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Q21355 (GST4_CAEEL) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 93. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Glutathione S-transferase 4

EC=2.5.1.18
Alternative name(s):
CeGST1
GST class-sigma
Gene names
Name:gst-4
ORF Names:K08F4.7
OrganismCaenorhabditis elegans [Reference proteome]
Taxonomic identifier6239 [NCBI]
Taxonomic lineageEukaryotaMetazoaEcdysozoaNematodaChromadoreaRhabditidaRhabditoideaRhabditidaePeloderinaeCaenorhabditis

Protein attributes

Sequence length207 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

Conjugation of reduced glutathione to a wide number of exogenous and endogenous hydrophobic electrophiles By similarity. UniProtKB P46436

Catalytic activity

RX + glutathione = HX + R-S-glutathione. UniProtKB P46436

Sequence similarities

Belongs to the GST superfamily. Sigma family. UniProtKB P46436

Contains 1 GST C-terminal domain.

Contains 1 GST N-terminal domain.

Ontologies

Keywords
   Molecular functionTransferase
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Biological_processglutathione metabolic process

Inferred from direct assay PubMed 12757851. Source: WormBase

   Cellular_componentcontractile fiber

Inferred from direct assay PubMed 12757851. Source: WormBase

   Molecular_functionglutathione transferase activity

Inferred from direct assay PubMed 12757851. Source: WormBase

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 207207Glutathione S-transferase 4
PRO_0000185927

Regions

Domain2 – 7978GST N-terminal
Domain81 – 207127GST C-terminal
Region50 – 512Glutathione binding By similarity
Region63 – 642Glutathione binding By similarity

Sites

Binding site81Glutathione By similarity
Binding site391Glutathione By similarity
Binding site431Glutathione By similarity

Sequences

Sequence LengthMass (Da)Tools
Q21355 [UniParc].

Last modified November 1, 1996. Version 1.
Checksum: 7152BC3F891B61FB

FASTA20723,891
        10         20         30         40         50         60 
MPNYKLLYFD ARALAEPIRI MFAMLNVPYE DYRVSVEEWS KLKPTTPFGQ LPILQVDGEQ 

        70         80         90        100        110        120 
FGQSMSITRY LARKFGLAGK TAEEEAYADS IVDQYRDFIF FFRQFTSSVF YGSDADHINK 

       130        140        150        160        170        180 
VRFEVVEPAR DDFLAIINKF LAKSKSGFLV GDSLTWADIV IADNLTSLLK NGFLDFNKEK 

       190        200 
KLEEFYNKIH SIPEIKNYVA TRKDSIV 

« Hide

References

« Hide 'large scale' references
[1]"Identification of stress-responsive genes in Caenorhabditis elegans using RT-PCR differential display."
Tawe W.N., Eschbach M.-L., Walter R.D., Henkle-Duehrsen K.
Nucleic Acids Res. 26:1621-1627(1998) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
Strain: Bristol N2.
[2]"Genome sequence of the nematode C. elegans: a platform for investigating biology."
The C. elegans sequencing consortium
Science 282:2012-2018(1998) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: Bristol N2.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AF010239 mRNA. Translation: AAB65417.1.
Z68879 Genomic DNA. Translation: CAA93086.1.
PIRT37462.
RefSeqNP_501848.1. NM_069447.6.
UniGeneCel.19516.

3D structure databases

ProteinModelPortalQ21355.
SMRQ21355. Positions 1-205.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

BioGrid42988. 1 interaction.
DIPDIP-24743N.
MINTMINT-1096462.
STRING6239.K08F4.7.1.

Proteomic databases

PaxDbQ21355.
PRIDEQ21355.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblMetazoaK08F4.7; K08F4.7; K08F4.7.
GeneID177886.
KEGGcel:CELE_K08F4.7.
UCSCK08F4.7.1. c. elegans.

Organism-specific databases

CTD177886.
WormBaseK08F4.7; CE06155; WBGene00001752; gst-4.

Phylogenomic databases

eggNOGCOG0625.
HOGENOMHOG000115733.
InParanoidQ21355.
KOK00799.
OMAFWEEDEN.
OrthoDBEOG78WKT1.
PhylomeDBQ21355.

Family and domain databases

Gene3D1.20.1050.10. 1 hit.
3.40.30.10. 1 hit.
InterProIPR010987. Glutathione-S-Trfase_C-like.
IPR004045. Glutathione_S-Trfase_N.
IPR004046. GST_C.
IPR012336. Thioredoxin-like_fold.
[Graphical view]
PfamPF00043. GST_C. 1 hit.
PF02798. GST_N. 1 hit.
[Graphical view]
SUPFAMSSF47616. SSF47616. 1 hit.
SSF52833. SSF52833. 1 hit.
PROSITEPS50405. GST_CTER. 1 hit.
PS50404. GST_NTER. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

NextBio898796.

Entry information

Entry nameGST4_CAEEL
AccessionPrimary (citable) accession number: Q21355
Entry history
Integrated into UniProtKB/Swiss-Prot: March 28, 2003
Last sequence update: November 1, 1996
Last modified: April 16, 2014
This is version 93 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programCaenorhabditis annotation project

Relevant documents

SIMILARITY comments

Index of protein domains and families

Caenorhabditis elegans

Caenorhabditis elegans: entries, gene names and cross-references to WormBase