Q21389 (LGE1_CAEEL) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Glycosyltransferase-like protein LARGE
EC=2.4.-.-

Gene names

Name:	lge-1
ORF Names:	K09C8.4

Organism

Caenorhabditis elegans

Taxonomic identifier

6239 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Nematoda › Chromadorea › Rhabditida › Rhabditoidea › Rhabditidae › Peloderinae › Caenorhabditis

Protein attributes

Sequence length	631 AA.
Sequence status	Complete.
Protein existence	Evidence at transcript level

General annotation (Comments)

Function	Probable glycosyltransferase By similarity.
Subcellular location	Golgi apparatus membrane; Single-pass type II membrane protein By similarity.
Sequence similarities	Belongs to the glycosyltransferase 8 family.

Ontologies

Keywords
Cellular component	Golgi apparatus Membrane
Domain	Signal-anchor Transmembrane Transmembrane helix
Molecular function	Glycosyltransferase Transferase
PTM	Glycoprotein
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Cellular component	Golgi membrane Inferred from electronic annotation. Source: UniProtKB-SubCell integral to membrane Inferred from electronic annotation. Source: UniProtKB-KW
Molecular function	transferase activity, transferring glycosyl groups Inferred from electronic annotation. Source: UniProtKB-KW
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 631	631	Glycosyltransferase-like protein LARGE		PRO_0000226818
Regions
	Topological domain	1 – 6	6	Cytoplasmic Potential
	Transmembrane	7 – 27	21	Helical; Signal-anchor for type II membrane protein; Potential
	Topological domain	28 – 631	604	Lumenal Potential
Amino acid modifications
	Glycosylation	95	1	N-linked (GlcNAc...) Potential
	Glycosylation	105	1	N-linked (GlcNAc...) Potential
	Glycosylation	167	1	N-linked (GlcNAc...) Potential
	Glycosylation	177	1	N-linked (GlcNAc...) Potential
	Glycosylation	287	1	N-linked (GlcNAc...) Potential
	Glycosylation	400	1	N-linked (GlcNAc...) Potential
	Glycosylation	485	1	N-linked (GlcNAc...) Potential
	Glycosylation	502	1	N-linked (GlcNAc...) Potential
	Glycosylation	521	1	N-linked (GlcNAc...) Potential
	Glycosylation	529	1	N-linked (GlcNAc...) Potential
	Glycosylation	593	1	N-linked (GlcNAc...) Potential

Sequences

	Sequence		Length	Mass (Da)
	Q21389 [UniParc]. Last modified March 7, 2006. Version 3. Checksum: F184CCC5C4959C90	FASTA	631	74,525
	10 20 30 40 50 60 MQSNYSISYF LLILFTGTSS YFTIWNFVDH TRVGAFPEED YIRLAYIIGG NFMTRLMFMQ 70 80 90 100 110 120 HFKSVLKYSD HFFRLHLITD ENHRSDIHEL MTSWNISNCE WFFHNLTEFE KRVAWIPNSH 130 140 150 160 170 180 YSKYYGLSKL LIPEIIGNDI GKIMFMDVDI IFQTNIFDLW KQFRNFNNSQ VFGMVENLSD 190 200 210 220 230 240 WYLNKDGKKS VWPALGRGFN TGIIMFDLDK LRKNGWASKW RVVANKYLRI HGKTAMSDQD 250 260 270 280 290 300 IFNAYIHDYP TEIIQIPCAY NYQLGALTKS KELCPETPLA LHFNSQNKTV GKNYAFFDKI 310 320 330 340 350 360 RKAFDEMDGS DLKRRRRSFK GNNQKDICHE YLPLDNFRII PNAIGRMTKP AELCMVTQFS 370 380 390 400 410 420 KDRLNHFLES ANAWRHPIST AVYGKDKDLL DIAKAVTELN RTDITIHLVF EEPTESWMLD 430 440 450 460 470 480 SLYPINFLRN VAIEHANCKY ILMTDVDFVV LGDYGTIIDQ TGNLKQKEVL VIPALEMTYP 490 500 510 520 530 540 QLRLNLSNFL SRKDLVIEHL LNKTIQTFRE TIWPSSHVPT NISKWIKSNR TYMVNYEKNY 550 560 570 580 590 600 EPYFVIKKEE CPFYDQRFGG FGWNKVTHVM QLKMMNYKFL VSPTSFMIHQ NHNASKSLKR 610 620 630 WRRDPHYQKC LHTLKNKFMK KTASRLGIKL R

References

[1]	"Genome sequence of the nematode C. elegans: a platform for investigating biology." The C. elegans sequencing consortium Science 282:2012-2018(1998) [PubMed: 9851916] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: Bristol N2.

Cross-references

Sequence databases
EMBL GenBank DDBJ	Z68006 Genomic DNA. Translation: CAA91997.4.
PIR	T23541.
UniGene	Cel.695.
3D structure databases
ProteinModelPortal	Q21389.
ModBase	Search...
Protein family/group databases
CAZy	GT49. Glycosyltransferase Family 49. GT8. Glycosyltransferase Family 8.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
EnsemblMetazoa	K09C8.4; K09C8.4; K09C8.4.
UCSC	K09C8.4. c. elegans.
Organism-specific databases
WormBase	K09C8.4; CE44089; WBGene00010716; lge-1.
Phylogenomic databases
eggNOG	meNOG04984.
GeneTree	EMGT00050000002786.
HOGENOM	HBG387493.
Gene expression databases
ArrayExpress	Q21389.
Family and domain databases
InterPro	IPR002495. Glyco_trans_8. [Graphical view]
Pfam	PF01501. Glyco_transf_8. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

LGE1_CAEEL

Accession

Primary (citable) accession number: Q21389

Entry history

Integrated into UniProtKB/Swiss-Prot:	March 7, 2006
Last sequence update:	March 7, 2006
Last modified:	September 21, 2011
This is version 71 of the entry and version 3 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Caenorhabditis annotation project