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Protein

Glutathione S-transferase 4

Gene

gst-4

Organism
Caenorhabditis elegans
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Conjugation of reduced glutathione to a wide number of exogenous and endogenous hydrophobic electrophiles (By similarity). May play a role in the detoxification of reactive oxygen species produced during pathogenic bacterial infection (PubMed:22216003).By similarity1 Publication

Catalytic activityi

RX + glutathione = HX + R-S-glutathione.By similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei8GlutathioneBy similarity1
Binding sitei39GlutathioneBy similarity1
Binding sitei43GlutathioneBy similarity1

GO - Molecular functioni

  • glutathione transferase activity Source: WormBase

GO - Biological processi

  • glutathione metabolic process Source: WormBase

Keywordsi

Molecular functionTransferase

Enzyme and pathway databases

ReactomeiR-CEL-156590 Glutathione conjugation
R-CEL-2162123 Synthesis of Prostaglandins (PG) and Thromboxanes (TX)

Names & Taxonomyi

Protein namesi
Recommended name:
Glutathione S-transferase 4 (EC:2.5.1.18)
Alternative name(s):
CeGST1
GST class-sigma
Gene namesi
Name:gst-4
ORF Names:K08F4.7
OrganismiCaenorhabditis elegans
Taxonomic identifieri6239 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaNematodaChromadoreaRhabditidaRhabditoideaRhabditidaePeloderinaeCaenorhabditis
Proteomesi
  • UP000001940 Componenti: Chromosome IV

Organism-specific databases

WormBaseiK08F4.7 ; CE06155 ; WBGene00001752 ; gst-4

Subcellular locationi

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001859271 – 207Glutathione S-transferase 4Add BLAST207

Proteomic databases

EPDiQ21355
PaxDbiQ21355
PeptideAtlasiQ21355
PRIDEiQ21355

Expressioni

Inductioni

By paraquat.1 Publication

Gene expression databases

BgeeiWBGene00001752

Interactioni

Protein-protein interaction databases

BioGridi42988, 1 interactor
DIPiDIP-24743N
STRINGi6239.K08F4.7

Structurei

3D structure databases

ProteinModelPortaliQ21355
SMRiQ21355
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini2 – 79GST N-terminalAdd BLAST78
Domaini81 – 207GST C-terminalAdd BLAST127

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni49 – 51Glutathione bindingBy similarity3
Regioni63 – 64Glutathione bindingBy similarity2

Sequence similaritiesi

Belongs to the GST superfamily. Sigma family.Curated

Phylogenomic databases

eggNOGiENOG410IN5I Eukaryota
ENOG4111I69 LUCA
GeneTreeiENSGT00670000097856
HOGENOMiHOG000115733
InParanoidiQ21355
KOiK00799
OMAiFFRQFTS
OrthoDBiEOG091G0MBB
PhylomeDBiQ21355

Family and domain databases

InterProiView protein in InterPro
IPR010987 Glutathione-S-Trfase_C-like
IPR036282 Glutathione-S-Trfase_C_sf
IPR004045 Glutathione_S-Trfase_N
IPR004046 GST_C
IPR036249 Thioredoxin-like_sf
PfamiView protein in Pfam
PF14497 GST_C_3, 1 hit
PF02798 GST_N, 1 hit
SUPFAMiSSF47616 SSF47616, 1 hit
SSF52833 SSF52833, 1 hit
PROSITEiView protein in PROSITE
PS50405 GST_CTER, 1 hit
PS50404 GST_NTER, 1 hit

Sequencei

Sequence statusi: Complete.

Q21355-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MPNYKLLYFD ARALAEPIRI MFAMLNVPYE DYRVSVEEWS KLKPTTPFGQ
60 70 80 90 100
LPILQVDGEQ FGQSMSITRY LARKFGLAGK TAEEEAYADS IVDQYRDFIF
110 120 130 140 150
FFRQFTSSVF YGSDADHINK VRFEVVEPAR DDFLAIINKF LAKSKSGFLV
160 170 180 190 200
GDSLTWADIV IADNLTSLLK NGFLDFNKEK KLEEFYNKIH SIPEIKNYVA

TRKDSIV
Length:207
Mass (Da):23,891
Last modified:November 1, 1996 - v1
Checksum:i7152BC3F891B61FB
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF010239 mRNA Translation: AAB65417.1
Z68879 Genomic DNA Translation: CAA93086.1
PIRiT37462
RefSeqiNP_501848.1, NM_069447.6
UniGeneiCel.19516

Genome annotation databases

EnsemblMetazoaiK08F4.7; K08F4.7; WBGene00001752
GeneIDi177886
KEGGicel:CELE_K08F4.7
UCSCiK08F4.7.1 c. elegans

Similar proteinsi

Entry informationi

Entry nameiGST4_CAEEL
AccessioniPrimary (citable) accession number: Q21355
Entry historyiIntegrated into UniProtKB/Swiss-Prot: March 28, 2003
Last sequence update: November 1, 1996
Last modified: May 23, 2018
This is version 122 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programCaenorhabditis annotation project

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

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