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Protein

Putative sodium-dependent excitatory amino acid transporter glt-3

Gene

glt-3

Organism
Caenorhabditis elegans
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

GO - Molecular functioni

Keywordsi

Biological processSymport, Transport

Enzyme and pathway databases

ReactomeiR-CEL-210455 Astrocytic Glutamate-Glutamine Uptake And Metabolism
R-CEL-210500 Glutamate Neurotransmitter Release Cycle
R-CEL-425393 Transport of inorganic cations/anions and amino acids/oligopeptides

Protein family/group databases

TCDBi2.A.23.2.9 the dicarboxylate/amino acid:cation (na(+) or h(+)) symporter (daacs) family

Names & Taxonomyi

Protein namesi
Recommended name:
Putative sodium-dependent excitatory amino acid transporter glt-3
Gene namesi
Name:glt-3
ORF Names:K08F4.4
OrganismiCaenorhabditis elegans
Taxonomic identifieri6239 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaNematodaChromadoreaRhabditidaRhabditoideaRhabditidaePeloderinaeCaenorhabditis
Proteomesi
  • UP000001940 Componenti: Chromosome IV

Organism-specific databases

WormBaseiK08F4.4 ; CE06152 ; WBGene00001621 ; glt-3

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 5CytoplasmicSequence analysis5
Transmembranei6 – 26HelicalSequence analysisAdd BLAST21
Transmembranei46 – 66HelicalSequence analysisAdd BLAST21
Transmembranei83 – 103HelicalSequence analysisAdd BLAST21
Topological domaini104 – 181ExtracellularSequence analysisAdd BLAST78
Transmembranei182 – 202HelicalSequence analysisAdd BLAST21
Transmembranei222 – 242HelicalSequence analysisAdd BLAST21
Transmembranei264 – 284HelicalSequence analysisAdd BLAST21
Transmembranei352 – 372HelicalSequence analysisAdd BLAST21
Transmembranei383 – 402HelicalSequence analysisAdd BLAST20

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002020751 – 532Putative sodium-dependent excitatory amino acid transporter glt-3Add BLAST532

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi164N-linked (GlcNAc...) asparagine1 Publication1
Glycosylationi169N-linked (GlcNAc...) asparagine1 Publication1

Keywords - PTMi

Glycoprotein

Proteomic databases

EPDiQ21353
PaxDbiQ21353
PeptideAtlasiQ21353
PRIDEiQ21353

PTM databases

iPTMnetiQ21353

Expressioni

Gene expression databases

BgeeiWBGene00001621

Interactioni

Protein-protein interaction databases

BioGridi42985, 2 interactors
DIPiDIP-27068N
STRINGi6239.K08F4.4

Structurei

3D structure databases

ProteinModelPortaliQ21353
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG3787 Eukaryota
COG1301 LUCA
GeneTreeiENSGT00760000119117
HOGENOMiHOG000208776
InParanoidiQ21353
KOiK05613
OMAiWISALMW
OrthoDBiEOG091G0UCE
PhylomeDBiQ21353

Family and domain databases

InterProiView protein in InterPro
IPR001991 Na-dicarboxylate_symporter
IPR018107 Na-dicarboxylate_symporter_CS
IPR036458 Na:dicarbo_symporter_sf
PfamiView protein in Pfam
PF00375 SDF, 1 hit
SUPFAMiSSF118215 SSF118215, 2 hits
PROSITEiView protein in PROSITE
PS00713 NA_DICARBOXYL_SYMP_1, 1 hit
PS00714 NA_DICARBOXYL_SYMP_2, 1 hit

Sequencei

Sequence statusi: Complete.

Q21353-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MGMKKDLLLV LTIESVVLGV VLGFVIRPFN PSNDTISLIG FPGEIFMQIV
60 70 80 90 100
EMMILPLIMS SVISALAQVR ARDARRIGIV TIIYYMITTF LATFTGIILV
110 120 130 140 150
SSIHPGDPEL IHELGEGTLE NTALSTLDTF LDQIRNMFPE NIIQATFQQV
160 170 180 190 200
QTEYMPIKPS RVRNATSMNM TSEVLHKQTL TYTNEMNVLG LIVFCSGFGI
210 220 230 240 250
ILSILGDQAR LMINFFIVLD AIIMRWISAL MWCYPIGILS LVCKNIIDID
260 270 280 290 300
NLTETAQALA MYVVTVICGL MIHSLLTLPL LYFLVTKKSP FAFMTGMLQA
310 320 330 340 350
LATAFGTASS GATLPVTFRA LEENLKIDRR VTRFVLPLGA TITMDGTALY
360 370 380 390 400
EAVAVIFIAQ LHNIKLSLMD LVTISITTTV ASIGSGSVPA GLDTIVIVLT
410 420 430 440 450
TVGLPAKDLS LLLTVDWLLD RIRTSVNVLG DSFGAGIIHH LTRSSLLEAD
460 470 480 490 500
TDELIRQIRE DIDILNNPHQ DTLPISHHSV QSTIQNTQNA MQAPHVYSKS
510 520 530
ARASFAPIPN EEERKALLKE SIALNKSDTH IV
Length:532
Mass (Da):58,470
Last modified:November 1, 1996 - v1
Checksum:iFA370EAD3796E5DF
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Z68879 Genomic DNA Translation: CAA93084.1
PIRiT23481
RefSeqiNP_501844.1, NM_069443.5
UniGeneiCel.12625

Genome annotation databases

EnsemblMetazoaiK08F4.4; K08F4.4; WBGene00001621
GeneIDi177882
KEGGicel:CELE_K08F4.4
UCSCiK08F4.4 c. elegans

Similar proteinsi

Entry informationi

Entry nameiEAA3_CAEEL
AccessioniPrimary (citable) accession number: Q21353
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 15, 1998
Last sequence update: November 1, 1996
Last modified: May 23, 2018
This is version 124 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programCaenorhabditis annotation project

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

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