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Protein

Gelsolin-like protein 1

Gene

gsnl-1

Organism
Caenorhabditis elegans
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Calcium-regulated, actin-modulating protein that binds to the plus (or barbed) ends of actin monomers or filaments, preventing monomer exchange (end-blocking or capping). Binds actin but does not nucleate actin polymerization, albeit slows down elongation by blocking the barbed ends.2 Publications

GO - Molecular functioni

  • actin filament binding Source: WormBase
  • actin monomer binding Source: WormBase
  • calcium ion binding Source: InterPro
  • phosphatidylinositol-4,5-bisphosphate binding Source: WormBase

GO - Biological processi

  • actin filament severing Source: WormBase
  • actin nucleation Source: InterPro
  • barbed-end actin filament capping Source: WormBase
Complete GO annotation...

Keywords - Molecular functioni

Actin capping

Keywords - Ligandi

Actin-binding, Calcium

Names & Taxonomyi

Protein namesi
Recommended name:
Gelsolin-like protein 11 Publication
Gene namesi
Name:gsnl-1Imported
ORF Names:K06A4.3
OrganismiCaenorhabditis elegans
Taxonomic identifieri6239 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaNematodaChromadoreaRhabditidaRhabditoideaRhabditidaePeloderinaeCaenorhabditis
Proteomesi
  • UP000001940 Componenti: Chromosome V

Organism-specific databases

WormBaseiK06A4.3; CE06107; WBGene00010593; gsnl-1.

Subcellular locationi

  • Cytoplasmcytoskeleton By similarity

GO - Cellular componenti

  • actin cytoskeleton Source: WormBase
  • striated muscle dense body Source: WormBase
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Cytoskeleton

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 475475Gelsolin-like protein 1PRO_0000412119Add
BLAST

Proteomic databases

EPDiQ21253.
PaxDbiQ21253.
PRIDEiQ21253.

Expressioni

Gene expression databases

BgeeiWBGene00010593.

Interactioni

Subunit structurei

Monomer. Binds to actin monomers and filaments.

GO - Molecular functioni

  • actin filament binding Source: WormBase
  • actin monomer binding Source: WormBase

Protein-protein interaction databases

STRINGi6239.K06A4.3.

Structurei

3D structure databases

ProteinModelPortaliQ21253.
SMRiQ21253. Positions 8-455.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Repeati27 – 10579Gelsolin-like 1Sequence analysisAdd
BLAST
Repeati148 – 20861Gelsolin-like 2Sequence analysisAdd
BLAST
Repeati275 – 34167Gelsolin-like 3Sequence analysisAdd
BLAST
Repeati375 – 44773Gelsolin-like 4Sequence analysisAdd
BLAST

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni1 – 239239Necessary for barbed end capping activity1 PublicationAdd
BLAST
Regioni1 – 131131Actin binding, actin severing, Ca-sensitive1 PublicationAdd
BLAST
Regioni70 – 734Actin-actin interfilament contact pointBy similarity
Regioni133 – 22795Required for phosphatidylinositol 4,5-bisphosphate binding and regulation1 PublicationAdd
BLAST
Regioni240 – 475236F- and G-actin binding, Ca-independent1 PublicationAdd
BLAST
Regioni248 – 348101Inhibitory for phosphatidylinositol 4,5-bisphosphate binding activity1 PublicationAdd
BLAST

Sequence similaritiesi

Belongs to the villin/gelsolin family.Sequence analysis
Contains 4 gelsolin-like repeats.Sequence analysis

Keywords - Domaini

Repeat

Phylogenomic databases

eggNOGiKOG0443. Eukaryota.
ENOG410XR0A. LUCA.
GeneTreeiENSGT00760000119111.
HOGENOMiHOG000021608.
InParanoidiQ21253.
OMAiDDDDNYW.
OrthoDBiEOG091G05SC.
PhylomeDBiQ21253.

