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Q21743

- GST9_CAEEL

UniProt

Q21743 - GST9_CAEEL

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Protein

Probable glutathione S-transferase 9

Gene

gst-9

Organism
Caenorhabditis elegans
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi

Functioni

Conjugation of reduced glutathione to a wide number of exogenous and endogenous hydrophobic electrophiles.By similarity

Catalytic activityi

RX + glutathione = HX + R-S-glutathione.By similarity

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei8 – 81GlutathioneBy similarity
Binding sitei39 – 391GlutathioneBy similarity
Binding sitei43 – 431GlutathioneBy similarity

GO - Molecular functioni

  1. glutathione transferase activity Source: UniProtKB-EC
Complete GO annotation...

Keywords - Molecular functioni

Transferase

Enzyme and pathway databases

ReactomeiREACT_184548. Detoxification of Reactive Oxygen Species.
REACT_263468. Glutathione conjugation.

Names & Taxonomyi

Protein namesi
Recommended name:
Probable glutathione S-transferase 9 (EC:2.5.1.18)
Alternative name(s):
GST class-sigma
Gene namesi
Name:gst-9
ORF Names:R05F9.5
OrganismiCaenorhabditis elegans
Taxonomic identifieri6239 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaNematodaChromadoreaRhabditidaRhabditoideaRhabditidaePeloderinaeCaenorhabditis
ProteomesiUP000001940: Chromosome II

Organism-specific databases

WormBaseiR05F9.5; CE04807; WBGene00001757; gst-9.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 206206Probable glutathione S-transferase 9PRO_0000185932Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi6239.R05F9.5.

Structurei

3D structure databases

ProteinModelPortaliQ21743.
SMRiQ21743. Positions 1-204.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini2 – 7978GST N-terminalAdd
BLAST
Domaini81 – 206126GST C-terminalAdd
BLAST

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni50 – 512Glutathione bindingBy similarity
Regioni63 – 642Glutathione bindingBy similarity

Sequence similaritiesi

Belongs to the GST superfamily. Sigma family.Curated
Contains 1 GST C-terminal domain.Curated
Contains 1 GST N-terminal domain.Curated

Phylogenomic databases

eggNOGiNOG276829.
GeneTreeiENSGT00670000097856.
HOGENOMiHOG000115733.
InParanoidiQ21743.
OMAiLESAWID.
OrthoDBiEOG78WKT1.
PhylomeDBiQ21743.

Family and domain databases

Gene3Di1.20.1050.10. 1 hit.
3.40.30.10. 1 hit.
InterProiIPR010987. Glutathione-S-Trfase_C-like.
IPR004045. Glutathione_S-Trfase_N.
IPR004046. GST_C.
IPR012336. Thioredoxin-like_fold.
[Graphical view]
PfamiPF00043. GST_C. 1 hit.
PF02798. GST_N. 1 hit.
[Graphical view]
SUPFAMiSSF47616. SSF47616. 1 hit.
SSF52833. SSF52833. 1 hit.
PROSITEiPS50405. GST_CTER. 1 hit.
PS50404. GST_NTER. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q21743-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MVSYKLIYFQ SRGNGEIARQ VFAFAGQEFI DERISKEQWA EIKNMTPFGQ
60 70 80 90 100
VPVLEVDGRQ LAQSITIVRY LSKQFGISGK SSWEEAQVDA LGDQFKDYRV
110 120 130 140 150
EARPFFRAKM GFSDGDVDQL YKDLFVPAFN KMYSIFTESL KSSGSGFLVG
160 170 180 190 200
DSLTWMDLAI AQHSADLLEA DGKILDTFLE MKDHQKKIHS IPNVKKWIEK

RPVTSR
Length:206
Mass (Da):23,537
Last modified:November 1, 1996 - v1
Checksum:i3C4B2ADC081970D4
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
FO081120 Genomic DNA. Translation: CCD69273.1.
PIRiT16683.
T16685.
RefSeqiNP_001022266.1. NM_001027095.1.
UniGeneiCel.14654.

Genome annotation databases

EnsemblMetazoaiR05F9.5; R05F9.5; WBGene00001757.
GeneIDi187615.
KEGGicel:CELE_R05F9.5.
UCSCiR05F9.5. c. elegans.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
FO081120 Genomic DNA. Translation: CCD69273.1 .
PIRi T16683.
T16685.
RefSeqi NP_001022266.1. NM_001027095.1.
UniGenei Cel.14654.

3D structure databases

ProteinModelPortali Q21743.
SMRi Q21743. Positions 1-204.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 6239.R05F9.5.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblMetazoai R05F9.5 ; R05F9.5 ; WBGene00001757 .
GeneIDi 187615.
KEGGi cel:CELE_R05F9.5.
UCSCi R05F9.5. c. elegans.

Organism-specific databases

CTDi 187615.
WormBasei R05F9.5 ; CE04807 ; WBGene00001757 ; gst-9.

Phylogenomic databases

eggNOGi NOG276829.
GeneTreei ENSGT00670000097856.
HOGENOMi HOG000115733.
InParanoidi Q21743.
OMAi LESAWID.
OrthoDBi EOG78WKT1.
PhylomeDBi Q21743.

Enzyme and pathway databases

Reactomei REACT_184548. Detoxification of Reactive Oxygen Species.
REACT_263468. Glutathione conjugation.

Miscellaneous databases

NextBioi 935874.

Family and domain databases

Gene3Di 1.20.1050.10. 1 hit.
3.40.30.10. 1 hit.
InterProi IPR010987. Glutathione-S-Trfase_C-like.
IPR004045. Glutathione_S-Trfase_N.
IPR004046. GST_C.
IPR012336. Thioredoxin-like_fold.
[Graphical view ]
Pfami PF00043. GST_C. 1 hit.
PF02798. GST_N. 1 hit.
[Graphical view ]
SUPFAMi SSF47616. SSF47616. 1 hit.
SSF52833. SSF52833. 1 hit.
PROSITEi PS50405. GST_CTER. 1 hit.
PS50404. GST_NTER. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Genome sequence of the nematode C. elegans: a platform for investigating biology."
    The C. elegans sequencing consortium
    Science 282:2012-2018(1998) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: Bristol N2.

Entry informationi

Entry nameiGST9_CAEEL
AccessioniPrimary (citable) accession number: Q21743
Secondary accession number(s): Q21744
Entry historyi
Integrated into UniProtKB/Swiss-Prot: March 28, 2003
Last sequence update: November 1, 1996
Last modified: November 26, 2014
This is version 94 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programCaenorhabditis annotation project

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Caenorhabditis elegans
    Caenorhabditis elegans: entries, gene names and cross-references to WormBase
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3