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Protein

Probable voltage-dependent anion-selective channel

Gene

vdac-1

Organism
Caenorhabditis elegans
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Forms a channel through the cell membrane that allows diffusion of small hydrophilic molecules.By similarity

GO - Molecular functioni

GO - Biological processi

  • mitochondrion organization Source: WormBase

Keywordsi

Molecular functionPorin
Biological processIon transport, Transport

Enzyme and pathway databases

ReactomeiR-CEL-5205685 Pink/Parkin Mediated Mitophagy
R-CEL-5689880 Ub-specific processing proteases

Names & Taxonomyi

Protein namesi
Recommended name:
Probable voltage-dependent anion-selective channel
Gene namesi
Name:vdac-1
ORF Names:R05G6.7
OrganismiCaenorhabditis elegans
Taxonomic identifieri6239 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaNematodaChromadoreaRhabditidaRhabditoideaRhabditidaePeloderinaeCaenorhabditis
Proteomesi
  • UP000001940 Componenti: Chromosome IV

Organism-specific databases

WormBaseiR05G6.7 ; CE29443 ; WBGene00019900 ; vdac-1

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Membrane, Mitochondrion, Mitochondrion outer membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000505211 – 283Probable voltage-dependent anion-selective channelAdd BLAST283

Proteomic databases

EPDiQ21752
PaxDbiQ21752
PeptideAtlasiQ21752
PRIDEiQ21752

Expressioni

Gene expression databases

BgeeiWBGene00019900

Interactioni

Protein-protein interaction databases

BioGridi42642, 3 interactors
IntActiQ21752, 1 interactor
STRINGi6239.R05G6.7.2

Structurei

3D structure databases

ProteinModelPortaliQ21752
SMRiQ21752
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domaini

Consists mainly of membrane-spanning sided beta-sheets.By similarity

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane beta strand

Phylogenomic databases

eggNOGiKOG3126 Eukaryota
ENOG410ZBK1 LUCA
GeneTreeiENSGT00390000011336
HOGENOMiHOG000188277
InParanoidiQ21752
KOiK15040
OMAiAKINNAG
OrthoDBiEOG091G0F0O
PhylomeDBiQ21752

Family and domain databases

Gene3Di2.40.160.10, 1 hit
InterProiView protein in InterPro
IPR023614 Porin_dom_sf
IPR001925 Porin_Euk
IPR027246 Porin_Euk/Tom40
PfamiView protein in Pfam
PF01459 Porin_3, 1 hit
PRINTSiPR00185 EUKARYTPORIN

Sequencei

Sequence statusi: Complete.

Q21752-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAPPTFADLG KSAKDLFNKG YNFGFLKIDS TTRAGDNKEV EFKSAASHNI
60 70 80 90 100
GSGKLGGNLD VKYKIPQYGI TLTEKWNTEN QLGTVIEVNE QFGRGLKVTL
110 120 130 140 150
DSLYAPHAGK RSGKVKLDWA LPTARVTADV GVTSAPVINA AGVFSRDGWL
160 170 180 190 200
IGAAATFDSS SNKLAATSLA FGHSTPQYTL HSFVINSTDF GASLYHKVAS
210 220 230 240 250
NVEVGTQLGW KVGGNGADYA LATKYAPSRD LTVRAKVNSS SQVAVAATHS
260 270 280
LSPALKLTLS TQFNLAANDA HKFGLGLEFD PSN
Length:283
Mass (Da):29,961
Last modified:May 27, 2002 - v2
Checksum:i060141EEA5060290
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
FO081426 Genomic DNA Translation: CCD71556.1
PIRiT29355
RefSeqiNP_501211.1, NM_068810.5
UniGeneiCel.5105

Genome annotation databases

EnsemblMetazoaiR05G6.7; R05G6.7; WBGene00019900
GeneIDi177524
KEGGicel:CELE_R05G6.7
UCSCiR05G6.7.1 c. elegans

Similar proteinsi

Entry informationi

Entry nameiVDAC_CAEEL
AccessioniPrimary (citable) accession number: Q21752
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 15, 1999
Last sequence update: May 27, 2002
Last modified: May 23, 2018
This is version 114 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programCaenorhabditis annotation project

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

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