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Q21355

- GST4_CAEEL

UniProt

Q21355 - GST4_CAEEL

Protein

Glutathione S-transferase 4

Gene

gst-4

Organism
Caenorhabditis elegans
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 95 (01 Oct 2014)
      Sequence version 1 (01 Nov 1996)
      Previous versions | rss
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    Functioni

    Conjugation of reduced glutathione to a wide number of exogenous and endogenous hydrophobic electrophiles.By similarity

    Catalytic activityi

    RX + glutathione = HX + R-S-glutathione.By similarity

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Binding sitei8 – 81GlutathioneBy similarity
    Binding sitei39 – 391GlutathioneBy similarity
    Binding sitei43 – 431GlutathioneBy similarity

    GO - Molecular functioni

    1. glutathione transferase activity Source: WormBase

    GO - Biological processi

    1. glutathione metabolic process Source: WormBase

    Keywords - Molecular functioni

    Transferase

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Glutathione S-transferase 4 (EC:2.5.1.18)
    Alternative name(s):
    CeGST1
    GST class-sigma
    Gene namesi
    Name:gst-4
    ORF Names:K08F4.7
    OrganismiCaenorhabditis elegans
    Taxonomic identifieri6239 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaEcdysozoaNematodaChromadoreaRhabditidaRhabditoideaRhabditidaePeloderinaeCaenorhabditis
    ProteomesiUP000001940: Chromosome IV

    Organism-specific databases

    WormBaseiK08F4.7; CE06155; WBGene00001752; gst-4.

    Subcellular locationi

    GO - Cellular componenti

    1. contractile fiber Source: WormBase

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 207207Glutathione S-transferase 4PRO_0000185927Add
    BLAST

    Proteomic databases

    PaxDbiQ21355.
    PRIDEiQ21355.

    Interactioni

    Protein-protein interaction databases

    BioGridi42988. 1 interaction.
    DIPiDIP-24743N.
    MINTiMINT-1096462.
    STRINGi6239.K08F4.7.1.

    Structurei

    3D structure databases

    ProteinModelPortaliQ21355.
    SMRiQ21355. Positions 1-205.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini2 – 7978GST N-terminalAdd
    BLAST
    Domaini81 – 207127GST C-terminalAdd
    BLAST

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni50 – 512Glutathione bindingBy similarity
    Regioni63 – 642Glutathione bindingBy similarity

    Sequence similaritiesi

    Belongs to the GST superfamily. Sigma family.Curated
    Contains 1 GST C-terminal domain.Curated
    Contains 1 GST N-terminal domain.Curated

    Phylogenomic databases

    eggNOGiCOG0625.
    GeneTreeiENSGT00670000097856.
    HOGENOMiHOG000115733.
    InParanoidiQ21355.
    KOiK00799.
    OMAiFWEEDEN.
    OrthoDBiEOG78WKT1.
    PhylomeDBiQ21355.

    Family and domain databases

    Gene3Di1.20.1050.10. 1 hit.
    3.40.30.10. 1 hit.
    InterProiIPR010987. Glutathione-S-Trfase_C-like.
    IPR004045. Glutathione_S-Trfase_N.
    IPR004046. GST_C.
    IPR012336. Thioredoxin-like_fold.
    [Graphical view]
    PfamiPF00043. GST_C. 1 hit.
    PF02798. GST_N. 1 hit.
    [Graphical view]
    SUPFAMiSSF47616. SSF47616. 1 hit.
    SSF52833. SSF52833. 1 hit.
    PROSITEiPS50405. GST_CTER. 1 hit.
    PS50404. GST_NTER. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q21355-1 [UniParc]FASTAAdd to Basket

