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Protein

Kynurenine 3-monooxygenase

Gene

kmo-1

Organism
Caenorhabditis elegans
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Catalyzes the hydroxylation of L-kynurenine (L-Kyn) to form 3-hydroxy-L-kynurenine (L-3OHKyn). Required for synthesis of quinolinic acid.UniRule annotation

Catalytic activityi

L-kynurenine + NADPH + O2 = 3-hydroxy-L-kynurenine + NADP+ + H2O.UniRule annotation

Cofactori

FADUniRule annotation

Pathwayi: NAD(+) biosynthesis

This protein is involved in step 1 of the subpathway that synthesizes quinolinate from L-kynurenine.UniRule annotation
Proteins known to be involved in the 3 steps of the subpathway in this organism are:
  1. Kynurenine 3-monooxygenase (kmo-1)
  2. Kynureninase (flu-2)
  3. 3-hydroxyanthranilate 3,4-dioxygenase (haao-1)
This subpathway is part of the pathway NAD(+) biosynthesis, which is itself part of Cofactor biosynthesis.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes quinolinate from L-kynurenine, the pathway NAD(+) biosynthesis and in Cofactor biosynthesis.

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Monooxygenase, Oxidoreductase

Keywords - Biological processi

Pyridine nucleotide biosynthesis

Keywords - Ligandi

FAD, Flavoprotein, NADP

Enzyme and pathway databases

ReactomeiR-CEL-71240. Tryptophan catabolism.
UniPathwayiUPA00253; UER00328.

Names & Taxonomyi

Protein namesi
Recommended name:
Kynurenine 3-monooxygenaseUniRule annotation (EC:1.14.13.9UniRule annotation)
Alternative name(s):
Kynurenine 3-hydroxylaseUniRule annotation
Gene namesi
Name:kmo-1UniRule annotation
ORF Names:R07B7.5
OrganismiCaenorhabditis elegans
Taxonomic identifieri6239 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaNematodaChromadoreaRhabditidaRhabditoideaRhabditidaePeloderinaeCaenorhabditis
Proteomesi
  • UP000001940 Componenti: Chromosome V

Organism-specific databases

WormBaseiR07B7.5; CE06267; WBGene00011089; kmo-1.

Subcellular locationi

  • Mitochondrion UniRule annotation
  • Membrane UniRule annotation; Multi-pass membrane protein UniRule annotation

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei395 – 41521HelicalUniRule annotationAdd
BLAST
Transmembranei432 – 45221HelicalUniRule annotationAdd
BLAST

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Membrane, Mitochondrion

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 461461Kynurenine 3-monooxygenasePRO_0000361911Add
BLAST

Proteomic databases

EPDiQ21795.
PaxDbiQ21795.
PRIDEiQ21795.

Interactioni

Protein-protein interaction databases

STRINGi6239.R07B7.5.

Structurei

3D structure databases

ProteinModelPortaliQ21795.
SMRiQ21795. Positions 1-390.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the aromatic-ring hydroxylase family. KMO subfamily.UniRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG2614. Eukaryota.
COG0654. LUCA.
GeneTreeiENSGT00390000000747.
HOGENOMiHOG000251788.
InParanoidiQ21795.
KOiK00486.
OMAiQPMISVK.
OrthoDBiEOG7KSX8D.
PhylomeDBiQ21795.

Family and domain databases

Gene3Di3.50.50.60. 2 hits.
HAMAPiMF_01971. Kynurenine_monooxygenase.
InterProiIPR002938. FAD-bd.
IPR023753. FAD/NAD-binding_dom.
IPR027545. Kynurenine_monooxygenase.
[Graphical view]
PfamiPF01494. FAD_binding_3. 1 hit.
[Graphical view]
SUPFAMiSSF51905. SSF51905. 2 hits.

Sequencei

Sequence statusi: Complete.

