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Protein

Cation-transporting ATPase catp-5

Gene

catp-5

Organism
Caenorhabditis elegans
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at transcript leveli

Functioni

Involved in the uptake and/or transport of polyamines, probably through ATP hydrolysis. This contributes to the maintenance of intracellular polyamine levels. Polyamines are essential for cell proliferation and are implicated in cellular processes, ranging from DNA replication to apoptosis.1 Publication

Catalytic activityi

ATP + H2O = ADP + phosphate.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei5034-aspartylphosphate intermediateBy similarity1
Metal bindingi883MagnesiumBy similarity1
Metal bindingi887MagnesiumBy similarity1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionHydrolase
LigandATP-binding, Magnesium, Metal-binding, Nucleotide-binding

Enzyme and pathway databases

ReactomeiR-CEL-936837. Ion transport by P-type ATPases.

Names & Taxonomyi

Protein namesi
Recommended name:
Cation-transporting ATPase catp-5Imported (EC:3.6.3.-)
Gene namesi
Name:catp-51 PublicationImported
ORF Names:K07E3.7Imported
OrganismiCaenorhabditis elegans
Taxonomic identifieri6239 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaNematodaChromadoreaRhabditidaRhabditoideaRhabditidaePeloderinaeCaenorhabditis
Proteomesi
  • UP000001940 Componenti: Chromosome X

Organism-specific databases

WormBaseiK07E3.7a; CE37253; WBGene00019493; catp-5.
K07E3.7b; CE37254; WBGene00019493; catp-5.

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 68CytoplasmicSequence analysisAdd BLAST68
Transmembranei69 – 89HelicalSequence analysisAdd BLAST21
Topological domaini90 – 209ExtracellularSequence analysisAdd BLAST120
Transmembranei210 – 230HelicalSequence analysisAdd BLAST21
Topological domaini231 – 242CytoplasmicSequence analysisAdd BLAST12
Transmembranei243 – 263HelicalSequence analysisAdd BLAST21
Topological domaini264 – 297ExtracellularSequence analysisAdd BLAST34
Transmembranei298 – 318HelicalSequence analysisAdd BLAST21
Topological domaini319 – 414CytoplasmicSequence analysisAdd BLAST96
Transmembranei415 – 435HelicalSequence analysisAdd BLAST21
Topological domaini436 – 451ExtracellularSequence analysisAdd BLAST16
Transmembranei452 – 472HelicalSequence analysisAdd BLAST21
Topological domaini473 – 935CytoplasmicSequence analysisAdd BLAST463
Transmembranei936 – 956HelicalSequence analysisAdd BLAST21
Topological domaini957 – 962ExtracellularSequence analysis6
Transmembranei963 – 983HelicalSequence analysisAdd BLAST21
Topological domaini984 – 1007CytoplasmicSequence analysisAdd BLAST24
Transmembranei1008 – 1028HelicalSequence analysisAdd BLAST21
Topological domaini1029 – 1046ExtracellularSequence analysisAdd BLAST18
Transmembranei1047 – 1067HelicalSequence analysisAdd BLAST21
Topological domaini1068 – 1085CytoplasmicSequence analysisAdd BLAST18
Transmembranei1086 – 1106HelicalSequence analysisAdd BLAST21
Topological domaini1107 – 1120ExtracellularSequence analysisAdd BLAST14
Transmembranei1121 – 1141HelicalSequence analysisAdd BLAST21
Topological domaini1142 – 1203CytoplasmicSequence analysisAdd BLAST62

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Disruption phenotypei

Disrupts the polyamine uptake and/or transport of the polyamine conjugate Ant-4,4 and norspermidine, a toxic structural analog of the polyamine spermidine. Intracellular levels of the natural polyamines spermidine and putrescine are as wild-type. Double knockout with either odc-1 or smd-1 (two enzymes involved in polyamine synthesis) results in a reduced brood size, delayed postembryonic development and reduced intracellular levels of spermidine. Double knockout with odc-1 results in reduced levels of the polyamine putrescine, while double knockout with smd-1 results in increased accumulation of putrescine.1 Publication

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000463561 – 1203Cation-transporting ATPase catp-5CuratedAdd BLAST1203

Keywords - PTMi

Phosphoprotein

Proteomic databases

EPDiQ21286.
PaxDbiQ21286.
PeptideAtlasiQ21286.
PRIDEiQ21286.

PTM databases

iPTMnetiQ21286.

Expressioni

Tissue specificityi

Expressed in the 20 intestinal cells and in the excretory cell.1 Publication

Developmental stagei

Not expressed in embryos, but expressed at all larval stages of development and in adults.1 Publication

Gene expression databases

BgeeiWBGene00019493.
ExpressionAtlasiQ21286. baseline.

Interactioni

Protein-protein interaction databases

STRINGi6239.K07E3.7b.

Structurei

3D structure databases

ProteinModelPortaliQ21286.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG0208. Eukaryota.
ENOG410XRCA. LUCA.
GeneTreeiENSGT00530000063001.
HOGENOMiHOG000171813.
InParanoidiQ21286.
KOiK14951.
OMAiLPEWGVK.
OrthoDBiEOG091G01IL.
PhylomeDBiQ21286.

