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Q215D6

- LPXB_RHOPB

UniProt

Q215D6 - LPXB_RHOPB

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Protein

Lipid-A-disaccharide synthase

Gene
lpxB, RPC_2449
Organism
Rhodopseudomonas palustris (strain BisB18)
Status
Reviewed - Annotation score: 2 out of 5 - Protein inferred from homologyi

Functioni

Condensation of UDP-2,3-diacylglucosamine and 2,3-diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell By similarity.UniRule annotation

Catalytic activityi

UDP-2,3-bis(3-hydroxytetradecanoyl)glucosamine + 2,3-bis(3-hydroxytetradecanoyl)-beta-D-glucosaminyl 1-phosphate = UDP + 2,3-bis(3-hydroxytetradecanoyl)-D-glucosaminyl-1,6-beta-D-2,3-bis(3-hydroxytetradecanoyl)-beta-D-glucosaminyl 1-phosphate.UniRule annotation

Pathwayi

GO - Molecular functioni

  1. lipid-A-disaccharide synthase activity Source: UniProtKB-EC

GO - Biological processi

  1. lipid A biosynthetic process Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Glycosyltransferase, Transferase

Keywords - Biological processi

Lipid A biosynthesis, Lipid biosynthesis, Lipid metabolism

Enzyme and pathway databases

BioCyciRPAL316056:GH3E-2478-MONOMER.
UniPathwayiUPA00359; UER00481.

Protein family/group databases

CAZyiGT19. Glycosyltransferase Family 19.

Names & Taxonomyi

Protein namesi
Recommended name:
Lipid-A-disaccharide synthase (EC:2.4.1.182)
Gene namesi
Name:lpxB
Ordered Locus Names:RPC_2449
OrganismiRhodopseudomonas palustris (strain BisB18)
Taxonomic identifieri316056 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaRhizobialesBradyrhizobiaceaeRhodopseudomonas
ProteomesiUP000001948: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 396396Lipid-A-disaccharide synthaseUniRule annotationPRO_0000255215Add
BLAST

Proteomic databases

PRIDEiQ215D6.

Interactioni

Protein-protein interaction databases

STRINGi316056.RPC_2449.

Structurei

3D structure databases

ProteinModelPortaliQ215D6.

Family & Domainsi

Sequence similaritiesi

Belongs to the LpxB family.

Phylogenomic databases

eggNOGiCOG0763.
HOGENOMiHOG000018004.
KOiK00748.
OMAiRRSEIRH.
OrthoDBiEOG6FBWZR.

Family and domain databases

HAMAPiMF_00392. LpxB.
InterProiIPR003835. Glyco_trans_19.
[Graphical view]
PfamiPF02684. LpxB. 1 hit.
[Graphical view]
TIGRFAMsiTIGR00215. lpxB. 1 hit.

Sequencei

Sequence statusi: Complete.

Q215D6-1 [UniParc]FASTAAdd to Basket

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MTAVATHAVR KIFLIATEES GDRLGASLMR ELRDRLGAAV RFEGVGGRAM    50
AREGLTSLFP IEELSIIGLS AVARRLPTIL RHIRTAAHAA LQAAPDVLVI 100
IDSPDFTHRV ARRVRARDPS IPIVNYVSPT VWAWRPGRAK VMRKYVDHVL 150
ALLPFEPDEY RRLQGPPCSY VGHPLTEQIA TLRPNPEEQL RRDAAPPVLL 200
VLPGSRRSEI RHHMAVFGEA LGLLQAQGVA FELILPTMPH LEALIAEALK 250
HWPLQPRVVV GENDKRAAFR IARAALAKSG TVTLELAVAG VPMVTAYRAG 300
QLEAWIVRRR ITSASVILAN LVVGENVAPE YLQEECTAPT LAAALRDVLA 350
DSPLRQRQLA AFGRIDAIMS TGAQSPSACA ADIVLGLLPA AAPALR 396
Length:396
Mass (Da):43,002
Last modified:April 18, 2006 - v1
Checksum:i1301C262E03031FB
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000301 Genomic DNA. Translation: ABD88000.1.
RefSeqiYP_532319.1. NC_007925.1.

Genome annotation databases

EnsemblBacteriaiABD88000; ABD88000; RPC_2449.
GeneIDi3971379.
KEGGirpc:RPC_2449.
PATRICi23269634. VBIRhoPal29154_2513.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000301 Genomic DNA. Translation: ABD88000.1 .
RefSeqi YP_532319.1. NC_007925.1.

3D structure databases

ProteinModelPortali Q215D6.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 316056.RPC_2449.

Protein family/group databases

CAZyi GT19. Glycosyltransferase Family 19.

Proteomic databases

PRIDEi Q215D6.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai ABD88000 ; ABD88000 ; RPC_2449 .
GeneIDi 3971379.
KEGGi rpc:RPC_2449.
PATRICi 23269634. VBIRhoPal29154_2513.

Phylogenomic databases

eggNOGi COG0763.
HOGENOMi HOG000018004.
KOi K00748.
OMAi RRSEIRH.
OrthoDBi EOG6FBWZR.

Enzyme and pathway databases

UniPathwayi UPA00359 ; UER00481 .
BioCyci RPAL316056:GH3E-2478-MONOMER.

Family and domain databases

HAMAPi MF_00392. LpxB.
InterProi IPR003835. Glyco_trans_19.
[Graphical view ]
Pfami PF02684. LpxB. 1 hit.
[Graphical view ]
TIGRFAMsi TIGR00215. lpxB. 1 hit.
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: BisB18.

Entry informationi

Entry nameiLPXB_RHOPB
AccessioniPrimary (citable) accession number: Q215D6
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 31, 2006
Last sequence update: April 18, 2006
Last modified: May 14, 2014
This is version 47 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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