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Protein
Submitted name:

AcetylCholine Receptor

Gene

acr-10

Organism
Caenorhabditis elegans
Status
Unreviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Ion channel, Ligand-gated ion channelSAAS annotation, ReceptorSAAS annotationImported

Keywords - Biological processi

Ion transport, Transport

Enzyme and pathway databases

ReactomeiR-CEL-629594. Highly calcium permeable postsynaptic nicotinic acetylcholine receptors.

Names & Taxonomyi

Protein namesi
Submitted name:
AcetylCholine ReceptorImported
Gene namesi
Name:acr-10Imported
ORF Names:CELE_R02E12.8Imported, R02E12.8Imported
OrganismiCaenorhabditis elegansImported
Taxonomic identifieri6239 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaNematodaChromadoreaRhabditidaRhabditoideaRhabditidaePeloderinaeCaenorhabditis
Proteomesi
  • UP000001940 Componenti: Chromosome X

Organism-specific databases

WormBaseiR02E12.8; CE48006; WBGene00000049; acr-10.

Subcellular locationi

  • Cell junctionsynapsepostsynaptic cell membrane SAAS annotation; Multi-pass membrane protein SAAS annotation
  • Cell membrane SAAS annotation; Multi-pass membrane protein SAAS annotation

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei242 – 26726HelicalSequence analysisAdd
BLAST
Transmembranei274 – 29219HelicalSequence analysisAdd
BLAST
Transmembranei304 – 32926HelicalSequence analysisAdd
BLAST
Transmembranei532 – 55120HelicalSequence analysisAdd
BLAST

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cell junction, Cell membraneSAAS annotation, Membrane, Postsynaptic cell membraneSAAS annotation, Synapse

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2323Sequence analysisAdd
BLAST
Chaini24 – 557534Sequence analysisPRO_5004199589Add
BLAST

Keywords - PTMi

Disulfide bondSAAS annotation

Proteomic databases

PRIDEiQ21645.

Structurei

3D structure databases

ProteinModelPortaliQ21645.
SMRiQ21645. Positions 24-332.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini28 – 241214Neur_chan_LBDInterPro annotationAdd
BLAST
Domaini248 – 544297Neur_chan_membInterPro annotationAdd
BLAST

Sequence similaritiesi

Belongs to the ligand-gated ion channel (TC 1.A.9) family. [View classification]UniRule annotationSAAS annotation

Keywords - Domaini

SignalSequence analysis, Transmembrane, Transmembrane helixSequence analysisSAAS annotation

Phylogenomic databases

GeneTreeiENSGT00790000122957.
HOGENOMiHOG000006756.
InParanoidiQ21645.
OMAiYNSASED.
OrthoDBiEOG72JWGV.

Family and domain databases

Gene3Di1.20.120.370. 2 hits.
2.70.170.10. 1 hit.
InterProiIPR027361. Acetylcholine_rcpt_TM.
IPR006202. Neur_chan_lig-bd.
IPR006201. Neur_channel.
IPR006029. Neurotrans-gated_channel_TM.
IPR018000. Neurotransmitter_ion_chnl_CS.
IPR002394. Nicotinic_acetylcholine_rcpt.
[Graphical view]
PANTHERiPTHR18945. PTHR18945. 2 hits.
PfamiPF02931. Neur_chan_LBD. 1 hit.
PF02932. Neur_chan_memb. 1 hit.
[Graphical view]
PRINTSiPR00254. NICOTINICR.
PR00252. NRIONCHANNEL.
SUPFAMiSSF63712. SSF63712. 1 hit.
SSF90112. SSF90112. 2 hits.
TIGRFAMsiTIGR00860. LIC. 1 hit.
PROSITEiPS00236. NEUROTR_ION_CHANNEL. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q21645-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MLIRFFVLCL FFILSLIIIE SECSKAENKL YRDILQGYLK LARPVRYPRN
60 70 80 90 100
VLKVHMKVFL QQILNLDGQN QIIEVNAWLK YVWMDYRLQW DPLQYDNITS
110 120 130 140 150
IRFAGGENQI WRPDILLYNS ASEDFDSSFK SNEVVYNTGE VNWIPPGIFR
160 170 180 190 200
ASCKMDITYF PFDDQVCYLK FGSWTYHGLA LDLSIIAEED DSELSIDLST
210 220 230 240 250
YTPSGEWHLT KAPAVKDVKY NSCCKEPYST VTFYMFLRRR TLFYLFNIIL
260 270 280 290 300
PSLLISIMTL MGFCLPAHDM SEKIGYQTTI LLSICFFVTI VSEMTPPTSE
310 320 330 340 350
SVPLLGMFFS SLTLISSVST AFTITVLNFR YRQVQNIHMH PIFYKVFLIW
360 370 380 390 400
IPWLLLMKRP GVFYKKRRAT VQAREEISFF DNGDDDCCPK PPEFDYSLSI
410 420 430 440 450
DSADTLPLPP RPKPLLKKMH SVPAEHLHLD RKVGDGILKS QRRPLVLTKN
460 470 480 490 500
VNKSHSLRSR RFTQFEKYIK KCIDDAKLRK NSTYSTYSMM IITYYRQIDE
510 520 530 540 550
MLKLLNRRLD KQRKYLFKQE DWKFAAMALD RLCLLLITLL IVMCLFGMIL

