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Protein

Zinc metalloproteinase nas-11

Gene

nas-11

Organism
Caenorhabditis elegans
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Metalloprotease.By similarity

Cofactori

Zn2+By similarityNote: Binds 1 zinc ion per subunit.By similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi430Zinc; catalyticBy similarity1
Active sitei431By similarity1
Metal bindingi434Zinc; catalyticBy similarity1
Metal bindingi440Zinc; catalyticBy similarity1

GO - Molecular functioni

Keywordsi

Molecular functionHydrolase, Metalloprotease, Protease
LigandMetal-binding, Zinc

Protein family/group databases

MEROPSiM12.A36

Names & Taxonomyi

Protein namesi
Recommended name:
Zinc metalloproteinase nas-11 (EC:3.4.24.-By similarity)
Alternative name(s):
Nematode astacin 11
Gene namesi
Name:nas-11
ORF Names:K11G12.1
OrganismiCaenorhabditis elegans
Taxonomic identifieri6239 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaNematodaChromadoreaRhabditidaRhabditoideaRhabditidaePeloderinaeCaenorhabditis
Proteomesi

Organism-specific databases

WormBaseiK11G12.1a ; CE36313 ; WBGene00003530 ; nas-11
K11G12.1b ; CE37260 ; WBGene00003530 ; nas-11

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Secreted

Pathology & Biotechi

Disruption phenotypei

Defects lead to retarded growth.1 Publication

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 17Sequence analysisAdd BLAST17
PropeptideiPRO_000044265818 – 328By similarityAdd BLAST311
ChainiPRO_0000028915329 – 579Zinc metalloproteinase nas-11Add BLAST251

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi256N-linked (GlcNAc...) asparagine1 Publication1
Glycosylationi454N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi539 ↔ 575PROSITE-ProRule annotation
Disulfide bondi546 ↔ 568PROSITE-ProRule annotation
Disulfide bondi555 ↔ 572PROSITE-ProRule annotation

Keywords - PTMi

Cleavage on pair of basic residues, Disulfide bond, Glycoprotein, Zymogen

Proteomic databases

EPDiQ21432
PaxDbiQ21432
PeptideAtlasiQ21432
PRIDEiQ21432

PTM databases

iPTMnetiQ21432

Expressioni

Tissue specificityi

Expressed in the anterior part of the intestine, CEP neurons and to a lesser extent in hypodermis.1 Publication

Gene expression databases

BgeeiWBGene00003530

Interactioni

Protein-protein interaction databases

BioGridi45867, 1 interactor
DIPiDIP-24488N
STRINGi6239.K11G12.1a

Structurei

3D structure databases

ProteinModelPortaliQ21432
SMRiQ21432
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini539 – 575ShKTPROSITE-ProRule annotationAdd BLAST37

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi301 – 311Poly-AspAdd BLAST11

Sequence similaritiesi

Belongs to the peptidase M12A family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiKOG3714 Eukaryota
ENOG410ZPX7 LUCA
GeneTreeiENSGT00760000119227
HOGENOMiHOG000018720
InParanoidiQ21432
OMAiFITINWS
OrthoDBiEOG091G05O5
PhylomeDBiQ21432

Family and domain databases

CDDicd04280 ZnMc_astacin_like, 1 hit
Gene3Di3.40.390.10, 1 hit
InterProiView protein in InterPro
IPR034035 Astacin-like_dom
IPR024079 MetalloPept_cat_dom_sf
IPR001506 Peptidase_M12A
IPR017368 Peptidase_M12A_astacin-9/10/11
IPR006026 Peptidase_Metallo
IPR003582 ShKT_dom
PfamiView protein in Pfam
PF01400 Astacin, 1 hit
PF01549 ShK, 1 hit
PIRSFiPIRSF038055 Nas9/Nas10/Nas11, 1 hit
PRINTSiPR00480 ASTACIN
SMARTiView protein in SMART
SM00254 ShKT, 1 hit
SM00235 ZnMc, 1 hit
PROSITEiView protein in PROSITE
PS51670 SHKT, 1 hit

