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Protein

Putative sodium-dependent excitatory amino acid transporter glt-3

Gene

glt-3

Organism
Caenorhabditis elegans
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at protein leveli

Functioni

GO - Molecular functioni

Complete GO annotation...

Keywords - Biological processi

Symport, Transport

Enzyme and pathway databases

ReactomeiR-CEL-210500. Glutamate Neurotransmitter Release Cycle.
R-CEL-425393. Transport of inorganic cations/anions and amino acids/oligopeptides.

Protein family/group databases

TCDBi2.A.23.2.9. the dicarboxylate/amino acid:cation (na(+) or h(+)) symporter (daacs) family.

Names & Taxonomyi

Protein namesi
Recommended name:
Putative sodium-dependent excitatory amino acid transporter glt-3
Gene namesi
Name:glt-3
ORF Names:K08F4.4
OrganismiCaenorhabditis elegans
Taxonomic identifieri6239 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaNematodaChromadoreaRhabditidaRhabditoideaRhabditidaePeloderinaeCaenorhabditis
Proteomesi
  • UP000001940 Componenti: Chromosome IV

Organism-specific databases

WormBaseiK08F4.4; CE06152; WBGene00001621; glt-3.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 55CytoplasmicSequence analysis
Transmembranei6 – 2621HelicalSequence analysisAdd
BLAST
Transmembranei46 – 6621HelicalSequence analysisAdd
BLAST
Transmembranei83 – 10321HelicalSequence analysisAdd
BLAST
Topological domaini104 – 18178ExtracellularSequence analysisAdd
BLAST
Transmembranei182 – 20221HelicalSequence analysisAdd
BLAST
Transmembranei222 – 24221HelicalSequence analysisAdd
BLAST
Transmembranei264 – 28421HelicalSequence analysisAdd
BLAST
Transmembranei352 – 37221HelicalSequence analysisAdd
BLAST
Transmembranei383 – 40220HelicalSequence analysisAdd
BLAST

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 532532Putative sodium-dependent excitatory amino acid transporter glt-3PRO_0000202075Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi164 – 1641N-linked (GlcNAc...)1 Publication
Glycosylationi169 – 1691N-linked (GlcNAc...)1 Publication

Keywords - PTMi

Glycoprotein

Proteomic databases

EPDiQ21353.
PaxDbiQ21353.
PRIDEiQ21353.

PTM databases

iPTMnetiQ21353.

Interactioni

Protein-protein interaction databases

BioGridi42985. 2 interactions.
DIPiDIP-27068N.
MINTiMINT-1103840.
STRINGi6239.K08F4.4.

Structurei

3D structure databases

ProteinModelPortaliQ21353.
SMRiQ21353. Positions 16-438.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG3787. Eukaryota.
COG1301. LUCA.
GeneTreeiENSGT00760000119117.
HOGENOMiHOG000208776.
InParanoidiQ21353.
OMAiRIVSWIL.
OrthoDBiEOG7RV9G2.
PhylomeDBiQ21353.

Family and domain databases

Gene3Di1.10.3860.10. 2 hits.
InterProiIPR001991. Na-dicarboxylate_symporter.
IPR018107. Na-dicarboxylate_symporter_CS.
[Graphical view]
PANTHERiPTHR11958. PTHR11958. 1 hit.
PfamiPF00375. SDF. 1 hit.
[Graphical view]
PRINTSiPR00173. EDTRNSPORT.
SUPFAMiSSF118215. SSF118215. 2 hits.
PROSITEiPS00713. NA_DICARBOXYL_SYMP_1. 1 hit.
PS00714. NA_DICARBOXYL_SYMP_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q21353-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MGMKKDLLLV LTIESVVLGV VLGFVIRPFN PSNDTISLIG FPGEIFMQIV
60 70 80 90 100
EMMILPLIMS SVISALAQVR ARDARRIGIV TIIYYMITTF LATFTGIILV
110 120 130 140 150
SSIHPGDPEL IHELGEGTLE NTALSTLDTF LDQIRNMFPE NIIQATFQQV
160 170 180 190 200
QTEYMPIKPS RVRNATSMNM TSEVLHKQTL TYTNEMNVLG LIVFCSGFGI
210 220 230 240 250
ILSILGDQAR LMINFFIVLD AIIMRWISAL MWCYPIGILS LVCKNIIDID
260 270 280 290 300
NLTETAQALA MYVVTVICGL MIHSLLTLPL LYFLVTKKSP FAFMTGMLQA
310 320 330 340 350
LATAFGTASS GATLPVTFRA LEENLKIDRR VTRFVLPLGA TITMDGTALY
360 370 380 390 400
EAVAVIFIAQ LHNIKLSLMD LVTISITTTV ASIGSGSVPA GLDTIVIVLT
410 420 430 440 450
TVGLPAKDLS LLLTVDWLLD RIRTSVNVLG DSFGAGIIHH LTRSSLLEAD
460 470 480 490 500
TDELIRQIRE DIDILNNPHQ DTLPISHHSV QSTIQNTQNA MQAPHVYSKS
510 520 530
ARASFAPIPN EEERKALLKE SIALNKSDTH IV
Length:532
Mass (Da):58,470
Last modified:November 1, 1996 - v1
Checksum:iFA370EAD3796E5DF
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Z68879 Genomic DNA. Translation: CAA93084.1.
PIRiT23481.
RefSeqiNP_501844.1. NM_069443.5.
UniGeneiCel.12625.