STPHFEP
Length:557
Mass (Da):65,262
Last modified:February 6, 2013 - v4
Checksum:i646405E88DF4ED52
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BX284606 Genomic DNA. Translation: CCD64659.2.
RefSeqiNP_508692.3. NM_076291.3.

Genome annotation databases

EnsemblMetazoaiR02E12.8; R02E12.8; WBGene00000049.
GeneIDi191598.
KEGGicel:CELE_R02E12.8.
UCSCiR02E12.8. c. elegans.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BX284606 Genomic DNA. Translation: CCD64659.2.
RefSeqiNP_508692.3. NM_076291.3.

3D structure databases

ProteinModelPortaliQ21645.
SMRiQ21645. Positions 24-332.
ModBaseiSearch...
MobiDBiSearch...

Proteomic databases

PRIDEiQ21645.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblMetazoaiR02E12.8; R02E12.8; WBGene00000049.
GeneIDi191598.
KEGGicel:CELE_R02E12.8.
UCSCiR02E12.8. c. elegans.

Organism-specific databases

CTDi191598.
WormBaseiR02E12.8; CE48006; WBGene00000049; acr-10.

Phylogenomic databases

GeneTreeiENSGT00790000122957.
HOGENOMiHOG000006756.
InParanoidiQ21645.
OMAiYNSASED.
OrthoDBiEOG72JWGV.

Enzyme and pathway databases

ReactomeiR-CEL-629594. Highly calcium permeable postsynaptic nicotinic acetylcholine receptors.

Family and domain databases

Gene3Di1.20.120.370. 2 hits.
2.70.170.10. 1 hit.
InterProiIPR027361. Acetylcholine_rcpt_TM.
IPR006202. Neur_chan_lig-bd.
IPR006201. Neur_channel.
IPR006029. Neurotrans-gated_channel_TM.
IPR018000. Neurotransmitter_ion_chnl_CS.
IPR002394. Nicotinic_acetylcholine_rcpt.
[Graphical view]
PANTHERiPTHR18945. PTHR18945. 2 hits.
PfamiPF02931. Neur_chan_LBD. 1 hit.
PF02932. Neur_chan_memb. 1 hit.
[Graphical view]
PRINTSiPR00254. NICOTINICR.
PR00252. NRIONCHANNEL.
SUPFAMiSSF63712. SSF63712. 1 hit.
SSF90112. SSF90112. 2 hits.
TIGRFAMsiTIGR00860. LIC. 1 hit.
PROSITEiPS00236. NEUROTR_ION_CHANNEL. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "Genome sequence of the nematode C. elegans: a platform for investigating biology."
    Caenorhabditis elegans Sequencing Consortium
    Sulson J.E., Waterston R.
    Science 282:2012-2018(1998) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: Bristol N2Imported.

Entry informationi

Entry nameiQ21645_CAEEL
AccessioniPrimary (citable) accession number: Q21645
Entry historyi
Integrated into UniProtKB/TrEMBL: November 1, 1996
Last sequence update: February 6, 2013
Last modified: July 6, 2016
This is version 136 of the entry and version 4 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.