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Protein

Probable voltage-dependent anion-selective channel

Gene

vdac-1

Organism
Caenorhabditis elegans
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Forms a channel through the cell membrane that allows diffusion of small hydrophilic molecules.By similarity

GO - Molecular functioni

GO - Biological processi

  • mitochondrion organization Source: WormBase
Complete GO annotation...

Keywords - Molecular functioni

Porin

Keywords - Biological processi

Ion transport, Transport

Enzyme and pathway databases

ReactomeiR-CEL-5205685. Pink/Parkin Mediated Mitophagy.

Names & Taxonomyi

Protein namesi
Recommended name:
Probable voltage-dependent anion-selective channel
Gene namesi
Name:vdac-1
ORF Names:R05G6.7
OrganismiCaenorhabditis elegans
Taxonomic identifieri6239 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaNematodaChromadoreaRhabditidaRhabditoideaRhabditidaePeloderinaeCaenorhabditis
Proteomesi
  • UP000001940 Componenti: Chromosome IV

Organism-specific databases

WormBaseiR05G6.7; CE29443; WBGene00019900; vdac-1.

Subcellular locationi

  • Mitochondrion outer membrane By similarity; Multi-pass membrane protein By similarity

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Membrane, Mitochondrion, Mitochondrion outer membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 283283Probable voltage-dependent anion-selective channelPRO_0000050521Add
BLAST

Proteomic databases

EPDiQ21752.
PaxDbiQ21752.

Expressioni

Gene expression databases

BgeeiWBGene00019900.

Interactioni

Protein-protein interaction databases

BioGridi42642. 3 interactions.
IntActiQ21752. 1 interaction.
MINTiMINT-1049694.
STRINGi6239.R05G6.7.2.

Structurei

3D structure databases

ProteinModelPortaliQ21752.
SMRiQ21752. Positions 3-280.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domaini

Consists mainly of membrane-spanning sided beta-sheets.By similarity

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane beta strand

Phylogenomic databases

eggNOGiKOG3126. Eukaryota.
ENOG410ZBK1. LUCA.
GeneTreeiENSGT00390000011336.
HOGENOMiHOG000188277.
InParanoidiQ21752.
KOiK15040.
OMAiANDAHKF.
OrthoDBiEOG091G0F0O.
PhylomeDBiQ21752.

Family and domain databases

Gene3Di2.40.160.10. 1 hit.
InterProiIPR023614. Porin_dom.
IPR001925. Porin_Euk.
IPR027246. Porin_Euk/Tom40.
[Graphical view]
PfamiPF01459. Porin_3. 1 hit.
[Graphical view]
PRINTSiPR00185. EUKARYTPORIN.

Sequencei

Sequence statusi: Complete.

Q21752-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAPPTFADLG KSAKDLFNKG YNFGFLKIDS TTRAGDNKEV EFKSAASHNI
60 70 80 90 100
GSGKLGGNLD VKYKIPQYGI TLTEKWNTEN QLGTVIEVNE QFGRGLKVTL
110 120 130 140 150
DSLYAPHAGK RSGKVKLDWA LPTARVTADV GVTSAPVINA AGVFSRDGWL
160 170 180 190 200
IGAAATFDSS SNKLAATSLA FGHSTPQYTL HSFVINSTDF GASLYHKVAS
210 220 230 240 250
NVEVGTQLGW KVGGNGADYA LATKYAPSRD LTVRAKVNSS SQVAVAATHS
260 270 280
LSPALKLTLS TQFNLAANDA HKFGLGLEFD PSN
Length:283
Mass (Da):29,961
Last modified:May 27, 2002 - v2
Checksum:i060141EEA5060290
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
FO081426 Genomic DNA. Translation: CCD71556.1.
PIRiT29355.
RefSeqiNP_501211.1. NM_068810.5.
UniGeneiCel.5105.

Genome annotation databases

EnsemblMetazoaiR05G6.7; R05G6.7; WBGene00019900.
GeneIDi177524.
KEGGicel:CELE_R05G6.7.
UCSCiR05G6.7.1. c. elegans.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
FO081426 Genomic DNA. Translation: CCD71556.1.
PIRiT29355.
RefSeqiNP_501211.1. NM_068810.5.
UniGeneiCel.5105.

3D structure databases

ProteinModelPortaliQ21752.
SMRiQ21752. Positions 3-280.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi42642. 3 interactions.
IntActiQ21752. 1 interaction.
MINTiMINT-1049694.
STRINGi6239.R05G6.7.2.

Proteomic databases

EPDiQ21752.
PaxDbiQ21752.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblMetazoaiR05G6.7; R05G6.7; WBGene00019900.
GeneIDi177524.
KEGGicel:CELE_R05G6.7.
UCSCiR05G6.7.1. c. elegans.

Organism-specific databases

CTDi177524.
WormBaseiR05G6.7; CE29443; WBGene00019900; vdac-1.

Phylogenomic databases

eggNOGiKOG3126. Eukaryota.
ENOG410ZBK1. LUCA.
GeneTreeiENSGT00390000011336.
HOGENOMiHOG000188277.
InParanoidiQ21752.
KOiK15040.
OMAiANDAHKF.
OrthoDBiEOG091G0F0O.
PhylomeDBiQ21752.

Enzyme and pathway databases

ReactomeiR-CEL-5205685. Pink/Parkin Mediated Mitophagy.

Miscellaneous databases

PROiQ21752.

Gene expression databases

BgeeiWBGene00019900.

Family and domain databases

Gene3Di2.40.160.10. 1 hit.
InterProiIPR023614. Porin_dom.
IPR001925. Porin_Euk.
IPR027246. Porin_Euk/Tom40.
[Graphical view]
PfamiPF01459. Porin_3. 1 hit.
[Graphical view]
PRINTSiPR00185. EUKARYTPORIN.
ProtoNetiSearch...

Entry informationi

Entry nameiVDAC_CAEEL
AccessioniPrimary (citable) accession number: Q21752
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 15, 1999
Last sequence update: May 27, 2002
Last modified: September 7, 2016
This is version 103 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programCaenorhabditis annotation project

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Caenorhabditis elegans
    Caenorhabditis elegans: entries, gene names and cross-references to WormBase
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.