:Golgi membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0016021; C:integral to membrane; IEA:UniProtKB-KW.
DR   GO; GO:0017110; F:nucleoside-diphosphatase activity; IEA:EC.
DR   GO; GO:0030154; P:cell differentiation; IEA:UniProtKB-KW.
DR   GO; GO:0007506; P:gonadal mesoderm development; IEA:UniProtKB-KW.
DR   InterPro; IPR000407; GDA1_CD39_NTPase.
DR   PANTHER; PTHR11782; GDA1_CD39_NTPase; 1.
DR   Pfam; PF01150; GDA1_CD39; 1.
DR   PROSITE; PS01238; GDA1_CD39_NTPASE; 1.
PE   1: Evidence at protein level;
KW   Complete proteome; Developmental protein; Differentiation;
KW   Glycoprotein; Golgi apparatus; Gonadal differentiation; Hydrolase;
KW   Membrane; Transmembrane.
FT   CHAIN         1    552       Nucleoside-diphosphatase mig-23.
FT                                /FTId=PRO_0000209923.
FT   TOPO_DOM      1      6       Cytoplasmic (Potential).
FT   TRANSMEM      7     27       Potential.
FT   TOPO_DOM     28    489       Lumenal (Potential).
FT   TRANSMEM    490    510       Potential.
FT   TOPO_DOM    511    552       Cytoplasmic (Potential).
FT   CARBOHYD    190    190       N-linked (GlcNAc...) (Potential).
FT   CARBOHYD    284    284       N-linked (GlcNAc...) (Potential).
FT   MUTAGEN     268    268       G->E: In k166; reduced migration of the
FT                                gonad arms in both the anterior and
FT                                posterior direction.
FT   MUTAGEN     290    290       D->N: In k146; reduced migration of the
FT                                gonad arms in both the anterior and
FT                                posterior direction.
SQ   SEQUENCE   552 AA;  62511 MW;  E5DC32C858AE4D94 CRC64;
     MRVSLRFTIL AVSAMIFFPV IVFIYVVEAH TSPKVIADDQ ERSYGVICDA GSTGTRLFVY
     NWISTSDSEL IQIEPVIYDN KPVMKKISPG LSTFGTKPAQ AAEYLRPLME LAERHIPEEK
     RPYTPVFIFA TAGMRLIPDE QKEAVLKNLR NKLPKITSMQ VLKEHIRIIE GKWEGIYSWI
     AVNYALGKFN KTATLDFPGT SPAHARQKTV GMIDMGGASA QIAFELPDTD SFSSINVENI
     NLGCREDDSL FKYKLFVTTF LGYGVNEGIR KYEHMLLSKL KDQNGTVIQD DCMPLNLHKT
     VTLENGENFV RRGTGNWNTC SNEVKKLLNP ESSSEVCKAE AAKCYFGAVP APSIPLSNIE
     MYGFSEYWYS THDVLGLGGQ YDAENIAKKT QQYCSKRWST IQAESKKQLY PRADEERLRT
     QCFKSAWITS VLHDGFSVDK THNKFQSVST IAGQEVQWAL GAMIYHMRFF PLRDSSRNLI
     VKETHSSSES LWAPLFFLSA VFCLFVLVCA KEQSVLCFDD KRRSSFGMSR SQYSYKMLKE
     NRTSSSFLEN FA
//