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Q215D6

- LPXB_RHOPB

UniProt

Q215D6 - LPXB_RHOPB

Protein

Lipid-A-disaccharide synthase

Gene

lpxB

Organism
Rhodopseudomonas palustris (strain BisB18)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi
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    • History
      Entry version 48 (01 Oct 2014)
      Sequence version 1 (18 Apr 2006)
      Previous versions | rss
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    Functioni

    Condensation of UDP-2,3-diacylglucosamine and 2,3-diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell.UniRule annotation

    Catalytic activityi

    UDP-2,3-bis(3-hydroxytetradecanoyl)glucosamine + 2,3-bis(3-hydroxytetradecanoyl)-beta-D-glucosaminyl 1-phosphate = UDP + 2,3-bis(3-hydroxytetradecanoyl)-D-glucosaminyl-1,6-beta-D-2,3-bis(3-hydroxytetradecanoyl)-beta-D-glucosaminyl 1-phosphate.UniRule annotation

    Pathwayi

    GO - Molecular functioni

    1. lipid-A-disaccharide synthase activity Source: UniProtKB-EC

    GO - Biological processi

    1. lipid A biosynthetic process Source: UniProtKB-KW

    Keywords - Molecular functioni

    Glycosyltransferase, Transferase

    Keywords - Biological processi

    Lipid A biosynthesis, Lipid biosynthesis, Lipid metabolism

    Enzyme and pathway databases

    BioCyciRPAL316056:GH3E-2478-MONOMER.
    UniPathwayiUPA00359; UER00481.

    Protein family/group databases

    CAZyiGT19. Glycosyltransferase Family 19.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Lipid-A-disaccharide synthaseUniRule annotation (EC:2.4.1.182UniRule annotation)
    Gene namesi
    Name:lpxBUniRule annotation
    Ordered Locus Names:RPC_2449
    OrganismiRhodopseudomonas palustris (strain BisB18)
    Taxonomic identifieri316056 [NCBI]
    Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaRhizobialesBradyrhizobiaceaeRhodopseudomonas
    ProteomesiUP000001948: Chromosome

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 396396Lipid-A-disaccharide synthasePRO_0000255215Add
    BLAST

    Proteomic databases

    PRIDEiQ215D6.

    Interactioni

    Protein-protein interaction databases

    STRINGi316056.RPC_2449.

    Structurei

    3D structure databases

    ProteinModelPortaliQ215D6.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the LpxB family.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG0763.
    HOGENOMiHOG000018004.
    KOiK00748.
    OMAiRRSEIRH.
    OrthoDBiEOG6FBWZR.

    Family and domain databases

    HAMAPiMF_00392. LpxB.
    InterProiIPR003835. Glyco_trans_19.
    [Graphical view]
    PfamiPF02684. LpxB. 1 hit.
    [Graphical view]
    TIGRFAMsiTIGR00215. lpxB. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    Q215D6-1 [UniParc]FASTAAdd to Basket

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    MTAVATHAVR KIFLIATEES GDRLGASLMR ELRDRLGAAV RFEGVGGRAM    50
    AREGLTSLFP IEELSIIGLS AVARRLPTIL RHIRTAAHAA LQAAPDVLVI 100
    IDSPDFTHRV ARRVRARDPS IPIVNYVSPT VWAWRPGRAK VMRKYVDHVL 150
    ALLPFEPDEY RRLQGPPCSY VGHPLTEQIA TLRPNPEEQL RRDAAPPVLL 200
    VLPGSRRSEI RHHMAVFGEA LGLLQAQGVA FELILPTMPH LEALIAEALK 250
    HWPLQPRVVV GENDKRAAFR IARAALAKSG TVTLELAVAG VPMVTAYRAG 300
    QLEAWIVRRR ITSASVILAN LVVGENVAPE YLQEECTAPT LAAALRDVLA 350
    DSPLRQRQLA AFGRIDAIMS TGAQSPSACA ADIVLGLLPA AAPALR 396
    Length:396
    Mass (Da):43,002
    Last modified:April 18, 2006 - v1
    Checksum:i1301C262E03031FB
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000301 Genomic DNA. Translation: ABD88000.1.
    RefSeqiYP_532319.1. NC_007925.1.

    Genome annotation databases

    EnsemblBacteriaiABD88000; ABD88000; RPC_2449.
    GeneIDi3971379.
    KEGGirpc:RPC_2449.
    PATRICi23269634. VBIRhoPal29154_2513.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000301 Genomic DNA. Translation: ABD88000.1 .
    RefSeqi YP_532319.1. NC_007925.1.

    3D structure databases

    ProteinModelPortali Q215D6.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 316056.RPC_2449.

    Protein family/group databases

    CAZyi GT19. Glycosyltransferase Family 19.

    Proteomic databases

    PRIDEi Q215D6.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai ABD88000 ; ABD88000 ; RPC_2449 .
    GeneIDi 3971379.
    KEGGi rpc:RPC_2449.
    PATRICi 23269634. VBIRhoPal29154_2513.

    Phylogenomic databases

    eggNOGi COG0763.
    HOGENOMi HOG000018004.
    KOi K00748.
    OMAi RRSEIRH.
    OrthoDBi EOG6FBWZR.

    Enzyme and pathway databases

    UniPathwayi UPA00359 ; UER00481 .
    BioCyci RPAL316056:GH3E-2478-MONOMER.

    Family and domain databases

    HAMAPi MF_00392. LpxB.
    InterProi IPR003835. Glyco_trans_19.
    [Graphical view ]
    Pfami PF02684. LpxB. 1 hit.
    [Graphical view ]
    TIGRFAMsi TIGR00215. lpxB. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: BisB18.

    Entry informationi

    Entry nameiLPXB_RHOPB
    AccessioniPrimary (citable) accession number: Q215D6
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: October 31, 2006
    Last sequence update: April 18, 2006
    Last modified: October 1, 2014
    This is version 48 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3