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Protein
Submitted name:

SPeCtrin

Gene

spc-1

Organism
Caenorhabditis elegans
Status
Unreviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at protein leveli

Functioni

GO - Molecular functioni

GO - Biological processi

  • embryonic body morphogenesis Source: WormBase
  • nematode larval development Source: WormBase
  • positive regulation of multicellular organism growth Source: WormBase
  • regulation of locomotion Source: WormBase
Complete GO annotation...

Enzyme and pathway databases

ReactomeiR-CEL-375165. NCAM signaling for neurite out-growth.
R-CEL-5673001. RAF/MAP kinase cascade.
R-CEL-6807878. COPI-mediated anterograde transport.
SignaLinkiQ21408.

Names & Taxonomyi

Protein namesi
Submitted name:
SPeCtrinImported
Gene namesi
Name:spc-1Imported
ORF Names:CELE_K10B3.10Imported, K10B3.10Imported
OrganismiCaenorhabditis elegansImported
Taxonomic identifieri6239 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaNematodaChromadoreaRhabditidaRhabditoideaRhabditidaePeloderinaeCaenorhabditis
Proteomesi
  • UP000001940 Componenti: Chromosome X

Organism-specific databases

WormBaseiK10B3.10b; CE46456; WBGene00004951; spc-1.

PTM / Processingi

Proteomic databases

PaxDbiQ21408.

Expressioni

Gene expression databases

BgeeiWBGene00004951.
ExpressionAtlasiQ21408. baseline.

Interactioni

Protein-protein interaction databases

STRINGi6239.K10B3.10b.

Structurei

3D structure databases

ProteinModelPortaliQ21408.
SMRiQ21408. Positions 988-1040, 1301-1506.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini983 – 104260SH3InterPro annotationAdd
BLAST
Domaini2282 – 231736EF-handInterPro annotationAdd
BLAST
Domaini2325 – 236036EF-handInterPro annotationAdd
BLAST

Coiled coil

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Coiled coili307 – 34135Sequence analysisAdd
BLAST
Coiled coili1165 – 119228Sequence analysisAdd
BLAST
Coiled coili1232 – 127342Sequence analysisAdd
BLAST
Coiled coili1655 – 168935Sequence analysisAdd
BLAST
Coiled coili2190 – 222738Sequence analysisAdd
BLAST

Sequence similaritiesi

Contains 1 SH3 domain.UniRule annotation

Keywords - Domaini

Coiled coilSequence analysis, SH3 domainUniRule annotation

Phylogenomic databases

eggNOGiKOG0035. Eukaryota.
COG5069. LUCA.
GeneTreeiENSGT00760000118813.
HOGENOMiHOG000246965.
InParanoidiQ21408.
OMAiRDAHAQF.
OrthoDBiEOG091G006T.

