Q21743 (GST9_CAEEL) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Probable glutathione S-transferase 9
EC=2.5.1.18

Alternative name(s):
GST class-sigma

Gene names

Name:	gst-9
ORF Names:	R05F9.5

Organism

Caenorhabditis elegans

Taxonomic identifier

6239 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Nematoda › Chromadorea › Rhabditida › Rhabditoidea › Rhabditidae › Peloderinae › Caenorhabditis

Protein attributes

Sequence length	206 AA.
Sequence status	Complete.
Protein existence	Evidence at transcript level

General annotation (Comments)

Function	Conjugation of reduced glutathione to a wide number of exogenous and endogenous hydrophobic electrophiles By similarity. UniProtKB P46436
Catalytic activity	RX + glutathione = HX + R-S-glutathione. UniProtKB P46436
Sequence similarities	Belongs to the GST superfamily. Sigma family. UniProtKB P46436 Contains 1 GST C-terminal domain. Contains 1 GST N-terminal domain.

Ontologies

Keywords
Molecular function	Transferase
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological process	lipid storage Inferred from mutant phenotype. Source: WormBase positive regulation of growth rate Inferred from mutant phenotype. Source: WormBase
Molecular function	glutathione transferase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 206	206	Probable glutathione S-transferase 9		PRO_0000185932
Regions
	Domain	2 – 79	78	GST N-terminal
	Domain	81 – 206	126	GST C-terminal
	Region	50 – 51	2	Glutathione binding By similarity
	Region	63 – 64	2	Glutathione binding By similarity
Sites
	Binding site	8	1	Glutathione By similarity
	Binding site	39	1	Glutathione By similarity
	Binding site	43	1	Glutathione By similarity

Sequences

	Sequence		Length	Mass (Da)
	Q21743 [UniParc]. Last modified November 1, 1996. Version 1. Checksum: 3C4B2ADC081970D4	FASTA	206	23,537
	10 20 30 40 50 60 MVSYKLIYFQ SRGNGEIARQ VFAFAGQEFI DERISKEQWA EIKNMTPFGQ VPVLEVDGRQ 70 80 90 100 110 120 LAQSITIVRY LSKQFGISGK SSWEEAQVDA LGDQFKDYRV EARPFFRAKM GFSDGDVDQL 130 140 150 160 170 180 YKDLFVPAFN KMYSIFTESL KSSGSGFLVG DSLTWMDLAI AQHSADLLEA DGKILDTFLE 190 200 MKDHQKKIHS IPNVKKWIEK RPVTSR

References

[1]	"Genome sequence of the nematode C. elegans: a platform for investigating biology." The C. elegans sequencing consortium Science 282:2012-2018(1998) [PubMed: 9851916] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: Bristol N2.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	FO081120 Genomic DNA. Translation: CCD69273.1.
PIR	T16683. T16685.
RefSeq	NP_001022266.1. NM_001027095.1.
UniGene	Cel.14654.
3D structure databases
ProteinModelPortal	Q21743.
SMR	Q21743. Positions 1-204.
ModBase	Search...
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
EnsemblMetazoa	R05F9.5; R05F9.5; R05F9.5.
GeneID	187615.
KEGG	cel:R05F9.5.
UCSC	R05F9.5. c. elegans.
Organism-specific databases
CTD	187615.
WormBase	R05F9.5; CE04807; WBGene00001757; gst-9.
Phylogenomic databases
eggNOG	meNOG14525.
GeneTree	EMGT00050000007317.
HOGENOM	HBG563238.
InParanoid	Q21743.
OMA	FESHERT.
PhylomeDB	Q21743.
Gene expression databases
ArrayExpress	Q21743.
Family and domain databases
InterPro	IPR010987. Glutathione-S-Trfase_C-like. IPR004045. Glutathione_S-Trfase_N. IPR017933. Glutathione_S_Trfase/Cl_chnl_C. IPR004046. GST_C. IPR012336. Thioredoxin-like_fold. [Graphical view]
Gene3D	G3DSA:1.20.1050.10. GST_C_like. 1 hit. G3DSA:3.40.30.10. Thioredoxin_fold. 1 hit.
Pfam	PF00043. GST_C. 1 hit. PF02798. GST_N. 1 hit. [Graphical view]
SUPFAM	SSF47616. GST_C_like. 1 hit. SSF52833. Thiordxn-like_fd. 1 hit.
PROSITE	PS50405. GST_CTER. 1 hit. PS50404. GST_NTER. 1 hit. [Graphical view]
ProtoNet	Search...
Other
NextBio	935874.

Entry information

Entry name

GST9_CAEEL

Accession

Primary (citable) accession number: Q21743
Secondary accession number(s): Q21744

Entry history

Integrated into UniProtKB/Swiss-Prot:	March 28, 2003
Last sequence update:	November 1, 1996
Last modified:	December 14, 2011
This is version 76 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Caenorhabditis annotation project