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Protein
Submitted name:

TWiK family of potassium channels

Gene

twk-26

Organism
Caenorhabditis elegans
Status
Unreviewed-Annotation score: Annotation score: 1 out of 5-Protein inferred from homologyi

Functioni

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Ion channelUniRule annotationSAAS annotationImported

Keywords - Biological processi

Ion transport, Transport

Enzyme and pathway databases

ReactomeiR-CEL-1299344. TWIK-related spinal cord K+ channel (TRESK).

Names & Taxonomyi

Protein namesi
Submitted name:
TWiK family of potassium channelsImported
Gene namesi
Name:twk-26Imported
ORF Names:C33D12.3Imported, CELE_C33D12.3Imported
OrganismiCaenorhabditis elegansImported
Taxonomic identifieri6239 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaNematodaChromadoreaRhabditidaRhabditoideaRhabditidaePeloderinaeCaenorhabditis
Proteomesi
  • UP000001940 Componenti: Chromosome X

Organism-specific databases

WormBaseiC33D12.3; CE04766; WBGene00006679; twk-26.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei87 – 104HelicalSequence analysisAdd BLAST18
Transmembranei183 – 204HelicalSequence analysisAdd BLAST22
Transmembranei211 – 232HelicalSequence analysisAdd BLAST22
Transmembranei269 – 291HelicalSequence analysisAdd BLAST23
Transmembranei303 – 323HelicalSequence analysisAdd BLAST21
Transmembranei335 – 356HelicalSequence analysisAdd BLAST22

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Membrane

PTM / Processingi

Proteomic databases

PaxDbiQ21467.

Expressioni

Gene expression databases

BgeeiWBGene00006679.

Interactioni

Protein-protein interaction databases

STRINGi6239.C33D12.3.

Structurei

3D structure databases

ProteinModelPortaliQ21467.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini184 – 240Ion_trans_2InterPro annotationAdd BLAST57
Domaini279 – 354Ion_trans_2InterPro annotationAdd BLAST76

Sequence similaritiesi

Belongs to the two pore domain potassium channel (TC 1.A.1.8) family. [View classification]UniRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helixSequence analysisSAAS annotation

Phylogenomic databases

eggNOGiKOG1418. Eukaryota.
COG1226. LUCA.
GeneTreeiENSGT00700000104522.
HOGENOMiHOG000020179.
InParanoidiQ21467.
KOiK05323.
OMAiTERNNCI.
OrthoDBiEOG091G06KM.
PhylomeDBiQ21467.

Family and domain databases

InterProiIPR003280. 2pore_dom_K_chnl.
IPR003092. 2pore_dom_K_chnl_TASK.
IPR013099. K_chnl_dom.
[Graphical view]
PfamiPF07885. Ion_trans_2. 2 hits.
[Graphical view]
PRINTSiPR01333. 2POREKCHANEL.
PR01095. TASKCHANNEL.

Sequencei

Sequence statusi: Complete.

Q21467-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MDVAIKESEI QARSRIIKNH LTERNNCIVL KIDTHMSKVE DMSPFGFHFE
60 70 80 90 100
FDEKKYKERK KQIRKQKITR FFAWLAYYHH KFGIRHVTLI ALLVGYVFLG
110 120 130 140 150
GFMFEKLESP RELEDLKETI VLMQGIIDEE TTDIINVTLS TNGTDRVNKL
160 170 180 190 200
AKLIKRYYKT MLEAEGRFHG SVWHKAENLD MHLMWYFSSA TFYSMTLFST
210 220 230 240 250
IGYGTISCQT VWGRTLSMIY ASIGLPIMLV VLGDIGEWFQ KILTNGYIFL
260 270 280 290 300
LLKYKKLRKQ PVNRKKNEIL LPMWLALFLV LAYILICTLT IKMFDHNEGN
310 320 330 340 350
KPGIGFFDAF YFTFISLTTI GLGDVMPYNI QYSPFLAAAF LLGLALISIV
360 370 380 390 400
NTSIYAQLYQ MFFNMINSVE DQLDRIHSSN HKGPGYKVFH DMEPVFRMLV
410 420 430 440 450
CTFPPSHPQT RIKFAAVVRD SFRRDKEKKR ESNTSDQIKL RTRTESDIPA
460 470 480 490 500
HDGFHLWMTK RAKKRQMEQE NEDLHAARRR APTLGAFGGF DMNLFKRGRS
510
NTSPFEKNDS EETEESDVE
Length:519
Mass (Da):60,447
Last modified:May 24, 2005 - v3
Checksum:i5B67830C211B6A6F
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BX284606 Genomic DNA. Translation: CCD66472.1.
PIRiT43529.
RefSeqiNP_508522.2. NM_076121.5.
UniGeneiCel.239.

Genome annotation databases

EnsemblMetazoaiC33D12.3; C33D12.3; WBGene00006679.
GeneIDi180592.
KEGGicel:CELE_C33D12.3.
UCSCiC33D12.3. c. elegans.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BX284606 Genomic DNA. Translation: CCD66472.1.
PIRiT43529.
RefSeqiNP_508522.2. NM_076121.5.
UniGeneiCel.239.

3D structure databases

ProteinModelPortaliQ21467.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi6239.C33D12.3.

Proteomic databases

PaxDbiQ21467.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblMetazoaiC33D12.3; C33D12.3; WBGene00006679.
GeneIDi180592.
KEGGicel:CELE_C33D12.3.
UCSCiC33D12.3. c. elegans.

Organism-specific databases

CTDi180592.
WormBaseiC33D12.3; CE04766; WBGene00006679; twk-26.

Phylogenomic databases

eggNOGiKOG1418. Eukaryota.
COG1226. LUCA.
GeneTreeiENSGT00700000104522.
HOGENOMiHOG000020179.
InParanoidiQ21467.
KOiK05323.
OMAiTERNNCI.
OrthoDBiEOG091G06KM.
PhylomeDBiQ21467.

Enzyme and pathway databases

ReactomeiR-CEL-1299344. TWIK-related spinal cord K+ channel (TRESK).

Gene expression databases

BgeeiWBGene00006679.

Family and domain databases

InterProiIPR003280. 2pore_dom_K_chnl.
IPR003092. 2pore_dom_K_chnl_TASK.
IPR013099. K_chnl_dom.
[Graphical view]
PfamiPF07885. Ion_trans_2. 2 hits.
[Graphical view]
PRINTSiPR01333. 2POREKCHANEL.
PR01095. TASKCHANNEL.
ProtoNetiSearch...

Entry informationi

Entry nameiQ21467_CAEEL
AccessioniPrimary (citable) accession number: Q21467
Secondary accession number(s): Q22905, Q9TZP7
Entry historyi
Integrated into UniProtKB/TrEMBL: November 1, 1996
Last sequence update: May 24, 2005
Last modified: November 30, 2016
This is version 123 of the entry and version 3 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.