Family and domain databases

Gene3Di1.10.238.10. 2 hits.
InterProiIPR011992. EF-hand-dom_pair.
IPR014837. EF-hand_Ca_insen.
IPR018247. EF_Hand_1_Ca_BS.
IPR002048. EF_hand_dom.
IPR001452. SH3_domain.
IPR018159. Spectrin/alpha-actinin.
IPR013315. Spectrin_alpha_SH3.
IPR002017. Spectrin_repeat.
[Graphical view]
PfamiPF13499. EF-hand_7. 1 hit.
PF08726. EFhand_Ca_insen. 1 hit.
PF00018. SH3_1. 1 hit.
PF00435. Spectrin. 20 hits.
[Graphical view]
PRINTSiPR00452. SH3DOMAIN.
PR01887. SPECTRNALPHA.
SMARTiSM00054. EFh. 2 hits.
SM00326. SH3. 1 hit.
SM00150. SPEC. 20 hits.
[Graphical view]
SUPFAMiSSF47473. SSF47473. 1 hit.
SSF50044. SSF50044. 1 hit.
PROSITEiPS00018. EF_HAND_1. 1 hit.
PS50222. EF_HAND_2. 2 hits.
PS50002. SH3. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q21408-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MADSNDTHAP PEPVLEVPPP QEIRILETAD DIHQRRQEVL GHYSIFKDHS
60 70 80 90 100
QTKRDRLEEA RQFQYFKRDA DELNVWILEK LQTAQEENFR DPSNLQAKIQ
110 120 130 140 150
KHEAFEAEVQ AHAKTIANLD KTGNAMIQHN HFASEHIKKR LEELHALWDK
160 170 180 190 200
LFFKLKDKGI KLQQALKLLH FIRQCDEILY WIREKETYVT AEDMGMDLEH
210 220 230 240 250
VEILQRKFDD FLKELGNHQY RINEINQAAD KLVEEGHSEH DQIYKKRDDV
260 270 280 290 300
NDAWHRLNTL AATRKEGLFG AHQVQRFNRD ADETLAWIGE KDLALSSDDY
310 320 330 340 350
GRDLNNVQAL QRKHEGTERD LAALEGKMLQ LEKEAHKLAE THPDRAEAIH
360 370 380 390 400
QKNDDTKAAW NALKEKAQHR KDGLERSFQL HRFLADYRDL ISWIGDMKAV
410 420 430 440 450
IGADELAKDV AGAEALLESH QEHKGEIDAR ADSFNQTASA GQKLVEMGIP
460 470 480 490 500
ESPEVQEKLE KLDHEKSSLL GLWEERRILY EQCMDLQLFY RDTEQAETWM
510 520 530 540 550
NKQEAFLANT DLGDSLDSVE HLIKKHEDFE KSLAAQEEKI NALDEFATKL
560 570 580 590 600
IQGQHYAADD VAERRQALLD RRRRLLDRAR QRGNALKESY KRQTFDRDCD
610 620 630 640 650
EMVSWITEKL STARDDSYLD PTNIRGKLQK HINFEQELKA NENRLDDIRS
660 670 680 690 700
TGEQIIDSGH FAADHIGDRL RQVNNLWNEL VDATNKKGAK LREAGNEQQF
710 720 730 740 750
NRNIEDVEAW LSELEGQVAS EDYGKDLVSV QNLQKKIGLI ESDFNAHNDR
760 770 780 790 800
VDGIKQLAQQ FQEEEHFNAP VIVRKQENLQ QRYNALRDPL EKRKRKLGES
810 820 830 840 850
HQGNQLFRDI EDELAWIREK EQVAGSTNRG RDLIGVQNLI KKQQALIAEI
860 870 880 890 900
ANHDSQIESV SSAANDMIQQ GHFLAPEIRD KLAQLRDNWR ILKSKAEKRR
910 920 930 940 950
TDLDDSLQAH QYLSDANEAD AWMSEKEPIV GSTDYGKDED SAEALLKKHR
960 970 980 990 1000
ALLSDLEAFK GTIEDLRKQA SQCKYQEQPM GQLGRDCVLA LYDYQEKSPR
1010 1020 1030 1040 1050
EVSMKKGDVL TLLNASNRDW WKVEVNDRQG FVPAAYVKRI EPGTAQQHAQ
1060 1070 1080 1090 1100
QQVNSIGGKQ SEIEDKYQRL MMLGETRKRK LEEACKGYQL LREANDLAEW
1110 1120 1130 1140 1150
IKSRTNMAEE AVAAQQEIGT DLEQVEVLQK KFDDFKGDLK ANEVRLQEMN
1160 1170 1180 1190 1200
QIATALTSVG QTETAVRIRQ QIEDLNARWR ALEEQTEQRE QQLGSAHEVQ
1210 1220 1230 1240 1250
RFHRDVDETR DWIQEKDDAL DSEDFGRDLR SVQALQRKHE GVERDLAALG
1260 1270 1280 1290 1300
DKIKSLDEKA NRLRQSHPEA AEQIYDLQRE LNEQWNRLTS KANNRKEKLL
1310 1320 1330 1340 1350
DSYDYQRFLS DYRDLMQWIA SMNQLVSSQE LANDVTGAEA LLERHQEYRT
1360 1370 1380 1390 1400
EIDSRAATFQ AFDQFGNQLL NSHHYAAGDI ENRLQGVNEA RKGLEDAWVA
1410 1420 1430 1440 1450
RRNILDQCLE LQLFYRDCEQ ADTWMSAREA FLAQEDPSGD NVESLIKKHE
1460 1470 1480 1490 1500
DFDKAINTQE EKIKGLKLFA ESLIKNNHYD SPAVTRKRDQ ILDRWNGLKE
1510 1520 1530 1540 1550
ALIQKRFKLG ESQTLQQFSR DADEIENWMT EKFQIAQEEN YRDPTNIQQK
1560 1570 1580 1590 1600
HQKQQAFEAE LHANSDRIAA IIQAGNNLIE NAKCGGGEAA VSARLKALND
1610 1620 1630 1640 1650
QWDLLVKTTT EKSYRLKEAN KQKSFMAAVK DLEFWLGEVE ILLQSEDYGK
1660 1670 1680 1690 1700
DLASVENLLK KHSLLEADIV AHQDRVGEMN EQADSLLEND QFQGQQIAER
1710 1720 1730 1740 1750
RKLIADRYDG VKKMATDRRD KLSKALNVHQ FFRDIDDEES WIKEKKLLVS
1760 1770 1780 1790 1800
SDDYGRDLPG VQNLRRKHRR IDTELASHEP QVSLVKLKGE ELLRSAAEAG
1810 1820 1830 1840 1850
VGEDQIKKRM EDLEQSWGQI RDLTGNRHQR LDESEAFQAF LGDVEEEEAW
1860 1870 1880 1890 1900
MNEKQQILGS DNFGENMAGV QGLLKKHDTF QVDLELHKQR VADLINKGDT
1910 1920 1930 1940 1950
LIHNGNHHAP HIKQRCDQLR ARLIEIESMA EGRLAKLRDN SAYLQFMWKC
1960 1970 1980 1990 2000
DVVESWIAEK EQQVRSEDFG RDLSSVQILL TKQEAFDAGL NAFEHEGIQR
2010 2020 2030 2040 2050
ITELKDQLVS SEHQQSPAIE KRHTNVIQRW QNLLAHSEAR RQKLLKMQQQ
2060 2070 2080 2090 2100
FKQIEELYLA FAKKASTFNS WFENAEEDLT DPVRCNSLEE IRALRDAHGE
2110 2120 2130 2140 2150
FQRSLSSAEE DFRQLQDLDR RIKSFNVGPN PYTWFTMDAL EDTWRNLQRI
2160 2170 2180 2190 2200
IKEREQELAR EHQRQEENDK LRREFAKLAN AFHAWLTNTR QEMMEAGGTL
2210 2220 2230 2240 2250
EEQLDAVERK AKEIKANKGQ LRQIEEKGAM LERNLILDNR YTEHSTVGIA
2260 2270 2280 2290 2300
QAWDQLDQLA MRMQHNLEQQ IQARNQSGVS EEALREFSMM FKHFDKEKTG
2310 2320 2330 2340 2350
RLDHQQFKSC LRALGYDLPM VDEGQPEPEF QRILDIVDPN RDGYVTLQEY
2360 2370 2380 2390 2400
MAFMISKETE NIQSSEEIEM AFRALSKEFR PYVTAEELYA NLTPEQAEFC
2410 2420 2430
IRRMKPYMDA ISGRSIQGGL DYEQFVHALF QS
Length:2,432
Mass (Da):282,300
Last modified:January 25, 2012 - v2
Checksum:i43054437043143E3
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BX284606 Genomic DNA. Translation: CCD64607.1.
RefSeqiNP_001257000.1. NM_001270071.1.
UniGeneiCel.458.