Genome annotation databases

EnsemblMetazoaiK08F4.4; K08F4.4; WBGene00001621.
GeneIDi177882.
KEGGicel:CELE_K08F4.4.
UCSCiK08F4.4. c. elegans.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Z68879 Genomic DNA. Translation: CAA93084.1.
PIRiT23481.
RefSeqiNP_501844.1. NM_069443.5.
UniGeneiCel.12625.

3D structure databases

ProteinModelPortaliQ21353.
SMRiQ21353. Positions 16-438.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi42985. 2 interactions.
DIPiDIP-27068N.
MINTiMINT-1103840.
STRINGi6239.K08F4.4.

Protein family/group databases

TCDBi2.A.23.2.9. the dicarboxylate/amino acid:cation (na(+) or h(+)) symporter (daacs) family.

PTM databases

iPTMnetiQ21353.

Proteomic databases

EPDiQ21353.
PaxDbiQ21353.
PRIDEiQ21353.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblMetazoaiK08F4.4; K08F4.4; WBGene00001621.
GeneIDi177882.
KEGGicel:CELE_K08F4.4.
UCSCiK08F4.4. c. elegans.

Organism-specific databases

CTDi177882.
WormBaseiK08F4.4; CE06152; WBGene00001621; glt-3.

Phylogenomic databases

eggNOGiKOG3787. Eukaryota.
COG1301. LUCA.
GeneTreeiENSGT00760000119117.
HOGENOMiHOG000208776.
InParanoidiQ21353.
OMAiRIVSWIL.
OrthoDBiEOG7RV9G2.
PhylomeDBiQ21353.

Enzyme and pathway databases

ReactomeiR-CEL-210500. Glutamate Neurotransmitter Release Cycle.
R-CEL-425393. Transport of inorganic cations/anions and amino acids/oligopeptides.

Miscellaneous databases

PROiQ21353.

Family and domain databases

Gene3Di1.10.3860.10. 2 hits.
InterProiIPR001991. Na-dicarboxylate_symporter.
IPR018107. Na-dicarboxylate_symporter_CS.
[Graphical view]
PANTHERiPTHR11958. PTHR11958. 1 hit.
PfamiPF00375. SDF. 1 hit.
[Graphical view]
PRINTSiPR00173. EDTRNSPORT.
SUPFAMiSSF118215. SSF118215. 2 hits.
PROSITEiPS00713. NA_DICARBOXYL_SYMP_1. 1 hit.
PS00714. NA_DICARBOXYL_SYMP_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "Genome sequence of the nematode C. elegans: a platform for investigating biology."
    The C. elegans sequencing consortium
    Science 282:2012-2018(1998) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: Bristol N2.
  2. "Proteomics reveals N-linked glycoprotein diversity in Caenorhabditis elegans and suggests an atypical translocation mechanism for integral membrane proteins."
    Kaji H., Kamiie J., Kawakami H., Kido K., Yamauchi Y., Shinkawa T., Taoka M., Takahashi N., Isobe T.
    Mol. Cell. Proteomics 6:2100-2109(2007) [PubMed] [Europe PMC] [Abstract]
    Cited for: GLYCOSYLATION [LARGE SCALE ANALYSIS] AT ASN-164 AND ASN-169, IDENTIFICATION BY MASS SPECTROMETRY.
    Strain: Bristol N2.

Entry informationi

Entry nameiEAA3_CAEEL
AccessioniPrimary (citable) accession number: Q21353
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 15, 1998
Last sequence update: November 1, 1996
Last modified: July 6, 2016
This is version 108 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programCaenorhabditis annotation project

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Caenorhabditis elegans
    Caenorhabditis elegans: entries, gene names and cross-references to WormBase
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.