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Protein

Zinc metalloproteinase nas-10

Gene

nas-10

Organism
Caenorhabditis elegans
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Probable metalloprotease.By similarity

Catalytic activityi

Hydrolysis of peptide bonds in substrates containing five or more amino acids, preferentially with Ala in P1', and Pro in P2'.

Cofactori

Zn2+By similarityNote: Binds 1 zinc ion per subunit.By similarity

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi414 – 4141Zinc; catalyticBy similarity
Active sitei415 – 4151By similarity
Metal bindingi418 – 4181Zinc; catalyticBy similarity
Metal bindingi424 – 4241Zinc; catalyticBy similarity

GO - Molecular functioni

Complete GO annotation...

Keywords - Molecular functioni

Hydrolase, Metalloprotease, Protease

Keywords - Ligandi

Metal-binding, Zinc

Protein family/group databases

MEROPSiM12.A35.

Names & Taxonomyi

Protein namesi
Recommended name:
Zinc metalloproteinase nas-10 (EC:3.4.24.21)
Alternative name(s):
Nematode astacin 10
Gene namesi
Name:nas-10
ORF Names:K09C8.3
OrganismiCaenorhabditis elegans
Taxonomic identifieri6239 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaNematodaChromadoreaRhabditidaRhabditoideaRhabditidaePeloderinaeCaenorhabditis
Proteomesi
  • UP000001940 Componenti: Chromosome X

Organism-specific databases

WormBaseiK09C8.3a; CE03479; WBGene00003529; nas-10.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 560560Zinc metalloproteinase nas-10PRO_0000078185Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Disulfide bondi524 ↔ 560PROSITE-ProRule annotation
Disulfide bondi531 ↔ 553PROSITE-ProRule annotation
Disulfide bondi540 ↔ 557PROSITE-ProRule annotation

Keywords - PTMi

Disulfide bond

Proteomic databases

EPDiQ21388.
PaxDbiQ21388.

Expressioni

Gene expression databases

ExpressionAtlasiQ21388. baseline and differential.

Structurei

3D structure databases

ProteinModelPortaliQ21388.
SMRiQ21388. Positions 299-518.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini524 – 56037ShKTPROSITE-ProRule annotationAdd
BLAST

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi111 – 1144Poly-Pro
Compositional biasi187 – 22741Gln-richAdd
BLAST

Sequence similaritiesi

Belongs to the peptidase M12A family.Curated
Contains 1 ShKT domain.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiKOG3714. Eukaryota.
ENOG410ZPX7. LUCA.
GeneTreeiENSGT00760000119227.
HOGENOMiHOG000018720.
InParanoidiQ21388.
KOiK08076.
OMAiAVNIAKP.
OrthoDBiEOG7TTQCD.
PhylomeDBiQ21388.

Family and domain databases

Gene3Di3.40.390.10. 1 hit.
InterProiIPR024079. MetalloPept_cat_dom.
IPR001506. Peptidase_M12A.
IPR017368. Peptidase_M12A_astacin-9/10/11.
IPR006026. Peptidase_Metallo.
IPR003582. ShKT_dom.
[Graphical view]
PfamiPF01400. Astacin. 1 hit.
PF01549. ShK. 1 hit.
[Graphical view]
PIRSFiPIRSF038055. Nas9/Nas10/Nas11. 1 hit.
PRINTSiPR00480. ASTACIN.
SMARTiSM00254. ShKT. 1 hit.
SM00235. ZnMc. 1 hit.
[Graphical view]
PROSITEiPS51670. SHKT. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q21388-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MYTITDLKTI NRKQKQAYLQ EKLICSRHCW LTHTTSKHIN IQWTTLIPHI
60 70 80 90 100
RCRGFNNGPH PNSRPGSRPN SPLGDIFGNI NGMVKGITDQ IGKIAQGLDV
110 120 130 140 150
NNDLGKMAHG PPPPQSEWVE HARRFCRRFP GHPKCRGQLP QFNDIGSMLN
160 170 180 190 200
GILVDSGKWL PKVPFINIRD PLSGINSDLK NALNGIQVQF GQISQQFANN
210 220 230 240 250
IRNICQQMNC KQQQQKNVQM KQAILKQTVD FEKKVFGNNV ADKMNLRFDR
260 270 280 290 300
TLQLKQALLE KAQLKGVVAP EDNGVFDKDL LLTETQANFM LNELGKGGEG
310 320 330 340 350
AIPMPGSAKA KRASIFFEQN LIQKWPSTSP IPYTFDSSLD NLDQNDVRGA
360 370 380 390 400
ISEIEQKTCI RFKYFASPPK GNHINYQKVN SPSFCGLSYI GRVEPANPVY
410 420 430 440 450
LSFQCGNGRG IAVHETMHAL GVNHQHLRMD RDKHIKVDWS NINPQQYDAF
460 470 480 490 500
VVADSKLYTT YGVKYAYDSI MHYNAYTGAV NIAKPTMIPL VNQQANIGLL
510 520 530 540 550
GQRAKMSNAD VEILNKMYCK SAGCDDKNVY CGAWALQDLC NNPNHNVWMR
560
SNCRKSCNFC
Length:560
Mass (Da):63,041
Last modified:November 1, 1996 - v1
Checksum:i4490B5456DA7256A
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Z68006 Genomic DNA. Translation: CAA91996.1.
PIRiT23540.
RefSeqiNP_001257125.1. NM_001270196.1.
UniGeneiCel.696.