Sequences (2)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform a (identifier: Q21432-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MTPSLVFLIV VIVVVEGQGW RPWDRFNHPG NFGNWGGNNW GTRQRNQEPH
60 70 80 90 100
DIPPPVPPPG FRGNNDRFGG NIIKVVEIID LGKSKNRGDI LSDFKDVHKK
110 120 130 140 150
HRHLGRKEWK GKVKQFCHRF PGHPNCRRGK VPDQKELEEM IGQFSKGGIG
160 170 180 190 200
RFLKRVPKIY IEDPLARVDP KLKGFLENAG RGFGHVSSEH VNKLRDICKR
210 220 230 240 250
RKCREQPESA KKTRELFTQK LADFETKIAG KDKTDSVQLR FDRTLQIKEA
260 270 280 290 300
LLEKGNLTAD IVPVDNGVYD LDTMLTEEQA NILLNELNKA GVGDDEIPLP
310 320 330 340 350
DADTDDEDDD DSTNSASGAA PGSSRLKKSA LYFEGNLIKK WDPSSPIRYV
360 370 380 390 400
LDSSLEDLDK NDVRAAIYEI EKNTCIRFKE LSSPPTGSHI VYYKVDSPTF
410 420 430 440 450
CGLSYVGRAD PANPVYLSFG CDNNKGVAIH ETMHALGVAH QHLRNDRDQF
460 470 480 490 500
ITINWSNIDP QQYDAFVVVD SKLYTSYGVK YAYDSIMHYN GYTAAQNIAI
510 520 530 540 550
PTMNPKTNSA VNLKVLGQRQ KMGTTDIELL KKMYCQPGCD DKNVYCGAWA
560 570
LKDLCKNPGH DQYMAANCKK SCGLCAIGK
Note: No experimental confirmation available.
Length:579
Mass (Da):65,031
Last modified:March 1, 2004 - v2
Checksum:i2E98DC8E8AAAB744
GO
Isoform b (identifier: Q21432-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     400-455: FCGLSYVGRA...DRDQFITINW → LTKELQFMKQ...WIQNCTLHTE
     456-579: Missing.

Note: No experimental confirmation available.
Show »
Length:455
Mass (Da):51,639
Checksum:i4100A3CA90772C71
GO

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_012354400 – 455FCGLS…ITINW → LTKELQFMKQCMRSELPIST FAMIVINLLLLIGVTLIHNN TMHLLWWIQNCTLHTE in isoform b. CuratedAdd BLAST56
Alternative sequenceiVSP_012355456 – 579Missing in isoform b. CuratedAdd BLAST124

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
FO081325 Genomic DNA Translation: CCD70792.1
FO081325 Genomic DNA Translation: CCD70793.1
PIRiT16617
RefSeqiNP_001024789.1, NM_001029618.4 [Q21432-1]
NP_001024790.1, NM_001029619.5 [Q21432-2]
UniGeneiCel.17648

Genome annotation databases

EnsemblMetazoaiK11G12.1a; K11G12.1a; WBGene00003530 [Q21432-1]
GeneIDi180938
KEGGicel:CELE_K11G12.1
UCSCiK11G12.1b c. elegans [Q21432-1]

Keywords - Coding sequence diversityi

Alternative splicing

Similar proteinsi

Entry informationi

Entry nameiNAS11_CAEEL
AccessioniPrimary (citable) accession number: Q21432
Secondary accession number(s): Q65ZJ6
Entry historyiIntegrated into UniProtKB/Swiss-Prot: January 4, 2005
Last sequence update: March 1, 2004
Last modified: May 23, 2018
This is version 129 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programCaenorhabditis annotation project

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Caenorhabditis elegans
    Caenorhabditis elegans: entries, gene names and cross-references to WormBase
  2. Peptidase families
    Classification of peptidase families and list of entries
  3. SIMILARITY comments
    Index of protein domains and families

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