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Protein
Submitted name:

AQuaPorin or aquaglyceroporin related

Gene

aqp-7

Organism
Caenorhabditis elegans
Status
Unreviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

GO - Molecular functioni

  • glycerol channel activity Source: GO_Central
  • substrate-specific channel activity Source: WormBase
  • urea transmembrane transporter activity Source: GO_Central
  • water channel activity Source: WormBase

GO - Biological processi

  • cellular water homeostasis Source: GO_Central
  • glycerol transport Source: WormBase
  • ion transmembrane transport Source: GO_Central
  • urea transmembrane transport Source: GO_Central
  • water transport Source: WormBase
Complete GO annotation...

Keywords - Biological processi

TransportUniRule annotation

Enzyme and pathway databases

ReactomeiR-CEL-432030. Transport of glycerol from adipocytes to the liver by Aquaporins.
R-CEL-432040. Vasopressin regulates renal water homeostasis via Aquaporins.
R-CEL-432047. Passive transport by Aquaporins.

Names & Taxonomyi

Protein namesi
Submitted name:
AQuaPorin or aquaglyceroporin relatedImported
Gene namesi
Name:aqp-7Imported
ORF Names:CELE_M02F4.8Imported, M02F4.8Imported
OrganismiCaenorhabditis elegansImported
Taxonomic identifieri6239 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaNematodaChromadoreaRhabditidaRhabditoideaRhabditidaePeloderinaeCaenorhabditis
Proteomesi
  • UP000001940 Componenti: Chromosome X

Organism-specific databases

WormBaseiM02F4.8; CE34058; WBGene00000175; aqp-7.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei21 – 4727HelicalSequence analysisAdd
BLAST
Transmembranei53 – 7220HelicalSequence analysisAdd
BLAST
Transmembranei101 – 12424HelicalSequence analysisAdd
BLAST
Transmembranei160 – 17920HelicalSequence analysisAdd
BLAST
Transmembranei191 – 21323HelicalSequence analysisAdd
BLAST
Transmembranei239 – 26224HelicalSequence analysisAdd
BLAST

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Membrane

PTM / Processingi

Proteomic databases

EPDiQ21473.
PaxDbiQ21473.

Interactioni

Protein-protein interaction databases

STRINGi6239.M02F4.8.1.

Structurei

3D structure databases

ProteinModelPortaliQ21473.
SMRiQ21473. Positions 22-253.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the MIP/aquaporin (TC 1.A.8) family. [View classification]UniRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helixSequence analysis

Phylogenomic databases

eggNOGiKOG0224. Eukaryota.
COG0580. LUCA.
GeneTreeiENSGT00510000046311.
HOGENOMiHOG000288287.
InParanoidiQ21473.
KOiK09886.
OMAiNTWININ.
PhylomeDBiQ21473.

Family and domain databases

Gene3Di1.20.1080.10. 1 hit.
InterProiIPR023271. Aquaporin-like.
IPR000425. MIP.
IPR022357. MIP_CS.
[Graphical view]
PANTHERiPTHR19139. PTHR19139. 1 hit.
PfamiPF00230. MIP. 1 hit.
[Graphical view]
PRINTSiPR00783. MINTRINSICP.
SUPFAMiSSF81338. SSF81338. 1 hit.
TIGRFAMsiTIGR00861. MIP. 1 hit.
PROSITEiPS00221. MIP. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q21473-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAAELERTEQ VRAKIQIKNP LLRNALSEFF GTFLLLFIGI GIVMQFILSN
60 70 80 90 100
EKLNTWININ LGWGLAIAFT VYTCSKTSGG HFNPAVSIAF LTLGKLPFKD
110 120 130 140 150
FLVYCVVQTI GAALGSAAAF GLYYDQFVKF AGAYRTILGP KATAGCFCSY
160 170 180 190 200
PALHVSNTTA FFDQFAGTAL LVLFVCVVID KRNGIPGAAH PLLFGLVVMM
210 220 230 240 250
IGTAYGMNLG YPINPARDLG PRLFSFFIYG SGVFSYHSYY FWIPVIAPLF
260 270 280 290
GAIFGAWSYT FFVGAHIPDQ RETTYVLVDE ANQPLKLATD A
Length:291
Mass (Da):31,882
Last modified:June 1, 2003 - v2
Checksum:i9295807A43E5CBBE
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BX284606 Genomic DNA. Translation: CCD66489.1.
PIRiT16635.
RefSeqiNP_508515.2. NM_076114.4.
UniGeneiCel.6245.

Genome annotation databases

EnsemblMetazoaiM02F4.8.1; M02F4.8.1; WBGene00000175.
M02F4.8.2; M02F4.8.2; WBGene00000175.
GeneIDi180589.
KEGGicel:CELE_M02F4.8.
UCSCiM02F4.8.2. c. elegans.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BX284606 Genomic DNA. Translation: CCD66489.1.
PIRiT16635.
RefSeqiNP_508515.2. NM_076114.4.
UniGeneiCel.6245.

3D structure databases

ProteinModelPortaliQ21473.
SMRiQ21473. Positions 22-253.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi6239.M02F4.8.1.

Proteomic databases

EPDiQ21473.
PaxDbiQ21473.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblMetazoaiM02F4.8.1; M02F4.8.1; WBGene00000175.
M02F4.8.2; M02F4.8.2; WBGene00000175.
GeneIDi180589.
KEGGicel:CELE_M02F4.8.
UCSCiM02F4.8.2. c. elegans.

Organism-specific databases

CTDi180589.
WormBaseiM02F4.8; CE34058; WBGene00000175; aqp-7.

Phylogenomic databases

eggNOGiKOG0224. Eukaryota.
COG0580. LUCA.
GeneTreeiENSGT00510000046311.
HOGENOMiHOG000288287.
InParanoidiQ21473.
KOiK09886.
OMAiNTWININ.
PhylomeDBiQ21473.

Enzyme and pathway databases

ReactomeiR-CEL-432030. Transport of glycerol from adipocytes to the liver by Aquaporins.
R-CEL-432040. Vasopressin regulates renal water homeostasis via Aquaporins.
R-CEL-432047. Passive transport by Aquaporins.

Miscellaneous databases

PROiQ21473.

Family and domain databases

Gene3Di1.20.1080.10. 1 hit.
InterProiIPR023271. Aquaporin-like.
IPR000425. MIP.
IPR022357. MIP_CS.
[Graphical view]
PANTHERiPTHR19139. PTHR19139. 1 hit.
PfamiPF00230. MIP. 1 hit.
[Graphical view]
PRINTSiPR00783. MINTRINSICP.
SUPFAMiSSF81338. SSF81338. 1 hit.
TIGRFAMsiTIGR00861. MIP. 1 hit.
PROSITEiPS00221. MIP. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "Genome sequence of the nematode C. elegans: a platform for investigating biology."
    Caenorhabditis elegans Sequencing Consortium
    Sulson J.E., Waterston R.
    Science 282:2012-2018(1998) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: Bristol N2Imported.

Entry informationi

Entry nameiQ21473_CAEEL
AccessioniPrimary (citable) accession number: Q21473
Entry historyi
Integrated into UniProtKB/TrEMBL: November 1, 1996
Last sequence update: June 1, 2003
Last modified: July 6, 2016
This is version 130 of the entry and version 2 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Proteomics identificationCombined sources, Reference proteomeImported

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.