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Protein
Submitted name:

PIX (PAK (P21-activated kinase) Interacting eXchange factor) homolog

Gene

pix-1

Organism
Caenorhabditis elegans
Status
Unreviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

GO - Molecular functioni

GO - Biological processi

  • gonad morphogenesis Source: WormBase
  • inductive cell migration Source: WormBase
  • neuron migration Source: WormBase
  • regulation of Rho protein signal transduction Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

KinaseImported, Transferase

Enzyme and pathway databases

ReactomeiR-CEL-182971. EGFR downregulation.
R-CEL-193648. NRAGE signals death through JNK.
R-CEL-194840. Rho GTPase cycle.
R-CEL-3928664. Ephrin signaling.
R-CEL-416482. G alpha (12/13) signalling events.
R-CEL-446388. Regulation of cytoskeletal remodeling and cell spreading by IPP complex components.
SignaLinkiQ21430.

Names & Taxonomyi

Protein namesi
Submitted name:
PIX (PAK (P21-activated kinase) Interacting eXchange factor) homologImported
Gene namesi
Name:pix-1Imported
ORF Names:CELE_K11E4.4Imported, K11E4.4Imported
OrganismiCaenorhabditis elegansImported
Taxonomic identifieri6239 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaNematodaChromadoreaRhabditidaRhabditoideaRhabditidaePeloderinaeCaenorhabditis
Proteomesi
  • UP000001940 Componenti: Chromosome X

Organism-specific databases

WormBaseiK11E4.4a; CE42239; WBGene00010776; pix-1.

Subcellular locationi

GO - Cellular componenti

  • cell-cell adherens junction Source: WormBase
  • cell periphery Source: WormBase
  • cytoplasm Source: WormBase
  • hemidesmosome Source: WormBase
Complete GO annotation...

PTM / Processingi

Proteomic databases

EPDiQ21430.
PaxDbiQ21430.

Expressioni

Gene expression databases

BgeeiWBGene00010776.
ExpressionAtlasiQ21430. baseline.

Interactioni

Protein-protein interaction databases

STRINGi6239.K11E4.4a.

Structurei

3D structure databases

ProteinModelPortaliQ21430.
SMRiQ21430. Positions 9-280.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini6 – 6560SH3InterPro annotationAdd
BLAST
Domaini92 – 269178DH (DBL-homology)InterPro annotationAdd
BLAST

Phylogenomic databases

eggNOGiKOG2070. Eukaryota.
ENOG410XNNP. LUCA.
GeneTreeiENSGT00760000118925.
HOGENOMiHOG000018393.
InParanoidiQ21430.
OMAiDHELGMV.
OrthoDBiEOG091G04XA.
PhylomeDBiQ21430.

Family and domain databases

Gene3Di1.20.900.10. 1 hit.
InterProiIPR000219. DH-domain.
IPR032409. GEF_CC.
IPR001452. SH3_domain.
[Graphical view]
PfamiPF16523. betaPIX_CC. 1 hit.
PF00621. RhoGEF. 1 hit.
PF14604. SH3_9. 1 hit.
[Graphical view]
SMARTiSM00325. RhoGEF. 1 hit.
SM00326. SH3. 1 hit.
[Graphical view]
SUPFAMiSSF48065. SSF48065. 1 hit.
SSF50044. SSF50044. 1 hit.
PROSITEiPS50010. DH_2. 1 hit.
PS50002. SH3. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q21430-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MEPGSGSPLS ARAKFQFEGS NNDELSFDKD DIITITQQQE GGWWEGTHEG
60 70 80 90 100
VTGWFPCAYV TLITEKDKLQ RSRSVPNATA KEVVSVGAQP DYRDLVLKSY
110 120 130 140 150
IESEKEYMQS LLKTLQSLLI PIGASKILTA PEYCTLVGNF EVIYTLKRDL
160 170 180 190 200
FEQLEREQNE ELPKMRVGGM FMNAALELRT ALMSYADNHP DAVEVLKKKQ
210 220 230 240 250
KELEKVVKSQ DREYKELVLG LSEPLRHVER YYNLLQELER IVPANHPDRG
260 270 280 290 300
DLQRGSAVFR ETKDLCETLR KQKEAQLDFL FVSKVDKVVS ASERGSILYV
310 320 330 340 350
GVANVEYKKA DAVDRFVALF TKYIMFFEVT KDMTYDIKEK FTVSGFIVRK
360 370 380 390 400
KEATEISFDR PNTGEFTLTM VSTGGEVERF LVALAKAENV AIITPTTTIL
410 420 430 440 450
RRPSKNANDT MNQSQTQGAE TPLVAKPPLH PPGNSDQQYS MMNKRKSSKN
460 470 480 490 500
FDDSLNLGNM KFDHELGMVL PEGFELPTSS RNSRNTADNL QFSQFPSFFL
510 520 530 540 550
SGNAGKRGDR NIRLRKDAAR DEEIEFETLR ILEGYCVETG GGQSDFHANE
560 570 580 590 600
SYQQPHLIVA EDEKILMEEM IGDEVVLQEK SIVDAVYAIK DQLSFLQTEF
610 620 630 640
QKLAKVVESE QKARRRLEHN LPKMSGVISP DGSSSTPRKE INSFDL
Length:646
Mass (Da):73,145
Last modified:April 29, 2008 - v3
Checksum:i3DFED59801F7D806
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BX284606 Genomic DNA. Translation: CAA94159.2.
RefSeqiNP_001257227.1. NM_001270298.1.
UniGeneiCel.669.

