Reviewed, UniProtKB/Swiss-Prot Q21355 (GST4_CAEEL)

Names and origin

Protein names

Recommended name:
    Glutathione S-transferase 4
    EC=2.5.1.18
Alternative name(s):
    GST class-sigma
    CeGST1

Gene names

Name:	gst-4
ORF Names:	K08F4.7

Organism

Caenorhabditis elegans [Complete proteome]

Taxonomic identifier

6239 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Nematoda › Chromadorea › Rhabditida › Rhabditoidea › Rhabditidae › Peloderinae › Caenorhabditis

Protein attributes

Sequence length	207 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Evidence at transcript level.

General annotation (Comments)

Function	Conjugation of reduced glutathione to a wide number of exogenous and endogenous hydrophobic electrophiles By similarity. UniProtKB P46436
Catalytic activity	RX + glutathione = HX + R-S-glutathione. UniProtKB P46436
Sequence similarities	Belongs to the GST superfamily. Sigma family. UniProtKB P46436 Contains 1 GST C-terminal domain. Contains 1 GST N-terminal domain.

Ontologies

Keywords
Molecular function	Transferase
Technical term	Complete proteome
Gene Ontology (GO)
Molecular function	glutathione transferase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 207	207	Glutathione S-transferase 4		PRO_0000185927
Regions
	Domain	2 – 79	78	GST N-terminal
	Domain	81 – 207	127	GST C-terminal

Sequences

	Sequence		Length	Mass (Da)
	Q21355-1 [UniParc]. Last modified November 1, 1996. Version 1. Checksum: 7152BC3F891B61FB	FASTA	207	23,891
	10 20 30 40 50 60 MPNYKLLYFD ARALAEPIRI MFAMLNVPYE DYRVSVEEWS KLKPTTPFGQ LPILQVDGEQ 70 80 90 100 110 120 FGQSMSITRY LARKFGLAGK TAEEEAYADS IVDQYRDFIF FFRQFTSSVF YGSDADHINK 130 140 150 160 170 180 VRFEVVEPAR DDFLAIINKF LAKSKSGFLV GDSLTWADIV IADNLTSLLK NGFLDFNKEK 190 200 KLEEFYNKIH SIPEIKNYVA TRKDSIV

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Identification of stress-responsive genes in Caenorhabditis elegans using RT-PCR differential display." Tawe W.N., Eschbach M.-L., Walter R.D., Henkle-Duehrsen K. Nucleic Acids Res. 26:1621-1627(1998) [PubMed: 9512531] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA]. Strain: Bristol N2.
[2]	"Genome sequence of the nematode C. elegans: a platform for investigating biology." The C. elegans sequencing consortium Science 282:2012-2018(1998) [PubMed: 9851916] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: Bristol N2.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBLGenBankDDBJ	AF010239 mRNA. Translation: AAB65417.1. Z68879 Genomic DNA. Translation: CAA93086.1.
PIR	T37462.
RefSeq	NP_501848.1.
UniGene	Cel.19516
3D structure databases
HSSP	HSSP built from PDB template 1PD2 based on UniProtKB O35543.
ModBase	Search...
Protein-protein interaction databases
DIP	DIP:24743N.
IntAct	Q21355. 1 interaction.
STRING	Q21355.
Genome annotation databases
Ensembl	K08F4.7.1; K08F4.7.1; K08F4.7; Caenorhabditis elegans. [Genome view] K08F4.7.2; K08F4.7.2; K08F4.7; Caenorhabditis elegans. [Genome view]
GeneID	177886.
KEGG	cel:K08F4.7.
NMPDR	fig|6239.3.peg.14802.
UCSC	K08F4.7.1. c. elegans.
Organism-specific databases
CTD	177886.
WormBase	WBGene00001752. gst-4.
WormPep	K08F4.7. CE06155. [WorfDB]
Phylogenomic databases
OMA	KEWIASR.
Enzyme and pathway databases
BRENDA	2.5.1.18. 672.
Gene expression databases
ArrayExpress	Q21355.
Family and domain databases
InterPro	IPR004045. Glutathione_S-Trfase_N. IPR017933. Glutathione_S_Trfase/Cl_chnl_C. IPR004046. GST_C. IPR012335. Thioredoxin_fold. [Graphical view]
Gene3D	G3DSA:3.40.30.10. Thioredoxin_fold. 1 hit.
Pfam	PF00043. GST_C. 1 hit. PF02798. GST_N. 1 hit. [Graphical view]
PROSITE	PS50405. GST_CTER. 1 hit. PS50404. GST_NTER. 1 hit. [Graphical view]
ProtoNet	Search...
Other Resources
NextBio	898796.

Entry information

Entry name

GST4_CAEEL

Accession

Primary (citable) accession number: Q21355

Entry history

Integrated into UniProtKB/Swiss-Prot:	March 28, 2003
Last sequence update:	November 1, 1996
Last modified:	November 3, 2009
This is version 62 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

Caenorhabditis annotation project