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Protein

Zinc metalloproteinase nas-3

Gene

nas-3

Organism
Caenorhabditis elegans
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Metalloprotease.By similarity

Cofactori

Zn2+By similarityNote: Binds 1 zinc ion per subunit.By similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi169Zinc; catalyticPROSITE-ProRule annotation1
Active sitei170PROSITE-ProRule annotation1
Metal bindingi173Zinc; catalyticPROSITE-ProRule annotation1
Metal bindingi179Zinc; catalyticPROSITE-ProRule annotation1

GO - Molecular functioni

Keywordsi

Molecular functionHydrolase, Metalloprotease, Protease
LigandMetal-binding, Zinc

Protein family/group databases

MEROPSiM12.A16

Names & Taxonomyi

Protein namesi
Recommended name:
Zinc metalloproteinase nas-3 (EC:3.4.24.-By similarity)
Alternative name(s):
Nematode astacin 3
Gene namesi
Name:nas-3
ORF Names:K06A4.1
OrganismiCaenorhabditis elegans
Taxonomic identifieri6239 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaNematodaChromadoreaRhabditidaRhabditoideaRhabditidaePeloderinaeCaenorhabditis
Proteomesi

Organism-specific databases

WormBaseiK06A4.1 ; CE35894 ; WBGene00003522 ; nas-3

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_0000028908? – 292Zinc metalloproteinase nas-3
Signal peptidei1 – 16Sequence analysisAdd BLAST16
PropeptideiPRO_000044265117 – ?Curated

Keywords - PTMi

Zymogen

Proteomic databases

PaxDbiQ21252
PRIDEiQ21252

Expressioni

Gene expression databases

BgeeiWBGene00003522

Interactioni

Protein-protein interaction databases

STRINGi6239.K06A4.1

Structurei

3D structure databases

ProteinModelPortaliQ21252
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the peptidase M12A family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiKOG3714 Eukaryota
ENOG410ZPX7 LUCA
GeneTreeiENSGT00760000119227
HOGENOMiHOG000021605
InParanoidiQ21252
KOiK08076
OMAiPWQKRDY
OrthoDBiEOG091G0FB4
PhylomeDBiQ21252

Family and domain databases

Gene3Di3.40.390.10, 1 hit
InterProiView protein in InterPro
IPR024079 MetalloPept_cat_dom_sf
IPR001506 Peptidase_M12A
IPR006026 Peptidase_Metallo
PfamiView protein in Pfam
PF01400 Astacin, 1 hit
PRINTSiPR00480 ASTACIN
SMARTiView protein in SMART
SM00235 ZnMc, 1 hit
PROSITEiView protein in PROSITE
PS00142 ZINC_PROTEASE, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q21252-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MYRFIIFFSL LALTASKVSE PEKDDEIAVK IPTKRSVSEP PKDDDIAVKI
60 70 80 90 100
PMRKKRGIAI HPWQWESHLW PNAEVPYDIA SHYTATERGI ILSAMEAFRD
110 120 130 140 150
VTCVRFRPRR STDKHYLQIN KHYQLERCFS YIGRQSSRWL FGTRDGKVET
160 170 180 190 200
RMKLDPSCLL YNGRGTVMHE LMHILGFYHE HQRDDRDRRI GGSASHYNFK
210 220 230 240 250
IYQRAKSYYM GGYDANSIMH YNFGSVPWQK RDYFSPSDIR NINTLYKCNN
260 270 280 290
RVVSKFPSTI PSTSTTTTKA PQFELFEKKQ IESNSLFRRR RS
Length:292
Mass (Da):34,400
Last modified:July 5, 2004 - v2
Checksum:i0CDC6A600AB5EC48
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Z70755 Genomic DNA Translation: CAA94781.2
AJ561200 mRNA Translation: CAD99180.1
PIRiT23354
RefSeqiNP_505445.2, NM_073044.4
UniGeneiCel.3128

Genome annotation databases

EnsemblMetazoaiK06A4.1; K06A4.1; WBGene00003522
GeneIDi187045
KEGGicel:CELE_K06A4.1
UCSCiK06A4.1 c. elegans

Entry informationi

Entry nameiNAS3_CAEEL
AccessioniPrimary (citable) accession number: Q21252
Secondary accession number(s): Q7Z0P2
Entry historyiIntegrated into UniProtKB/Swiss-Prot: January 4, 2005
Last sequence update: July 5, 2004
Last modified: May 23, 2018
This is version 113 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programCaenorhabditis annotation project

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Caenorhabditis elegans
    Caenorhabditis elegans: entries, gene names and cross-references to WormBase
  2. Peptidase families
    Classification of peptidase families and list of entries
  3. SIMILARITY comments
    Index of protein domains and families

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