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Q21355

- GST4_CAEEL

UniProt

Q21355 - GST4_CAEEL

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Protein

Glutathione S-transferase 4

Gene

gst-4

Organism
Caenorhabditis elegans
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli

Functioni

Conjugation of reduced glutathione to a wide number of exogenous and endogenous hydrophobic electrophiles.By similarity

Catalytic activityi

RX + glutathione = HX + R-S-glutathione.By similarity

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei8 – 81GlutathioneBy similarity
Binding sitei39 – 391GlutathioneBy similarity
Binding sitei43 – 431GlutathioneBy similarity

GO - Molecular functioni

  1. glutathione transferase activity Source: WormBase

GO - Biological processi

  1. glutathione metabolic process Source: WormBase
Complete GO annotation...

Keywords - Molecular functioni

Transferase

Names & Taxonomyi

Protein namesi
Recommended name:
Glutathione S-transferase 4 (EC:2.5.1.18)
Alternative name(s):
CeGST1
GST class-sigma
Gene namesi
Name:gst-4
ORF Names:K08F4.7
OrganismiCaenorhabditis elegans
Taxonomic identifieri6239 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaNematodaChromadoreaRhabditidaRhabditoideaRhabditidaePeloderinaeCaenorhabditis
ProteomesiUP000001940: Chromosome IV

Organism-specific databases

WormBaseiK08F4.7; CE06155; WBGene00001752; gst-4.

Subcellular locationi

GO - Cellular componenti

  1. contractile fiber Source: WormBase
Complete GO annotation...

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 207207Glutathione S-transferase 4PRO_0000185927Add
BLAST

Proteomic databases

PaxDbiQ21355.
PRIDEiQ21355.

Interactioni

Protein-protein interaction databases

BioGridi42988. 1 interaction.
DIPiDIP-24743N.
MINTiMINT-1096462.
STRINGi6239.K08F4.7.1.

Structurei

3D structure databases

ProteinModelPortaliQ21355.
SMRiQ21355. Positions 1-205.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini2 – 7978GST N-terminalAdd
BLAST
Domaini81 – 207127GST C-terminalAdd
BLAST

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni50 – 512Glutathione bindingBy similarity
Regioni63 – 642Glutathione bindingBy similarity

Sequence similaritiesi

Belongs to the GST superfamily. Sigma family.Curated
Contains 1 GST C-terminal domain.Curated
Contains 1 GST N-terminal domain.Curated

Phylogenomic databases

eggNOGiCOG0625.
GeneTreeiENSGT00670000097856.
HOGENOMiHOG000115733.
InParanoidiQ21355.
KOiK00799.
OMAiFWEEDEN.
OrthoDBiEOG78WKT1.
PhylomeDBiQ21355.

Family and domain databases

Gene3Di1.20.1050.10. 1 hit.
3.40.30.10. 1 hit.
InterProiIPR010987. Glutathione-S-Trfase_C-like.
IPR004045. Glutathione_S-Trfase_N.
IPR004046. GST_C.
IPR012336. Thioredoxin-like_fold.
[Graphical view]
PfamiPF00043. GST_C. 1 hit.
PF02798. GST_N. 1 hit.
[Graphical view]
SUPFAMiSSF47616. SSF47616. 1 hit.
SSF52833. SSF52833. 1 hit.
PROSITEiPS50405. GST_CTER. 1 hit.
PS50404. GST_NTER. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q21355-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MPNYKLLYFD ARALAEPIRI MFAMLNVPYE DYRVSVEEWS KLKPTTPFGQ
60 70 80 90 100
LPILQVDGEQ FGQSMSITRY LARKFGLAGK TAEEEAYADS IVDQYRDFIF
110 120 130 140 150
FFRQFTSSVF YGSDADHINK VRFEVVEPAR DDFLAIINKF LAKSKSGFLV
160 170 180 190 200
GDSLTWADIV IADNLTSLLK NGFLDFNKEK KLEEFYNKIH SIPEIKNYVA

TRKDSIV
Length:207
Mass (Da):23,891
Last modified:November 1, 1996 - v1
Checksum:i7152BC3F891B61FB
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF010239 mRNA. Translation: AAB65417.1.
Z68879 Genomic DNA. Translation: CAA93086.1.
PIRiT37462.
RefSeqiNP_501848.1. NM_069447.6.
UniGeneiCel.19516.

Genome annotation databases

EnsemblMetazoaiK08F4.7; K08F4.7; WBGene00001752.
GeneIDi177886.
KEGGicel:CELE_K08F4.7.
UCSCiK08F4.7.1. c. elegans.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF010239 mRNA. Translation: AAB65417.1 .
Z68879 Genomic DNA. Translation: CAA93086.1 .
PIRi T37462.
RefSeqi NP_501848.1. NM_069447.6.
UniGenei Cel.19516.

3D structure databases

ProteinModelPortali Q21355.
SMRi Q21355. Positions 1-205.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 42988. 1 interaction.
DIPi DIP-24743N.
MINTi MINT-1096462.
STRINGi 6239.K08F4.7.1.

Proteomic databases

PaxDbi Q21355.
PRIDEi Q21355.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblMetazoai K08F4.7 ; K08F4.7 ; WBGene00001752 .
GeneIDi 177886.
KEGGi cel:CELE_K08F4.7.
UCSCi K08F4.7.1. c. elegans.

Organism-specific databases

CTDi 177886.
WormBasei K08F4.7 ; CE06155 ; WBGene00001752 ; gst-4.

Phylogenomic databases

eggNOGi COG0625.
GeneTreei ENSGT00670000097856.
HOGENOMi HOG000115733.
InParanoidi Q21355.
KOi K00799.
OMAi FWEEDEN.
OrthoDBi EOG78WKT1.
PhylomeDBi Q21355.

Miscellaneous databases

NextBioi 898796.

Family and domain databases

Gene3Di 1.20.1050.10. 1 hit.
3.40.30.10. 1 hit.
InterProi IPR010987. Glutathione-S-Trfase_C-like.
IPR004045. Glutathione_S-Trfase_N.
IPR004046. GST_C.
IPR012336. Thioredoxin-like_fold.
[Graphical view ]
Pfami PF00043. GST_C. 1 hit.
PF02798. GST_N. 1 hit.
[Graphical view ]
SUPFAMi SSF47616. SSF47616. 1 hit.
SSF52833. SSF52833. 1 hit.
PROSITEi PS50405. GST_CTER. 1 hit.
PS50404. GST_NTER. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Identification of stress-responsive genes in Caenorhabditis elegans using RT-PCR differential display."
    Tawe W.N., Eschbach M.-L., Walter R.D., Henkle-Duehrsen K.
    Nucleic Acids Res. 26:1621-1627(1998) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Strain: Bristol N2.
  2. "Genome sequence of the nematode C. elegans: a platform for investigating biology."
    The C. elegans sequencing consortium
    Science 282:2012-2018(1998) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: Bristol N2.

Entry informationi

Entry nameiGST4_CAEEL
AccessioniPrimary (citable) accession number: Q21355
Entry historyi
Integrated into UniProtKB/Swiss-Prot: March 28, 2003
Last sequence update: November 1, 1996
Last modified: October 1, 2014
This is version 95 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programCaenorhabditis annotation project

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Caenorhabditis elegans
    Caenorhabditis elegans: entries, gene names and cross-references to WormBase
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3