Genome annotation databases

EnsemblMetazoaiK10B3.10b; K10B3.10b; WBGene00004951.
GeneIDi180603.
UCSCiK10B3.10. c. elegans.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BX284606 Genomic DNA. Translation: CCD64607.1.
RefSeqiNP_001257000.1. NM_001270071.1.
UniGeneiCel.458.

3D structure databases

ProteinModelPortaliQ21408.
SMRiQ21408. Positions 988-1040, 1301-1506.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi6239.K10B3.10b.

Proteomic databases

PaxDbiQ21408.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblMetazoaiK10B3.10b; K10B3.10b; WBGene00004951.
GeneIDi180603.
UCSCiK10B3.10. c. elegans.

Organism-specific databases

CTDi180603.
WormBaseiK10B3.10b; CE46456; WBGene00004951; spc-1.

Phylogenomic databases

eggNOGiKOG0035. Eukaryota.
COG5069. LUCA.
GeneTreeiENSGT00760000118813.
HOGENOMiHOG000246965.
InParanoidiQ21408.
OMAiRDAHAQF.
OrthoDBiEOG091G006T.

Enzyme and pathway databases

ReactomeiR-CEL-375165. NCAM signaling for neurite out-growth.
R-CEL-5673001. RAF/MAP kinase cascade.
R-CEL-6807878. COPI-mediated anterograde transport.
SignaLinkiQ21408.

Gene expression databases

BgeeiWBGene00004951.
ExpressionAtlasiQ21408. baseline.

Family and domain databases

Gene3Di1.10.238.10. 2 hits.
InterProiIPR011992. EF-hand-dom_pair.
IPR014837. EF-hand_Ca_insen.
IPR018247. EF_Hand_1_Ca_BS.
IPR002048. EF_hand_dom.
IPR001452. SH3_domain.
IPR018159. Spectrin/alpha-actinin.
IPR013315. Spectrin_alpha_SH3.
IPR002017. Spectrin_repeat.
[Graphical view]
PfamiPF13499. EF-hand_7. 1 hit.
PF08726. EFhand_Ca_insen. 1 hit.
PF00018. SH3_1. 1 hit.
PF00435. Spectrin. 20 hits.
[Graphical view]
PRINTSiPR00452. SH3DOMAIN.
PR01887. SPECTRNALPHA.
SMARTiSM00054. EFh. 2 hits.
SM00326. SH3. 1 hit.
SM00150. SPEC. 20 hits.
[Graphical view]
SUPFAMiSSF47473. SSF47473. 1 hit.
SSF50044. SSF50044. 1 hit.
PROSITEiPS00018. EF_HAND_1. 1 hit.
PS50222. EF_HAND_2. 2 hits.
PS50002. SH3. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiQ21408_CAEEL
AccessioniPrimary (citable) accession number: Q21408
Entry historyi
Integrated into UniProtKB/TrEMBL: November 1, 1996
Last sequence update: January 25, 2012
Last modified: September 7, 2016
This is version 138 of the entry and version 2 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Proteomics identificationCombined sources, Reference proteomeImported

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.