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    MPNYKLLYFD ARALAEPIRI MFAMLNVPYE DYRVSVEEWS KLKPTTPFGQ    50
    LPILQVDGEQ FGQSMSITRY LARKFGLAGK TAEEEAYADS IVDQYRDFIF 100
    FFRQFTSSVF YGSDADHINK VRFEVVEPAR DDFLAIINKF LAKSKSGFLV 150
    GDSLTWADIV IADNLTSLLK NGFLDFNKEK KLEEFYNKIH SIPEIKNYVA 200
    TRKDSIV 207
    Length:207
    Mass (Da):23,891
    Last modified:November 1, 1996 - v1
    Checksum:i7152BC3F891B61FB
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF010239 mRNA. Translation: AAB65417.1.
    Z68879 Genomic DNA. Translation: CAA93086.1.
    PIRiT37462.
    RefSeqiNP_501848.1. NM_069447.6.
    UniGeneiCel.19516.

    Genome annotation databases

    EnsemblMetazoaiK08F4.7; K08F4.7; WBGene00001752.
    GeneIDi177886.
    KEGGicel:CELE_K08F4.7.
    UCSCiK08F4.7.1. c. elegans.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF010239 mRNA. Translation: AAB65417.1 .
    Z68879 Genomic DNA. Translation: CAA93086.1 .
    PIRi T37462.
    RefSeqi NP_501848.1. NM_069447.6.
    UniGenei Cel.19516.

    3D structure databases

    ProteinModelPortali Q21355.
    SMRi Q21355. Positions 1-205.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 42988. 1 interaction.
    DIPi DIP-24743N.
    MINTi MINT-1096462.
    STRINGi 6239.K08F4.7.1.

    Proteomic databases

    PaxDbi Q21355.
    PRIDEi Q21355.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblMetazoai K08F4.7 ; K08F4.7 ; WBGene00001752 .
    GeneIDi 177886.
    KEGGi cel:CELE_K08F4.7.
    UCSCi K08F4.7.1. c. elegans.

    Organism-specific databases

    CTDi 177886.
    WormBasei K08F4.7 ; CE06155 ; WBGene00001752 ; gst-4.

    Phylogenomic databases

    eggNOGi COG0625.
    GeneTreei ENSGT00670000097856.
    HOGENOMi HOG000115733.
    InParanoidi Q21355.
    KOi K00799.
    OMAi FWEEDEN.
    OrthoDBi EOG78WKT1.
    PhylomeDBi Q21355.

    Miscellaneous databases

    NextBioi 898796.

    Family and domain databases

    Gene3Di 1.20.1050.10. 1 hit.
    3.40.30.10. 1 hit.
    InterProi IPR010987. Glutathione-S-Trfase_C-like.
    IPR004045. Glutathione_S-Trfase_N.
    IPR004046. GST_C.
    IPR012336. Thioredoxin-like_fold.
    [Graphical view ]
    Pfami PF00043. GST_C. 1 hit.
    PF02798. GST_N. 1 hit.
    [Graphical view ]
    SUPFAMi SSF47616. SSF47616. 1 hit.
    SSF52833. SSF52833. 1 hit.
    PROSITEi PS50405. GST_CTER. 1 hit.
    PS50404. GST_NTER. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Identification of stress-responsive genes in Caenorhabditis elegans using RT-PCR differential display."
      Tawe W.N., Eschbach M.-L., Walter R.D., Henkle-Duehrsen K.
      Nucleic Acids Res. 26:1621-1627(1998) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
      Strain: Bristol N2.
    2. "Genome sequence of the nematode C. elegans: a platform for investigating biology."
      The C. elegans sequencing consortium
      Science 282:2012-2018(1998) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: Bristol N2.

    Entry informationi

    Entry nameiGST4_CAEEL
    AccessioniPrimary (citable) accession number: Q21355
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: March 28, 2003
    Last sequence update: November 1, 1996
    Last modified: October 1, 2014
    This is version 95 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programCaenorhabditis annotation project

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Caenorhabditis elegans
      Caenorhabditis elegans: entries, gene names and cross-references to WormBase
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3