Q21565 (AMT3_CAEEL) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Putative ammonium transporter 3

Gene names

Name:	amt-3
ORF Names:	M195.3

Organism

Caenorhabditis elegans

Taxonomic identifier

6239 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Nematoda › Chromadorea › Rhabditida › Rhabditoidea › Rhabditidae › Peloderinae › Caenorhabditis

Protein attributes

Sequence length	687 AA.
Sequence status	Complete.
Protein existence	Evidence at transcript level

General annotation (Comments)

Function	Involved in the uptake of ammonia Probable.
Subcellular location	Membrane; Multi-pass membrane protein Probable.
Sequence similarities	Belongs to the ammonia transporter channel (TC 1.A.11.2) family. [View classification]

Ontologies

Keywords
Biological process	Ammonia transport Transport
Cellular component	Membrane
Domain	Transmembrane Transmembrane helix
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Cellular component	integral to membrane Inferred from electronic annotation. Source: UniProtKB-KW
Molecular function	ammonium transmembrane transporter activity Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 687	687	Putative ammonium transporter 3		PRO_0000139753
Regions
	Transmembrane	39 – 59	21	Helical; Potential
	Transmembrane	77 – 97	21	Helical; Potential
	Transmembrane	134 – 154	21	Helical; Potential
	Transmembrane	162 – 182	21	Helical; Potential
	Transmembrane	196 – 216	21	Helical; Potential
	Transmembrane	240 – 260	21	Helical; Potential
	Transmembrane	272 – 292	21	Helical; Potential
	Transmembrane	299 – 319	21	Helical; Potential
	Transmembrane	323 – 343	21	Helical; Potential
	Transmembrane	352 – 372	21	Helical; Potential
	Transmembrane	404 – 424	21	Helical; Potential

Sequences

	Sequence		Length	Mass (Da)
	Q21565 [UniParc]. Last modified April 11, 2003. Version 2. Checksum: 90EA97A928918E01	FASTA	687	73,938
	10 20 30 40 50 60 MAGPEGSIFN ASAMQIVQIH HYAEGSVTPE VDKLYQDDAV WIISSSFIIF TMHSGFGLLE 70 80 90 100 110 120 SGSVSAKDEV NIMVKNVVDV VFGGLSYWSC GFGFSYGDIP EWRNPYVGFG KFFYDPTRDY 130 140 150 160 170 180 GTRETINQEG WSYASFLFQL SLATTASTIV SGAVAERAKL KSYILLGCIV ILIQALPAHW 190 200 210 220 230 240 VWDKEGVFYK KGVVDFAGCS AVHLVGGIIG LIATVFLKPR RNRFNEDSVH QMSSPTNALL 250 260 270 280 290 300 GTFLLWWGWF GINAGSVWGI TGGRWRLGAR AAVATIMASI GGGATAITIS FVKTKKLQVN 310 320 330 340 350 360 FLINGILSSI VSITAICAVS RPWHALVIGS ISSVFSIAVL PLLDRLHIDD PVGIVPIHLT 370 380 390 400 410 420 SSIWGMIAVG IFCEEDKYLG SATNNRSGLL YSWSFELLWV QLQCTAAILI YSATTGFLAL 430 440 450 460 470 480 FLISKSPLGL RVTDYEEQIG ADVIEHGLAG TNVARYVLEK PLSTRTFQTV TKAITKWKML 490 500 510 520 530 540 AKKKSRQKRM EAAKLKRQEE QETFTNGTAI ANGNGNVLHH RTNATESNGT GAPKRSNGPA 550 560 570 580 590 600 FNNQITPLAV SSTVSTARNG PSTGRRTEST AIEIEQPIEA VPPEVVAAAV LPPEERPGPS 610 620 630 640 650 660 TNSNVSIEAS VEKSPSSSTS RRSISIRSSP SIHTVSAIST AAPDSRPSTA SATSIISKKS 670 680 SKNSTVGKFV KAPAPRALSP PDNNPPV

References

[1]	"Genome sequence of the nematode C. elegans: a platform for investigating biology." The C. elegans sequencing consortium Science 282:2012-2018(1998) [PubMed: 9851916] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: Bristol N2.

Cross-references

Sequence databases
EMBL GenBank DDBJ	Z66498 Genomic DNA. Translation: CAA91293.2.
PIR	T23804.
RefSeq	NP_495761.2. NM_063360.5.
UniGene	Cel.5140.
3D structure databases
ProteinModelPortal	Q21565.
SMR	Q21565. Positions 34-452.
ModBase	Search...
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
EnsemblMetazoa	M195.3; M195.3; M195.3.
GeneID	174338.
KEGG	cel:M195.3.
UCSC	M195.3. c. elegans.
Organism-specific databases
CTD	174338.
WormBase	M195.3; CE32912; WBGene00000135; amt-3.
Phylogenomic databases
eggNOG	meNOG07036.
GeneTree	EMGT00050000009536.
HOGENOM	HBG677626.
InParanoid	Q21565.
OMA	WHALVIG.
PhylomeDB	Q21565.
Gene expression databases
ArrayExpress	Q21565.
Family and domain databases
InterPro	IPR001905. Ammonium_transpt. IPR018047. Ammonium_transpt_CS. IPR024041. NH4_transpt_AmtB-like. [Graphical view]
Gene3D	G3DSA:1.10.3430.10. G3DSA:1.10.3430.10. 1 hit.
PANTHER	PTHR11730. Ammonium_transpt. 1 hit.
Pfam	PF00909. Ammonium_transp. 1 hit. [Graphical view]
SUPFAM	SSF111352. RH_like_transpt. 1 hit.
TIGRFAMs	TIGR00836. Amt. 1 hit.
PROSITE	PS01219. AMMONIUM_TRANSP. 1 hit. [Graphical view]
ProtoNet	Search...
Other
NextBio	883614.

Entry information

Entry name

AMT3_CAEEL

Accession

Primary (citable) accession number: Q21565

Entry history

Integrated into UniProtKB/Swiss-Prot:	July 15, 1998
Last sequence update:	April 11, 2003
Last modified:	September 21, 2011
This is version 69 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Caenorhabditis annotation project