Family and domain databases

Gene3Di3.40.20.10. 4 hits.
InterProiIPR029006. ADF-H/Gelsolin-like_dom.
IPR030004. Gelsolin.
IPR007123. Gelsolin-like_dom.
IPR007122. Villin/Gelsolin.
[Graphical view]
PANTHERiPTHR11977. PTHR11977. 1 hit.
PTHR11977:SF39. PTHR11977:SF39. 1 hit.
PfamiPF00626. Gelsolin. 4 hits.
[Graphical view]
PRINTSiPR00597. GELSOLIN.
SMARTiSM00262. GEL. 4 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q21253-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MGGTSLDPAL AEIGKKNGLL VWRINKFVLE PVPEVDHGVF YIGDAYIALY
60 70 80 90 100
QKYDGCWDVH FWLGKNASTD EIGVAAIKTV EIDDSLGGIP TQHREIQNYE
110 120 130 140 150
SPLFLSYFPD GIRYVSGGYE SGYRHVDDQF KNWKPHLFHC KGKRNVRCTE
160 170 180 190 200
VECEVNSLNL GDVFILDLGK DLYVWMPPES GRLERIKGMA RAKNIADHER
210 220 230 240 250
MGIPKVHILD DVEWDNDSTF WSYFGGVSSV RKVSKGKDDD DNYWKRLTEQ
260 270 280 290 300
ITLWKVSDAS GAAKVSMVSQ GENIRKEQLD PKDAFILDAI NGGIFVWIGH
310 320 330 340 350
ECTLEERSKA LIWGQNYLKQ HHLPRWTQVT RVLESAESTQ FTQWFRDWVD
360 370 380 390 400
EKKKNTFTPL LFQVSDESGL LHVEEIANFT QEDLDGDDVM ILDALNSIYV
410 420 430 440 450
WVGANANANE KKEALNTAKL YLEKDKLPRH KKTAIDTIFQ GKEPPTFKKF
460 470
FPSWDDNLFK NEVRSVQNMR RLLFH
Length:475
Mass (Da):54,592
Last modified:November 1, 1996 - v1
Checksum:i70369567F80280F5
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Z70755 Genomic DNA. Translation: CAA94782.1.
PIRiT23355.
RefSeqiNP_505448.1. NM_073047.5.
UniGeneiCel.3126.

Genome annotation databases

EnsemblMetazoaiK06A4.3; K06A4.3; WBGene00010593.
GeneIDi179328.
KEGGicel:CELE_K06A4.3.
UCSCiK06A4.3. c. elegans.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Z70755 Genomic DNA. Translation: CAA94782.1.
PIRiT23355.
RefSeqiNP_505448.1. NM_073047.5.
UniGeneiCel.3126.

3D structure databases

ProteinModelPortaliQ21253.
SMRiQ21253. Positions 8-455.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi6239.K06A4.3.

Proteomic databases

EPDiQ21253.
PaxDbiQ21253.
PRIDEiQ21253.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblMetazoaiK06A4.3; K06A4.3; WBGene00010593.
GeneIDi179328.
KEGGicel:CELE_K06A4.3.
UCSCiK06A4.3. c. elegans.

Organism-specific databases

CTDi179328.
WormBaseiK06A4.3; CE06107; WBGene00010593; gsnl-1.

Phylogenomic databases

eggNOGiKOG0443. Eukaryota.
ENOG410XR0A. LUCA.
GeneTreeiENSGT00760000119111.
HOGENOMiHOG000021608.
InParanoidiQ21253.
OMAiDDDDNYW.
OrthoDBiEOG091G05SC.
PhylomeDBiQ21253.

Miscellaneous databases

PROiQ21253.

Gene expression databases

BgeeiWBGene00010593.

Family and domain databases

Gene3Di3.40.20.10. 4 hits.
InterProiIPR029006. ADF-H/Gelsolin-like_dom.
IPR030004. Gelsolin.
IPR007123. Gelsolin-like_dom.
IPR007122. Villin/Gelsolin.
[Graphical view]
PANTHERiPTHR11977. PTHR11977. 1 hit.
PTHR11977:SF39. PTHR11977:SF39. 1 hit.
PfamiPF00626. Gelsolin. 4 hits.
[Graphical view]
PRINTSiPR00597. GELSOLIN.
SMARTiSM00262. GEL. 4 hits.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiGELS1_CAEEL
AccessioniPrimary (citable) accession number: Q21253
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 27, 2011
Last sequence update: November 1, 1996
Last modified: September 7, 2016
This is version 98 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programCaenorhabditis annotation project

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Caenorhabditis elegans
    Caenorhabditis elegans: entries, gene names and cross-references to WormBase
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.