Genome annotation databases

EnsemblMetazoaiK09C8.3a; K09C8.3a; WBGene00003529.
GeneIDi181287.
KEGGicel:CELE_K09C8.3.
UCSCiK09C8.3. c. elegans.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Z68006 Genomic DNA. Translation: CAA91996.1.
PIRiT23540.
RefSeqiNP_001257125.1. NM_001270196.1.
UniGeneiCel.696.

3D structure databases

ProteinModelPortaliQ21388.
SMRiQ21388. Positions 299-518.
ModBaseiSearch...
MobiDBiSearch...

Protein family/group databases

MEROPSiM12.A35.

Proteomic databases

EPDiQ21388.
PaxDbiQ21388.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblMetazoaiK09C8.3a; K09C8.3a; WBGene00003529.
GeneIDi181287.
KEGGicel:CELE_K09C8.3.
UCSCiK09C8.3. c. elegans.

Organism-specific databases

CTDi181287.
WormBaseiK09C8.3a; CE03479; WBGene00003529; nas-10.

Phylogenomic databases

eggNOGiKOG3714. Eukaryota.
ENOG410ZPX7. LUCA.
GeneTreeiENSGT00760000119227.
HOGENOMiHOG000018720.
InParanoidiQ21388.
KOiK08076.
OMAiAVNIAKP.
OrthoDBiEOG7TTQCD.
PhylomeDBiQ21388.

Miscellaneous databases

NextBioi913288.
PROiQ21388.

Gene expression databases

ExpressionAtlasiQ21388. baseline and differential.

Family and domain databases

Gene3Di3.40.390.10. 1 hit.
InterProiIPR024079. MetalloPept_cat_dom.
IPR001506. Peptidase_M12A.
IPR017368. Peptidase_M12A_astacin-9/10/11.
IPR006026. Peptidase_Metallo.
IPR003582. ShKT_dom.
[Graphical view]
PfamiPF01400. Astacin. 1 hit.
PF01549. ShK. 1 hit.
[Graphical view]
PIRSFiPIRSF038055. Nas9/Nas10/Nas11. 1 hit.
PRINTSiPR00480. ASTACIN.
SMARTiSM00254. ShKT. 1 hit.
SM00235. ZnMc. 1 hit.
[Graphical view]
PROSITEiPS51670. SHKT. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Genome sequence of the nematode C. elegans: a platform for investigating biology."
    The C. elegans sequencing consortium
    Science 282:2012-2018(1998) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: Bristol N2.
  2. "The astacin protein family in Caenorhabditis elegans."
    Moehrlen F., Hutter H., Zwilling R.
    Eur. J. Biochem. 270:4909-4920(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NOMENCLATURE.

Entry informationi

Entry nameiNAS10_CAEEL
AccessioniPrimary (citable) accession number: Q21388
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 4, 2005
Last sequence update: November 1, 1996
Last modified: May 11, 2016
This is version 105 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programCaenorhabditis annotation project

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Caenorhabditis elegans
    Caenorhabditis elegans: entries, gene names and cross-references to WormBase
  2. Peptidase families
    Classification of peptidase families and list of entries
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.