Q21795-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MPSVAIAGAG LVGALNACFF AQKGWDVSVY EFRKDIRTMK HVQGRSINLA
60 70 80 90 100
LSQRGKSALE AVGLKEYIVN QGVPLYARLI HNKDGKTYSR QPYGKPGEHI
110 120 130 140 150
VSINRRHLNE VMITQAEKSP NVKFFFEHKV KNVDYDKKQL VVQCTSQPSK
160 170 180 190 200
IPTFGNKSPP QEHAEFHVEA DLILACDGAY SAVRRSLMTI PRFDFSQEYI
210 220 230 240 250
EHGYVELNIM ANNNEFAFEE NVFHLWPRGH FTLIALANRD KTFTVTIFAP
260 270 280 290 300
FSEFEKHMST SEDVLSFFEE NFPDAFLLLG KEHIADTFNR VKPQPLVSIK
310 320 330 340 350
CSPHSFFDNL VLMGDAAHAM VPFYGQGMNC GFEDCLVFSE TLEEYGNDIA
360 370 380 390 400
KAVKVYSDGR VNDAHSINDL AMYNYEELKD LVNKSSYKLR KKFDTIMNSI
410 420 430 440 450
FPKSWIPLYS MVTFSRIPYS EVIERRKRQD KILSRIMTTT STLALIGAAA
460
GIYVNRGKLG L
Length:461
Mass (Da):52,312
Last modified:November 1, 1996 - v1
Checksum:i5521B3A0A15C9E87
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Z75955 Genomic DNA. Translation: CAB00114.1.
PIRiT24012.
RefSeqiNP_506025.1. NM_073624.3.
UniGeneiCel.2875.

Genome annotation databases

EnsemblMetazoaiR07B7.5; R07B7.5; WBGene00011089.
GeneIDi179657.
KEGGicel:CELE_R07B7.5.
UCSCiR07B7.5. c. elegans.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Z75955 Genomic DNA. Translation: CAB00114.1.
PIRiT24012.
RefSeqiNP_506025.1. NM_073624.3.
UniGeneiCel.2875.

3D structure databases

ProteinModelPortaliQ21795.
SMRiQ21795. Positions 1-390.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi6239.R07B7.5.

Proteomic databases

EPDiQ21795.
PaxDbiQ21795.
PRIDEiQ21795.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblMetazoaiR07B7.5; R07B7.5; WBGene00011089.
GeneIDi179657.
KEGGicel:CELE_R07B7.5.
UCSCiR07B7.5. c. elegans.

Organism-specific databases

CTDi179657.
WormBaseiR07B7.5; CE06267; WBGene00011089; kmo-1.

Phylogenomic databases

eggNOGiKOG2614. Eukaryota.
COG0654. LUCA.
GeneTreeiENSGT00390000000747.
HOGENOMiHOG000251788.
InParanoidiQ21795.
KOiK00486.
OMAiQPMISVK.
OrthoDBiEOG7KSX8D.
PhylomeDBiQ21795.

Enzyme and pathway databases

UniPathwayiUPA00253; UER00328.
ReactomeiR-CEL-71240. Tryptophan catabolism.

Miscellaneous databases

PROiQ21795.

Family and domain databases

Gene3Di3.50.50.60. 2 hits.
HAMAPiMF_01971. Kynurenine_monooxygenase.
InterProiIPR002938. FAD-bd.
IPR023753. FAD/NAD-binding_dom.
IPR027545. Kynurenine_monooxygenase.
[Graphical view]
PfamiPF01494. FAD_binding_3. 1 hit.
[Graphical view]
SUPFAMiSSF51905. SSF51905. 2 hits.
ProtoNetiSearch...

Publicationsi

  1. "Genome sequence of the nematode C. elegans: a platform for investigating biology."
    The C. elegans sequencing consortium
    Science 282:2012-2018(1998) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: Bristol N2.

Entry informationi

Entry nameiKMO_CAEEL
AccessioniPrimary (citable) accession number: Q21795
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 10, 2009
Last sequence update: November 1, 1996
Last modified: June 8, 2016
This is version 108 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programCaenorhabditis annotation project

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Caenorhabditis elegans
    Caenorhabditis elegans: entries, gene names and cross-references to WormBase
  2. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.