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Protein

Zinc metalloproteinase nas-3

Gene

nas-3

Organism
Caenorhabditis elegans
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

Probable metalloprotease.By similarity

Catalytic activityi

Hydrolysis of peptide bonds in substrates containing five or more amino acids, preferentially with Ala in P1', and Pro in P2'.

Cofactori

Zn2+By similarityNote: Binds 1 zinc ion per subunit.By similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi169Zinc; catalyticPROSITE-ProRule annotation1
Active sitei170PROSITE-ProRule annotation1
Metal bindingi173Zinc; catalyticPROSITE-ProRule annotation1
Metal bindingi179Zinc; catalyticPROSITE-ProRule annotation1

GO - Molecular functioni

Complete GO annotation...

Keywords - Molecular functioni

Hydrolase, Metalloprotease, Protease

Keywords - Ligandi

Metal-binding, Zinc

Protein family/group databases

MEROPSiM12.A16.

Names & Taxonomyi

Protein namesi
Recommended name:
Zinc metalloproteinase nas-3 (EC:3.4.24.21)
Alternative name(s):
Nematode astacin 3
Gene namesi
Name:nas-3
ORF Names:K06A4.1
OrganismiCaenorhabditis elegans
Taxonomic identifieri6239 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaNematodaChromadoreaRhabditidaRhabditoideaRhabditidaePeloderinaeCaenorhabditis
Proteomesi
  • UP000001940 Componenti: Chromosome V

Organism-specific databases

WormBaseiK06A4.1; CE35894; WBGene00003522; nas-3.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 16Sequence analysisAdd BLAST16
ChainiPRO_000002890817 – 292Zinc metalloproteinase nas-3Add BLAST276

Proteomic databases

PaxDbiQ21252.

Expressioni

Gene expression databases

BgeeiWBGene00003522.

Interactioni

Protein-protein interaction databases

STRINGi6239.K06A4.1.

Structurei

3D structure databases

ProteinModelPortaliQ21252.
SMRiQ21252.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the peptidase M12A family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiKOG3714. Eukaryota.
ENOG410ZPX7. LUCA.
GeneTreeiENSGT00760000119227.
HOGENOMiHOG000021605.
InParanoidiQ21252.
KOiK08076.
OMAiPWQKRDY.
OrthoDBiEOG091G0FB4.
PhylomeDBiQ21252.

Family and domain databases

Gene3Di3.40.390.10. 1 hit.
InterProiIPR024079. MetalloPept_cat_dom.
IPR001506. Peptidase_M12A.
IPR006026. Peptidase_Metallo.
[Graphical view]
PfamiPF01400. Astacin. 1 hit.
[Graphical view]
PRINTSiPR00480. ASTACIN.
SMARTiSM00235. ZnMc. 1 hit.
[Graphical view]
PROSITEiPS00142. ZINC_PROTEASE. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q21252-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MYRFIIFFSL LALTASKVSE PEKDDEIAVK IPTKRSVSEP PKDDDIAVKI
60 70 80 90 100
PMRKKRGIAI HPWQWESHLW PNAEVPYDIA SHYTATERGI ILSAMEAFRD
110 120 130 140 150
VTCVRFRPRR STDKHYLQIN KHYQLERCFS YIGRQSSRWL FGTRDGKVET
160 170 180 190 200
RMKLDPSCLL YNGRGTVMHE LMHILGFYHE HQRDDRDRRI GGSASHYNFK
210 220 230 240 250
IYQRAKSYYM GGYDANSIMH YNFGSVPWQK RDYFSPSDIR NINTLYKCNN
260 270 280 290
RVVSKFPSTI PSTSTTTTKA PQFELFEKKQ IESNSLFRRR RS
Length:292
Mass (Da):34,400
Last modified:July 5, 2004 - v2
Checksum:i0CDC6A600AB5EC48
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Z70755 Genomic DNA. Translation: CAA94781.2.
AJ561200 mRNA. Translation: CAD99180.1.
PIRiT23354.
RefSeqiNP_505445.2. NM_073044.4.
UniGeneiCel.3128.

Genome annotation databases

EnsemblMetazoaiK06A4.1; K06A4.1; WBGene00003522.
GeneIDi187045.
KEGGicel:CELE_K06A4.1.
UCSCiK06A4.1. c. elegans.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Z70755 Genomic DNA. Translation: CAA94781.2.
AJ561200 mRNA. Translation: CAD99180.1.
PIRiT23354.
RefSeqiNP_505445.2. NM_073044.4.
UniGeneiCel.3128.

3D structure databases

ProteinModelPortaliQ21252.
SMRiQ21252.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi6239.K06A4.1.

Protein family/group databases

MEROPSiM12.A16.

Proteomic databases

PaxDbiQ21252.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblMetazoaiK06A4.1; K06A4.1; WBGene00003522.
GeneIDi187045.
KEGGicel:CELE_K06A4.1.
UCSCiK06A4.1. c. elegans.

Organism-specific databases

CTDi187045.
WormBaseiK06A4.1; CE35894; WBGene00003522; nas-3.

Phylogenomic databases

eggNOGiKOG3714. Eukaryota.
ENOG410ZPX7. LUCA.
GeneTreeiENSGT00760000119227.
HOGENOMiHOG000021605.
InParanoidiQ21252.
KOiK08076.
OMAiPWQKRDY.
OrthoDBiEOG091G0FB4.
PhylomeDBiQ21252.

Miscellaneous databases

PROiQ21252.

Gene expression databases

BgeeiWBGene00003522.

Family and domain databases

Gene3Di3.40.390.10. 1 hit.
InterProiIPR024079. MetalloPept_cat_dom.
IPR001506. Peptidase_M12A.
IPR006026. Peptidase_Metallo.
[Graphical view]
PfamiPF01400. Astacin. 1 hit.
[Graphical view]
PRINTSiPR00480. ASTACIN.
SMARTiSM00235. ZnMc. 1 hit.
[Graphical view]
PROSITEiPS00142. ZINC_PROTEASE. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiNAS3_CAEEL
AccessioniPrimary (citable) accession number: Q21252
Secondary accession number(s): Q7Z0P2
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 4, 2005
Last sequence update: July 5, 2004
Last modified: November 2, 2016
This is version 107 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programCaenorhabditis annotation project

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Caenorhabditis elegans
    Caenorhabditis elegans: entries, gene names and cross-references to WormBase
  2. Peptidase families
    Classification of peptidase families and list of entries
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.