Family and domain databases

Gene3Di3.40.1110.10. 1 hit.
3.40.50.1000. 1 hit.
InterProiView protein in InterPro
IPR023299. ATPase_P-typ_cyto_domN.
IPR018303. ATPase_P-typ_P_site.
IPR023298. ATPase_P-typ_TM_dom.
IPR008250. ATPase_P-typ_transduc_dom_A.
IPR036412. HAD-like_sf.
IPR023214. HAD_sf.
IPR006544. P-type_TPase_V.
IPR001757. P_typ_ATPase.
PfamiView protein in Pfam
PF12409. P5-ATPase. 1 hit.
SUPFAMiSSF56784. SSF56784. 3 hits.
SSF81653. SSF81653. 1 hit.
SSF81660. SSF81660. 2 hits.
SSF81665. SSF81665. 3 hits.
TIGRFAMsiTIGR01494. ATPase_P-type. 3 hits.
TIGR01657. P-ATPase-V. 1 hit.
PROSITEiView protein in PROSITE
PS00154. ATPASE_E1_E2. 1 hit.

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform bImported (identifier: Q21286-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MNTSEREPLL DTTTRNRVYD TTDNPSTKIM KREKDNPKAK TTSFNQGKLN
60 70 80 90 100
IGEETCDLYA YKETIGRQIL FWLLTIVTLG FYQLLAYWVK SLFVKVRFQP
110 120 130 140 150
TSHDECEYVM VEDIHGTQTI KEVFKAESDV GLARPTRSGK QEKVKVMRFF
160 170 180 190 200
TYRKIKYIWY EKDQEWLNPA DMDSAAPFNI YQKLTLDVIG LKEQDVIASR
210 220 230 240 250
KIYNMNALAL ALTPILVILF KEVLGPFYLF QCFSVALWYS DNYAYYASVI
260 270 280 290 300
VIITVGSAAV AVYQMRAQEK RIRNMVGDTI SVIVRRDGHD ITIDASEIVP
310 320 330 340 350
MDILILPSNT FILPCDCLLM NGTVIVNEAM LTGESVPVTK ASLKEADECG
360 370 380 390 400
PEIRLSSEHN RHTLFSGTTV LQTRNYKGQP VMARVIRTGF STLKGQLVRS
410 420 430 440 450
IMYPKPQEKE ALKDVMVFIL VLGFIALIGF IYTVIEMVSR GESLKHIIIR
460 470 480 490 500
SLDIITIVVP PALPAAMSVG IINANSRLKK KKIFCTSPTT VNVCGLINVA
510 520 530 540 550
CFDKTGTLTE DGLDFNCLKA IRKNEDGKPE FTSEFEELDP VKLSAENANL
560 570 580 590 600
NIVVAAASCH SLTRIDGTLH GDPLELILVE KSKWIIEEAV NSDEETQDFD
610 620 630 640 650
TVQPTVLRPP PEQATYHPEN NEYSVIKQHP FNSALQRMSV IISTPSEHSA
660 670 680 690 700
HDMMVFTKGS PEMIASLCIP DTIPEDYMEV VDEYAQRGFR LIAVASKAVH
710 720 730 740 750
LNFAKALKTP RDIMESELEF LGLIVMENRL KDVTLSVINE LSVANIRCVM
760 770 780 790 800
VTGDNLLTAM SVARECGIIR PTKKAFLITH SKTEKDPLGR TKLFIKESVS
810 820 830 840 850
SSENDIDTDS EVRAFDRKAV LRTATYQMAI AGPTYSVITH EYPELVDRIT
860 870 880 890 900
AMCDVYARMA PDQKAQLIGA LQEIGAKVSM CGDGANDCAA LKAAHAGISL
910 920 930 940 950
SQAEASIAAP FTSNVPDIRC VPTVIKEGRC ALVTSYAVSK YMAAYSLNEF
960 970 980 990 1000
LSVMLLYNDG TNISDGQFLY IDLVLITLVA LFLGNTEASR KLSGIPPPRR
1010 1020 1030 1040 1050
LATSAFYFSV FGQMFFNIIT QTTGYLLVRG QSWYVPNPEE LDNTTTMIGT
1060 1070 1080 1090 1100
TVFFTSCCMY LGYAFVYSKG HPYRRSVFTN WLLCGIIFVI GAINMVMIFT
1110 1120 1130 1140 1150
NMGFLMNLMG FVYVPSTSMR FILLAISLAG VFLSLLYEHF FVEKVVAIHF
1160 1170 1180 1190 1200
ESYLRQRRLR NGDPSLSAYE KILAAIGSSP RWFEDEINLS KSIDRKETIE

SKC
Length:1,203
Mass (Da):134,704
Last modified:January 4, 2005 - v4
Checksum:i474DAF607FF8BFA0
GO
Isoform aImported (identifier: Q21286-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-29: Missing.

Show »
Length:1,174
Mass (Da):131,352
Checksum:i136A66790C63D166
GO

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0124581 – 29Missing in isoform a. CuratedAdd BLAST29

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
FO080274 Genomic DNA. Translation: CCD62517.1.
FO080274 Genomic DNA. Translation: CCD62518.1.
PIRiA89583.
RefSeqiNP_001024767.1. NM_001029596.2. [Q21286-2]
NP_001024768.1. NM_001029597.1. [Q21286-1]
UniGeneiCel.718.

Genome annotation databases

EnsemblMetazoaiK07E3.7b; K07E3.7b; WBGene00019493. [Q21286-1]
GeneIDi181067.
KEGGicel:CELE_K07E3.7.

Keywords - Coding sequence diversityi

Alternative splicing

Similar proteinsi

Entry informationi

Entry nameiCATP5_CAEEL
AccessioniPrimary (citable) accession number: Q21286
Secondary accession number(s): Q10461, Q65ZI7, Q65ZI8
Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 30, 2000
Last sequence update: January 4, 2005
Last modified: October 25, 2017
This is version 135 of the entry and version 4 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programCaenorhabditis annotation project

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Caenorhabditis elegans
    Caenorhabditis elegans: entries, gene names and cross-references to WormBase
  2. SIMILARITY comments
    Index of protein domains and families