Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein
Submitted name:

PIX (PAK (p21-activated kinase) Interacting eXchange factor) homolog

Gene

pix-1

Organism
Caenorhabditis elegans
Status
Unreviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

GO - Molecular functioni

GO - Biological processi

  • gonad morphogenesis Source: WormBase
  • inductive cell migration Source: WormBase
  • neuron migration Source: WormBase
  • regulation of Rho protein signal transduction Source: InterPro

Keywordsi

Molecular functionKinaseImported, Transferase

Enzyme and pathway databases

ReactomeiR-CEL-182971 EGFR downregulation
R-CEL-193648 NRAGE signals death through JNK
R-CEL-194840 Rho GTPase cycle
R-CEL-3928664 Ephrin signaling
R-CEL-416482 G alpha (12/13) signalling events
R-CEL-446388 Regulation of cytoskeletal remodeling and cell spreading by IPP complex components
SignaLinkiQ21430

Names & Taxonomyi

Protein namesi
Submitted name:
PIX (PAK (p21-activated kinase) Interacting eXchange factor) homologImported
Gene namesi
Name:pix-1Imported
ORF Names:CELE_K11E4.4Imported, K11E4.4Imported
OrganismiCaenorhabditis elegansImported
Taxonomic identifieri6239 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaNematodaChromadoreaRhabditidaRhabditoideaRhabditidaePeloderinaeCaenorhabditis
Proteomesi
  • UP000001940 Componenti: Chromosome X

Organism-specific databases

WormBaseiK11E4.4a ; CE42239 ; WBGene00010776 ; pix-1

Subcellular locationi

PTM / Processingi

Proteomic databases

EPDiQ21430
PaxDbiQ21430
PeptideAtlasiQ21430

Expressioni

Gene expression databases

BgeeiWBGene00010776
ExpressionAtlasiQ21430 baseline and differential

Interactioni

GO - Molecular functioni

Protein-protein interaction databases

STRINGi6239.K11E4.4a

Structurei

3D structure databases

ProteinModelPortaliQ21430
SMRiQ21430
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini6 – 65SH3InterPro annotationAdd BLAST60
Domaini92 – 269DHInterPro annotationAdd BLAST178

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili193 – 213Sequence analysisAdd BLAST21

Keywords - Domaini

Coiled coilSequence analysis, SH3 domainPROSITE-ProRule annotationSAAS annotation

Phylogenomic databases

eggNOGiKOG2070 Eukaryota
ENOG410XNNP LUCA
GeneTreeiENSGT00920000148946
HOGENOMiHOG000018393
InParanoidiQ21430
OMAiIMFFEVT
OrthoDBiEOG091G04XA
PhylomeDBiQ21430

Family and domain databases

CDDicd00160 RhoGEF, 1 hit
Gene3Di1.20.900.10, 1 hit
InterProiView protein in InterPro
IPR035899 DBL_dom_sf
IPR000219 DH-domain
IPR032409 GEF_CC
IPR036028 SH3-like_dom_sf
IPR001452 SH3_domain
PfamiView protein in Pfam
PF16523 betaPIX_CC, 1 hit
PF00621 RhoGEF, 1 hit
PF14604 SH3_9, 1 hit
SMARTiView protein in SMART
SM00325 RhoGEF, 1 hit
SM00326 SH3, 1 hit
SUPFAMiSSF48065 SSF48065, 1 hit
SSF50044 SSF50044, 1 hit
PROSITEiView protein in PROSITE
PS50010 DH_2, 1 hit
PS50002 SH3, 1 hit

Sequencei

Sequence statusi: Complete.

Q21430-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MEPGSGSPLS ARAKFQFEGS NNDELSFDKD DIITITQQQE GGWWEGTHEG
60 70 80 90 100
VTGWFPCAYV TLITEKDKLQ RSRSVPNATA KEVVSVGAQP DYRDLVLKSY
110 120 130 140 150
IESEKEYMQS LLKTLQSLLI PIGASKILTA PEYCTLVGNF EVIYTLKRDL
160 170 180 190 200
FEQLEREQNE ELPKMRVGGM FMNAALELRT ALMSYADNHP DAVEVLKKKQ
210 220 230 240 250
KELEKVVKSQ DREYKELVLG LSEPLRHVER YYNLLQELER IVPANHPDRG
260 270 280 290 300
DLQRGSAVFR ETKDLCETLR KQKEAQLDFL FVSKVDKVVS ASERGSILYV
310 320 330 340 350
GVANVEYKKA DAVDRFVALF TKYIMFFEVT KDMTYDIKEK FTVSGFIVRK
360 370 380 390 400
KEATEISFDR PNTGEFTLTM VSTGGEVERF LVALAKAENV AIITPTTTIL
410 420 430 440 450
RRPSKNANDT MNQSQTQGAE TPLVAKPPLH PPGNSDQQYS MMNKRKSSKN
460 470 480 490 500
FDDSLNLGNM KFDHELGMVL PEGFELPTSS RNSRNTADNL QFSQFPSFFL
510 520 530 540 550
SGNAGKRGDR NIRLRKDAAR DEEIEFETLR ILEGYCVETG GGQSDFHANE
560 570 580 590 600
SYQQPHLIVA EDEKILMEEM IGDEVVLQEK SIVDAVYAIK DQLSFLQTEF
610 620 630 640
QKLAKVVESE QKARRRLEHN LPKMSGVISP DGSSSTPRKE INSFDL
Length:646
Mass (Da):73,145
Last modified:April 29, 2008 - v3
Checksum:i3DFED59801F7D806
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BX284606 Genomic DNA Translation: CAA94159.2
RefSeqiNP_001257227.1, NM_001270298.1
UniGeneiCel.669

Genome annotation databases

EnsemblMetazoaiK11E4.4a; K11E4.4a; WBGene00010776
GeneIDi181490
KEGGicel:CELE_K11E4.4
UCSCiK11E4.4 c. elegans

Similar proteinsi

Entry informationi

Entry nameiQ21430_CAEEL
AccessioniPrimary (citable) accession number: Q21430
Entry historyiIntegrated into UniProtKB/TrEMBL: November 1, 1996
Last sequence update: April 29, 2008
Last modified: June 20, 2018
This is version 142 of the entry and version 3 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Proteomics identificationCombined sources, Reference proteomeImported

We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.

Do not show this banner again
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health