Q21795 (KMO_CAEEL) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Kynurenine 3-monooxygenase
EC=1.14.13.9

Alternative name(s):
Kynurenine 3-hydroxylase

Gene names

ORF Names:

R07B7.5

Organism

Caenorhabditis elegans

Taxonomic identifier

6239 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Nematoda › Chromadorea › Rhabditida › Rhabditoidea › Rhabditidae › Peloderinae › Caenorhabditis

Protein attributes

Sequence length	461 AA.
Sequence status	Complete.
Protein existence	Evidence at transcript level

General annotation (Comments)

Function	Catalyzes the hydroxylation of L-kynurenine (L-Kyn) to form 3-hydroxy-L-kynurenine (L-3OHKyn). Required for synthesis of quinolinic acid By similarity.
Catalytic activity	L-kynurenine + NADPH + O2 = 3-hydroxy-L-kynurenine + NADP+ + H2O.
Cofactor	FAD By similarity.
Pathway	Cofactor biosynthesis; NAD(+) biosynthesis; quinolinate from L-kynurenine: step 1/3.
Subcellular location	Mitochondrion By similarity. Membrane; Multi-pass membrane protein Potential.
Sequence similarities	Belongs to the aromatic-ring hydroxylase family. KMO subfamily.

Ontologies

Keywords
Biological process	Pyridine nucleotide biosynthesis
Cellular component	Membrane Mitochondrion
Domain	Transmembrane Transmembrane helix
Ligand	FAD Flavoprotein NADP
Molecular function	Monooxygenase Oxidoreductase
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological process	NAD metabolic process Inferred from sequence or structural similarity. Source: UniProtKB pyridine nucleotide biosynthetic process Inferred from electronic annotation. Source: UniProtKB-KW
Cellular component	integral to membrane Inferred from electronic annotation. Source: UniProtKB-KW mitochondrial outer membrane Inferred from sequence or structural similarity. Source: UniProtKB
Molecular function	kynurenine 3-monooxygenase activity Inferred from sequence or structural similarity. Source: UniProtKB
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 461	461	Kynurenine 3-monooxygenase		PRO_0000361911
Regions
	Transmembrane	395 – 415	21	Helical; Potential
	Transmembrane	432 – 455	24	Helical; Potential

Sequences

	Sequence		Length	Mass (Da)
	Q21795 [UniParc]. Last modified November 1, 1996. Version 1. Checksum: 5521B3A0A15C9E87	FASTA	461	52,312
	10 20 30 40 50 60 MPSVAIAGAG LVGALNACFF AQKGWDVSVY EFRKDIRTMK HVQGRSINLA LSQRGKSALE 70 80 90 100 110 120 AVGLKEYIVN QGVPLYARLI HNKDGKTYSR QPYGKPGEHI VSINRRHLNE VMITQAEKSP 130 140 150 160 170 180 NVKFFFEHKV KNVDYDKKQL VVQCTSQPSK IPTFGNKSPP QEHAEFHVEA DLILACDGAY 190 200 210 220 230 240 SAVRRSLMTI PRFDFSQEYI EHGYVELNIM ANNNEFAFEE NVFHLWPRGH FTLIALANRD 250 260 270 280 290 300 KTFTVTIFAP FSEFEKHMST SEDVLSFFEE NFPDAFLLLG KEHIADTFNR VKPQPLVSIK 310 320 330 340 350 360 CSPHSFFDNL VLMGDAAHAM VPFYGQGMNC GFEDCLVFSE TLEEYGNDIA KAVKVYSDGR 370 380 390 400 410 420 VNDAHSINDL AMYNYEELKD LVNKSSYKLR KKFDTIMNSI FPKSWIPLYS MVTFSRIPYS 430 440 450 460 EVIERRKRQD KILSRIMTTT STLALIGAAA GIYVNRGKLG L

References

[1]	"Genome sequence of the nematode C. elegans: a platform for investigating biology." The C. elegans sequencing consortium Science 282:2012-2018(1998) [PubMed: 9851916] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: Bristol N2.

Cross-references

Sequence databases
EMBL GenBank DDBJ	Z75955 Genomic DNA. Translation: CAB00114.1.
PIR	T24012.
RefSeq	NP_506025.1. NM_073624.2.
UniGene	Cel.2875.
3D structure databases
ProteinModelPortal	Q21795.
SMR	Q21795. Positions 1-134.
ModBase	Search...
Protein-protein interaction databases
STRING	Q21795.
Proteomic databases
PRIDE	Q21795.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
EnsemblMetazoa	R07B7.5; R07B7.5; R07B7.5.
GeneID	179657.
KEGG	cel:R07B7.5.
NMPDR	fig|6239.3.peg.19896.
UCSC	R07B7.5. c. elegans.
Organism-specific databases
CTD	179657.
WormBase	R07B7.5; CE06267; WBGene00011089.
Phylogenomic databases
eggNOG	meNOG05088.
GeneTree	EMGT00050000009966.
HOGENOM	HBG430104.
InParanoid	Q21795.
OMA	YFPDAIP.
PhylomeDB	Q21795.
Gene expression databases
ArrayExpress	Q21795.
Family and domain databases
InterPro	IPR002938. mOase_FAD-bd. IPR003042. Rng_hydrolase-like. [Graphical view]
KO	K00486.
Pfam	PF01494. FAD_binding_3. 1 hit. [Graphical view]
PRINTS	PR00420. RNGMNOXGNASE.
ProtoNet	Search...
Other
NextBio	906326.

Entry information

Entry name

KMO_CAEEL

Accession

Primary (citable) accession number: Q21795

Entry history

Integrated into UniProtKB/Swiss-Prot:	February 10, 2009
Last sequence update:	November 1, 1996
Last modified:	November 16, 2011
This is version 72 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Caenorhabditis annotation project