Genome annotation databases

EnsemblMetazoaiK11E4.4a; K11E4.4a; WBGene00010776.
GeneIDi181490.
KEGGicel:CELE_K11E4.4.
UCSCiK11E4.4. c. elegans.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BX284606 Genomic DNA. Translation: CAA94159.2.
RefSeqiNP_001257227.1. NM_001270298.1.
UniGeneiCel.669.

3D structure databases

ProteinModelPortaliQ21430.
SMRiQ21430. Positions 9-280.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi6239.K11E4.4a.

Proteomic databases

EPDiQ21430.
PaxDbiQ21430.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblMetazoaiK11E4.4a; K11E4.4a; WBGene00010776.
GeneIDi181490.
KEGGicel:CELE_K11E4.4.
UCSCiK11E4.4. c. elegans.

Organism-specific databases

CTDi181490.
WormBaseiK11E4.4a; CE42239; WBGene00010776; pix-1.

Phylogenomic databases

eggNOGiKOG2070. Eukaryota.
ENOG410XNNP. LUCA.
GeneTreeiENSGT00760000118925.
HOGENOMiHOG000018393.
InParanoidiQ21430.
OMAiDHELGMV.
OrthoDBiEOG091G04XA.
PhylomeDBiQ21430.

Enzyme and pathway databases

ReactomeiR-CEL-182971. EGFR downregulation.
R-CEL-193648. NRAGE signals death through JNK.
R-CEL-194840. Rho GTPase cycle.
R-CEL-3928664. Ephrin signaling.
R-CEL-416482. G alpha (12/13) signalling events.
R-CEL-446388. Regulation of cytoskeletal remodeling and cell spreading by IPP complex components.
SignaLinkiQ21430.

Gene expression databases

BgeeiWBGene00010776.
ExpressionAtlasiQ21430. baseline.

Family and domain databases

Gene3Di1.20.900.10. 1 hit.
InterProiIPR000219. DH-domain.
IPR032409. GEF_CC.
IPR001452. SH3_domain.
[Graphical view]
PfamiPF16523. betaPIX_CC. 1 hit.
PF00621. RhoGEF. 1 hit.
PF14604. SH3_9. 1 hit.
[Graphical view]
SMARTiSM00325. RhoGEF. 1 hit.
SM00326. SH3. 1 hit.
[Graphical view]
SUPFAMiSSF48065. SSF48065. 1 hit.
SSF50044. SSF50044. 1 hit.
PROSITEiPS50010. DH_2. 1 hit.
PS50002. SH3. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiQ21430_CAEEL
AccessioniPrimary (citable) accession number: Q21430
Entry historyi
Integrated into UniProtKB/TrEMBL: November 1, 1996
Last sequence update: April 29, 2008
Last modified: September 7, 2016
This is version 127 of the entry and version 3 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Proteomics identificationCombined sources, Reference proteomeImported

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.